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    • 118. 发明公开
    • 클러스테린 양의 감소에 의한 흑색종의 치료
    • 通过在CLUSTERIN水平中减少麻醉剂治疗
    • KR1020050058425A
    • 2005-06-16
    • KR1020057002964
    • 2003-08-21
    • 더 유니버시티 오브 브리티쉬 콜롬비아
    • 글리브마틴이얀센브르크하르트
    • A61K31/715A61K48/00C12N15/11
    • C12N15/113A61K31/712A61K38/00C12N2310/315C12N2310/321C12N2310/341C12N2310/346C12N2310/3525
    • Treatment of melanoma is achieved through reduction in the effective amount of clusterin in melanoma cells. Thus, in accordance with one aspect of the invention, there is provided a method for treatment of melanoma in a mammalian subject, preferably a human, comprising the step of administering to the subject a therapeutic agent effective to reduce the effective amount of clusterin in the melanoma cells. The therapeutic agent may be, for example, an antisense ODN or small inhibitory RNA (siRNA) compound targeted to clusterin. The present invention also provides a method for regulating expression of bcl- xL in a subject or cell line comprising administering to the subject or cell line an agent effective to modulate the amount of clusterin expression. In particular, in clusterin expressing cells, the expression of bcl-xL is down-regulated when the effective amount of clusterin is reduced. Such inhibition is significant because bcl-xL is known to act as an inhibitor of apoptosis.
    • 通过减少黑素瘤细胞中的聚集蛋白的有效量来实现黑素瘤的治疗。 因此,根据本发明的一个方面,提供了一种治疗哺乳动物受试者,优选人类的黑素瘤的方法,包括向受试者施用有效降低其中有效量的聚集蛋白的治疗剂的步骤 黑素瘤细胞。 治疗剂可以是例如靶向簇蛋白的反义ODN或小的抑制性RNA(siRNA)化合物。 本发明还提供调节受试者或细胞系中bcl-xL表达的方法,其包括向受试者或细胞系施用有效调节聚集蛋白表达量的试剂。 特别地,在簇蛋白表达细胞中,当有效量的聚集蛋白降低时,bcl-xL的表达下调。 这种抑制是显着的,因为已知bcl-xL作为凋亡抑制剂。