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    • 14. 发明公开
    • 마나산틴 A 또는 마나산틴 B를 포함하는 비알코올성 지방간 질환 예방 또는 치료용 조성물
    • A组合物,用于预防或治疗非酒精性脂肪肝疾病,包括Manassantin A或Manassantin B
    • KR1020170013086A
    • 2017-02-06
    • KR1020150106051
    • 2015-07-27
    • 대한민국(농촌진흥청장)
    • 한신희박춘근최애진차선우박충범산얄,에이런제이민해기
    • A61K31/34A61K31/36A23L1/30
    • 본발명은마나산틴 A(manassantin A) 또는마나산틴 B(manassantin B)을포함하는비알코올성지방간질환예방또는치료용조성물에관한것으로, 본발명의마나산틴 A(manassantin A) 또는마나산틴 B(manassantin B)을포함하는비알코올성지방간질환예방또는치료용조성물은종래합성약제조성물이유발하는심혈관작용, 중추작용, 간장장애및 신장장애등 여러부작용이없으며, 비알코올성지방간질환에의한염증감소, 비알코올성지방간진행및 전이억제, 간내 지질축적억제, 항세포사멸효과및 세포의자식작용(autophagy) 활성촉진효과를가지고있으므로, 비알코올성지방간예방및/또는치료용약학적조성물또는비알코올성지방간및/또는개선용건강기능성식품조성물로유용하게활용될수 있다.
    • 本发明涉及用于非酒精性脂肪肝疾病预防或治疗的含有manassantin A或manassantin B的组合物。 由于含有用于非酒精性脂肪肝疾病预防或治疗本发明的马那他汀A或马那他汀B的组合物不具有常规合成药物组合物引起的心血管作用,中枢作用,肝损伤和肾脏疾病等各种副作用, 具有减少由非酒精性脂肪肝疾病引起的感染,抑制非酒精性脂肪肝疾病的进展和转移,抑制肝脏中的脂质储存,抗细胞凋亡和自噬激活促进的作用,所述组合物含有马桑汀A或 用于非酒精性脂肪肝疾病预防或治疗本发明的马那他丁B可有效地用作非酒精性脂肪肝预防和/或治疗的药物组合物或用于非酒精性脂肪肝预防和/ 或改进。
    • 17. 发明公开
    • 건지황 가공방법
    • 通过挤出生产雷米霉素制剂
    • KR1020140062870A
    • 2014-05-26
    • KR1020120129755
    • 2012-11-15
    • 대한민국(농촌진흥청장)
    • 최애진박춘근강용구이정훈박충범
    • A23L19/00A23L33/00A23P1/02
    • A23L19/01A23P10/20A23V2002/00A23V2300/16
    • The present invention relates to a manufacturing process for processed roots of Rehmannia glutinosa Liboschitz var. purpurea Makino and, more specifically, to a manufacturing process for processed roots of Rehmannia glutinosa Liboschitz var. purpurea Makino using extrusion molding which enables the processed roots of Rehmannia glutinosa Liboschitz var. purpurea Makino to be manufactured conveniently for a short time by designing an extrusion molding apparatus qualified certain conditions and manufacturing the processed roots of Rehmannia glutinosa Liboschitz var. purpurea Makino using the same apparatus according to the conditions. The manufacturing process for the processed roots of Rehmannia glutinosa Liboschitz var. purpurea Makino using extrusion molding according to a desirable embodiment of the present invention comprises: a step for pulverizing dried roots of Rehmannia glutinosa Liboschitz var. purpurea Makino into 100 mesh or smaller; and a step for putting fine powder of the pulverized dried roots of Rehmannia glutinosa Liboschitz var. purpurea Makino into the extrusion molding apparatus and extruding. Also, the extrusion molding apparatus according to a desirable embodiment of the present invention comprises: a casing (100) in which a slot (60), wherein the fine powder is inserted, and a nozzle (50), which is discharged when extruded, are formed; a screw (20) which is rotated to extrude the fine powder inserted into the casing (100); a driving motor (10) which is connected to the screw (20) to drive the same; and multiple barrels (30) which is installed on the external surface of the casing (100), in which the screw (20) is installed, to adjust different temperatures at every interval of a certain length.
