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121. 发明公开

KR1020090098491A 단백질간의 상호작용 관계 정보 및 단백질 신호전달 경로정보의 맵핑을 통한 단백질과 신호전달 경로와의상호관계를 도출하고 도식화하는 방법 및 시스템 有权
标题翻译：通过蛋白质 - 蛋白质相互作用和信号途径信息的方式和系统提取和显示蛋白质与信号途径之间的相互作用网络
公开(公告)号：KR1020090098491A
公开(公告)日：2009-09-17
申请号：KR1020080023917
申请日：2008-03-14
申请人： 씨비에스바이오사이언스 주식회사
发明人： 박진영 , 홍석주 , 김종민 , 이창배
IPC分类号： G06F17/30 , G06F19/18
CPC分类号： G06F19/18 , G06F19/26 , G06F19/28
摘要： A method and a system for extracting relation with a signal transfer path with protein using the signal transfer path information are provided to supply foundation of a direction in a biological function research. A user inputs a keyword(S310). A start protein name is selected between the protein listed according to the search word and the start protein name(S320). The user sets up the filtration condition for the information acquisition(S330). Information through a protein interaction processor from a database in the interaction distance(S340, S350). A screen configuration module arranges the protein information to screen according to the interaction distance(S360).
摘要翻译：提供一种利用信号传递路径信息提取与蛋白质信号传递路径关系的方法和系统，为生物学功能研究中的方向提供基础。用户输入关键字（S310）。在根据搜索词列出的蛋白质和起始蛋白质名称之间选择起始蛋白质名称（S320）。用户设置信息获取的过滤条件（S330）。信息通过蛋白质交互处理器从数据库的交互距离（S340，S350）。屏幕配置模块根据交互距离将蛋白质信息排列到屏幕上（S360）。

122. 发明公开

KR1020090069326A Ｔ 세포 에피토프 데이터베이스들 有权
标题翻译： T细胞EPITOPE DATABASES
公开(公告)号：KR1020090069326A
公开(公告)日：2009-06-30
申请号：KR1020097009517
申请日：2007-10-11
申请人： 안티토페 리미티드
发明人： 카,프랭크 , 바커,메튜,파울
IPC分类号： G06F19/10 , G01N33/48 , G01N33/68
CPC分类号： G06F19/28 , G06F19/22
摘要： The invention relates to databases of T cell epitopes, especially helper T cell epitopes, for rapid interrogation of protein sequences for the presence of T cell epitopes. The invention includes full or partial databases and data structures of T cell epitopes including epitopes identified especially by ex vivo T cell assays with test peptides and includes T cell epitopes identified by extrapolation of data from test peptides. The present invention also includes high throughput methods for determining the T cell epitope activity of peptides for subsequent inclusion in databases and data structures including methods where subsets of T cells especially regulatory T cells are removed or inhibited from T cell assays in order to maximize the sensitivity of detection of T cell epitope activity.
摘要翻译：本发明涉及用于T细胞表位存在的蛋白质序列的快速询问的T细胞表位的数据库，特别是辅助T细胞表位。本发明包括T细胞表位的全部或部分数据库和数据结构，包括特异性通过具有测试肽的离体T细胞测定鉴定的表位，并且包括通过外推测试肽数据而鉴定的T细胞表位。本发明还包括用于确定肽的T细胞表位活性以用于随后包含在数据库和数据结构中的高通量方法，包括其中T细胞特别是调节性T细胞的亚群从T细胞测定中去除或抑制的方法，以使灵敏度最大化检测T细胞表位活性。

