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    • 23. 发明公开
    • 신규한 비타민 유도체 및 그의 합성방법
    • 新维生素衍生物及其合成方法
    • KR1020080020242A
    • 2008-03-05
    • KR1020060083459
    • 2006-08-31
    • 주식회사 참 존
    • 민석기엄상용김종헌박우정
    • C07D401/12C07D403/14C07D403/12
    • Novel vitamin derivatives are provided to improve stability of physiological properties for vitamin C having antioxidative effects and vitamin E having skin-activating effects by combining them by means of hydroxy acid, so that the useful effects of vitamin C and E are exhibited simultaneously and stably. The vitamin derivatives represented by the formula(1) are provided, wherein R1, R2 and R3 are each independently hydrogen or methyl group; R4 is C1-C20 alkylene group; the vitamin derivatives include 3-(tocopheryl acyl)-L-ascorbic acid represented by the formula(2) and 3-(tocopheryl acetyl)-L-ascorbic acid represented by the formula(3), and are synthesized by treating compounds represented by the formula(7) with acid catalyst and water to remove acetal group; and the acid catalyst is sulfuric acid, hydrochloric acid, phosphoric acid, acetic acid or trifluoroacetic acid.
    • 提供新颖的维生素衍生物,以通过羟基酸组合使维生素C具有抗氧化作用的维生素C和具有皮肤活化作用的维生素E的生理特性的稳定性,使得维生素C和E的有用效果同时且稳定地显现。 提供由式(1)表示的维生素衍生物,其中R1,R2和R3各自独立地为氢或甲基; R4是C1-C20亚烷基; 维生素衍生物包括由式(2)表示的3-(生育酚酰基)-L-抗坏血酸和由式(3)表示的3-(生育酚乙酰基)-L-抗坏血酸,并且通过处理由式 式(7)用酸催化剂和水去除缩醛基; 酸催化剂为硫酸,盐酸,磷酸,乙酸或三氟乙酸。
    • 27. 发明公开
    • 자작나무 껍질 추출물을 함유하는 피부 주름개선 화장료조성물
    • 用于减少皱纹的化妆品组合物,包括BETULA PLATYPHYLLA提取物
    • KR1020030067554A
    • 2003-08-14
    • KR1020030007523
    • 2003-02-06
    • 주식회사 참 존
    • 김종헌엄상용정의수
    • A61K8/97A61Q19/08
    • A61K8/97A61K2800/782A61Q19/08
    • PURPOSE: A cosmetic composition containing a Betula platyphylla extract having excellent wrinkle-reducing effect and skin and collagenase activity inhibiting effect is provided. The composition has excellent cell regenerating and collagen formation-promoting effect and stability when blended as a cosmetic and thus can be used as a cosmetic effective in decreasing skin wrinkles. CONSTITUTION: The cosmetic composition contains 0.0001 to 5% by weight of an extract of Betula platyphylla var. japonica(Miquel) Hara, based on the total weight of the composition. The Betula platyphylla extract is obtained by soaking 1 to 15 times in a solvent at 4 to 30deg.C for 3 to 20 days or extracting at 50 to 100deg.C for 3 to 24hr. The solvent is selected from water, C1-4 lower alcohol or a mixed solvent thereof and ethylacetate. Before and after the extraction of the Betula platyphylla, a diethylether soluble component is removed from the extract.
    • 目的:提供具有优异的皱纹减轻效果和皮肤和胶原酶活性抑制作用的含有白桦提取物的化妆品组合物。 当作为化妆品混合时,该组合物具有优异的细胞再生和胶原形成促进作用和稳定性,因此可用作有效减少皮肤皱纹的化妆品。 构成:化妆品组合物含有0.0001至5重量%的Betula platyphylla var。 粳米(Miquel)Hara,基于组合物的总重量。 通过在4〜30℃的溶剂中浸泡1〜15次,持续3〜20天,或在50〜100℃下提取3〜24小时,得到桦木提取物。 溶剂选自水,C 1-4低级醇或其混合溶剂和乙酸乙酯。 在提取桦树之前和之后,从提取物中除去二乙醚可溶性成分。