专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明公开

KR1020090029339A 약물 담지 미립구의 제조방법 및 장치와 이를 이용하여제조된 전립선 비대증 치료용 제제 失效
标题翻译：药物加载微生物的制备方法及其装置及其治疗引发的预防性高血压的药物
公开(公告)号：KR1020090029339A
公开(公告)日：2009-03-23
申请号：KR1020070094497
申请日：2007-09-18
申请人： 한양대학교 산학협력단
发明人： 좌용호 , 안국환 , 이학종
IPC分类号： A61K9/16 , A61P13/08 , A61K47/30
CPC分类号： A61K9/124 , A61K9/0019 , A61K47/593 , A61K47/61 , A61K47/6905 , B82Y5/00
摘要： A preparation method of drug loading microcarrier is provided to locally cure diseases by directly injecting it on the affected part, and to cure BPH(Benign Prostatic Hypertrophy) by controlling the properties of drug loading microcarrier. A preparation method of drug loading microcarrier comprises the steps of: (S1) preparing the solution containing biodegradable polymer, drug and solvent; (S2) spraying the manufactured solution into aerosol particles by using a sprayer; (S3) transferring the sprayed aerosol to a chamber heated in advance with carrier gas and drying it; and (S4) collecting the dried drug loading microcarrier.
摘要翻译：提供药物载体微载体的制备方法，通过直接注射到患部进行局部治疗，并通过控制药物载体微载体的性质来治疗BPH（良性前列腺肥大症）。载药微载体的制备方法包括以下步骤：（S1）制备含有可生物降解的聚合物，药物和溶剂的溶液; （S2）使用喷雾器将制成的溶液喷雾成气溶胶颗粒; （S3）将喷雾的气溶胶转移到预先用载气加热并干燥的室中; 和（S4）收集干燥的药物加载微载体。

42. 发明公开

KR1020080096834A 분자 각인 폴리머의 개선된 제조법 有权
标题翻译：改进分子印迹聚合物的制备
公开(公告)号：KR1020080096834A
公开(公告)日：2008-11-03
申请号：KR1020087022727
申请日：2007-02-21
申请人： 미프살러스 에이피에스
发明人： 크리스텐센,제스퍼스베닝 , 닐센,클라우스그레고리우스 , 크로그,니콜라스오토
IPC分类号： B01J20/26 , A61K31/74 , C08J9/00
CPC分类号： B01J20/26 , A61K31/74 , A61K47/58 , A61K47/593 , B01J20/268 , B01J20/3057
摘要： One aspect is a method for improved preparation of molecular imprinted polymer (MIP) particles, where initial compositions comprising insoluble MIP particles are enriched for those MIP particles that bind a particular target molecule, thus excluding non-binding and weakly binding particles from the final composition. Enrichment is typically accomplished via use of chromatographic methods capable of separating particulate material or by means of agglutination. Another aspect is preparation of improved insoluble MIPs by use of extended micronization of raw MIP particles with a view to expose a large number of binding sites per mass unit of MIP particles. In preferred embodiments the two aspects are combined. The resulting improved MIPs may be used for diagnostic, analytical and therapeutic purposes, notably as orally administered drugs which can bind substances such as cholesterol and bile acids and bile acid salts in the gastrointestinal tract.
摘要翻译：一个方面是改进制备分子印迹聚合物（MIP）颗粒的方法，其中包含不溶性MIP颗粒的初始组合物富集用于结合特定靶分子的那些MIP颗粒，从而从最终组合物排除非结合和弱结合的颗粒。富集通常通过使用能够分离颗粒材料或通过凝集的色谱方法来实现。另一方面是通过使用原始MIP颗粒的延长微粉化来制备改进的不溶性MIP，以期暴露每质量单位MIP颗粒的大量结合位点。在优选实施例中，组合了两个方面。所得到的改进的MIP可以用于诊断，分析和治疗目的，特别是作为口服给药的药物，其可以在胃肠道中结合胆固醇和胆汁酸和胆汁酸盐等物质。