123. 发明公开

KR1020090040597A 온톨로지를 이용한 공간의 상황정보 병합시스템 有权
标题翻译：空间背景法和空间复制
公开(公告)号：KR1020090040597A
公开(公告)日：2009-04-27
申请号：KR1020070106028
申请日：2007-10-22
申请人： 경희대학교 산학협력단
发明人： 권오병 , 박태환 , 심재문 , 이남연 , 최윤형
IPC分类号： G06Q10/04 , G06F19/28 , G06Q20/20 , H04N21/61
CPC分类号： G06Q10/04 , G06F19/28 , G06Q20/206 , H04N21/6125
摘要： A space context information merge method using ontology and a space copier are provided to edit and merge context information of a specific space through the space copier in a ubiquitous environment, thereby making an atmosphere of a space without visiting the specific space. A space copier stores and displays a plurality of space files(S500). A space master server transmits a space file to the space copier again(S502). The space copier displays context information of the specific space. If a user selects to edit(S504), a context information level of the space is set(S506). It is determined whether space files are at least two(S510). If the files are at least two, context information of corresponding space files are merged and displayed(S512). If re-editing is not selected(S514), the space files are stored per an intrinsic ID number(S516).
摘要翻译：提供了一种使用本体和空间复印机的空间上下文信息合并方法，可在无处不在的环境中通过空间复印机编辑和合并特定空间的上下文信息，从而形成空间气氛，而无需访问特定空间。空间复印机存储并显示多个空间文件（S500）。空间主服务器再次将空间文件发送到空间复制机（S502）。空间复印机显示特定空间的上下文信息。如果用户选择编辑（S504），则设置空格的上下文信息等级（S506）。确定空间文件是否为至少两个（S510）。如果文件是至少两个，则合并并显示对应的空间文件的上下文信息（S512）。如果未选择重新编辑（S514），则根据固有ID号（S516）存储空格文件。

124. 发明公开

KR1020090013198A 질병 상태에 대한 개별화된 의료 개입을 결정하기 위한 시스템 및 방법 有权
标题翻译：用于确定疾病状态的个体化医疗干预的系统和方法
公开(公告)号：KR1020090013198A
公开(公告)日：2009-02-04
申请号：KR1020087028343
申请日：2007-05-18
申请人： 몰큘라 프로파일링 인스티튜트, 아이엔씨
发明人： 반호프,디알.다니엘디. , 페니,디알.로버트
IPC分类号： G01N33/48 , G01N33/68 , C12Q1/68
CPC分类号： G01N33/57488 , C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/574 , G01N33/6893 , G01N2333/71 , G01N2333/91205 , G01N2333/914 , G06F19/00 , G06F19/18 , G06F19/20 , G06F19/28 , G06F19/34 , G06F19/3481 , G16H15/00 , G16H50/20 , G01N33/68
摘要： A system and method for determining individualized medical intervention for a particular disease state, and especially for cancers, that includes the molecular profiling of a biological sample from the patient, determining whether any molecular findings including one or more genes, one or more gene expressed proteins, one or more molecular mechanisms, and/or combinations of such exhibit a change in expression compared to a reference, and identifying a non-specific disease therapy or agent capable of interacting with the genes, gene expressed proteins, molecular mechanisms, or combinations of such molecular findings that exhibited a change in expression.
摘要翻译：用于确定特定疾病状态，特别是癌症的个体化医疗干预的系统和方法，其包括来自患者的生物样品的分子谱图，确定是否包括一个或多个基因的任何分子发现，一种或多种基因表达的蛋白质，一种或多种分子机制和/或其组合与参考文献相比表现出变化，并且鉴定能够与基因相互作用的非特异性疾病治疗或试剂，基因表达的蛋白质，分子机制或组合这种表达变化的分子发现。

125. 发明公开

KR1020090004332A 온톨로지를 이용한 공간의 상황정보 복사/붙여넣기 시스템 有权
标题翻译：空间上下文复印/ PASTE系统
公开(公告)号：KR1020090004332A
公开(公告)日：2009-01-12
申请号：KR1020070109986
申请日：2007-10-31
申请人： 경희대학교 산학협력단
发明人： 권오병 , 박태환 , 심재문
IPC分类号： G06Q10/04 , G06F19/28
CPC分类号： G06Q10/043 , G06F19/28 , G06Q10/047
摘要： A system for copying and pasting contextual information of specific space using ontology is provided to use for an electronic commerce, a climate information offer service, a location information offer service and a financial transaction and solve a localization problem according to the time and space by selectively copying the specific space with a user. A system for copying and pasting contextual information of specific space comprises a plurality of contextual information sensing unit(100), a wireless network(200), storage unites(300, 400, 700), a copying machine(500) and a plurality of output unit(600). The storage unites are divided into a space master server, a contextual information of individual storing server and space master UDDI. The contextual information sensing unit includes a control module transmitting the contextual information of specific space stored in a database to the storage unites, a contextual information control module controlling the information about transmitting and receiving of the storage unites, a contextual information data base storing identification number and the contextual information of specific space, read by the contextual information control module and a communication module providing a communication interface in order to perform smooth wireless telecommunication.
摘要翻译：提供了使用本体复制和粘贴特定空间的上下文信息的系统，用于电子商务，气候信息提供服务，位置信息提供服务和金融交易，并且通过选择性地根据时间和空间来解决定位问题用户复制特定的空间。用于复制和粘贴特定空间的上下文信息的系统包括多个上下文信息感测单元（100），无线网络（200），存储单元（300,400,700），复印机（500）和多个输出单元（600）。存储单元分为空间主服务器，个人存储服务器和空间主服务器UDDI的上下文信息。上下文信息感测单元包括：控制模块，将存储在数据库中的特定空间的上下文信息发送到存储单元;控制关于存储单元的发送和接收的信息的上下文信息控制模块;存储识别号码的上下文信息数据库以及由上下文信息控制模块读取的特定空间的上下文信息和提供通信接口以便执行平滑无线电信的通信模块。

