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    • 71. 发明授权
    • 피부 미백 활성을 갖는 2,4-디하이드록시신남산 에스테르
    • 具有配制和分解活性的2,4-羟基磷酸酯
    • KR100960263B1
    • 2010-06-07
    • KR1020090065030
    • 2009-07-16
    • 장문식
    • 장문식주영운염을균김경동전옥선문종국김동원
    • C07C69/732A61K31/216A61K8/365
    • PURPOSE: A 2,4-hydroxycinnamic ester compound is provided to reduce the cytotoxin, to prevent tyrosinase from being activated, and to reduce the generation of melanin. CONSTITUTION: A 2,4-hydroxycinnamic ester compound marked with chemical formula 1, or its pharmaceutically acceptable salt is selected from the group consisting of 4-methylbenzyl 3-(2,4-dihydroxy phenyl) acrylate or 4- fluorobenzyl 3-acrylate. The 2,4-hydroxycinnamic ester compound is obtained by performing the reaction of phenyl-substituted alkyl bromide and 2,4-dihydroxy cinnamic acid under the presence of KHCO_3. A skin cosmetic composition contains the 2,4-hydroxycinnamic ester compound as an active ingredient.
    • 目的:提供2,4-羟基肉桂酯化合物以减少细胞毒素,防止酪氨酸酶被活化,并减少黑色素的产生。 构成:用化学式1表示的2,4-羟基肉桂酸酯化合物或其药学上可接受的盐选自3-(2,4-二羟基苯基)丙烯酸4-甲基苄酯或3-丙烯酸4-氟苄酯。 通过在KHCO 3存在下进行苯基取代的烷基溴和2,4-二羟基肉桂酸的反应,得到2,4-羟基肉桂酸酯化合物。 皮肤化妆品组合物含有2,4-羟基肉桂酸酯化合物作为活性成分。
    • 73. 发明公开
    • 항산화, 항염 및 항주름 효과를 가지는 화장료 조성물
    • 具有抗氧化剂的化妆品组合物,抗炎和抗皱效果
    • KR1020090079277A
    • 2009-07-22
    • KR1020080005133
    • 2008-01-17
    • 장문식
    • 장문식김동원문종국조은주전옥선유근실박송아
    • A61K8/97A61Q19/00A61Q19/08
    • A61K8/97A61K36/53A61K2800/522A61K2800/82A61K2800/85A61Q19/08
    • A cosmetic composition containing herb extract by low temperature ultrasonic wave is provided to protect atopic dermatitis, relieve skin and have the effects of removing DPPH(1,1-diphenyl-2 picrylhydrazyl radical) and superoxide anion, collagenase activation suppression, cell proliferation promotion, lipoxygenase activation suppression. A cosmetic composition having antioxidation, anti-inflammation, anti-wrinkle effects comprises 0.1-20 weight% of herb fermentation extract. The herb fermentation extract further comprises 1-30 weight% of lavender, 1-30 weight% of oregano, 1-30 weight% of rosemary, and 1-30 weight% of thyme. A method for manufacturing the herb fermentation extract comprises: a step of heating lavender, oregano, rosemary and thyme at 80-100°C for 30 minute to one hour to lower the contamination of microorganism; a step of fermenting the mixture with Bacillus sp. microorganism to produce a polymer material; a step of adding low alcohol in a volume ratio of 1:1-1:5; a step of extracting the mixture and collecting the extract; a step of concentrating and purifying the extract; and a step of filtering at 4°C with 10 kDa of membrane filter to remove a material of low molecule.
