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61. 发明公开

KR1020140048777A 과산화수소의 분해를 촉매하는 포토프린을 사용한 일련의 약물 有权
标题翻译：一系列使用紫外线的药物催化分解过氧化氢
公开(公告)号：KR1020140048777A
公开(公告)日：2014-04-24
申请号：KR1020120156537
申请日：2012-12-28
申请人： 베이징 탑 그레이드- 강 밍 메디칼 디바이시즈 아이엔씨.
发明人： 정쥔 , 순치인
IPC分类号： A61K51/08 , A61K49/20 , A61K38/42
CPC分类号： A61K41/0042 , A61K31/409 , A61K31/495 , A61K41/0052 , A61K41/0057
摘要： The present invention relates to a drug manufactured on a base for generating singlet oxygen by decomposing hydrogen peroxide in a body with photofrin as a catalyst. The drug is used for a chemodynamic therapy (CDT), a radiochemodynamic therapy (RCDT), or a radiodynamic therapy (RDT). Compared to a traditional photodynamic therapy (PDT), the CDT and RCDT do not require a light source, oxygen, and intervention means, is quantitative, has good treatment effect, has a simple operation, can be repeatedly treated, and is easy to apply. [Reference numerals] (AA) After the irradiation
摘要翻译：本发明涉及通过用作为催化剂的光卟酚分解身体中的过氧化氢而在用于产生单线态氧的基底上制造的药物。该药用于化学疗法（CDT），放射化学疗法（RCDT）或放射疗法（RDT）。与传统光动力治疗（PDT）相比，CDT和RCDT不需要光源，氧气和干预手段，是定量的，治疗效果好，操作简单，可以反复治疗，易于应用。 [附图标记]（AA）照射后

62. 发明公开

KR1020120055604A 광역학 치료를 사용하는 암의 치료 방법 无效
标题翻译：使用光化疗法治疗癌症
公开(公告)号：KR1020120055604A
公开(公告)日：2012-05-31
申请号：KR1020127005792
申请日：2010-08-06
申请人： 헬스 리서치 인코포레이티드
发明人： 판데이라빈드라케이 , 도거티토마스제이 , 포터윌리엄
IPC分类号： A61K31/409 , A61K41/00 , A61K9/00 , A61N5/06 , A61M37/00
CPC分类号： A61N5/0601 , A61K41/0071 , A61N5/062 , A61N2005/0604 , A61N2005/0659 , A61N2005/0662 , A61K31/409 , A61K9/0019 , A61M37/00
摘要： 본 발명은 생리적으로 상용되는 매질 중 2-(1-헥실옥시에틸)-2-데비닐 피로페오포바이드-에이(HPPH)를 3 내지 5 mg/m
2 신체 표면적의 수준의 암 조직을 갖는 환자에게 주사하는 단계; 2-(1-헥실옥시에틸)-2-데비닐 피로페오포바이드-에이(HPPH)가 암 조직에 바람직하게 흡수되도록 24 내지 60시간의 기간 동안 대기하는 단계; 및 암 조직을 약 75 내지 약 200 J/cm의 에너지를 갖는 약 665 ± 5 nm의 파장의 빛에 노출시키는 단계를 포함하는, 상부 호흡기계 내의 암 조직의 치료 방법에 관한 것이다.

63. 发明公开

KR1020110000523A 항암 화학요법제-클로린 유도체의 접합체, 이를 함유하는 광감작제 및 이를 포함하는 암 치료용 조성물 有权
标题翻译：抗生素化学代谢氯胺衍生物，包含它的光致抗体和用于治疗包括其的癌症的组合物
公开(公告)号：KR1020110000523A
公开(公告)日：2011-01-03
申请号：KR1020100060372
申请日：2010-06-25
申请人： 주식회사 진코스
发明人： 안웅식 , 배수미 , 가린데브,오윤빌리그 , 바토그토크흐,간트므르 , 문란영
IPC分类号： A61K47/48 , A61K33/24 , A61K31/409 , A61P35/00
CPC分类号： A61K41/0071 , A61K33/14 , A61K47/546 , A61K47/50 , A61K31/409 , A61K33/24 , A61K2300/00
摘要： PURPOSE: A composition containing a photosensitizer with cancer chemotherapeutic agent-chlorine derivative assembly is provided to reduce toxicity of the chemotherapeutic agent. CONSTITUTION: A cancer chemotherapeutic agent-chlorine derivative assembly has a structure of chemical formula 1, 2 or 3. The cancer chemotherapeutic agent is cisplatin or paclitaxel. A composition for treating cancer contains the assembly as an active ingredient. A kit for treating cancer comprises the composition and light source for irradiating 650 nm-800 nm of beam. A photosensitizer contains the assembly.
摘要翻译：目的：提供含有癌症化学治疗剂 - 氯衍生物组合物的光敏剂的组合物，以减少化学治疗剂的毒性。构成：癌症化学治疗剂 - 氯衍生物组件具有化学式1,2或3的结构。癌症化学治疗剂是顺铂或紫杉醇。用于治疗癌症的组合物含有组合物作为活性成分。用于治疗癌症的试剂盒包括用于照射650nm-800nm光束的组合物和光源。光敏剂包含组件。