126. 发明公开

KR1020090004331A 온톨로지를 이용한 공간의 상황정보 복사/붙여넣기 방법 有权
标题翻译：空间背景复制/ PASTE方法
公开(公告)号：KR1020090004331A
公开(公告)日：2009-01-12
申请号：KR1020070109984
申请日：2007-10-31
申请人： 경희대학교 산학협력단
发明人： 권오병 , 박태환 , 심재문
IPC分类号： G06F19/28 , G06Q10/04 , G06Q10/10
CPC分类号： G06F19/28 , G06Q10/04 , G06Q10/101 , G06Q10/103
摘要： A method for copying and pasting contextual information of specific space using ontology is provided to use for an electronic commerce, a climate information offer service, a location information offer service and a financial transaction. A copying machine using ontology comprises a sensing unit, a storage unit and an output unit. The sensing unit includes a plurality of contextual information detecting devices. The storage unit is divided into a space master server, an individual contextual information storing server and a space master UDDI. The output unit includes a plurality of output devices. A method for copying and pasting contextual information a step of grasping and storing the location information of a copying device, a step of receiving and storing the contextual information through the sensing unit located in the specific space, a step of transmitting the information to a storage unit and a step of outputting the stored information of specific space through a outputting device.
摘要翻译：提供一种使用本体复制和粘贴特定空间的上下文信息的方法，用于电子商务，气候信息提供服务，位置信息提供服务和金融交易。使用本体的复印机包括感测单元，存储单元和输出单元。感测单元包括多个上下文信息检测装置。存储单元分为空间主服务器，单独上下文信息存储服务器和空间主服务器UDDI。输出单元包括多个输出装置。一种用于复制和粘贴上下文信息的方法，该方法是抓住和存储复制设备的位置信息的步骤，通过位于特定空间中的感测单元接收和存储上下文信息的步骤，将信息发送到存储器单元以及通过输出装置输出存储的特定空间的信息的步骤。

127. 发明公开

KR1020090003380A 온라인 중앙 데이터베이스를 이용한 동물 및 관련 부산물의이력/품질 관리 및 맞춤형 정보제공 서비스 방법 및 그시스템 有权
标题翻译：动物质量管理服务方式，其副产品，使用在线数据库提供自定义信息及其系统
公开(公告)号：KR1020090003380A
公开(公告)日：2009-01-12
申请号：KR1020070055208
申请日：2007-06-05
申请人： 이학모
发明人： 이학모
IPC分类号： G06Q50/10 , G06Q10/08 , G06F19/28 , G06Q10/06 , G06K17/00
CPC分类号： G06Q50/10 , G06F19/28 , G06K17/0025 , G06Q10/06395 , G06Q10/0833
摘要： A method and an apparatus for providing history/quality control of animal and related by-product and customized information are provided to maximize reliability of the quality of by-product and final product produced from animal and improve productivity of the by-product and final product. A method for providing history/quality control of animal and related by-product and customized information includes a step(1) of registering user information in an information generating object database in real time, a step(6) of receiving information on animal and registering the information in an animal database, a step(7) of transmitting an identification number of the registered animal to a terminal, a step of receiving basic information, history information and by-product quality information on the animal and constructing a database composed of the received information, and a step of providing the information constructed as the database to a user.
摘要翻译：提供了一种用于提供动物及相关副产品和定制信息的历史/质量控制的方法和装置，以最大限度地提高从动物产生的副产品和最终产品的质量的可靠性，并提高副产品和最终产品的生产率。用于提供动物及相关副产品和定制信息的历史/质量控制的方法包括：实时地在信息生成对象数据库中注册用户信息的步骤（1）;接收关于动物和登记的信息的步骤（6）动物数据库中的信息，向终端发送登记动物的识别号码的步骤（7），接收关于动物的基本信息，历史信息和副产品质量信息的步骤，构建由接收到的信息，以及将构成数据库的信息提供给用户的步骤。

