专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

KR1020130085308A 인간 배아줄기세포 유래 혈관주위 전구세포의 제조방법 및 이를 포함하는 세포치료 조성물 有权
标题翻译：用于生产人胚胎干细胞衍生的外源性原核细胞的方法和包含其的细胞疗法的组合物
公开(公告)号：KR1020130085308A
公开(公告)日：2013-07-29
申请号：KR1020120006371
申请日：2012-01-19
申请人： (주)차바이오텍 , 차의과학대학교 산학협력단
发明人： 김정모 , 송원경 , 정형민
IPC分类号： C12N5/071 , C12N5/00 , C12N9/76
CPC分类号： C12N5/0692 , A61K35/00 , C12N5/0662 , C12N2501/155 , C12N2506/02 , C12N5/0068 , C12N9/6427 , C12N2501/105 , C12N2501/165 , C12N2533/52 , C12N2533/54
摘要： PURPOSE: A manufacturing method of a human embryonic stem cell originated pericyte progenitor cell is provided to manufacture a human embryonic stem cell originated pericyte progenitor cell which is able to be useful as a cytotherapy composition for treatment or prevention of cardiovascular diseases or retinal disorders. CONSTITUTION: A manufacturing method of a pericyte progenitor cell from a stem cell comprises 1) a step of treating a stem cell originated embryoid body with a bone morphogenetic protein 4 (BMP4) growth factor to differentiate to a mesodermal cell; 2) a step of isolating the embryoid body including the differentiated mesodermal cell to a single cell; and 3) a step of cultivating the isolated single cell in a petri dish coated with a substrate, and proliferating the attached cells only by natural selection; The stem cell in step 1) is selected from the group consisting of human embryonic stem cell, induced pluripotent stem cell (iPSC) and somatic cell nuclear transfer cell (SCNT). A pharmaceutical composition for prevention and treatment of cardiovascular diseases includes the pericyte progenitor cell as an active ingredient.
摘要翻译：目的：提供一种人胚胎干细胞产生的周细胞祖细胞的制造方法，用于制造能够用作治疗或预防心血管疾病或视网膜疾病的细胞疗法组合物的源于人胚胎干细胞的周细胞祖细胞。构成：来自干细胞的周细胞祖细胞的制造方法包括1）用骨形态发生蛋白4（BMP4）生长因子处理源自干细胞的胚状体的步骤，以分化成中胚层细胞; 2）将包括分化的中胚层细胞的胚状体分离成单个细胞的步骤; 和3）在涂覆有底物的陪替氏培养皿中培养分离的单细胞的步骤，并且仅通过自然选择增殖附着的细胞; 步骤1）中的干细胞选自人胚胎干细胞，诱导多能干细胞（iPSC）和体细胞核转移细胞（SCNT）。用于预防和治疗心血管疾病的药物组合物包括周细胞祖细胞作为活性成分。

2. 发明授权

KR101972766B1 인간 다능성 줄기세포 단일세포의 계대배양 방법, 및 이를 이용한 형질전환 인간 다능성 줄기세포 제조 방법 有权
公开(公告)号：KR101972766B1
公开(公告)日：2019-04-29
申请号：KR1020120041753
申请日：2012-04-20
申请人： (주)차바이오텍 , 차의과학대학교 산학협력단
发明人： 김정모 , 문성환 , 박순정 , 정형민 , 황성규
IPC分类号： C12N5/0735 , C12N5/074 , C12N15/86

3. 发明授权

KR101477016B1 인간 배아줄기세포 유래 혈관주위 전구세포의 제조방법 및 이를 포함하는 세포치료 조성물 有权
标题翻译：用于生产人胚胎干细胞衍生的血管周围祖细胞的方法和包含其的细胞疗法组合物
公开(公告)号：KR101477016B1
公开(公告)日：2014-12-29
申请号：KR1020120006371
申请日：2012-01-19
申请人： (주)차바이오텍 , 차의과학대학교 산학협력단
发明人： 김정모 , 송원경 , 정형민
IPC分类号： C12N5/071 , C12N5/00 , C12N9/76
CPC分类号： C12N5/0692 , A61K35/00 , C12N5/0662 , C12N2501/155 , C12N2506/02
摘要： 본발명은줄기세포의배상체로부터혈관주위전구세포를제조하는방법, 이를유효성분으로포함하는심혈관질환또는망막질환의예방또는치료용세포치료조성물, 및상기조성물을이용하여심혈관질환또는망막질환을치료하는방법에관한것이다. 보다구체적으로, 줄기세포배상체에 BMP4 성장인자를처리하여중배엽성세포로의분화를유도하고, 상기분화된중배엽성세포를포함하는배상체를단일세포로분리한후, 기질이코팅된배양접시에배양하여부착된세포만을자연선택으로증식시키는줄기세포로부터의혈관주위전구세포제조방법, 상기방법으로제조된혈관주위전구세포, 이를유효성분으로포함하는심혈관질환또는망막질환의예방또는치료용세포치료조성물, 및상기조성물을이용하여심혈관질환또는망막질환을치료하는방법에관한것이다.

4. 发明公开

KR1020130118674A 인간 다능성 줄기세포 단일세포의 계대배양 방법, 및 이를 이용한 형질전환 인간 다능성 줄기세포 제조 방법 审中-实审
标题翻译：用于人单核细胞干细胞的再培养的方法及使用其制备转化的人肺细胞干细胞的方法
公开(公告)号：KR1020130118674A
公开(公告)日：2013-10-30
申请号：KR1020120041753
申请日：2012-04-20
申请人： (주)차바이오텍 , 차의과학대학교 산학협력단
发明人： 김정모 , 문성환 , 박순정 , 정형민 , 황성규
IPC分类号： C12N5/074 , C12N5/0735 , C12N5/02 , C12N15/86
摘要： PURPOSE: A subculture method of human pluripotent stem cells (hPSCs) is provided to allow isolated hPSCs, hart to culture, to form cell colonies and to be subcultured with maintaining pluripotency, so that the clonal isolated hPSCs are used for follow-up studies such as gene transduction, differentiation induction, etc. CONSTITUTION: A subculture method of hPSC single cells comprises: a step of preparing isolated hPSC single cells; and a step of enhancing colony formation potency by suppressing Gi-mediated GPCR signal transduction in the hPSC single cells. A manufacturing method of hPSC colonies comprises: a step of preparing isolated hPSC single cells; and a step of enhancing colony formation potency by suppressing Gi-mediated GPCR signal transduction in the hPSC single cells. [Reference numerals] (AA) Single hESC; (BB) Cell group forming area
摘要翻译：目的：提供人多能干细胞（hPSC）的传代培养方法，以允许分离的hPSC，hart培养，形成细胞集落，并保持多能性进行传代培养，使得克隆分离的hPSC用于后续研究，作为基因转导，分化诱导等。构成：hPSC单细胞的传代培养方法包括：制备分离的hPSC单细胞的步骤; 以及通过抑制hPSC单细胞中的Gi介导的GPCR信号转导来增强集落形成能力的步骤。 hPSC菌落的制备方法包括：制备分离的hPSC单细胞的步骤; 以及通过抑制hPSC单细胞中的Gi介导的GPCR信号转导来增强集落形成能力的步骤。（附图标记）（AA）单个hESC; （BB）细胞组形成区

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式