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51. 发明公开

KR1020110043201A 항원 약물을 포함하는 점안 접종용 백신 无效
标题翻译：用于包含抗原药物的眼部免疫的疫苗
公开(公告)号：KR1020110043201A
公开(公告)日：2011-04-27
申请号：KR1020090100219
申请日：2009-10-21
申请人： 연세대학교 산학협력단
发明人： 서경률
IPC分类号： A61K39/112 , A61K39/13 , A61K39/145 , A61P37/00
CPC分类号： Y02A50/388 , Y02A50/407 , Y02A50/472 , Y02A50/482 , Y02A50/484 , A61K39/0275 , A61K9/0048 , A61K39/0291 , A61K2039/522
摘要： PURPOSE: A vaccine for eye drop vaccination containing an antigen drug is provided to ensure low side effects in a whole body and to reduce pain. CONSTITUTION: A vaccine for eye drop vaccination containing an antigen drug contains whole-cell bacteria antigen, toxoid antigen, virus antigen, and coat polysaccharide antigen. The whole-cell bacteria are selected from the group consisting of cholera, pertussis, bubonic plague, and BCG antigen. The toxoid antigen is selected from the group consisting of salmonella, yersinia sp. bacteria, diphtheria, tetanus, and pertussis antigen.
摘要翻译：目的：提供含有抗原药物的滴眼剂接种疫苗，以确保全身的低副作用，减轻疼痛。构成：含有抗原药物的滴眼剂接种疫苗含有全细胞细菌抗原，类毒素抗原，病毒抗原和外壳多糖抗原。全细胞细菌选自霍乱，百日咳，瘟疫和BCG抗原。类毒素抗原选自沙门氏菌属，耶尔森氏菌属细菌，白喉，破伤风和百日咳抗原。

52. 发明公开

KR1020100110434A 호중구를 이용한 병원균의 약독화 방법 有权
标题翻译：使用中性粒细胞衰竭的方法
公开(公告)号：KR1020100110434A
公开(公告)日：2010-10-13
申请号：KR1020090028760
申请日：2009-04-03
申请人： 대한민국(농림축산식품부 농림축산검역본부장)
发明人： 이희수 , 김애란 , 임숙경 , 조윤상 , 임춘태 , 윤민 , 정석찬
IPC分类号： A61K39/112 , C12N5/07 , A61K39/10 , A61P37/00
CPC分类号： A61K39/0275 , A61K2039/522
摘要： PURPOSE: A method for attenuating pathogen by co-culture of pathogen and neutrophil is provided to attenuate without high technology and safely apply to human body. CONSTITUTION: A pathogen is attenuated by co-culture of pathogen and neutrophils. The neutrophil is isolated from poultry, pig, lamb, horse, cat, dog or human. A method for co-culture of pathogen and neutrophil comprises: a step of co-culture of neutrophili and pathogen for 10 minutes to two hours; a step of killing pathogen; and a step of collecting and dissolving neutrophil. The attenuated pathogen is ST31-N5th-1(KACC 91447P) or ST31-N20th-B10th-12(KACC 91448P). A vaccine composition contains attenuated pathogenic mutant.
摘要翻译：目的：通过病原体和嗜中性粒细胞的共培养来减轻病原体的方法，无需高技术的减毒，安全应用于人体。构成：通过病原体和嗜中性粒细胞的共培养来减轻病原体。嗜中性粒细胞与家禽，猪，羊，马，猫，狗或人类分离。病原体和嗜中性粒细胞的共培养方法包括：将嗜中性粒细胞和病原体共培养10分钟至2小时的步骤; 杀死病原体的一个步骤; 和收集和溶解嗜中性粒细胞的步骤。减毒病原体是ST31-N5th-1（KACC91447P）或ST31-N20th-B10th-12（KACC91448P）。疫苗组合物含有减毒致病突变体。