43. 发明授权

KR100851270B1 약물 전달 운반체로서의 다중팔 블록 공중합체 有权
标题翻译：多臂嵌段共聚物作为药物递送车辆
公开(公告)号：KR100851270B1
公开(公告)日：2008-08-08
申请号：KR1020037009604
申请日：2002-01-22
申请人： 넥타르 테라퓨틱스 에이엘, 코포레이션
发明人： 자오쉬안
IPC分类号： A61K47/48
CPC分类号： C08G63/914 , A61K31/724 , A61K31/74 , A61K31/77 , A61K47/593 , A61K47/60 , A61K47/6949 , B82Y5/00 , C08G65/2609 , C08G81/00 , C08G2650/24 , C08L71/02 , C08L2205/05 , C08L2666/18
摘要： 본 발명은 폴리올의 잔기를 포함하는 중심 코어 분자 및 중심 코어 분자에 공유 부착된 3 개 이상의 공중합체 팔을 포함하는, 약물 전달 운반체로서 유용한 다중팔 블록 공중합체를 제공한다 (각각의 공중합체 팔은 중심 코어 분자에 공유 부착된 내부 소수성 중합체 절편 및 소수성 중합체 절편에 공유 부착된 외부 친수성 중합체 절편을 포함하며, 여기서 중심 코어 분자 및 소수성 중합체 절편이 소수성 코어 영역을 규정한다). 소수성 생물학적 활성제의 용해도는 블록 공중합체의 소수성 코어 영역 내에 포획하여 개선될 수 있다. 또한 본 발명에는, 상기 블록 공중합체를 포함하는 약학 조성물, 상기 공중합체 및 약학 조성물의 제조 방법 및 약물 전달 운반체로서의 상기 블록 공중합체의 이용 방법이 포함된다.

44. 发明公开

KR1020080024594A 혈관신생-촉진 단백질 약물에 대한 서방형 국소 약물전달시스템 有权
标题翻译：用于控制释放促血糖蛋白药物的药物递送系统
公开(公告)号：KR1020080024594A
公开(公告)日：2008-03-19
申请号：KR1020060088891
申请日：2006-09-14
申请人： 광주과학기술원
发明人： 태기융 , 정용일
IPC分类号： A61K9/22 , A61K47/36 , B82Y5/00
CPC分类号： A61K47/593 , A61K9/0002 , A61K47/61 , A61K47/6903 , B82Y5/00
摘要： A drug delivery system for controlled release of angiogenesis-promoting protein drugs is provided to improve stability and controlled release properties of protein drugs to be delivered, and maximize topical delivery effects by reducing the initial burst of protein drugs, so that it is useful for treatment of disease associated with vascular closure or ischemic disease. A drug delivery system for controlled release of angiogenesis-promoting protein drugs comprises (a) the hydrogel complex containing (a-1) polysaccharide-functionalized nanoparticles containing (i) a core containing biodegradable polymer, (ii) a first hydrogel consisting of biocompatible polymer formed on the core and (iii) polysaccharide molecule non-covalently bound to the core and first hydrogel, and (a-2) a second hydrogel consisting of biocompatible polymer having cell-adhering activity as a carrier containing the nanoparticles, and (b) VEGF(vascular endothelial cell growth factor), FGF(fibroblast growth factor), PDGF(platelet-derived growth factor) or its combination which is non-covalently bound to the polysaccharide molecule.
摘要翻译：提供用于控制释放血管生成促进蛋白质药物的药物递送系统，以改善待递送的蛋白质药物的稳定性和控制释放性质，并通过减少蛋白质药物的初始爆发来最大限度地发挥局部递送效果，从而可用于治疗与血管闭合或缺血性疾病相关的疾病。用于控释血管生成促进蛋白质药物的药物递送系统包括（a）含有（a-1）多糖官能化纳米颗粒的水凝胶复合物，其包含（i）含有生物可降解聚合物的核心，（ii）由生物相容性聚合物和（a）由具有细胞粘附活性的生物相容性聚合物组成的第二水凝胶，所述生物相容性聚合物具有作为载体的纳米粒子，和（b）含有纳米粒子的载体， VEGF（血管内皮细胞生长因子），FGF（成纤维细胞生长因子），PDGF（血小板衍生生长因子）或其与多糖分子非共价结合的组合。

