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    • 21. 发明公开
    • 하고초, 애엽 추출물을 유효성분으로 포함하는 단백질 타이로신 탈인산화 효소 저해용 조성물
    • 抑制PTP1B含有PRUNELLAE,ARTEMISIA提取物的组合物
    • KR1020130055395A
    • 2013-05-28
    • KR1020110121119
    • 2011-11-18
    • (주)에스.앤.디
    • 여경목권상오김복남김재훈남충구김선표
    • A61K36/536A61K36/282A61P3/10A61P3/00
    • A61K36/536A23V2200/328A61K36/282A61K2236/51Y10S514/866
    • PURPOSE: A mixture of a Prunella vulgaris extract and an Artemisia argyi herb extract is provided to suppress PTP1B(protein tyrosine phosphatase B1), and to prevent or treat diabetes. CONSTITUTION: A composition for suppressing PTP1B contains a Prunella vulgaris extract and/or an Artemisia argyi herb extract in a ratio of 1:1. A drug composition contains the composition for suppressing PTP1B as an active ingredient. A health food composition contains the composition for suppressing PTP1B as an active ingredient. A method for preparing the composition for suppressing PTP1B comprises: a step of extracting Prunella vulgaris and Artemisia argyi herb with water and filtering; a step of concentrating the liquid; and a step of drying the concentrate. [Reference numerals] (AA,EE) Control group; (BB,GG) Artemisia argyi herb; (CC,FF) Prunella vulgaris; (DD,HH) Mixture of Prunella vulgaris and Artemisia argyi herb
    • 目的:提取寻常Pr草提取物和艾蒿草药提取物的混合物,以抑制PTP1B(蛋白酪氨酸磷酸酶B1),并预防或治疗糖尿病。 构成:用于抑制PTP1B的组合物含有比例为1:1的普通寻常提取物和/或艾蒿草药提取物。 药物组合物含有抑制PTP1B作为活性成分的组合物。 保健食品组合物含有抑制PTP1B作为活性成分的组合物。 制备抑制PTP1B的组合物的方法包括:用水提取普通蒿和艾蒿草药的步骤; 浓缩液体的步骤; 和干燥浓缩物的步骤。 (标号)(AA,EE)对照组; (BB,GG)艾蒿草药; (CC,FF)普通普洱 (DD,HH)寻常Pr草和艾蒿草药的混合物
    • 24. 发明授权
    • 고추 추출물을 발효공법에 의해 변형시킨 변형고추펙틴과 그 제조방법 및 용도
    • 使用和红辣椒提取物发酵的改良辣椒果胶的方法
    • KR100945717B1
    • 2010-03-08
    • KR1020070118368
    • 2007-11-20
    • (주)에스.앤.디
    • 여경목권상오이상영김복남박연심
    • C12P19/04C12P19/00
    • 본 발명은 고춧가루를 용매를 이용하여 펙틴을 추출하고, 상기 추출된 펙틴을 검정곰팡이(Aspergillus niger)로 발효시켜 생성되는 변형고추펙틴(MCP, Modified Capsicum Pectin)과, 그 제조방법 및 용도에 관한 것이다. 즉, 본 발명은 고춧가루로부터 펙틴을 함유한 추출물을 검정곰팡이(Aspergillus niger)로 발효시켜서, 고추 세포벽을 구성하고 있는 펙틴(pectin)화합물이 검정곰팡이(Aspergillus niger)로부터 분비되는 엔도폴리갈락투로나아제(endopolygalacturonase) 및 펙틴 메틸에스테라제(pectin methylesterase)에 의해 분해가 되도록 하여, 변형고추펙틴을 제조하는 방법을 제시한다.
      또한, 본 발명은 상기 제조된 변형고추펙틴(MCP)이 중금속(heavy metal)과 복합체 반응(Chelation)을 일으키는 것을 실험으로써 확인하여 장내 중금속 제거하는 효과가 있음을 밝혀내고, 시토킨(Cytokine) 유도 기능을 확인하여 인체면역성 증대 효과가 있음을 밝혀내고, 항산화 활성기능을 확인하여 항암 및 노화방지 효과가 있음을 밝혀낸다. 이를 통해, 상기 변형고추펙틴(MCP)을 유효한 성분으로 하는 식품(또는 조성물)은 장내 중금속 제거와, 인체면역성 증대, 항암 및 노화방지 효과를 가지는 기능성 식품으로서 활용이 가능함을 제시한다.