53. 发明公开

KR1020100108801A 약독화된 살모넬라 생백신 및 이의 제조방법 有权
标题翻译：生物降解的沙门氏菌疫苗及其生产方法
公开(公告)号：KR1020100108801A
公开(公告)日：2010-10-08
申请号：KR1020090027014
申请日：2009-03-30
申请人： 서울대학교산학협력단
发明人： 유상렬 , 최정준
IPC分类号： A61K39/112 , C12N1/21 , C12N15/09 , C12R1/42
CPC分类号： A61K39/0275 , A61K2039/522
摘要： PURPOSE: An attenuated salmonella live vaccine and a method for manufacturing the same are provided to completely protect a host from pathogenic salmonella strain and to apply to various fields. CONSTITUTION: A salmonella live vaccine is provided to removing ruvB gene from DNA of salmonella strain including ruvB gene or disrupting ruvB gene. The disruption of ruvB gene is performed by removing partial base sequence in ruvB gene or substituting partial base sequence in ruvB base. A salmonella vaccine composition contains salmonella sp. mutant strain and pharmaceutically acceptable carrier.
摘要翻译：目的：提供减毒沙门氏菌活疫苗及其制备方法，以完全保护宿主免受致病沙门氏菌菌株的侵袭，并适用于各种领域。构成：提供沙门氏菌活疫苗以从包括ruvB基因在内的沙门氏菌菌株的DNA中去除ruvB基因或破坏ruvB基因。通过去除ruvB基因中的部分碱基序列或用ruvB碱基中的部分碱基序列来进行ruvB基因的破坏。沙门氏菌疫苗组合物含有沙门氏菌属突变菌株和药学上可接受的载体。

54. 发明公开

KR1020090075824A 면역 반응을 향상시키는 조성물 및 방법 有权
标题翻译：组合物和增强免疫应答的方法
公开(公告)号：KR1020090075824A
公开(公告)日：2009-07-09
申请号：KR1020097007854
申请日：2007-09-18
申请人： 더 보드 오브 트러스티스 오브 더 유니버시티 오브 아칸소 , 더 텍사스 에이 & 엠 유니버시티 시스템
发明人： 보트제월터 , 하기스빌리 , 베르흐만뤽 , 권영민 , 콜킴벌리 , 콕스맨디 , 레이튼셰릴
IPC分类号： C12N1/20 , C12N1/21 , C12N15/31 , C12R1/42
CPC分类号： A61K39/145 , A61K35/74 , A61K39/00 , A61K39/0275 , A61K39/12 , A61K2035/11 , A61K2039/522 , A61K2039/523 , A61K2039/552 , A61K2039/55516 , A61K2039/6006 , A61K2039/6031 , C07H21/04 , C12N15/102 , C12N2760/16134 , Y02A50/482
摘要： Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD 154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.
摘要翻译：本文提供了肠炎沙门氏菌13A菌株和包含这些菌株的组合物。还提供了增强针对甲型流感的免疫应答的方法和降低与甲型流感感染相关的发病率的方法。还公开了通过表达能够结合CD40的CD154多肽增强对疫苗载体的免疫应答的方法。公开了开发细菌疫苗载体的方法。还公开了在细菌中产生无疤痕位点突变的方法。

55. 发明公开

KR1020090066272A 단백질 매트릭스 백신 및 그의 제조방법 및 백신 투여방법 有权
标题翻译：蛋白质基质疫苗及其制备和施用方法
公开(公告)号：KR1020090066272A
公开(公告)日：2009-06-23
申请号：KR1020097004799
申请日：2007-08-07
申请人： 프레지던트 앤드 펠로우즈 오브 하바드 칼리지
发明人： 메칼라노스,존,제이.
IPC分类号： A61K39/385 , A61K39/116 , A61K39/09 , A61P37/00
CPC分类号： A61K39/095 , A61K39/02 , A61K39/0275 , A61K39/0283 , A61K39/07 , A61K39/092 , A61K39/385 , A61K47/42 , A61K2039/6037 , A61K2039/645 , Y02A50/472 , Y02A50/482 , Y02A50/484
摘要： The invention relates to vaccine compositions having a carrier protein and an antigen of interest entrapped in a complex, methods of making such vaccines, and methods of vaccine administration.
摘要翻译：本发明涉及具有载体蛋白和包含在复合物中的目的抗原的疫苗组合物，制备这种疫苗的方法和疫苗施用方法。

