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1. 发明授权

KR101681654B1 효소적 위치선택반응에 의한 디아세틸세라마이드 유도체의 제조방법 有权
标题翻译：使用酶选择性反应制备二乙酰神经酰胺的方法
公开(公告)号：KR101681654B1
公开(公告)日：2016-12-01
申请号：KR1020140150084
申请日：2014-10-31
申请人： 한국과학기술연구원 , 주식회사 두산
发明人： 정찬성 , 송치만 , 표정인 , 문지영 , 정국훈 , 진성현 , 김상철 , 김아라
IPC分类号： C12P13/02 , C12N9/20 , C12N11/00
摘要： 본발명은트리아세틸세라마이드유도체를출발물질로하고, 특정의리파제효소를선택사용하여위치선택적으로디아세틸세라마이드유도체를효율적으로제조하는방법에관한것이다.
摘要翻译：本发明涉及以三乙酰神经酰胺衍生物为起始原料，有效地制备二乙酰神经酰胺衍生物的方法，并选择性地使用特定的脂肪酶。该制造方法通过对由化学式1表示的三乙酰神经酰胺衍生物进行酶反应来制造由化学式2表示的二乙酰基神经酰胺衍生物。

2. 发明公开

KR1020160050916A 효소적 위치선택반응에 의한 디아세틸세라마이드 유도체의 제조방법 有权
标题翻译：通过使用酶选择性反应制备二羧酸的方法
公开(公告)号：KR1020160050916A
公开(公告)日：2016-05-11
申请号：KR1020140150084
申请日：2014-10-31
申请人： 한국과학기술연구원 , 주식회사 두산
发明人： 정찬성 , 송치만 , 표정인 , 문지영 , 정국훈 , 진성현 , 김상철 , 김아라
IPC分类号： C12P13/02 , C12N9/20 , C12N11/00
CPC分类号： C12P13/02 , C12N9/20 , C12N11/00 , C12P13/00 , Y10S435/872
摘要： 본발명은트리아세틸세라마이드유도체를출발물질로하고, 특정의리파제효소를선택사용하여위치선택적으로디아세틸세라마이드유도체를효율적으로제조하는방법에관한것이다.
摘要翻译：本发明涉及以三乙酰神经酰胺衍生物为起始原料，有效地制备二乙酰神经酰胺衍生物的方法，并选择性地使用特定的脂肪酶。该制造方法通过对由化学式1表示的三乙酰神经酰胺衍生物进行酶反应来制造由化学式2表示的二乙酰基神经酰胺衍生物。

3. 发明授权

KR101589633B1 당세라마이드 유도체 및 이의 제조방법 有权
标题翻译：新型甘氨酸及其制备方法
公开(公告)号：KR101589633B1
公开(公告)日：2016-02-01
申请号：KR1020140124166
申请日：2014-09-18
申请人： 한국과학기술연구원 , 주식회사 두산
发明人： 정찬성 , 송치만 , 표정인 , 문지영 , 정국훈 , 진성현 , 김상철 , 김아라
IPC分类号： C08B37/00
CPC分类号： C08B37/00
摘要： 본발명은화장품원료및 생리활성물질로유용한신규의당세라마이드유도체및 이의제조방법에관한것이다.
摘要翻译：本发明涉及用作化妆品材料和生物活性物质的新颖的甘氨酰胺衍生物及其制造方法。

4. 发明授权

KR101577874B1 당세라마이드를 함유하는 피부 유사 지질 조성을 갖는 액정상 화장료 조성물 및 그 제조방법 有权
标题翻译：具有类似皮肤脂肪组合物和含有葡萄糖苷的液晶化妆品组合物及其制备方法
公开(公告)号：KR101577874B1
公开(公告)日：2015-12-15
申请号：KR1020130166173
申请日：2013-12-27
申请人： 주식회사 두산
发明人： 정국훈 , 한정준 , 진성현 , 김상철 , 김아라
IPC分类号： A61K8/68 , A61K8/14 , A61K8/02 , A61Q19/00
摘要： 본발명은세라마이드(Ceramide) 및당세라마이드(Glucosylceramide), 스핑고리피드(Sphingolipid)를함유하는피부장벽의세포간지질과유사한조성으로구성되는피부보호용화장료조성물및 이의제조방법을제공한다. 본발명에따른화장료조성물은표피에존재하는피부지질의구성성분을이용하여액정형태의조성물로제조하고, 여기에나노리포좀화된당세라마이드를활성성분으로포함시킴으로써, 피부침투가용이할뿐만아니라진피층까지당세라마이드가도달할수 있으므로피부침투성및 보습력을극대화할수 있다.

