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    • 11. 发明公开
    • 지질 유도체
    • 脂质衍生物
    • KR1020080105095A
    • 2008-12-03
    • KR1020087022994
    • 2007-03-23
    • 프로노바 바이오파마 너지 에이에스
    • 홀메이데,앤,크리스틴
    • C07C33/02C07C57/03C07C69/587C07C69/734
    • C07C69/587C07C33/02C07C43/178C07C57/03C07C59/58C07C69/734
    • The present invention relates to lipid compounds of the general formula (I): wherein-R1 and R2 are the same or different and may be selected from a group of substituents consisting of a hydrogen atom, an alkyl group, a halogen atom, and an alkoxy group;-X is COR3 or CH2OR4, wherein-R3 is selected from the group consisting of hydrogen, hydroxy, alkoxy, and amino,-wherein X further comprises carboxylic acid derivatives when R3 is hydroxy; and-R4 is selected from the group consisting of hydrogen, alkyl or acyl,-Y is a C9 to C21 alkene with one or more double bonds with E or Z configuration; or any pharmaceutically acceptable complex, solvate or pro-drug thereof. The present invention also relates to pharmaceutical compositions comprising such lipid compounds, and to such lipid compounds for use as medicaments or for diagnostic purposes. ® KIPO & WIPO 2009
    • 本发明涉及通式(I)的脂质化合物:其中-R 1和R 2相同或不同,并且可以选自由氢原子,烷基,卤素原子和 烷氧基; -X是COR 3或CH 2 OR 4,其中-R 3选自氢,羟基,烷氧基和氨基,其中当R 3是羟基时,X还包含羧酸衍生物; 和-R 4选自氢,烷基或酰基,-Y是具有一个或多个具有E或Z构型的双键的C 9至C 21烯烃; 或其药学上可接受的复合物,溶剂合物或前体药物。 本发明还涉及包含这种脂质化合物的药物组合物以及用作药物或用于诊断目的的这种脂质化合物。 ®KIPO&WIPO 2009