128. 发明授权

KR100799541B1 미지의 단백질 특성 예측 장치 및 그 방법 有权
标题翻译：未知蛋白特征预测的装置和方法
公开(公告)号：KR100799541B1
公开(公告)日：2008-01-31
申请号：KR1020060121754
申请日：2006-12-04
申请人： 한국전자통신연구원
发明人： 이용호 , 최재훈 , 박종민 , 방선이 , 박수준 , 박선희
IPC分类号： G06F19/20 , G06F19/18 , G01N33/50
CPC分类号： G06F19/28 , G06F19/22 , G06F19/24
摘要： A device and a method for predicting feature of unknown protein are provided to predict the feature of the unknown protein in a PPI(Protein-Protein Interaction) network by utilizing a feature relation matrix using level normalization of GO(Gene Ontology) terms and PPI data. A GO term normalizer(21) normalizes a GO term level by calculating similarity of the GO terms found in an external PPI network(14). A feature relation matrix generator(22) generates the feature relation matrix by using the data received from the PPI network and the GO term normalizer. A Chi-square value calculator(23) calculates a Chi-square value by using the data received from the PPI network and the GO terminal level normalizer. A protein feature predictor(24) predicts the feature of the unknown protein by using the Chi-square value and the feature relation matrix.
摘要翻译：提供了一种用于预测未知蛋白质特征的装置和方法，以通过使用GO（基因本体）术语和PPI数据的水平归一化的特征关系矩阵来预测PPI（蛋白质 - 蛋白质相互作用）网络中未知蛋白质的特征。 GO术语归一化器（21）通过计算外部PPI网络（14）中发现的GO术语的相似性来对GO项目级别进行归一化。特征关系矩阵生成器（22）通过使用从PPI网络和GO项目归一化器接收的数据来生成特征关系矩阵。卡方值计算器（23）通过使用从PPI网络和GO终端级别归一化器接收的数据来计算卡方值。蛋白质特征预测器（24）通过使用卡方值和特征关系矩阵预测未知蛋白质的特征。