64. 发明公开

KR1020100017768A 플루오렌, 안트라센, 잔텐, 디벤조수베론 및 아크리딘의 유도체 및 이의 용도 有权
标题翻译：荧光素，蒽醌，呫吨酮，二苯唑酮和吖啶的衍生物及其用途
公开(公告)号：KR1020100017768A
公开(公告)日：2010-02-16
申请号：KR1020097025845
申请日：2008-05-09
申请人： 도그우드 파마슈티컬스, 아이엔씨.
发明人： 촐로디위즐로우엠. , 장이 , 주크카리나 , 워티제프리더블유.에이치. , 올러조 , 스트로벨제프리 , 올러진 , 셀라판쉴라 , 파디아자낙
IPC分类号： C07D225/02 , A61K31/135 , A61K31/185 , A61P35/00
CPC分类号： A61K31/395 , A61K31/18 , A61K31/409 , A61K31/435 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/553 , C07C311/20 , C07C2601/14 , C07D211/96 , C07D295/26
摘要： Chemical agents, such as disulfonamide derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of the Wnt/β-catenin signaling pathway, and serve to reduce β-catenin levels present in cells, such as cancer cells, or where the agents modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.
摘要翻译：化学试剂，如芴，蒽，呫吨，二苯并uber酮和吖啶的二磺酰胺衍生物，以及类似的杂环结构（包括其盐），其作为抗癌剂和抗肿瘤剂，特别是在这些试剂调节Wnt活性的情况下 /β-连环蛋白信号通路，并且用于降低存在于诸如癌细胞的细胞中或其中调节细胞系统（包括癌细胞）中基因表达水平的β-连环蛋白水平，以及其中制备这种方法的方法药剂，以及含有活性成分的药剂和使用它们作为治疗剂的方法的药物组合物。

65. 发明公开

KR1020090114457A 비타민 및 미네랄 보충제의 개선된 안정성 有权
标题翻译：维生素和矿物质补充剂的改进稳定性
公开(公告)号：KR1020090114457A
公开(公告)日：2009-11-03
申请号：KR1020097019280
申请日：2008-02-14
申请人： 와이어쓰 엘엘씨
发明人： 골드버그,앨런,엠. , 딜스,스티븐 , 마크,윌리암 , 수튼,브루스 , 바이어레이,차드
IPC分类号： A61K33/26 , A61K33/06 , A61K31/375 , A61P3/02
CPC分类号： A61K33/42 , A23L5/41 , A23L33/15 , A23L33/16 , A23V2002/00 , A61K31/07 , A61K31/197 , A61K31/355 , A61K31/375 , A61K31/409 , A61K31/4415 , A61K31/455 , A61K31/51 , A61K31/519 , A61K31/525 , A61K31/59 , A61K33/00 , A61K33/06 , A61K33/26 , A61K33/30 , A61K33/32 , A61K33/34 , A61K45/06 , A61K2300/00 , A23V2250/702 , A23V2250/71 , A23V2250/712 , A23V2250/708 , A23V2250/704 , A23V2250/1578 , A23V2250/161 , A23V2250/1588 , A23V2250/1592 , A23V2250/1612 , A23V2250/1642 , A23V2250/159
摘要： The invention provides a multivitamin and mineral nutritional supplement composition comprising at least one polyvalent metal and at least one oxidizable vitamin with substantially improved resistance to reactions that lead to darkening and /or spotting and reactions that may reduce the potency of oxidizable vitamins. The composition is a multivitamin and mineral composition comprising at least one polyvalent metal and at least one oxidizable vitamin wherein the composition is substantially free of mobile bound water. The invention also includes methods for making such a composition and methods of preventing or reducing oxidation, improving the stability of oxidizable vitamins, and stabilizing the disintegration time of a multi-vitamin and mineral nutritional supplement composition.
摘要翻译：本发明提供一种多种维生素和矿物营养补充剂组合物，其包含至少一种多价金属和至少一种可氧化维生素，其具有显着改善的耐反应性，导致变暗和/或斑点以及可能降低可氧化维生素的效力的反应。所述组合物是包含至少一种多价金属和至少一种可氧化维生素的多种维生素和矿物质组合物，其中所述组合物基本上不含移动结合水。本发明还包括制备这样的组合物和预防或减少氧化，提高可氧化维生素的稳定性以及稳定多种维生素和矿物营养补充剂组合物的崩解时间的方法。