45. 发明公开

KR1020030089218A Ｔａｔ49-57 펩티드 또는 Ｔａｔ49-57 펩티드를 포함하는펩티드사슬과 생분해성 지방족 폴리에스테르계 고분자와의공유결합체 및 이를 이용하여 제조된 나노입자 有权
标题翻译：含有TAT49-57肽或TAT49-57含肽肽的生物可降解的聚氨酯与使用其制备的纳米颗粒结合
公开(公告)号：KR1020030089218A
公开(公告)日：2003-11-21
申请号：KR1020020027328
申请日：2002-05-17
申请人： 주식회사 아모레퍼시픽그룹
发明人： 박주영 , 남윤성 , 한상훈 , 장이섭
IPC分类号： C07K7/06 , B82Y5/00
CPC分类号： A61K47/645 , A61K47/593 , A61K47/62
摘要： PURPOSE: A conjugate of biodegradable aliphatic polyester with Tat49-57 peptide or Tat49-57 peptide-containing peptide chain, and a nanoparticle manufactured using the same conjugate are provided. The cell penetration of the nanoparticle is increased by exposing Tat peptide on the surface of the nanoparticle. CONSTITUTION: A conjugate of biodegradable aliphatic polyester with Tat49-57 peptide having the nucleotide sequence of SEQ ID NO: 1 or Tat49-57 peptide-containing peptide chain is provided, wherein the biodegradable aliphatic polyester is one or more components selected from copolymers manufactured from poly(D-lactic acid), poly(L-lactic acid), poly(D,L-lactic acid), poly(D-lactic acid-co-glycolic acid), poly(L-lactic acid-co-glycolic acid), poly(D,L-lactic acid-co-glycolic acid), poly(caprolactone), poly(valerolactone), poly(hydroxy butyrate), poly(hydroxy valerate), poly(1,4-dioxan-2-one), poly(ortho ester) and monomers thereof. A nanoparticle manufactured using the conjugate of biodegradable aliphatic polyester with Tat49-57 peptide or Tat49-57 peptide-containing peptide chain has average particle size of 1,000 nm or less.
摘要翻译：目的：提供可生物降解的脂族聚酯与Tat49-57肽或Tat49-57含肽肽链的共轭物，以及使用相同的缀合物制造的纳米颗粒。通过在纳米颗粒的表面上暴露Tat肽来增加纳米颗粒的细胞穿透。构成：提供可生物降解的脂族聚酯与具有SEQ ID NO：1或Tat49-57含肽肽链的核苷酸序列的Tat49-57肽的缀合物，其中可生物降解的脂族聚酯是一种或多种选自以下的共聚物：聚（D-乳酸），聚（L-乳酸），聚（D，L-乳酸），聚（D-乳酸 - 共 - 乙醇酸），聚（L-乳酸 - 共 - 乙醇酸）），聚（D，L-乳酸 - 共 - 乙醇酸），聚（己内酯），聚（戊内酯），聚（羟基丁酸酯），聚（羟基戊酸酯），聚（1,4-二恶烷-2-酮），聚（原酸酯）及其单体。使用生物降解性脂肪族聚酯与Tat49-57肽或Tat49-57含肽肽链的共轭物制造的纳米粒子的平均粒径为1000nm以下。

