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1. 发明专利

JP2006523715A Pharmaceutical combination of the neoplastic cox-2 inhibitors for the treatment of an alkylating anti-neoplastic agents 审中-公开
公开(公告)号：JP2006523715A
公开(公告)日：2006-10-19
申请号：JP2006513079
申请日：2004-04-16
申请人：ファルマシアコーポレイション
发明人：エル．マスフェラー，ジェイム
IPC分类号： A61K31/421 , A61K31/122 , A61K31/131 , A61K31/135 , A61K31/175 , A61K31/18 , A61K31/196 , A61K31/198 , A61K31/351 , A61K31/365 , A61K31/40 , A61K31/415 , A61K31/4184 , A61K31/42 , A61K31/444 , A61K31/445 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/541 , A61K31/566 , A61K31/569 , A61K31/635 , A61K31/6615 , A61K31/662 , A61K31/664 , A61K31/675 , A61K31/7004 , A61K33/24 , A61K41/00 , A61K45/00 , A61K45/06 , A61K51/08 , A61P35/00 , A61P43/00 , C07D207/34 , C07D213/61 , C07D215/54 , C07D231/12 , C07D233/16 , C07D235/02 , C07D239/42 , C07D239/54 , C07D261/08 , C07D263/08 , C07D307/58 , C07D309/10 , C07D311/22 , C07D311/58 , C07D311/92 , C07D335/06 , C07D401/12 , C07D405/04 , C07D407/04 , C07D407/12 , C07D409/04 , C07D417/12 , C07D471/04 , C07D491/04 , C07D493/04 , C07H11/00 , C07J1/00 , C07J5/00
CPC分类号： A61K31/135 , A61K31/415 , A61K31/42 , A61K31/445 , A61K31/505 , A61K31/506 , A61K31/675 , A61K33/24 , A61K41/00 , A61K41/0038 , A61K45/06 , C07D215/54 , C07D311/22 , C07D311/58 , C07D311/92 , C07D335/06 , C07D401/12 , C07D405/04 , C07D407/04 , C07D407/12 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04 , A61K2300/00
摘要：本発明は、ＣＯＸ−２阻害薬およびアルキル化型抗新生物薬の組合せ医薬を用いた哺乳類における新生物または新生物関連障害を治療し、予防しまたは抑制するための組成物および方法を提供する。

2. 发明专利

JP3718011B2 Conductive resin composition 失效
公开(公告)号：JP3718011B2
公开(公告)日：2005-11-16
申请号：JP26229996
申请日：1996-09-12
申请人：リケンテクノス株式会社
发明人：正樹榎本
IPC分类号： C07D263/08 , C08K3/00 , C08K5/3415 , C08L69/00 , H01B1/20
摘要： PROBLEM TO BE SOLVED: To further improve the heat resistance and strength characteristic of conductive polycarbonate by blending a specific compound. SOLUTION: An aromatic polycarbonate resin of 100 pts.wt., a conductive material of 5-150 pts.wt., and a 2-oxazoline ring containing compound expressed by a formula at 0.01-10 pts.wt. against the total 100 pts.wt. of both components are blended, where R1 -R6 indicate the alkyl group having the same or different hydrogen atoms or the carbon number of 1-10. Carbon black or carbon fibers are used for the conductive material, for example. 2-methyl-2-oxazoline is used for the 2-oxazoline ring containing compound, for example. The heat resistance and strength characteristic of the conductive carbonate can be further increased.

3. 发明专利

JP2644088B2 失效
公开(公告)号：JP2644088B2
公开(公告)日：1997-08-25
申请号：JP51744393
申请日：1993-03-10
申请人： FUAIZAA INC
发明人： MEIKAA JON II , UISHIIZU MAATEIN JEI
IPC分类号： A61K31/40 , A61K31/404 , A61K31/41 , A61P3/04 , A61P9/08 , A61P9/12 , A61P25/04 , A61P25/06 , A61P25/20 , A61P25/24 , A61P25/26 , A61P43/00 , C07D207/08 , C07D209/04 , C07D263/08 , C07D403/06 , C07D403/14 , C07D413/12 , C07D413/14
摘要： Compounds of the formula where W is n is 0, 1, or 2; m is 0, 1, 2, or 3; Y and G are each independently oxygen or sulfur; Z is -O-, -S-, -NH, or -CH2; R1 is hydrogen, C1 to C8 alkyl, substituted C1 to C8 alkyl substituted with one hydroxy, C3 to C8 alkenyl, C3 to C8 alkynyl, aryl, C1 to C3 alkylaryl, C1 to C3 alkylheteroaryl, or -Q-R4; R2 and R3 are each independently hydrogen, C1 to C6 alkyl, aryl, C1 to C3 alkylaryl, or C1 to C3 alkylheteroaryl; R4 is cyano, trifluoromethyl, -COR9, -CO2R9, -CONR9R10, -OR9, -SO2NR9R10, or -S(O)qR9; R9 and R10 are each independently hydrogen, C1 to C8 alkyl, C1 to C3 alkylaryl, aryl, or R9 and R10 may together be taken to form a three- to seven-membered alkyl ring or a three- to seven-membered heteroalkyl ring having 1 heteroatom of O; Q is C1 to C3 alkyl; R11 is hydrogen, -OR12, or -NHCOR12; R12 is hydrogen, C1 to C6 alkyl, aryl, or C1 to C3 alkyl-aryl; q is 0, 1, or 2; a first chiral carbon is designated by an asterisk; a second chiral carbon is designated by #; and the above aryl groups and the aryl moieties of the above alkyl-aryl groups are independently selected from phenyl and substituted phenyl, wherein said substituted phenyl may be substituted with one to three groups selected from C1 to C4 alkyl, halogen, hydroxy, cyano, carboxamido, nitro, and C1 to C4 alkoxy, and the pharmaceutically acceptable salts thereof. These compounds are useful in treating migraine and other disorders are new. These compounds are useful psychotherapeutics and are potent serotonin (5-HT1) agonists and may be used in the treatment of depression, anxiety, eating disorders, obesity, drug abuse, cluster headache, migraine, pain, and chronic paroxysmal hemicrania and headache associated with vascular disorders, and other disorders arising from deficient serotonergic neurotransmission. The compounds can also be used as centrally acting antihypertensives and vasodilators.