    • 提供含有低温超声波草药提取物的化妆品组合物,以保护特应性皮炎,缓解皮肤,并具有去除DPPH(1,1-二苯基-2-苦基肼基)和超氧阴离子,胶原酶活化抑制,细胞增殖促进作用, 脂氧合酶激活抑制。 具有抗氧化,抗炎,抗皱作用的化妆品组合物含有0.1-20重量%的草药发酵提取物。 草本发酵提取物还包含1-30重量%的薰衣草,1-30重量%的牛至,1-30重量%的迷迭香和1-30重量百里香的百里香。 制备草药发酵提取物的方法包括:在80-100℃下加热薰衣草,牛至,迷迭香和百里香30分钟至1小时以降低微生物污染的步骤; 用芽孢杆菌发酵混合物的步骤。 微生物生产聚合物材料; 以1:1-1:5的体积比添加低级醇的步骤; 提取混合物并收集提取物的步骤; 浓缩和提纯提取物的步骤; 以及在4℃下用10kDa膜过滤器过滤以除去低分子材料的步骤。
    • 74. 发明公开
    • 두피 보호 및 피부 진정 효과를 가지는 화장료 조성물
    • 具有调理皮肤作用的化妆品组合物
    • KR1020090029143A
    • 2009-03-20
    • KR1020070094440
    • 2007-09-17
    • 주식회사네이쳐빌장문식
    • 장문식이상문이민경김동원이준영문종국
    • A61K8/97A61Q19/00
    • A cosmetic composition is provided to ensure scalp protection and skin sedation effect by comprising fermentation extract of black beans, black sesamum indicum and black rice. A cosmetic composition having scalp protection and skin sedation effect comprises 0.1-15 weight%, preferably, 2 weight% of the fermentation extract of black beans, black sesamum indicum and black rice. A method for preparing the fermentation extract of black beans, black sesamum indicum and black rice comprises the steps of: mixing black beans, black sesamum indicum and black rice in a weigh ratio of 60:20:20; adding a mixture of 0.1-20.0 weight% in the culture fluid; producing a polymer by fermenting Bacillus species microorganism in the fermentation condition of 30-60°C, 5.5-8.5 pH and facultative anaerobe fermentation in the culture fluid; mixing the cultivating supernatant removed with fungi and ethanol in a volume ratio of 1:2; controlling the pH of the mixed solution by using 1N hydrochloric acid solution; collecting and re-dissolving the precipitate by mixing the mixed solution gradually to obtain the first refined material; and removing the low molecular weight substances and pulverizing, by dialyzing the refined material through a film filter of the molecular weight 10kD at 4°C.
    • 提供化妆品组合物以通过包括黑豆,黑芝麻和黑米的发酵提取物来确保头皮保护和皮肤镇静作用。 具有头皮保护和皮肤镇静效果的化妆品组合物包含黑豆,黑芝麻和黑米的发酵提取物的0.1-15重量%,优选2重量%。 制备黑豆,黑芝麻和黑米发酵提取物的方法包括以下步骤:将黑豆,黑芝麻和黑米以60:20:20的重量比混合; 在培养液中加入0.1-20.0重量%的混合物; 通过在培养液中发酵30-60℃,5.5-8.5 pH和兼性厌氧菌发酵条件下发酵芽孢杆菌属微生物生产聚合物; 将以真菌和乙醇取出的培养上清液以1:2的体积比混合; 用1N盐酸溶液控制混合溶液的pH值; 通过将混合溶液逐渐混合以收集和再溶解沉淀物以获得第一精制材料; 并通过在4℃下通过分子量为10kD的膜过滤器透析精制材料来除去低分子量物质并粉碎。
    • 75. 发明公开
    • 항노화 효과를 가지는 화장료 조성물
    • 具有抗衰老作用的化妆品组合物
    • KR1020090010274A
    • 2009-01-30
    • KR1020070073234
    • 2007-07-23
    • 오티씨코스메틱 주식회사장문식
    • 장문식김광옥이민경김동원이준영문종국
    • A61K8/97A61Q19/08
    • A61K8/97A61K36/16A61K36/60A61Q19/08Y10S514/844
    • A cosmetic composition comprising the extracts of complex fruits is provided to inhibit the skin aging by overcoming disadvantages of the ultraviolet screener, thereby developing the excellent ultraviolet screener. The cosmetic composition for inhibiting the skin aging comprises 0.1-10 wt.%, preferably 1 wt.% of the extracts of complex fruits including 10-30 wt.% of grapefruit, 10-30 wt.% of Citrus junos, 10-30 wt.% of Chinese quince, 10-30 wt.% of fig, 10-30 wt.% of pears and 10-30 wt.% of cherry. The manufacturing method of the anti-aging cosmetic composition comprises the steps of: mixing 10-40 wt.% of pomegranate, 10-40 wt.% of fig, 10-40 wt.% of mulberry and 10-40 wt.% of gingko; and extracting the mixture with hot water, and filtering and concentrating the extract under reduced pressure.