56. 发明公开

KR1020050008257A 장티푸스 협막 다당체와 일본 뇌염 바이러스의 혼합 백신제조 및 면역성 无效
标题翻译：沙门氏菌和日本食品病毒多糖的联合疫苗生产方法及其免疫原性
公开(公告)号：KR1020050008257A
公开(公告)日：2005-01-21
申请号：KR1020030048142
申请日：2003-07-15
申请人： 주식회사 백텍
发明人： 지희윤 , 김을제 , 장성홍
IPC分类号： A61K39/12
CPC分类号： Y02A50/39 , Y02A50/484 , A61K39/0275 , A61K39/12 , A61K2300/00 , Y10S514/885
摘要： PURPOSE: Provided are a production method of a conjugate vaccine of polysaccharide capsule of salmonella typhi and japanese encephalitis virus and its immunogenicity. Therefore, tow kinds of antigens are vaccinated at the same time. CONSTITUTION: The conjugate vaccine of polysaccharide capsule of salmonella typhi and japanese encephalitis virus is manufactured by conjugation method of Salmonella typhi Vi and tetanus toxoid. Therefore, it is increases the formation of IgG antibody by about 4-6 times. Also, the addition of aluminium hydroxide adjuvant increases the formation of IgG.
摘要翻译：目的：提供伤寒沙门氏菌和日本脑炎病毒多糖胶囊结合疫苗的制备方法及其免疫原性。因此，同时对两种抗原进行疫苗接种。构成：伤寒沙门氏菌和日本脑炎病毒多糖胶囊的结合疫苗是通过伤寒沙门氏菌和破伤风类毒素的共轭法制造的。因此，IgG抗体的形成增加约4-6倍。此外，加入氢氧化铝佐剂增加了IgG的形成。

57. 发明公开

KR1020040098349A 살모넬라증에 대한 면역을 유발하는 살모넬라 유래 특이단백질, 이를 코딩하는 유전자, 전기 단백질을 함유하는주사제 및 경구용 제제 有权
标题翻译： SALMONELLA特异性蛋白质诱导针对海绵体的免疫，其基因，注射和口服制剂
公开(公告)号：KR1020040098349A
公开(公告)日：2004-11-20
申请号：KR1020030030668
申请日：2003-05-14
申请人： (주)진바이오텍
发明人： 이동규 , 조경진 , 현연희 , 신상민
IPC分类号： C12N15/31
CPC分类号： A23K10/16 , A23K20/147 , A61K39/0275 , A61K2039/542 , A61K2039/552
摘要： PURPOSE: A salmonella-specific protein inducing immunity against salmonellosis, its gene, injection and oral preparations containing the same protein are provided, thereby preventing disease of domestic animals caused by Salmonella by injection or oral administration of the salmonella-specific protein. CONSTITUTION: The salmonella-specific protein inducing immunity against salmonellosis has the amino acid sequence of SEQ ID NO:2. A polynucleotide encoding the salmonella-specific protein has the nucleotide sequence of SEQ ID NO:1. The injection preparations contains the salmonella-specific protein inducing immunity against salmonellosis having the amino acid sequence of SEQ ID NO:2. The oral preparations contains the salmonella-specific protein inducing immunity against salmonellosis having the amino acid sequence of SEQ ID NO:2, wherein the oral preparations is fodder for domestic animals.
摘要翻译：目的：提供诱导针对沙门氏菌病的沙门氏菌特异性蛋白质，其基因，注射液和含有相同蛋白质的口服制剂，从而通过注射或口服沙门氏菌特异性蛋白质预防沙门氏菌引起的家畜疾病。构成：沙门氏菌特异性蛋白质诱导针对沙门氏菌病的免疫性具有SEQ ID NO：2的氨基酸序列。编码沙门氏菌特异性蛋白质的多核苷酸具有SEQ ID NO：1的核苷酸序列。注射制剂含有诱导针对具有SEQ ID NO：2的氨基酸序列的沙门氏菌病的沙门氏菌特异性蛋白质。口服制剂含有具有SEQ ID NO：2氨基酸序列的针对沙门氏菌病的沙门氏菌特异性蛋白质诱导免疫，其中口服制剂是家畜饲料。