5. 发明公开

KR1020030028080A 리소인지질의 수용성 조성물 失效
标题翻译：水溶性脂肪酸的水溶性组合物
公开(公告)号：KR1020030028080A
公开(公告)日：2003-04-08
申请号：KR1020010060015
申请日：2001-09-27
申请人： 주식회사 두산
发明人： 정국훈 , 양영래 , 고의찬
IPC分类号： A01N57/12
CPC分类号： A61Q19/08 , A61K8/553
摘要： PURPOSE: Provided is an aqueous composition of lysophospholipids containing lysophosphatidylethanolamine, lysophosphatidylinositol and lysophosphatidylcholine which are effective for the inhibition of cell senescence. The composition is soluble in water and is thus easily applied to a plant or an animal. CONSTITUTION: The aqueous composition of lysophospholipids contains lysophosphatidylethanolamine(LPE), lysophosphatidylcholine(LPC) and lysophosphatidylinositol(LPI). When the concentration of LPE to water is 0.1 to 5% by weight, the content of LPC is characteristically 20 to 60% by weight in the composition of lysophospholipids containing LPE and LPC. However, when the concentration of LPE to water is greater than 0.5% by weight and smaller than 2% by weight, each content of LPC, LPI and LPE is 10-50% by weight, 10-50% by weight and 40-60% by weight, respectively in the composition of lysophospholipids containing LPE, LPC and LPI.
摘要翻译：目的：提供含有溶血磷脂酰乙醇胺，溶血磷脂酰肌醇和溶血磷脂酰胆碱的溶血磷脂的水性组合物，其对抑制细胞衰老有效。组合物可溶于水，因此易于施用于植物或动物。构成：溶血磷脂的含水组合物含有溶血磷脂酰乙醇胺（LPE），溶血磷脂酰胆碱（LPC）和溶血磷脂酰肌醇（LPI）。当LPE与水的浓度为0.1〜5重量％时，在含有LPE和LPC的溶血磷脂的组成中，LPC的含量特征为20〜60重量％。然而，当LPE对水的浓度大于0.5重量％且小于2重量％时，LPC，LPI和LPE的每种含量为10-50重量％，10-50重量％和40-60重量％分别为含LPE，LPC和LPI的溶血磷脂的组成。

6. 发明授权

KR101763947B1 포스파티딜세린의 마이크로캡슐화 방법 有权
公开(公告)号：KR101763947B1
公开(公告)日：2017-08-01
申请号：KR1020110042580
申请日：2011-05-04
申请人： 주식회사 두산
发明人： 한지영 , 한정준 , 이관형 , 정국훈 , 황성기
IPC分类号： A61K9/50 , A61K31/685
CPC分类号： A61K9/5089 , A23J7/00 , A23V2002/00 , A61K9/5015 , A61K9/5036 , A61K31/685 , A23V2200/224 , A23V2250/1852 , A23V2250/5118
摘要： 본발명은 (a) 포스파티딜세린을식용유지에녹여포스파티딜세린액상조성물을제조하는단계; (b) 단계 (a) 이전, 이후또는이와동시에, 친유성및 친수성을갖도록가공된(modified) 가공전분을물과섞어전분수용액을준비하는단계; (c) 상기전분수용액을포스파티딜세린액상조성물과혼합균질화하여유화시키는단계; 및 (d) 얻어진유화액을건조하는단계를포함하는, 포스파티딜세린의마이크로캡슐화방법을제공한다.