46. 发明公开

KR1020020041712A 생분해성 고분자와 항암제의 접합체를 이용한 서방형미셀제제의 제조방법 失效
标题翻译：使用可生物降解聚合物和反应剂代理产生缓释药物释放微生物的方法
公开(公告)号：KR1020020041712A
公开(公告)日：2002-06-03
申请号：KR1020000071400
申请日：2000-11-28
申请人： 한국과학기술원
发明人： 박태관 , 유혁상
IPC分类号： A61K9/127
CPC分类号： A61K47/6907 , A61K31/337 , A61K31/513 , A61K31/704 , A61K33/24 , A61K47/593 , A61K47/60
摘要： PURPOSE: A process for producing a slowly drug-releasing micelle using a conjugation of a biodegradable polymer and an anticancer agent is provided, thereby the drug releasing rate can be controlled, so that the slowly drug-releasing micelle can be useful for treatment of cancer. CONSTITUTION: The process for producing a slowly drug-releasing micelle using a conjugation of a biodegradable polymer and an anticancer agent comprises the steps of: copolymerizing a biodegradable polyester polymer and polyethyleneglycol(PEG) in the presence of stannous octoate under vacuum condition at 160 to 200 deg.C for 2 to 6 hours to prepare a block copolymer having both hydrophobic region and hydrophilic region, wherein the end of the hydrophobic region has hydroxy group; dissolving the block copolymer in an organic solvent, reacting the block copolymer with a linker compound in the presence of pyridine and nitrogen to combine the linker compound with the hydroxy group of the block copolymer; reacting the block copolymer with hydrazine and combining the block copolymer with a drug to prepare a micelle unit; and dispersing the micelle unit in an aqueous solution.
摘要翻译：目的：提供使用可生物降解的聚合物和抗癌剂的缀合物制备缓慢释药的胶束的方法，从而可以控制药物释放速率，使得缓慢释药的胶束可用于治疗癌症。构成：使用可生物降解的聚合物和抗癌剂的缀合物制备缓慢释药的胶束的方法包括以下步骤：在160℃的真空条件下，在辛酸亚锡存在下将可生物降解的聚酯聚合物和聚乙二醇（PEG）共聚， 200℃下反应2〜6小时以制备具有疏水区域和亲水区域的嵌段共聚物，其中疏水区域的末端具有羟基; 将嵌段共聚物溶解在有机溶剂中，在吡啶和氮气存在下使嵌段共聚物与连接体化合物反应，将连接物与嵌段共聚物的羟基组合; 使嵌段共聚物与肼反应并将嵌段共聚物与药物混合以制备胶束单元; 并将胶束单元分散在水溶液中。

47. 发明授权

KR101916875B1 면역조절제-중합체성 화합물 有权
公开(公告)号：KR101916875B1
公开(公告)日：2018-11-08
申请号：KR1020117030993
申请日：2010-05-26
申请人： 셀렉타 바이오사이언시즈, 인크.
发明人： 제프,찰스 , 립포드,그레이슨,비. , 가오,윤 , 존스톤,로이드 , 푸,펜-니 , 키간,마크,제이. , 발드윈,샘
IPC分类号： C07D473/32 , A61K31/525 , A61K9/51 , A61K39/00
CPC分类号： A61K39/385 , A61K9/5138 , A61K39/0013 , A61K39/39 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/64 , A61K47/6925 , A61K47/6935 , A61K47/6937 , A61K2039/55511 , A61K2039/55544 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/62 , A61K2039/627 , B82Y5/00 , C07D471/04 , C07D473/34 , C08G63/06 , C08G63/08 , C08G63/912 , C08G64/42 , C08J3/24 , C08J2367/04
摘要： 본발명은면역조절제및 중합체또는그의단위(들)의공액결합물의조성물, 및관련화합물및 방법에관한것이다. 이공액결합물은합성나노운반체내에함유될수 있고, 면역조절제는합성나노운반체로부터 pH 감응성방식으로방출될수 있다.

48. 发明公开

KR1020170054434A 유전자 요법 항-바이러스 전달 벡터 면역 반응을 약화시키기 위한 방법 및 조성물 审中-实审
标题翻译：用于减毒基因疗法抗病毒递送载体免疫应答的方法和组合物
公开(公告)号：KR1020170054434A
公开(公告)日：2017-05-17
申请号：KR1020177009110
申请日：2015-09-07
申请人： 셀렉타 바이오사이언시즈, 인크.
发明人： 기시모토,다까시,케이
IPC分类号： A61K31/436 , A61K39/00 , A61K31/7088 , A61K38/48 , A61K9/51 , A61K47/50 , C12N15/86 , C12N7/00
CPC分类号： A61K48/00 , A61K9/1271 , A61K9/5115 , A61K9/5153 , A61K31/436 , A61K31/7088 , A61K39/001 , A61K45/06 , A61K47/593 , A61K47/6923 , A61K47/6929 , A61K47/6935 , A61K47/6937 , A61K48/005 , A61K2039/545 , A61K2039/577 , C12N7/00 , C12N15/86 , C12N2710/00041 , C12N2710/10032 , C12N2710/10043 , C12N2740/10041 , C12N2740/15032 , C12N2740/15043 , C12N2740/16043 , C12N2750/14132 , C12N2750/14141 , C12N2750/14143 , G06Q99/00 , A61K2300/00 , A61K38/4846
摘要： 본원에는바이러스전달벡터및 항원제시세포표적화면역억제제를투여하기위한방법및 관련조성물이제공된다.
摘要翻译：本文提供了用于施用病毒递送载体和抗原呈递细胞靶向免疫抑制剂的方法和相关组合物。

