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1. 发明公开

KR1020140035133A 전기 천공 장치 및 전기 천공 방법 审中-实审
标题翻译：电气设备和方法
公开(公告)号：KR1020140035133A
公开(公告)日：2014-03-21
申请号：KR1020120101606
申请日：2012-09-13
申请人： (주)아모레퍼시픽
发明人： 박진우 , 장지혜 , 김재관 , 황정환 , 박우람 , 이지해 , 배준호 , 김건형
IPC分类号： A61N1/18 , A61N1/32 , A61N1/30 , A61M37/00
摘要： An electroporation device according to an embodiment of the present invention comprises: multiple electrode pins touching skin to perforate the skin; a wiring board having a wiring pattern to transmit voltage to the multiple electrode pins; a voltage generating part generating the voltage transmitted to the multiple electrode pins through the wiring pattern of the wiring board; a controlling part controlling the polarity of the voltage transmitted to the multiple electrode pins to make any neighboring electrode pins among the multiple electrode pins have different polarities in every cycle; and a voltage compensating part measuring the resistance of the skin where the multiple electrode pins touch, and compensating the voltage level transmitted to the multiple electrode pins according to the resistance level. [Reference numerals] (110) Main body; (111) Power unit; (112) Voltage generating part; (113) Controlling part; (114) Operation display part; (115) Power display part; (116) Voltage compensating part; (120) Perforating part; (121) Wiring board; (122) Electrode pin; (123) Pin guide; (130) Piezo switch
摘要翻译：根据本发明的实施例的电穿孔装置包括：多个电极针接触皮肤以穿透皮肤; 具有向多个电极引脚传输电压的布线图案的布线板; 电压产生部件，通过布线板的布线图形产生传输到多个电极引脚的电压; 控制部分控制传输到多个电极引脚的电压的极性，使得多个电极引脚中的任何相邻的电极引脚在每个周期中具有不同的极性; 以及电压补偿部，其测量多个电极引脚接触的皮肤的电阻，并根据电阻水平补偿传输到多个电极引脚的电压电平。（附图标记）（110）主体; （111）动力单元; （112）电压产生部; （113）控制部分; （114）操作显示部分; （115）电源显示部分; （116）电压补偿部; （120）穿孔部分; （121）接线板; （122）电极针; （123）引脚引导; （130）压电开关

2. 发明授权

KR101729140B1 쓴 맛 또는 냄새가 차폐된 아미노산 조성물 有权
标题翻译：苦味或臭味掩蔽的氨基酸组合物
公开(公告)号：KR101729140B1
公开(公告)日：2017-04-26
申请号：KR1020100085038
申请日：2010-08-31
申请人： (주)아모레퍼시픽
发明人： 신광현 , 전재일 , 김재관 , 빈성아 , 우병영 , 배준호
IPC分类号： C08K5/20 , C08L33/00 , C08J3/12 , A61K31/194
摘要： 본발명은분지쇄아미노산및 카르복실기를포함하는고분자화합물을포함하는조성물을개시한다. 상기조성물은아미노산의쓴 맛또는냄새가차폐되어복용하기편리하다. 또한본 발명은분지쇄아미노산과카르복실기를포함하는고분자화합물을혼합하는단계를포함하는분지쇄아미노산의쓴 맛또는냄새차폐방법을개시한다.
摘要翻译：本发明公开了包含含有支链氨基酸和羧基的聚合物的组合物。该组合物很容易摄入，因为它可以防止苦味或氨基酸的味道。本发明还公开了支链氨基酸的苦味或气味遮蔽方法，其包括混合包含支链氨基酸和羧基的聚合物化合物的步骤。

3. 发明公开

KR1020110075011A 서방성 미립자 및 이의 제조방법 无效
标题翻译：缓释颗粒及其生产方法
公开(公告)号：KR1020110075011A
公开(公告)日：2011-07-05
申请号：KR1020117010529
申请日：2009-11-10
申请人： (주)아모레퍼시픽
发明人： 신광현 , 김재관 , 전재일 , 홍덕기 , 배준호
IPC分类号： A61K9/16 , A61K47/48
CPC分类号： A61K9/5047 , A61K9/5026 , A61K9/5042 , A61K9/16 , A61K47/50
摘要： PURPOSE: A sustained release fine particle containing a matrix containing pharmaceutically active ingredients and a sustained release layer is provided to ensure excellent elution effect. CONSTITUTION: A sustained release fine particle comprises: a matrix containing pharmacologically active ingredients; and a sustained release layer containing a sustained release membrane forming material on the matrix. The sustained release membrane forming material is a water insoluble polymer, enteric polymer, soluble polymer, or mixture thereof. The insoluble polymer is ethyl cellulose, cellulose ether, acrylic acid ethyl-methacrylic acid methyl-methacrylic acid trimethyl ammonium ethyl chloride copolymer, polyvinyl acetate, and acrylic acid ethyl-methacrylic acid methyl copolymer or dispersion solution thereof. The soluble polymer is hydroxypropyl cellulose, hydroxypropyl methyl cellulose, polyvinyl pyrolidone, or polyvinyl alcohol. The matrix further contains an excipient or binder.
摘要翻译：目的：提供含有含有药物活性成分和持续释放层的基质的缓释微粒，以确保优异的洗脱效果。构成：缓释微粒包括：含有药理活性成分的基质; 以及在基质上含有缓释膜形成材料的持续释放层。缓释膜形成材料是水不溶性聚合物，肠溶聚合物，可溶性聚合物或其混合物。不溶性聚合物是乙基纤维素，纤维素醚，丙烯酸乙基 - 甲基丙烯酸甲基 - 甲基丙烯酸三甲基铵乙基氯共聚物，聚乙酸乙烯酯和丙烯酸乙基 - 甲基丙烯酸甲基共聚物或其分散溶液。可溶性聚合物是羟丙基纤维素，羟丙基甲基纤维素，聚乙烯吡咯烷酮或聚乙烯醇。基质还含有赋形剂或粘合剂。