58. 发明授权

KR100202771B1 미생물감염에대한숙주의예방적치료용백신 失效
标题翻译：活生物体
公开(公告)号：KR100202771B1
公开(公告)日：1999-06-15
申请号：KR1019920702407
申请日：1991-03-28
申请人： 더 웰컴 파운데이션 리미티드
发明人： 고르단두간 , 이안조지찰스 , 카를로스에스테니오호르매쉬 , 캐빈스투아르트존슨 , 스티븐네빌채트필드
IPC分类号： C12N1/20
CPC分类号： C12N15/00 , A61K39/0275 , A61K2039/522 , C07K14/255 , C12N9/52 , Y02A50/482 , Y02A50/484 , Y10S424/826
摘要： Attenuated microorganism for use in immunoprophylaxis in which the attenuation is brought about by the presence of a mutation in the DNA sequence of the microorganism which encodes, or which regulates the expression of DNA encoding a protein that is produced in response to environmental stress, the microorganism optionally being capable of expressing DNA encoding a heterologous antigen.

59. 发明授权

KR101840360B1 브루셀라 균 주요 공통 항원을 발현하는 LPS의 O-항원 결실 비병원성 살모넬라 균주를 포함하는 브루셀라증 예방 또는 치료용 백신 조성물 有权
公开(公告)号：KR101840360B1
公开(公告)日：2018-03-20
申请号：KR1020160178943
申请日：2016-12-26
申请人： 전북대학교산학협력단
发明人： 이존화 , 조나탄넬시암다라 , 원가연 , 허진
IPC分类号： A61K39/112 , A61K39/02 , A23K10/16
CPC分类号： A23K10/16 , A61K39/0275 , A61K39/098 , Y02A50/482
摘要： 본발명은브루셀라균 주요공통항원을발현하는 LPS의 O-항원결실비병원성살모넬라균주을이용한브루셀라증예방용백신조성물에관한것이다. 본발명은브루셀라아보투스() 유래 BLS, Omp19, PrpA 및 SOD 항원의분비를증가시키도록개발된벡터로 LPS의 O-항원이결실된약독화살모넬라균을형질전환시키고상기형질전환된살모넬라변이주의혼합물을접종시킨마우스에서항원에대한체액성및 세포성면역반응유도및 도전감염시방어효과가우수함을확인하였다. 따라서, 본발명의변이주는안전하고경제적이며간편하게접종할수 있는브루셀라증및 살모넬라증예방또는치료용백신으로유용하게사용될것으로기대된다.

60. 发明授权

KR101835946B1 생백신의 제조 有权
标题翻译：生产活疫苗
公开(公告)号：KR101835946B1
公开(公告)日：2018-03-07
申请号：KR1020157014763
申请日：2013-09-05
申请人： 로만 아니말 헬쓰 게엠베하
发明人： 린데,클라우스 , 그로쎄-헤렌타이,안케
IPC分类号： C12N1/36 , C12N1/20 , C12R1/02 , C12R1/42 , A61K39/112 , A61K39/00
CPC分类号： A61K39/105 , A61K39/0275 , A61K2039/106 , A61K2039/522 , A61K2039/542 , A61K2039/55 , A61K2039/552 , C12N1/36 , C12R1/01 , C12R1/42 , Y02A50/482
摘要： 본원에는 3가지이상의약독화돌연변이를수반하는안정한박테리아를함유하는생백신의생성방법, 및상기방법에의해수득된박테리아를함유하는백신이기재되어있다.
摘要翻译：本文描述了用于生产含有携带三种或更多种减毒突变的稳定细菌的活疫苗和通过该方法获得的含有细菌的疫苗的方法。

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