49. 发明公开

KR1020170045346A 유전자 발현 조정성 항-바이러스 전달 벡터 면역 반응을 약화시키기 위한 방법 및 조성물 审中-实审
标题翻译：用于减弱基因表达调节抗病毒递送载体免疫应答的方法和组合物
公开(公告)号：KR1020170045346A
公开(公告)日：2017-04-26
申请号：KR1020177009112
申请日：2015-09-07
申请人： 셀렉타 바이오사이언시즈, 인크.
发明人： 기시모토,다까시,케이
IPC分类号： A61K31/436 , A61K48/00 , A61K31/7088 , A61K38/48 , A61K39/00 , A61K47/50 , A61K9/51
CPC分类号： A61K48/00 , A61K9/1271 , A61K9/5115 , A61K9/5153 , A61K31/436 , A61K31/7088 , A61K39/001 , A61K45/06 , A61K47/593 , A61K47/6923 , A61K47/6929 , A61K47/6935 , A61K47/6937 , A61K48/005 , A61K2039/545 , A61K2039/577 , C12N7/00 , C12N15/86 , C12N2710/00041 , C12N2710/10032 , C12N2710/10043 , C12N2740/10041 , C12N2740/15032 , C12N2740/15043 , C12N2740/16043 , C12N2750/14132 , C12N2750/14141 , C12N2750/14143 , G06Q99/00 , A61K2300/00 , A61K38/4846
摘要： 본원에는바이러스전달벡터및 항원제시세포표적화면역억제제를투여하기위한방법및 관련조성물이제공된다.
摘要翻译：本文提供了用于施用病毒递送载体和抗原呈递细胞靶向免疫抑制剂的方法和相关组合物。

50. 发明公开

KR1020170045345A 유전자 편집 항-바이러스 전달 벡터 면역 반응을 약화시키기 위한 방법 및 조성물 审中-实审
标题翻译：用于基因修饰抗病毒递送载体免疫应答的方法和组合物
公开(公告)号：KR1020170045345A
公开(公告)日：2017-04-26
申请号：KR1020177009111
申请日：2015-09-07
申请人： 셀렉타 바이오사이언시즈, 인크.
发明人： 기시모토,다까시,케이
IPC分类号： A61K31/436 , A61K48/00 , A61K31/7088 , A61K38/48 , A61K39/00 , A61K47/50 , A61K9/51 , C12N15/86
CPC分类号： A61K48/00 , A61K9/1271 , A61K9/5115 , A61K9/5153 , A61K31/436 , A61K31/7088 , A61K39/001 , A61K45/06 , A61K47/593 , A61K47/6923 , A61K47/6929 , A61K47/6935 , A61K47/6937 , A61K48/005 , A61K2039/545 , A61K2039/577 , C12N7/00 , C12N15/86 , C12N2710/00041 , C12N2710/10032 , C12N2710/10043 , C12N2740/10041 , C12N2740/15032 , C12N2740/15043 , C12N2740/16043 , C12N2750/14132 , C12N2750/14141 , C12N2750/14143 , G06Q99/00 , A61K2300/00 , A61K38/4846
摘要： 본원에는바이러스전달벡터및 항원제시세포표적화면역억제제를투여하기위한방법및 관련조성물이제공된다.
摘要翻译：本文提供了用于施用病毒递送载体和抗原呈递细胞靶向免疫抑制剂的方法和相关组合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式