7. 发明公开

KR1020120124745A 포스파티딜세린의 마이크로캡슐화 방법 有权
标题翻译：微波消解磷酸胆固醇的方法
公开(公告)号：KR1020120124745A
公开(公告)日：2012-11-14
申请号：KR1020110042580
申请日：2011-05-04
申请人： 주식회사 두산
发明人： 한지영 , 한정준 , 이관형 , 정국훈 , 황성기
IPC分类号： A61K9/50 , A61K31/685
CPC分类号： A61K9/5089 , A23J7/00 , A23V2002/00 , A61K9/5015 , A61K9/5036 , A61K31/685 , A23V2200/224 , A23V2250/1852 , A23V2250/5118
摘要： PURPOSE: A microcapsulation method of phosphatidyl serine is provided to prevent oxidation of phosphatidyl serine due to light or oxygen in the air and to improve dispersibility, solubility, and stability. CONSTITUTION: A microcapsulation method of phosphatidyl serine comprises: step (a) of dissolving phorphatidyl serine in a cooling oil and preparing a phosphatidyl serin liquid composition; step (b) of mixing modified starch and water and preparing a starch solution before or after step (a) or simultaneously; step (c) of mixing and homogenizing the starch solution and phosphatidyl serine liquid composition and emulsifying; and step (d) of drying the emulsified liquid. The phosphatidyl serine liquid composition contains fish oil containing DHA or EPA, Serenoa repens fruit extract, vitamin, or perfume.
摘要翻译：目的：提供磷脂酰丝氨酸的微胶囊化方法，以防止空气中由于光或氧引起的磷脂酰丝氨酸氧化，提高分散性，溶解性和稳定性。构成：磷脂酰丝氨酸的微胶囊化方法包括：将氢化菲基丝氨酸溶解在冷却油中并制备磷脂酰丝氨酸液体组合物的步骤（a）步骤（b）混合改性淀粉和水，并在步骤（a）或之前同时制备淀粉溶液; 步骤（c）将淀粉溶液和磷脂酰丝氨酸液体组合物混合均质并乳化; 和干燥乳化液的步骤（d）。磷脂酰丝氨酸液体组合物含有含有DHA或EPA，Serenoa repens水果提取物，维生素或香料的鱼油。

8. 发明公开

KR1020080011821A 산화칼슘을 포함하는 항균용 조성물 및 이를 이용한 식품의보존방법 无效
标题翻译：含有氧化钙的抗微生物组合物及使用其的食品保存方法
公开(公告)号：KR1020080011821A
公开(公告)日：2008-02-11
申请号：KR1020060072275
申请日：2006-07-31
申请人： 주식회사 두산
发明人： 최일 , 우동진 , 정국훈 , 김명옥 , 고의찬
IPC分类号： A23B7/157 , A23B7/155 , A23B7/00
摘要： An antimicrobial composition containing calcium oxide and additionally spirits is provided. A method of preserving food using the same is also provided to extend the shelf life of the food and thus to extend the distribution period. Calcium is ground and subjected to ashing at 550 to 3,000deg.C and an electric current passing at 220 to 5,000V for 60 to 180min to give an antimicrobial composition containing calcium oxide. The antimicrobial composition contains additionally spirits and has an antimicrobial activity against Bacillus cereus or Escherichia coli. The antimicrobial composition is formulated into powder, granule, tablet, pill, a sugar coated tablet, capsule, liquid, gel, syrup, slurry, suspension and injection solution.
摘要翻译：提供含有氧化钙和另外的精神的抗微生物组合物。还提供了使用其来保存食物的方法以延长食品的保存期限，从而延长分发期。研磨钙，在550〜3000℃进行灰化，通过220〜5000V的电流进行60〜180分钟，得到含有氧化钙的抗微生物组合物。抗微生物组合物另外含有精神，对蜡状芽孢杆菌或大肠杆菌具有抗菌活性。将抗微生物组合物配制成粉末，颗粒，片剂，丸剂，糖衣片，胶囊，液体，凝胶，糖浆，浆液，悬浮液和注射液。