129. 发明公开

KR1020070112785A 비드-기초 서열화를 위한 시약, 방법, 및 라이브러리 无效
标题翻译：用于基于BEAD的测序的试剂，方法和图谱
公开(公告)号：KR1020070112785A
公开(公告)日：2007-11-27
申请号：KR1020077019819
申请日：2006-02-01
申请人： 에이젠코트 바이오사이언스 코오포레이션
发明人： 맥커난,케빈 , 블란차드,알란 , 코틀러,레브 , 코스타,지나
IPC分类号： C12Q1/68 , G06F19/28
CPC分类号： C12Q1/6874 , B82Y15/00 , B82Y30/00 , C12Q1/68 , C12Q1/6837 , C12Q1/6844 , C12Q1/6869 , C12Q2533/107 , C12Q2537/165 , C12Q2565/102 , C12Q2565/137 , C12Q2565/513 , C12Q2565/518 , C12Q2565/537 , G06F19/28
摘要： The present invention provides methods for determining a nucleic acid sequence by performing successive cycles of duplex extension along a single stranded template. The cycles comprise steps of extension, ligation, and, preferably, cleavage. In certain embodiments the methods make use of extension probes containing phosphorothiolate linkages and employ agents appropriate to cleave such linkages. In certain embodiments the methods make use of extension probes containing an abasic residue or a damaged base and employ agents appropriate to cleave linkages between a nucleoside and an abasic residue and/or agents appropriate to remove a damaged base from a nucleic acid. The invention provides methods of determining information about a sequence using at least two distinguishably labeled probe families. In certain embodiments the methods acquire less than 2 bits of information from each of a plurality of nucleotides in the template in each cycle. In certain embodiments the sequencing reactions are performed on templates attached to beads, which are immobilized in or on a semi-solid support. The invention further provides sets of labeled extension probes containing phosphorothiolate linkages or trigger residues that are suitable for use in the method. In addition, the invention includes performing multiple sequencing reactions on a single template by removing initializing oligonucleotides and extended strands and performing subsequent reactions using different initializing oligonucleotides. The invention further provides efficient methods for preparing templates, particularly for performing sequencing multiple different templates in parallel. The invention also provides methods for performing ligation and cleavage. The invention also provides new libraries of nucleic acid fragments containing paired tags, and methods of preparing microparticles having multiple different templates (e.g., containing paired tags) attached thereto and of sequencing the templates individually. The invention also provides automated sequencing systems, flow cells, image processing methods, and computer-readable media that store computer-executable instructions (e.g., to perform the image-processing methods) and/or sequence information. In certain embodiments the sequence information is stored in a database.
摘要翻译：本发明提供了通过沿着单链模板进行连续循环的双链延伸来确定核酸序列的方法。循环包括延伸，连接和优选切割的步骤。在某些实施方案中，所述方法利用含有硫代磷酸酯键的延伸探针，并使用适合切割这种连接的试剂。在某些实施方案中，所述方法利用含有无碱基残基或受损碱基的延伸探针，并使用适于切割核苷和脱碱基残基之间的连接的试剂和/或适于从核酸中除去受损碱基的试剂。本发明提供使用至少两个可区分标记的探针家族确定关于序列的信息的方法。在某些实施方案中，该方法在每个周期中从模板中的多个核苷酸中的每一个获取少于2位的信息。在某些实施方案中，测序反应在附着于珠上的模板上进行，所述模板固定在半固体支持物中或半固体支持物上。本发明进一步提供了包含适合用于该方法的硫代磷酸酯键或触发性残基的标记的延伸探针的集合。此外，本发明包括通过除去初始化寡核苷酸和延伸的链并使用不同的初始化寡核苷酸进行后续反应，在单个模板上进行多个测序反应。本发明还提供了用于制备模板的有效方法，特别是用于并行地进行多个不同模板的排序。本发明还提供了进行连接和切割的方法。本发明还提供了含有配对标签的核酸片段的新文库，以及制备具有多个不同模板（例如，含有配对标签）的微粒和分别对模板进行测序的方法。本发明还提供自动排序系统，流动池，图像处理方法和存储计算机可执行指令（例如，执行图像处理方法）和/或序列信息的计算机可读介质。在某些实施例中，序列信息存储在数据库中。

130. 发明公开

KR1020070038925A 유전자 진단을 위한 마커 선택 프로그램을 포함하는 컴퓨터판독가능 매체, 마커 선택 장치 및 시스템, 및 유전자진단 함수 생성 장치 및 시스템 失效
标题翻译：包含用于遗传诊断的标记选择程序和标记选择装置和系统的计算机可读介质，以及遗传诊断功能创建装置和系统
公开(公告)号：KR1020070038925A
公开(公告)日：2007-04-11
申请号：KR1020060097973
申请日：2006-10-09
申请人： 가부시끼가이샤 도시바
发明人： 히라오까요시꼬 , 미야자끼가즈노리 , 이또사또시 , 하시모또미찌에 , 미시로순지
IPC分类号： G06F19/24 , G06F19/28
CPC分类号： G06F19/28 , G06F19/18
摘要： 유전자 진단에서 사용하기 위한 마커(marker)를 선택하는 마커 선택 프로그램이 제공된다. 이 프로그램에서, 서로 다른 개체군(population)에 속하는 표본(specimen)의 데이터를 각각 저장하는 적어도 2개의 표본 데이터베이스를 사용하여 분석이 수행된다. 모든 표본 데이터를 단일의 개체군으로 통합시키지 않고 분석을 수행함으로써, 소수 개체군(minority population)에 관한 정보가 유전자 검색에 확실히 반영될 수 있다. 각각의 개체군의 특성이 반영될 수 있기 때문에, 정확성이 높은 진단 함수가 얻어질 수 있고, 실용적인 진단 시스템을 제공한다.
유전자 진단, 진단 함수, 마커, 유전적 다형성, 대립 유전자

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