4. 发明专利

JPS5752349B2 失效
公开(公告)号：JPS5752349B2
公开(公告)日：1982-11-06
申请号：JP7478474
申请日：1974-06-29
IPC分类号： C07D217/06 , A61K31/365 , A61K31/40 , A61K31/42 , A61K31/443 , A61K31/445 , A61K31/47 , A61K31/472 , A61K31/495 , A61K31/535 , A61K31/54 , A61P25/04 , A61P29/00 , C07D211/00 , C07D217/00 , C07D263/08 , C07D295/14 , C07D307/00 , C07D307/83 , C07D405/06 , C07D413/06 , C07D417/06

5. 发明专利

JPS5616790B2 失效
公开(公告)号：JPS5616790B2
公开(公告)日：1981-04-18
申请号：JP8709774
申请日：1974-07-31
IPC分类号： C07D327/06 , B01J27/00 , C07B61/00 , C07D263/08 , C07D263/20 , C07D263/22 , C07D263/24 , C07D265/10 , C07D277/08 , C07D277/14 , C07D327/04 , C07D339/06 , C07D339/08

6. 发明专利

JPS5536491A SULFAMOYLBENZENE DERIVATIVE AND ITS MANUFACTURE 失效
公开(公告)号：JPS5536491A
公开(公告)日：1980-03-14
申请号：JP10413079
申请日：1979-08-17
申请人： HOECHST AG
发明人： DEIITERU MANIA , DEIITERU BORUMAN , BURUFU MERUKERU , ROOMAN MUSHIYABUETSUKU , MATSUKUSU ROPOTSUTO
IPC分类号： A61K31/235 , A61K31/42 , A61K31/421 , A61P7/10 , C07C67/00 , C07C301/00 , C07C303/40 , C07C311/16 , C07D263/08 , C07D263/10

7. 发明专利

JPS5175061A 22 okisazorinjudotaino seizoho 失效
标题翻译： 22 OKISAZORINJUDOTAINO SEIZOHO
公开(公告)号：JPS5175061A
公开(公告)日：1976-06-29
申请号：JP11738274
申请日：1974-10-11
申请人： Okawa Kenji
发明人： OOKAWA KENJI
IPC分类号： C07D263/16 , A61K31/425 , C07D263/08

8. 发明专利

JPS5047984A 失效
公开(公告)号：JPS5047984A
公开(公告)日：1975-04-28
申请号：JP8709774
申请日：1974-07-31
IPC分类号： C07D327/06 , B01J27/00 , C07B61/00 , C07D263/08 , C07D263/20 , C07D263/22 , C07D263/24 , C07D265/10 , C07D277/08 , C07D277/14 , C07D327/04 , C07D339/06 , C07D339/08 , C07D277/04

9. 发明专利

JPS4972250A 失效
公开(公告)号：JPS4972250A
公开(公告)日：1974-07-12
申请号：JP11768973
申请日：1973-10-19
IPC分类号： C07D263/10 , A61K31/42 , A61K31/421 , C07D263/08 , C07D263/14

10. 发明专利

JPH11269398A METHINE COMPOUND AND SILVER HALIDE PHOTOSENSITIVE MATERIAL CONTAINING THE COMPOUND 失效
公开(公告)号：JPH11269398A
公开(公告)日：1999-10-05
申请号：JP7093698
申请日：1998-03-19
申请人： FUJI PHOTO FILM CO LTD
发明人： KATO TAKASHI
IPC分类号： C07D277/28 , C07D235/14 , C07D263/08 , C07D277/82 , C07D417/10 , C07D417/14 , C08G73/02 , C08G75/00 , C09B23/00 , C09B69/10 , G03C1/12
摘要： PROBLEM TO BE SOLVED: To obtain the subject compound capable of providing highly sensitive silver halicle photosensitive material and useful as a sensitizing dye by including a specific recurring unit as a partial structure. SOLUTION: This methine compound contains a recurring unit of formula I [H1 to H3 are each a hemicyanine dye; A1 and A2 are each a coupling group; (q1) is 2-10,000] as a partial structure. The compound of formula I is obtained by carrying out polymerization by using a compound of formula III synthesized from a compound of formula II, a compound of formula IV and a compound of the formula nBu4 NclO4 (Bu is butyl). The compound is used for photosensitive materials such as photosensitive materials for color positive prints, photosensitive materials for color paper or photosensitive materials for color negative prints for the purpose of sensitizers, filters, antihalation or prevention, etc., of irradiation, and can be added not to only photosensitive emulsion layer, but also to an intermediate layer, a protective layer, a back layer, etc.

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