66. 发明公开

KR1020090108068A ＰＤＴ를 위한 치료적 ＨＰＰＨ 투여량 无效
标题翻译： PDT治疗HPPH剂量
公开(公告)号：KR1020090108068A
公开(公告)日：2009-10-14
申请号：KR1020097016431
申请日：2007-09-27
申请人： 헬스 리서치 인코포레이티드
发明人： 도허티토마스제이. , 판디라빈드라케이. , 포터윌리엄알.
IPC分类号： A61K31/409 , A61P35/00 , A61N5/067 , A61K31/7004
CPC分类号： A61K31/409
摘要： A method for treating cancer and other hyperproliferative tissues in humans that can be exposed to light comprising injection of HPPH at the equivalent to a dose of 0.05 to 0.1 1 mg/kg of body weight 24 hours post injection and exposing the tumor or other hyperproliferative tissue to 665 ±10 nm of light at 50 to 200 Joules/cm2.
摘要翻译：一种用于治疗可暴露于光的人类癌症和其它过度增生组织的方法，包括以相当于注射后24小时0.05至0.1mg / kg体重的剂量注射HPPH并暴露肿瘤或其它过度增生组织至50〜200焦耳/平方厘米的665±10纳米光。

67. 发明公开

KR1020080039968A 셀룰라이트 및 미용 용도를 위한 ＰＤＴ 처리 방법 有权
标题翻译：用于细胞和化妆品用途的PDT处理方法
公开(公告)号：KR1020080039968A
公开(公告)日：2008-05-07
申请号：KR1020087005284
申请日：2006-07-27
申请人： 바이오리텍 파마 마케팅 엘티디.
发明人： 카스트로,다닐오,수아레즈 , 뉴버거,울프강
IPC分类号： A61K31/555 , A61K31/409 , A61K9/127
CPC分类号： A61K31/555 , A61K8/494 , A61K31/409 , A61K2800/81 , A61Q19/06
摘要： A photosensitizer mixture and a method of treating cellulites by means of a percutaneous application of the mixture into the area of cellulite buildup followed by light illumination are presented. The photosensitizer can be combined with one or more cellular products including adipose cells and/or collagen that have been previously removed by liposuction. This mixture can also include other compounds such as Lipofundin MCT 10 % to improve the photosensitizer's diffusion or to dilute it Varying concentrations are used depending on the area of treatment as well as the stage of the cellulites and whether the cellulites present a depressed area in the skin or an elevated area. The cosmetic treatment method substantially reduces or removes localized lipodystrophies and/or flaccidity and/or cellulite by localized laser, LED or other light irradiation of the area of treatment having a photosensitizer applied therein. The light energy is applied to destroy the "fat" cells by a combination of chemical reactions, primarily, and temperature wherein the cell walls break releasing the cell fluid. The light radiation is generally applied through devices to guide the radiation to the area of treatment. One or more light sources such as laser diodes or LEDs may be coupled into one or more optical fibers to increase the area of coverage as well as increase the amount of radiation in that area of coverage. Optical fibers can be introduced percutaneously or possibly interstitially into the area of treatment. Cell fluid in the area of treatment is removed by a combination of techniques. Quick and lasting cosmetic changes in areas having prior untreatable cellulite fat tissues are achieved while minimizing trauma.
摘要翻译：提供了一种光敏剂混合物和通过将混合物经皮施用到脂肪团累积区域中随后进行光照射处理脂肪团的方法。光敏剂可以与一种或多种细胞产品组合，包括脂肪细胞和/或胶原蛋白，其先前通过吸脂除去。该混合物还可以包括其他化合物，例如Lipofundin MCT 10％，以改善光敏剂的扩散或稀释。根据治疗面积和脂肪团的阶段以及脂肪团是否存在凹陷区域，使用不同的浓度皮肤或高架区域。美容治疗方法通过局部激光，LED或其它应用光敏剂的治疗区域的其它光照射，显着地减少或去除局部的脂肪营养不良和/或脂肪酸和/或脂肪团。施加光能以通过化学反应（主要是）和细胞壁破坏释放细胞液体的温度的组合来破坏“脂肪”细胞。光辐射通常通过装置施加以将辐射引导到治疗区域。可以将一个或多个光源（例如激光二极管或LED）耦合到一个或多个光纤中，以增加覆盖区域以及增加覆盖区域中的辐射量。光纤经皮或间隙引入治疗区域。通过技术的组合去除处理区域中的细胞液。在具有先前不可治愈的脂肪脂肪组织的区域中实现快速和持久的化妆品变化，同时最小化创伤。