      고추, 펙틴, 변형고추펙틴, 중금속, 엔도폴리갈락투로나아제, 시토킨, 산화스트레스, 펙틴메틸에스테라아제, 발효, 기능성식품, red pepper, pectin, modified capsicum pectin, MCP, heavy metals, endopolygalacturonase, cytokines, oxidative stress, pectin methylesterase, fermentation, functional food
    • 29. 发明公开
    • 페닐아마이드 화합물을 유효성분으로 하는 고지혈증 치료용 복합 생약 추출물
    • 用于治疗高脂血症的复杂提取物
    • KR1020130025421A
    • 2013-03-11
    • KR1020130010580
    • 2013-01-30
    • (주)에스.앤.디
    • 여경목최상원권상오김복남김동희
    • A61K31/4045A61K31/135A61K36/286A61K36/906
    • A61K31/4045A61K31/165A61K36/286A61K36/906A61K2300/00
    • PURPOSE: A complex crude drug extract containing a phenylamide compound is provided to reduce side effects and toxicity, and to treat hyperlipidemia. CONSTITUTION: A complex crude drug extract for treating hyperlipidemia contains a serotonin derivative and a tyramine derivative in a weight ratio of 4:1. The serotonin derivative is N-(p-coumaroyl)serotonin(CS), N-feruloylserotonin(FS), or a mixture thereof. The tyramine derivative is dihydro-N-caffeoyltyramine(DCT), trans-N-caffeoyltyramine(t-CT), or a mixture thereof. [Reference numerals] (AA) Ginger + Safflower seed; (BB) Ginger 1 : Safflower seed B8; (CC) Ginger 1 : Safflower seed B4; (DD) Ginger 1 : Safflower seed B2; (EE) Ginger 1 : Safflower seed B1; (FF) Ginger 2 : Safflower seed B1; (GG) Ginger 4 : Safflower seed B1; (HH) Ginger 8 : Safflower seed B1; (II) Ginger 1 : Safflower seed A1; (JJ) Ginger 2 : Safflower seed A1; (KK) Ginger 4 : Safflower seed A1; (LL) Ginger 8 : Safflower seed A1
    • 目的:提供含有苯酰胺化合物的复合生物药物提取物,以减少副作用和毒性,并治疗高脂血症。 构成:用于治疗高脂血症的复杂生药提取物含有重量比为4:1的5-羟色胺衍生物和酪胺衍生物。 5-羟色胺衍生物是N-(对 - 香豆酰基)5-羟色胺(CS),N-亚铁血清素(FS)或其混合物。 酪胺衍生物是二氢-N-咖啡酰基酪氨酸(DCT),反式N-咖啡酰酪胺(t-CT)或其混合物。 (标号)(AA)姜+红花种子; (BB)姜1:红花种子B8; (CC)姜1:红花籽B4; (DD)姜1:红花籽B2; (EE)姜1:红花籽B1; (FF)姜2:红花籽B1; (GG)姜4:红花籽B1; (HH)姜8:红花籽B1; (二)姜1:红花籽A1; (JJ)姜2:红花籽A1; (KK)姜4:红花籽A1; (LL)姜8:红花籽A1
    • 30. 发明公开
    • 페닐아마이드 화합물을 유효성분으로 하는 고지혈증 치료용 복합 생약 추출물
    • 用于治疗高脂血症的复杂提取物
    • KR1020120115060A
    • 2012-10-17
    • KR1020110071839
    • 2011-07-20
    • (주)에스.앤.디
    • 여경목최상원권상오김복남김동희
    • A61K36/286A61K36/906A61P3/06
    • PURPOSE: A complex crude drug extract for treating hyperlipidemia which contains phenyl amide compound is provided to show HMG-CoR inhibition effects and ACAT inhibition effects related to treat and prevent the hyperlipidemia. CONSTITUTION: A complex crude drug extract for treating hyperlipidemia is composed of multiple extract of safflower seed and ginger. The mixing ratio of the safflower seed to ginger is 4:1 in the weight ratio. The Lycii Radicis Cortex extract is additionally added to the extract. The mixing ration of the safflower seed, ginger extract, and the Lycii Radicis Cortex extract is 5:1:1 in the weight ratio. The complex crude drug extract for treating hyperlipidemia is composed of serotonin derivative and tyramine derivative. The mixing ratio of serotonin derivative to the tyramine derivative is 4: 1 in the weight ratio. The serotonin derivative is a mixture of N-(p-coumaroyl) serotonin(CS), N- feruloylserotonin(FS), or a mixture thereof. [Reference numerals] (AA) Ginger+safflower seed; (BB) Ginger 1 : Safflower seed B3; (CC) Ginger 1 : Safflower seed B4; (DD) Ginger 1 : Safflower seed B2; (EE) Ginger 1 : Safflower seed B1; (FF) Ginger 2 : Safflower seed B1; (GG) Ginger 4 : Safflower seed B1; (HH) Ginger 8 : Safflower seed B1; (II) Ginger 1 : Safflower seed A1; (JJ) Ginger 2 : Safflower seed A1; (KK) Ginger 4 : Safflower seed A1; (LL) Ginger 8 : Safflower seed A1
    • 目的:提供一种用于治疗含有苯酰胺化合物的高脂血症的复合生药提取物,以显示与治疗和预防高脂血症相关的HMG-CoR抑制作用和ACAT抑制作用。 构成:用于治疗高脂血症的复方生药提取物由红花种子和姜的多次提取物组成。 红花种子与姜的混合比例为4:1。 提取物中还加入Lycii Radicis Cortex提取物。 红花种子,姜提取物和堇菜提取物的混合比例为5:1:1。 用于治疗高脂血症的复方生药提取物由5-羟色胺衍生物和酪胺衍生物组成。 5-羟色胺衍生物与酪胺衍生物的混合比例为重量比为4:1。 5-羟色胺衍生物是N-(对 - 香豆酰基)5-羟色胺(CS),N-阿魏酰基血清素(FS)或其混合物的混合物。 (标号)(AA)姜+红花种子; (BB)姜1:红花籽B3; (CC)姜1:红花籽B4; (DD)姜1:红花籽B2; (EE)姜1:红花籽B1; (FF)姜2:红花籽B1; (GG)姜4:红花籽B1; (HH)姜8:红花籽B1; (二)姜1:红花籽A1; (JJ)姜2:红花籽A1; (KK)姜4:红花籽A1; (LL)姜8:红花籽A1