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2. 发明公开

KR1020080020738A 항염활성 및 골대사 관련인자 억제활성을 나타내는까마귀쪽나무 추출물 有权
标题翻译：具有抗炎活性和骨代谢因子抑制活性的LITSEA JAPONICA提取物
公开(公告)号：KR1020080020738A
公开(公告)日：2008-03-06
申请号：KR1020060083944
申请日：2006-09-01
申请人： 재단법인 제주테크노파크
发明人： 박수영 , 정용환 , 윤원종 , 이정아 , 김지영 , 오대주 , 유은숙 , 이혜자
IPC分类号： A61K36/54 , A61P39/06
CPC分类号： A61K36/54 , A23V2200/304 , A61K2236/33 , Y10S514/825
摘要： A composition comprising the extract of Litsea japonica is provided to prevent and treat inflammatory disease and metabolic bone disease including osteoporosis and osteopetrosis by inhibiting inflammation and bone metabolic factors including IL-6(interleukin-6), COX-2(cyclooxygenase-2) and PGE2(prostaglandin E2) without side effects. A composition for preventing and treating inflammatory disease and metabolic bone disease comprises the extract of Litsea japonica which is prepared by drying leaf, stem or fruit of Litsea japonica juss in the shade, pulverizing the dried Litsea japonica juss, dipping the pulverized Litsea japonica juss in 80% ethanol, sonicating the Litsea japonica juss solution for 1 hour, repeating the sonication in three times to prepare the ethanol extract of Litsea japonica juss, collecting the supernatant and concentrating the supernatant under reduced pressure, suspending the concentrate in distilled water, and extracting the suspension with hexane, dichloromethane, ethyl acetate and butanol sequentially, and is formulated as food additives or drink.
摘要翻译：提供包含日本蓟马提取物的组合物，通过抑制炎症和包括IL-6（白细胞介素-6），COX-2（环氧合酶-2）和骨质疏松素-2）在内的骨代谢因子来预防和治疗包括骨质疏松和骨质疏松的炎性疾病和代谢性骨病， PGE2（前列腺素E2）无副作用。用于预防和治疗炎性疾病和代谢性骨疾病的组合物包括通过在树荫下干燥荔枝枣的叶，茎或果实制备的荔枝提取物，粉碎干燥的枸杞，将粉碎的荔枝粳稻 80％乙醇，将Litsea japonica juss溶液超声处理1小时，三次重复超声处理，制备日本it杷的乙醇提取物，收集上清液，减压浓缩上清液，将浓缩物悬浮于蒸馏水中，萃取依次用己烷，二氯甲烷，乙酸乙酯和丁醇悬浮，配制成食品添加剂或饮料。

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