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61. 发明公开

KR1020090110931A 신규한 화합물, 이의 제조방법 및 이의 용도 无效
标题翻译：新化合物，其制备方法和用途
公开(公告)号：KR1020090110931A
公开(公告)日：2009-10-23
申请号：KR1020097018625
申请日：2008-01-31
申请人： 룬드벡 엔에이 엘티디.
发明人： 투베손안더손헬렌 , 벨마르울프 , 할린잉그리드 , 스벤손례이프 , 프리트손인옐라
IPC分类号： C07C235/38 , A61K31/167 , A61P37/00 , A61P35/00
CPC分类号： C07C233/54 , C07C233/63 , C07C2601/02
摘要： A compound of formula (I) wherein X is CH=CH, CH2O wherein the oxygen atom is bound to ring B or OCH2wherein the oxygen atom is bound to ring A; Y is hydrogen, straight or branched C1-C6 alkyl or a pharmaceutically acceptable inorganic cation; R1 is ethyl or cyclopropyl; and R2 and R3 are the same or different and are selected from F, Cl, Br, CF3and OCF3. The compound is useful for the treatment of autoimmune diseases, inflammatory diseases, organ transplant rejection and malignant neoplasia. A pharmaceutical composition. A method for preparing the compound.
摘要翻译：式（I）的化合物，其中X为CH = CH，CH 2 O，其中氧原子与环B或OCH 2相连，其中氧原子与环A结合; Y是氢，直链或支链C 1 -C 6烷基或药学上可接受的无机阳离子; R1是乙基或环丙基; R2和R3相同或不同，选自F，Cl，Br，CF 3和OCF 3。该化合物可用于治疗自身免疫性疾病，炎性疾病，器官移植排斥和恶性肿瘤。药物组合物。一种制备该化合物的方法。

62. 发明公开

KR1020080114771A 카복실산 클로라이드 화합물의 제조방법 有权
标题翻译：羧酸氯化物生产方法
公开(公告)号：KR1020080114771A
公开(公告)日：2008-12-31
申请号：KR1020087023770
申请日：2007-03-29
申请人： 아지노모토 가부시키가이샤
发明人： 이시카와다쓰야 , 콘도우쇼우이치 , 다카하시사토지
IPC分类号： C07C51/60 , C07C61/15 , C07C233/63 , C07B53/00
CPC分类号： C07C231/02 , C07B53/00 , C07C51/60 , C07C2601/14 , C07C61/15 , C07C233/63
摘要： Disclosed is a process for production of a carboxylic acid chloride compound represented by the general formula (III), which comprises reacting a carboxylic acid compound represented by the general formula (I) with an acid chlorinating agent in the presence of an urea compound represented by the general formula (II). The process enables to produce the carboxylic acid chloride compound with a high purity or in high yield at a high reaction speed. The carboxylic acid chloride compound produced by the process is useful as an intermediate for the production of a D-penylalanine derivative which is used as a therapeutic agent for diabetes. (I) wherein the ring A represents a cyclohexane ring or a benzene ring; and R1 represents an alkyl group having 1 to 6 carbon atoms. (II) wherein R2 to R6 independently represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, or R5 and R6 may be bound to each other, and in this case,-R5-R6-represents an ethylene group or the like. (III) ® KIPO & WIPO 2009
摘要翻译：公开了一种制备由通式（III）表示的羧酰氯化合物的方法，该方法包括使通式（I）表示的羧酸化合物与酸式氯化剂在脲化合物通式（II）。该方法能够以高反应速度产生高纯度或高收率的羧酰氯化合物。通过该方法制备的羧酰氯化合物可用作生产用作糖尿病治疗剂的D- penylalanine衍生物的中间体。（I）其中环A表示环己烷环或苯环; R1表示碳原子数1〜6的烷基。（II）其中R2至R6独立地表示氢原子或具有1至3个碳原子的烷基，或者R5和R6可以彼此结合，在这种情况下，-R 5 -R 6 - 表示亚乙基或喜欢。（III）®KIPO＆WIPO 2009

63. 发明公开

KR1020080086937A 나테글리나이드의 다형태 无效
标题翻译：多聚甲醛的多晶型
公开(公告)号：KR1020080086937A
公开(公告)日：2008-09-26
申请号：KR1020087021427
申请日：2005-05-09
申请人： 테바 파마슈티컬 인더스트리즈 리미티드
发明人： 위젤,슐로미트 , 프렌켈,구스타보 , 곰,보아즈
IPC分类号： C07C233/63 , A61K31/16 , A61P3/00
CPC分类号： C07C231/24 , A61K31/198 , C07C233/63 , C07C2601/14
摘要： Provided are crystalline forms of nateglinide and processes for their preparation.
摘要翻译：提供那格列奈的结晶形式及其制备方法。