4. 发明授权

KR101417328B1 생체막 투과성 조성물 有权
标题翻译：生物膜渗透性成分
公开(公告)号：KR101417328B1
公开(公告)日：2014-07-08
申请号：KR1020120093838
申请日：2012-08-27
申请人： (주)아모레퍼시픽
发明人： 장지혜 , 김재관 , 박진우 , 배준호
IPC分类号： A61K47/42 , A61K47/48 , C07K7/08 , C12N15/09
摘要： 본 발명은 운반 대상 물질; 및 운반 대상 물질의 한쪽 또는 양쪽 말단에 결합된 서열 번호 1 또는 서열 번호 2의 아미노산 서열을 포함하는 저분자량 프로타민을 포함하는 생체막 투과성 조성물을 개시한다.

5. 发明公开

KR1020120021022A 쓴 맛 또는 냄새가 차폐된 아미노산 조성물 有权
标题翻译：氨基酸组成，其中BITTERNESS和SMELL被掩蔽
公开(公告)号：KR1020120021022A
公开(公告)日：2012-03-08
申请号：KR1020100085038
申请日：2010-08-31
申请人： (주)아모레퍼시픽
发明人： 신광현 , 전재일 , 김재관 , 빈성아 , 우병영 , 배준호
IPC分类号： C08K5/20 , C08L33/00 , C08J3/12 , A61K31/194
CPC分类号： C08K5/20 , A61K31/194 , C08J3/12 , C08L33/00
摘要： PURPOSE: An aminoacid composition containing branched amino acid is provided to shield include a bitter taste or inherent smell of branched chain amino acid by including a polymer compound containing a carboxyl group. CONSTITUTION: An aminoacid composition comprises a branched aminoacid, and a polymer compound containing carboxy group. The branched amino acid comprises one or more selected from a group consisting of isoleucine, leucine and valine. The polymer compound containing a carboxy group comprises one or more selected from a group consisting anionic polymethacrylic acid copolymer, cellulose acetate phthalate, polyvinyl acetate phthalate and hydroxypropyl methylcellulose phthalate.
摘要翻译：目的：提供含有支链氨基酸的氨基酸组合物，其包括含有羧基的高分子化合物，包括支链氨基酸的苦味或固有气味。构成：氨基酸组合物包含支链氨基酸和含有羧基的高分子化合物。支链氨基酸包含选自异亮氨酸，亮氨酸和缬氨酸的一种或多种。含有羧基的高分子化合物包括选自阴离子聚甲基丙烯酸共聚物，乙酸邻苯二甲酸纤维素，聚乙酸乙烯邻苯二甲酸酯和羟丙基甲基纤维素邻苯二甲酸酯中的一种或多种。

6. 发明授权

KR101979746B1 전기 천공 장치 有权
公开(公告)号：KR101979746B1
公开(公告)日：2019-05-17
申请号：KR1020120101606
申请日：2012-09-13
申请人： (주)아모레퍼시픽
发明人： 박진우 , 장지혜 , 김재관 , 황정환 , 박우람 , 이지해 , 배준호 , 김건형
IPC分类号： A61N1/32 , A61N1/04 , A61N1/36 , A61B5/053 , A61N1/06 , A61N1/02 , A61N1/08

7. 发明公开

KR1020130027078A 생체막 투과성 조성물 有权
标题翻译：生物膜渗透性组合物
公开(公告)号：KR1020130027078A
公开(公告)日：2013-03-14
申请号：KR1020120093838
申请日：2012-08-27
申请人： (주)아모레퍼시픽
发明人： 장지혜 , 김재관 , 박진우 , 배준호
IPC分类号： A61K47/42 , A61K47/48 , C07K7/08 , C12N15/09
CPC分类号： C07K7/08 , C07K2319/33
摘要： PURPOSE: A biological membrane permeable composition is provided to produce a carrying object substance with high vitality in high yield rate, and a composition with low molecular weight protamine combined to one end or both ends. CONSTITUTION: A biological membrane permeable composition includes a carrying object substance, and low molecular weight protamine. The low molecular weight protamine is combined to one or both ends of the carrying object substance, and has an amino acid sequence which has over 70% of homology to one or more of amino acid sequence with the amino acid sequence number 1 and the amino acid sequence number 2. The carrying object substance includes one or more selected from the group consisting of protein, polypeptide, peptide, nucleoacid, mRNA, and antisense RNA. The protein includes one selected from DKK-2(Dickkopf-related protein-2), adipokine, thrombospondin, and superoxide dismutase. The carrying object substance is one or more selected from growing factors, enzymes, hormones, transcription factors, toxin, antigen, and antibody. [Reference numerals] (AA) Concentration in cells(uM)
摘要翻译：目的：提供生物膜可渗透组合物以高产率生产具有高活力的携带物质，并将低分子量鱼精蛋白组合成一端或两端。构成：生物膜可渗透组合物包括载体物质和低分子量鱼精蛋白。低分子量鱼精蛋白与携带对象物质的一端或两端结合，具有氨基酸序列，其氨基酸序列与氨基酸序列号1的一个或多个氨基酸序列具有超过70％的同源性，氨基酸载体物质包括选自蛋白质，多肽，肽，核酸，mRNA和反义RNA的一种或多种。蛋白质包括选自DKK-2（Dickkopf相关蛋白-2），脂肪因子，血小板反应素和超氧化物歧化酶的一种。载体物质是选自生长因子，酶，激素，转录因子，毒素，抗原和抗体中的一种或多种。（标号）（AA）细胞浓度（uM）

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