68. 发明授权

KR100808630B1 클로린 화합물을 포함하는 경구투여용 항종양 조성물 有权
标题翻译：用于包含氯林化合物的口服药物的抗肿瘤药物组合物
公开(公告)号：KR100808630B1
公开(公告)日：2008-02-29
申请号：KR1020060136610
申请日：2006-12-28
申请人： 광주과학기술원
发明人： 김용철 , 박지용 , 김효준
IPC分类号： A61K31/409 , A61P35/00
CPC分类号： A61K31/409 , A61K45/06 , A61K2300/00
摘要： A composition comprising a chlorin compound is provided to be well absorbed into a gastrointestinal tract by being orally administered to show excellent antitumoric effect and be very safe to human body without cytotoxicity and immuno-toxicity. An antitumoric composition for oral administration comprises chlorin e6(13-carboxy-17-[2-carboxyethyl]-15-carboxymethyl-17,18-trans-dihydro-3-vinyl-8-ethyl-2,7,12,18-tetramethylporphyrin) compound represented by a formula(2) or a pharmaceutically acceptable salt thereof, which does not require light for the antitumoric activity. The composition further comprises at least one ingredient selected from the group consisting of beta-sitosterol, glycyrrhizic acid, lentinan, reishidin, letiporin, acacetin, zinc, selenium and amino acid.
摘要翻译：提供包含二氢卟酚化合物的组合物通过口服给药以良好地吸收到胃肠道中以显示出优异的抗肿瘤作用，并且对人体非常安全，无细胞毒性和免疫毒性。用于口服给药的抗肿瘤组合物包括二氢卟酚e6（13-羧基-17- [2-羧乙基] -15-羧甲基-17,18-反 - 二氢-3-乙烯基-8-乙基-2,7,12,18- 四甲基卟啉）化合物或其药学上可接受的盐，其不需要光的抗肿瘤活性。所述组合物还包含至少一种选自β-谷甾醇，甘草酸，香菇多糖，赖地啶，莱泊波宁，醋酸素，锌，硒和氨基酸的成分。

69. 发明公开

KR1020070114856A 개선된 혈관신생의 치료 방법 无效
标题翻译：改善治疗新生血管
公开(公告)号：KR1020070114856A
公开(公告)日：2007-12-04
申请号：KR1020077027215
申请日：2001-03-22
申请人： 노파르티스 아게
发明人： 브라젤로뮬러스킴브로
IPC分类号： A61K41/00 , A61K45/06 , A61P35/00
CPC分类号： A61K31/4025 , A61K31/409 , A61K31/501 , A61K31/553 , A61K41/0057 , A61K41/0071 , A61K45/06
摘要： The present invention describes an improved photodynamic treatment to treat subfoveal choroidal neovascularization (CNV).
摘要翻译：本发明描述了改进的光动力治疗以治疗中心凹脉络膜新生血管形成（CNV）。

70. 发明公开

KR1020060117914A 약물을 사용한 표적화된 국소 부위의 지방 분해 无效
标题翻译：药物靶向局部脂蛋白
公开(公告)号：KR1020060117914A
公开(公告)日：2006-11-17
申请号：KR1020067007762
申请日：2004-10-09
申请人： 메르츠 파마슈티컬즈 게엠베하
发明人： 보더케페테 , 푸쓰라이너 , 잔도브위르겐 , 고젤마튀아스 , 니에츄흐칼-하인츠 , 자틀러게르하르트 , 보겔게르하르트
IPC分类号： A61K31/683 , A61K31/409
CPC分类号： A61K45/06 , A61K9/127 , A61K31/409 , A61K31/685 , A61K2300/00
摘要： The invention relates to aqueous phospholipid systems, containing at least one phospholipid, at least one bile acid and water, which are suitable for producing medicaments for the treatment of adipose tissue diseases and which lead to the regression of the diseased proliferated adipose tissue.
摘要翻译：本发明涉及含有至少一种磷脂，至少一种胆汁酸和水的磷脂水溶液系统，其适用于生产用于治疗脂肪组织疾病的药物，并导致患病的增殖的脂肪组织的消退。

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