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    • 3. 发明公开
    • 디벤조-p-디옥신 유도체를 유효성분으로 함유하는 관절염치료용 조성물
    • 用于治疗含有二苯并对二氧基衍生物的神经元的组合物
    • KR1020090126925A
    • 2009-12-09
    • KR1020080053288
    • 2008-06-05
    • 주식회사 보타메디
    • 이행우신현철김성호박용주
    • A61K31/357A61P19/02
    • C07D493/04A61K9/127A61K31/357C07D319/24C07D407/12
    • PURPOSE: A composition containing dibenzo-p-dioxin derivative as an active ingredient is provided to suppress NF-kB and AP-1 activation and relieve degenerative arthritis and rherumatic arthritis without side effects or skin irritation. CONSTITUTION: A composition for treating arthritis contains 0.2-2 weight% of dibenzo-p-dioxin derivative of one chemical formula of chemical formulas 1 to 10. In chemical formulas 1-10, R is independently hydrogen, C1-C4 alkyl, C2-C10 alkenyl, phenyl, hydroxyphenyl, dihydroxyphenyl, phenyl-C1-C4 alkyl or R'(C=O) and R' is C1-C4 alkyl or C2-C20 alkenyl. The dibenzo-p-dioxin derivative is extracted from sea algae. The composition is used in the form of ointment, lotion, cream, gel, skin emulsion, skin suspension, and patch.
    • 目的:提供含有二苯并对二恶英衍生物作为活性成分的组合物,以抑制NF-kB和AP-1活化,并缓解退行性关节炎和无疼痛性关节炎,无副作用或皮肤刺激。 构成:用于治疗关节炎的组合物含有0.2-2重量%的化学式1至10的化学式的二苯并对二恶英衍生物。在化学式1-10中,R独立地为氢,C 1 -C 4烷基, C10烯基,苯基,羟基苯基,二羟基苯基,苯基-C 1 -C 4烷基或R'(C = O),R'是C 1 -C 4烷基或C 2 -C 20烯基。 从海藻中提取二苯并对二恶英衍生物。 该组合物以软膏,洗剂,霜剂,凝胶,皮肤乳液,皮肤悬浮液和贴剂的形式使用。