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2. 发明专利

JP2020517584A 修飾MRI造影剤およびその使用审中-公开
公开(公告)号：JP2020517584A
公开(公告)日：2020-06-18
申请号：JP2019553045
申请日：2018-04-25
申请人：ザリージェンツオブザユニバーシティオブカリフォルニア , ヴィビルホールディングスインコーポレイテッド , VYBYL HOLDINGS, INC.
发明人：クレアエルエムルグヤデール , ネイサンシーギアネッシ , カッサンドライーコールマン , マシューピートンプソン , トレフリーディトリ , ポールエイバーティン
IPC分类号： A61K49/10 , A61B5/055 , G01N24/00 , G01R33/56 , G01R33/50 , G01N24/08 , C07F5/00
摘要：本開示は、概して、MRI造影剤として有用な化合物を提供する。いくつかの態様において、本開示は、疎水性部分を含む1以上の部分を有するように化学修飾されているMRI造影剤を提供する。いくつかの態様において、本開示は、当該修飾MRI造影剤と、アルブミンまたはアルブミン模倣物などのタンパク質とを含む組成物を提供する。さらに、本開示は、これらの化合物および組成物の様々な使用を提供する。【選択図】図1

3. 发明专利

JPH1033504A NUCLEAR SPIN TOMOGRAPH 失效
公开(公告)号：JPH1033504A
公开(公告)日：1998-02-10
申请号：JP10554097
申请日：1997-04-23
申请人： SIEMENS AG
发明人： DEIMLING MICHAEL
IPC分类号： G01R33/48 , A61B5/055 , G01R33/50 , G01N33/48
摘要： PROBLEM TO BE SOLVED: To shorten time for measurement by receiving a nuclear magnetic resonance signal within different time intervals while irradiating it with a specified high frequency pulse for nuclear spin, and reconstituting an image from the difference of signals. SOLUTION: The time for measurement is shortened by preventing artifact by using lateral magnetization to be attenuated by a time constant T2. Namely, a 90 deg. high frequency pulse RF1 is turned on under the operation of a slice select gradient GS, and defading is performed by a negative gradient pulse GS . A pre-fading gradient pulse GRV is turned on in read direction. At the same time, a lot of 180 deg. high frequency pulses RF2 and RF5 are turned on as well. After nuclear magnetic resonance signals S1-S3 are detected, other nuclear magnetic resonance signals S1'-S3' are provided by resetting corresponding to an opposite direction gradient GR. Subtraction is operated between both resonance signals S1'-S3' and the image is reconstituted in row data matrix. The image can be formed in the row data matrix at high speed and the shortening of time for measurement can be attained.

10. 发明专利

JPS61266945A NUCLEAR MAGNETIC RESONANCE IMAGE PICKUP DEVICE 失效
公开(公告)号：JPS61266945A
公开(公告)日：1986-11-26
申请号：JP10954185
申请日：1985-05-22
申请人： YOKOGAWA ELECTRIC CORP
发明人： HIRATA TAKAAKI
IPC分类号： A61B10/00 , A61B5/055 , G01R33/48 , G01R33/50
摘要： PURPOSE:To find an accurate relaxation time and proton density by using a logical expression of signal intensity which contains the influence of a slice. CONSTITUTION:A 90 deg. pulse after Gaussian modulation is obtained by a controller 13 through a gate modulating circuit 17 and supplied to an RF transmitting coil 4 through an amplifier 18 to excite an objective. At the same time, a slanting magnetic field GZ is also applied to excite only a spin in a specific slice surface selectively. Then, phase encoding is performed with GY and a magnetic field GX is applied at the same time to make preparations for echo observation. The application of the slanting magnetic field is stopped and a 180 deg. pulse is applied to invert the spin. A spin echo signal detected by a receiving coil 5 is stored in a waveform memory 21 through a preamplifier 1 and a phase detecting circuit 20. An original image is obtained from many signals which differ in the quantity of phase encoding and relaxation times T1 and T2 and proton density rho are obtained from the obtained original image and logical expression.

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