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    • 6. 发明专利
    • Production of 2-substituted carboxylic acid
    • 生产2-取代的羧酸
    • JPH11279110A
    • 1999-10-12
    • JP9515398
    • 1998-03-25
    • Mitsubishi Rayon Co Ltd三菱レイヨン株式会社
    • FUJIMORI YUJITAGAWA YUICHIMORI KUNIOSASAKI TOMU
    • B01J23/42B01J23/44B01J23/62B01J23/644C07B61/00C07C51/235C07C53/124C07C53/134C07C55/08
    • Y02P20/52
    • PROBLEM TO BE SOLVED: To obtain the subject compound, useful as a stock for medicines and agrocbemicals, efficiently from a readily available, inexpensive stock by a simple procedure by reacting a specific substituted propanediol with an oxygen-containing gas in the presence of a metallic catalyst. SOLUTION: This compound, e.g. 3-hydroxyisobutyrate, is obtained by reacting (A) a 2-substituted-1,3-propanediol shown by the formula (R is a 1-6C alkyl or the like), e.g. 2-methyl-1,3-propanediol, in the presence of (B) a metallic catalyst, preferably containing at least one element selected from the platinum group metals, e.g. platinum and, at the same time, at least one of bismuth and lead, with (C) an oxygen-containing gas, preferably at pH 7 to 12 and 20 to 50 deg.C. It is preferable to use 50 to 150 wt.% of the component B on the reaction solution.
    • 要解决的问题:为了获得用作药物和农药的原料的主题化合物,可以通过简单的方法从容易获得的廉价原料中有效地通过在金属的存在下使特定的取代的丙二醇与含氧气体反应 催化剂。 解决方案:该化合物,例如 通过使(A)由式(R是1-6C烷基等)所示的2-取代-1,3-二丙二醇反应得到3-羟基异丁酸酯。 在(B)金属催化剂存在下,优选含有选自铂族金属的至少一种元素,例如2-甲基-1,3-丙二醇。 铂,并且同时具有铋和铅中的至少一种,(C)含氧气体,优选在pH7至12和20至50℃。 优选在反应溶液中使用50〜150重量%的B成分。