    • 提供包含复合果实提取物的化妆品组合物,通过克服紫外线洗涤剂的缺点来抑制皮肤老化,从而显影出优异的紫外线洗涤剂。 用于抑制皮肤老化的化妆品组合物包含0.1-10重量%,优选1重量%的复合果实提取物,包括10-30重量%的葡萄柚,10-30重量%的柑橘属杜鹃,10-30 中国柑橘的重量%,无花果的10-30重量%,梨的10-30重量%和樱桃的10-30重量%。 抗衰老化妆品组合物的制造方法包括以下步骤:混合10-40重量%的石榴,10-40重量%的无花果,10-40重量%的桑树和10-40重量%的 银杏; 并用热水提取混合物,并在减压下过滤和浓缩提取物。
    • 78. 发明公开
    • 천연 한방 식물추출물에 의한 두피 보호용 세정 조성물
    • 用自然植物提取物进行皮肤保护的清洁组合物
    • KR1020080099093A
    • 2008-11-12
    • KR1020070044746
    • 2007-05-08
    • 장문식
    • 장문식이문영이동선이준영김동원이민경
    • A61K8/97A61Q5/02
    • A61K8/97A61K2800/82A61Q5/02
    • A cleaning composition for protecting a scalp is provided to have an excellent scalp-protecting effect using a nature Korean medicine plant extract consisting of scutellariae Radix, coptidis Rhizoma, sophorae Radix, mori Radicis Cortex, to delay a depilation by generation of pimple and to improve pruritus of the scalp. A cleaning composition is a nature Korean medicine plant extract consisting of scutellariae Radix of 1 ~ 30 weight%, coptidis Rhizoma of 1 ~ 30 weight%, sophorae Radix of 1~20 weight%, mori Radicis Cortex of 1 ~ 30 weight%. The cleaning composition for protecting a scalp contains the nature Korean medicine plant extract and is manufactured as a shampoo, a rinse or a treatment.
    • 提供了一种用于保护头皮的清洁组合物,以使用由黄芩,黄连,槐草,堇青霉素组成的大韩民药植物提取物具有优异的头皮保护作用,通过产生疙瘩来延缓脱毛并改善 头皮瘙痒 清洁剂组合物是韩国药用植物提取物,由黄芩1〜30重量%,黄连1〜30重量%,枸杞1〜20重量%,木犀草1〜30重量%。 用于保护头皮的清洁组合物含有韩国药用植物提取物,并且被制成洗发剂,漂洗剂或治疗剂。
    • 79. 发明公开
    • 천연 한방 식물추출물을 함유한 세정 조성물
    • 含有天然植物提取物的清洁组合物
    • KR1020070103646A
    • 2007-10-24
    • KR1020060035511
    • 2006-04-19
    • 장성환장문식
    • 장성환장문식
    • A61K8/97A61Q19/10
    • A61K8/97A61K36/00A61K36/232A61K36/489A61K36/81A61K2236/30A61Q5/02A61Q5/12A61Q7/00Y10S514/88
    • A cleansing composition containing medicinal herb extracts is provided to serve improved reactive oxygen species-removing effect, skin-whitening effect, hair root-improving effect and hair and scalp-protecting effect derived from the medicinal herb extracts in addition to cleansing effects to the hair, thereby preventing hair loss. A cleansing composition contains 0.1-20 wt.%, preferably 5 wt.% of medicinal herb extracts including 1-20 wt.% of Sophora flavescens Aiton, 1-10 wt.% of red pepper, 1-20 wt.% of Angelica gigas radix, 1-20 wt.% of Cynanchum wilfordii, 1-20 wt.% of Angelica dahurica radix, 1-20 wt.% of Psoralea corylifolia Linne, 1-20 wt.% of pine resin, 1-20 wt.% of Asarum sieboldii MIQ., 1-10 wt.% of Lithospermum erythrorhizon SIEB. and 1-10 wt.% of Thuja orientalis Linn, and is formulated as shampoo, rinse or soap.
    • 提供含有药用草药提取物的清洁组合物,用于除了对头发的清洁作用之外,还提供了从药草提取物得到的改善的活性氧脱除效果,皮肤美白效果,发根改善效果以及头皮和头皮保护效果 ,从而防止脱发。 清洁组合物含有0.1-20重量%,优选5重量%的药用草药提取物,包括1-20重量%的苦参皂甙,1-10重量%的红辣椒,1-20重量%的当归 黑加仑,1-20%(重量)辛酸C(Cynanchum wilfordii),1-20%(重量)天竺葵,1-20%(重量)芍药,1-20%(重量)松树脂, Asarum sieboldii MIQ。%,百分之1-10重量百分比的紫草皂甙SIEB。 和1-10%(重量)的Thuja orientalis Linn,并配制成洗发剂,漂洗剂或肥皂。