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    • 5. 发明公开
    • 성장인자 복합체 및 세포 이동 및 성장의 조절
    • 生长因子复合物和细胞迁移和增长的调节
    • KR1020050103288A
    • 2005-10-28
    • KR1020057014530
    • 2004-02-05
    • 퀸스랜드 유니버시티 오브 테크놀로지
    • 업톤지타운크리스토퍼루크
    • C07K14/61
    • C07K14/78A61K38/00C07K14/65C07K2319/00C07K2319/50
    • Isolated protein complexes are provided comprising growth factors such as IGF-I, IGF-II, VEGF or PDGF, or at least domains thereof that enable binding to and activation of both a growth factor receptor, and an integrin receptor-binding domain of vitronectin or fibronectin. These protein complexes may be in the form of oligo-protein complexes or single, synthetic proteins where the growth factor and vitronectin or fibronectin sequences are joined by a linker sequence. In particular forms, vitronectin or fibronectin sequences do not include a heparin binding domain and/or polyanionic domain. Also provided are uses of these protein complexes for stimulating or inducing cell migration and/or proliferation which may have use in wound healing, tissue engineering, cosmetic and therapeutic treatments such as skin replacement and skin replenishment and treatment of burns where epithelial cell migration is required. In other embodiments, the invention provides inhibition of cancer cell metastasis, particularly in relation to breast cancer.
    • 提供了分离的蛋白质复合物,其包含生长因子如IGF-I,IGF-II,VEGF或PDGF,或至少其结构域,其能够结合并激活玻连蛋白的生长因子受体和整联蛋白受体结合结构域 纤连蛋白。 这些蛋白质复合物可以是寡蛋白复合物或单一合成蛋白质的形式,其中生长因子和玻连蛋白或纤连蛋白序列通过接头序列连接。 在特定形式中,玻连蛋白或纤连蛋白序列不包括肝素结合结构域和/或聚阴离子结构域。 还提供了这些蛋白质复合物用于刺激或诱导细胞迁移和/或增殖的用途,其可用于伤口愈合,组织工程,化妆品和治疗处理如皮肤替换和皮肤补充以及治疗需要上皮细胞迁移的灼伤 。 在其它实施方案中,本发明提供对癌细胞转移的抑制,特别是与乳腺癌相关。