    • 本发明涉及一种加工生根土壤的生产方法。 purpurea Makino,更具体地说,涉及地黄枸杞的生产过程。 purpurea Makino使用挤出成型,使得地黄枸杞的加工根。 purpurea Makino通过设计出符合某些条件的挤出成型设备,制造方便地短时间生产地黄土壤Liboschitz变种的加工根。 紫草根据条件使用相同的装置。 地黄枸杞加工根的制造工艺 根据本发明所希望的实施方案,使用挤压成型的紫草甙包括:粉碎地黄枸杞子干燥根的步骤。 purpurea Makino变成100目以下; 以及将地黄粉碎干燥根的细粉末放入地下的步骤。 purpurea Makino进入挤出成型设备和挤出。 此外,根据本发明的理想实施例的挤出成型装置包括:壳体(100),其中插入细粉末的狭槽(60)和在挤出时排出的喷嘴(50) 形成; 旋转以挤出插入到壳体(100)中的细粉末的螺杆(20); 驱动马达(10),其连接到所述螺杆(20)以驱动所述驱动马达; 以及安装在其中安装有螺钉(20)的壳体(100)的外表面上的多个筒(30),以在一定长度的每个间隔处调节不同的温度。
    • 18. 发明公开
    • 담마레인 트리테르펜 화합물을 함유하는 동맥경화증, 암 및 산화적 스트레스의 예방, 개선 및 치료용 조성물
    • 用于预防或治疗包含DAMMARANE TRITERPEN的ATHEROSCLEROSIS,DEMENTIA,CANCER和氧化应激的组合物
    • KR1020070111202A
    • 2007-11-21
    • KR1020060044286
    • 2006-05-17
    • 대한민국(농촌진흥청장)
    • 김금숙성낙술박충범이승은장인복정태숙정해영
    • A61K36/22A61P35/00A61P9/10
    • A composition comprising dammarane triterpenes is provided to inhibit activity of ACAT(acyl-CoA:cholesterol acyltransferase), remove reactive oxygen species, peroxynitrite and hydrogen peroxide, suppress production of nitrogen oxide and kill cancer cells without side effects, thereby preventing or treating atherosclerosis, dementia, cancer and oxidative stress. A composition for preventing or treating atherosclerosis, dementia, cancer and oxidative stress comprises dammarane triterpenes isolated from Rhus chinensis Mill., including 20-hydroxy-24-dammaren-3-one represented by the formula(1), 3-hydroxy-3, 3-oxodammar-20, 24E-dien-26-oic acid represented by the formula(2) and 19-epoxydammar-20, 24-dien-22, 26-olide represented by the formula(3), which are isolated by extracting the stem of Rhus chinensis Mill. with methanol, fractionating the crude extract with ethylacetate and water, concentrating the fraction under reduced pressure, and subjecting the concentrate to silica gel column chromatography.
    • 提供了含有马马龙三萜烯的组合物以抑制ACAT(酰基辅酶A:胆固醇酰基转移酶)的活性,去除活性氧,过氧亚硝酸盐和过氧化氢的活性,抑制氮氧化物的产生并杀死癌细胞而没有副作用,由此预防或治疗动脉粥样硬化, 痴呆,癌症和氧化应激。 用于预防或治疗动脉粥样硬化,痴呆,癌症和氧化应激的组合物包括从Rhus chinensis Mill分离的dammarane三萜烯,包括由式(1)表示的20-羟基-24-巴马仑-3-酮,3-羟基-3, 由式(2)表示的3-氧代醛-20,24E-二烯-26-酸和由式(3)表示的19-环氧基-20,20-二烯-22,26-二醇,其通过提取分离 枸杞子的茎。 用甲醇,用乙酸乙酯和水分离粗提物,减压浓缩,浓缩物经硅胶柱层析。