9. 发明公开

KR1020070071954A 산화칼슘을 함유하는 침지액 및 응고제를 이용한 칼슘강화두부의 제조방법 无效
标题翻译：使用溶解溶液和含有氧化钙的凝结剂制备钙膨胀的琼脂凝胶的方法
公开(公告)号：KR1020070071954A
公开(公告)日：2007-07-04
申请号：KR1020050135821
申请日：2005-12-30
申请人： 주식회사 두산
发明人： 최일 , 정국훈 , 허병석 , 고의찬
IPC分类号： A23L1/20
CPC分类号： A23L11/05 , A23L17/60 , A23V2200/218 , A23V2250/1578
摘要： A method of preparing calcium-fortified bean curd by immersing soybeans in immersion liquid containing calcium oxide and coagulating soybean milk with a coagulant containing calcium oxide is provided, in which the product is rich in calcium and useful in maintaining good health. First, soybeans are immersed in immersion liquid containing calcium oxide and crushed to produce soybean milk. Then, the soybean milk is coagulated with a coagulant, sterilized at 80 to 90deg.C for 30 to 40min and packaged with filling liquid containing calcium oxide. The calcium oxide is obtained by heating algae calcium at 550 to 3,000deg.C and applying a voltage of 220 to 5,000V for 60 to 180min. The coagulant is obtained by mixing 12 to 48% by weight of calcium oxide, 1 to 5% by weight of monoglyceride, 0.5 to 2.5% by weight of diglyceride, 20 to 40% by weight of vegetable oil and 29.5 to 41.5% by weight of distilled water and agitating.
摘要翻译：提供了一种通过将大豆浸入含有氧化钙的浸渍液中并用含氧化钙的凝结剂凝固豆浆而制备钙强化豆腐的方法，其中该产品富含钙并且有助于保持身体健康。首先，将大豆浸入含有氧化钙的浸渍液中并粉碎生产豆浆。然后，将豆浆用凝结剂凝结，在80〜90℃下灭菌30〜40分钟，并与含有氧化钙的填充液一起包装。氧化钙是通过将550〜3000℃的藻类钙加热并施加220〜5000V的电压60〜180分钟而得到的。凝结剂是将12〜48重量％的氧化钙，1〜5重量％的甘油单酯，0.5〜2.5重量％的甘油二酯，20〜40重量％的植物油和29.5〜41.5重量％的蒸馏水和搅拌。

10. 发明公开

KR1020070003633A 리소포스파티딜에탄올아민 또는 레시틴을 함유한 안정한수용성 조성물 有权
标题翻译：稳定的水溶性组合物，含有赖氨基甲酰胺和LECITHIN
公开(公告)号：KR1020070003633A
公开(公告)日：2007-01-05
申请号：KR1020060059487
申请日：2006-06-29
申请人： 주식회사 두산
发明人： 정국훈 , 홍지훈 , 양영래 , 오여록 , 고의찬
IPC分类号： C07F9/10 , C08K5/521
CPC分类号： C07F9/103 , A01N57/12 , A01N25/02 , A01N2300/00
摘要： A stable water soluble composition containing lysophosphatidylethanolamine(LPE) or lecithin is provided to prevent precipitation of lysophosphatidylethanolamine at room temperature below 20 deg. C, and maintain the transparent formulation of the composition during the long-term storage. The stable water soluble composition contains 0.1-50 wt.% of any one of lysophosphatidylethanolamine(LPE) and lecithin containing 3% or more of lysophosphatidylethanolamine(LPE), 0.1-60 wt.% of fatty acid or its salt and 10-99.8 wt.% of solvent; the fatty acid has the carbon number of 3 to 22; the salt of fatty acid is sodium salt, potassium salt, ammonium salt or ethanolamine salt; the solvent is a mixed solvent of water and alcohol; and the alcohol is ethanol, isopropanol, butanol, hexanol and oleyl alcohol.
摘要翻译：提供含有溶血磷脂酰乙醇胺（LPE）或卵磷脂的稳定的水溶性组合物，以防止溶血磷脂酰乙醇胺在室温低于20度时沉淀。并且在长期储存期间保持组合物的透明制剂。稳定的水溶性组合物含有0.1-30重量％的溶血磷脂酰乙醇胺（LPE）和含有3％以上溶血磷脂酰乙醇胺（LPE），0.1-60重量％脂肪酸或其盐的卵磷脂和10-99.8重量％％的溶剂; 脂肪酸的碳数为3〜22; 脂肪酸盐是钠盐，钾盐，铵盐或乙醇胺盐; 溶剂是水和醇的混合溶剂; 醇是乙醇，异丙醇，丁醇，己醇和油醇。

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