64. 发明公开

KR1020080000652A 아릴 알킬산 유도체 및 그의 용도 无效
标题翻译： ARYL ALKYL酸衍生物及其用途
公开(公告)号：KR1020080000652A
公开(公告)日：2008-01-02
申请号：KR1020077026676
申请日：2006-04-18
申请人： 바이엘 파마슈티칼스 코포레이션
发明人： 스미스,로저 , 로우,데릭 , 코이시,필립 , 캄벨,안-마리 , 왕,간 , 파텔,마노즈 , 본다,게오르지
IPC分类号： C07C233/53 , C07C233/55 , C07C233/30
CPC分类号： C07D209/24 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C235/40 , C07C235/56 , C07C275/42 , C07C311/08 , C07C311/13 , C07C311/21 , C07C311/29 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D207/06 , C07D209/08 , C07D209/42 , C07D209/44 , C07D211/16 , C07D213/56 , C07D213/75 , C07D215/08 , C07D235/06 , C07D239/16 , C07D261/10 , C07D265/30 , C07D295/205 , C07D307/14 , C07D307/30 , C07D307/52 , C07D307/85 , C07D309/04 , C07D309/08 , C07D333/24 , C07D333/62 , C07D333/68 , C07D335/02 , C07D401/04 , C07D405/12
摘要： This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
摘要翻译：本发明涉及某些芳基烷基酸化合物，组合物和治疗或预防肥胖症和相关疾病的方法。

65. 发明公开

KR1020070116133A Ｎ-알킬카르보닐-아미노산 에스테르 및Ｎ-알킬카르보닐-아미노 락톤 화합물 및 이의 용도 无效
标题翻译： N-烷基亚氨基氨基酸酯和N-烷基亚氨基 - 氨基酸酯化合物及其用途
公开(公告)号：KR1020070116133A
公开(公告)日：2007-12-06
申请号：KR1020077024165
申请日：2006-03-23
申请人： 웨이, 에드워드 택
发明人： 웨이,에드워드택
IPC分类号： C07C233/45 , C07C233/51 , C07C233/48
CPC分类号： C07D307/33 , C07B2200/07 , C07C233/63 , C07C2601/14
摘要： The present invention generally relates to refreshing, soothing, and cooling compounds that affect sensory processes. More particularly, the present invention pertains to certain N-alkylcarbonyl-amino acid ester and N-alkylcarbonyl-amino lactone compounds as described herein; compositions and articles comprising such compounds; and methods of treatment, for example, methods of alleviating the discomforts of irritation, itch, and pain in the skin and in the linings of the oral cavity and upper respiratory tract, for example, in methods of treatment of cough and/or asthma.
摘要翻译：本发明一般涉及影响感觉过程的清新，舒缓和冷却化合物。更具体地，本发明涉及本文所述的某些N-烷基羰基 - 氨基酸酯和N-烷基羰基 - 氨基内酯化合物; 包含这些化合物的组合物和制品; 和治疗方法，例如减轻口腔和上呼吸道的皮肤和内衬中刺激，瘙痒和疼痛的不适的方法，例如治疗咳嗽和/或哮喘的方法。

66. 发明公开

KR1020070094954A 11-베타-하이드록시스테로이드 데하이드로게나제 타입 1 효소의 억제제 失效
标题翻译： 11-羟基脱氢酶脱氢酶1型酶的抑制剂
公开(公告)号：KR1020070094954A
公开(公告)日：2007-09-27
申请号：KR1020077017918
申请日：2006-01-05
申请人： 애브비 인코포레이티드
发明人： 로데제프리제이 , 솨이치 , 린크제임스티 , 파텔지요티알 , 딘게스위르겐 , 소렌센브리안케이 , 융훙 , 예빈스에스 , 쿠루쿨라수리야라비
IPC分类号： C07D213/56 , C07D231/12 , C07D261/08 , A61K31/165
CPC分类号： C07D207/277 , C07C233/11 , C07C233/52 , C07C233/58 , C07C233/63 , C07C237/24 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/74 , C07D211/78 , C07D213/56 , C07D231/12 , C07D261/08 , C07D333/24
摘要： The present invention relates to compounds that are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.
摘要翻译：本发明涉及作为11-β-羟基类固醇脱氢酶1型酶的抑制剂的化合物。本发明还涉及11-β-羟基类固醇脱氢酶1型抑制剂用于治疗非胰岛素依赖性2型糖尿病，胰岛素抵抗，肥胖症，脂质障碍，代谢综合征和其他介导的疾病和病症的用途由过度的糖皮质激素作用。

67. 发明公开

KR1020070009726A 나테글리나이드의 다형태 无效
标题翻译：多聚甲醛的多晶型
公开(公告)号：KR1020070009726A
公开(公告)日：2007-01-18
申请号：KR1020067025109
申请日：2005-05-09
申请人： 테바 파마슈티컬 인더스트리즈 리미티드
发明人： 위젤,슬로미트 , 프렌켈,구스타보 , 곰,보아즈
IPC分类号： C07C231/24 , C07C233/63 , A61K31/16 , A61P3/00
CPC分类号： C07C231/24 , A61K31/198 , C07C233/63 , C07C2601/14
摘要： Provided are crystalline forms of nateglinide and processes for their preparation. ® KIPO & WIPO 2007
摘要翻译：提供那格列奈的结晶形式及其制备方法。 ®KIPO＆WIPO 2007

68. 发明授权

KR100554564B1 디아미노디카르복실산 및 그 중간체 失效
标题翻译：二氨基二羧酸及其中间体
公开(公告)号：KR100554564B1
公开(公告)日：2006-03-03
申请号：KR1020047004641
申请日：2002-12-12
申请人： 미쓰이 가가쿠 가부시키가이샤
发明人： 미따나루요시 , 지다미쯔아끼 , 이소까와모또아끼 , 가또우다까조우 , 나가이나오시
IPC分类号： C07C229/48
CPC分类号： C07C229/48 , C07C233/63
摘要： The present invention relates to a novel diaminodicarboxylic acid represented by general formula (1): (wherein A is an aliphatic group; one of R and R is a carboxyl group, and the other is an amino group or a carbamoyl group; and one of R and R is a carboxyl group, and the other is an amino group or a carbamoyl group), a carbamoyl compound which is a synthetic intermediate for the diaminodicarboxylic acid, and a process for producing the diaminodicarboxylic acid. The diaminodicarboxylic acid can be produced by Hofmann reaction of the carbamoyl compound and is a useful compound as a starting material for resins or an additive for resins.

69. 发明公开

KR1020040030658A 페록시좀 증식제 활성화 수용체의 조절제 无效
标题翻译：过氧化物酶体增殖物激活受体调节剂
公开(公告)号：KR1020040030658A
公开(公告)日：2004-04-09
申请号：KR1020037016048
申请日：2002-05-24
申请人： 일라이 릴리 앤드 캄파니
发明人： 고세트,린,스타시 , 그린,조나단,에드워드 , 헨리,제임스,로버트 , 존스,윈톤,데니스,주니어 , 매튜,도날드,폴 , 센,쾅,롱 , 스미스,다릴,린 , 반체,제니퍼,앤 , 와샤우스키,알랜,엠. , 곤잘레즈-가르시아,마리아로사리오
IPC分类号： C07D263/32
CPC分类号： C07D209/48 , C07C233/63 , C07C233/87 , C07C255/57 , C07C271/22 , C07C271/24 , C07C2601/04 , C07C2601/14 , C07D213/81 , C07D231/12 , C07D239/28 , C07D263/32 , C07D277/28 , C07D277/42 , C07D307/79 , C07D333/28 , C07D401/06 , C07D409/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D495/04
摘要： 본 발명은 증후군 X, 타입II 당뇨병, 과혈당, 고지혈증, 비만증, 응고병증, 고혈압, 아테롬성 동맥경화증 및 증후군 X과 관련된 다른 질병 및 심혈관계 질환을 치료하는데 유용한 화학식 I의 화합물 및 그의 제약학적으로 허용가능한 염, 용매화물, 수화물 또는 입체이성질체에 관한 것이다.

70. 发明公开

KR1020030059202A 아실페닐알라닌의 제조방법 有权
标题翻译： 아실페닐알라닌의제조방법
公开(公告)号：KR1020030059202A
公开(公告)日：2003-07-07
申请号：KR1020037005384
申请日：2001-10-16
申请人： 아지노모토 가부시키가이샤
发明人： 스미카와미치토 , 오가네다카오
IPC分类号： C07C231/02
CPC分类号： C07D213/82 , C07C231/02 , C07C2601/14 , C07C233/47 , C07C233/49 , C07C233/51 , C07C233/63 , C07C233/87 , C07C235/60
摘要： 본 발명은 의약품 등의 원료로서 유용성이 높은 아실페닐알라닌을 간편하면서도 또한 고순도로 제조하는 방법으로서, 산 클로라이드와 페닐알라닌을 유기 용매와 물의 혼합 용매 중에서 수산화칼륨을 사용하여 알칼리 조건하에 유지하면서 반응시킴을 특징으로 하는 아실페닐알라닌의 제조방법을 제공한다.
摘要翻译：本发明提供一种容易地制造作为医药品等的原料有用的高纯度酰基苯丙氨酸的方法，其包括使酰氯与苯丙氨酸在有机溶剂和水的混合溶剂中反应的工序，该溶剂在碱性条件下用氢氧化钾。

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