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    • 4. 发明专利
    • Producing method of purified lactic acid
    • 纯化乳酸的生产方法
    • JP2013043860A
    • 2013-03-04
    • JP2011182815
    • 2011-08-24
    • Hitachi Plant Technologies Ltd株式会社日立プラントテクノロジー
    • OKA KENICHIROMATSUO TOSHIAKIKAMIKAWA MASAYUKIOKAMOTO SHIGEYASUKONDO TAKEYUKI
    • C07C51/02B01D61/02B01D61/58C07C51/47C07C59/08C12P7/56
    • C12P7/56
    • PROBLEM TO BE SOLVED: To provide a producing method of purified lactic acid, which is a process of concentrating a lactic acid fermentation liquid at a low temperature.SOLUTION: The producing method of purified lactic acid comprises: a fermentation process where a pH adjusting agent containing calcium and a microorganism are added to a sugar-containing solution to produce lactic acid in the form of calcium lactate; and a purification process where sulfuric acid is added to a solution containing calcium lactate to separate calcium ions in the form of calcium sulfate. The producing method of purified lactic acid further comprises, prior to the process of adding sulfuric acid: a reverse osmosis membrane concentration process 140 where the solution containing calcium lactate is allowed to pass through a reverse osmosis membrane to remove water; a crystallization process 150 where the obtained concentrated liquid of calcium lactate is cooled to crystallize and remove the calcium lactate; and a reverse osmosis membrane concentration process 140 where the solution, from which calcium lactate has been removed, is heated and allowed to pass through the reverse osmosis membrane to remove water; wherein the crystallization process 150 and the subsequent reverse osmosis membrane concentration process 140 are repeated one or more times.
    • 待解决的问题:提供一种精制乳酸的制造方法,其是在低温下浓缩乳酸发酵液的方法。 解决方案:纯化乳酸的制备方法包括:发酵过程,其中将含有钙和微生物的pH调节剂加入到含糖溶液中以产生乳酸钙形式的乳酸; 以及将硫酸加入到含乳酸钙的溶液中以分离硫酸钙形式的钙离子的纯化方法。 纯化乳酸的制造方法还包括:在加入硫酸之前:反渗透膜浓缩法140,使含有乳酸钙的溶液通过反渗透膜以除去水; 结晶过程150,其中将所得乳酸钙的浓缩液冷却以结晶并除去乳酸钙; 和反渗透膜浓缩法140,其中从其中除去乳酸钙的溶液被加热并允许其通过反渗透膜以除去水; 其中结晶过程150和随后的反渗透膜浓缩过程140重复一次或多次。 版权所有(C)2013,JPO&INPIT
    • 6. 发明专利
    • Method of crystallizing hydroxycarboxylic acid
    • 水解羟基羧酸的方法
    • JP2012025757A
    • 2012-02-09
    • JP2011187565
    • 2011-08-30
    • Kaneka Corp株式会社カネカ
    • FUKAE MASABUMIHIRAISHI YOSHIRO
    • C07C51/43C07C51/02C07C59/46
    • C07C51/02C07C51/43C07C2602/28C07C59/46
    • PROBLEM TO BE SOLVED: To obtain a specific hydroxycarboxylic acid as a crystal in a high yield and in a high purity.SOLUTION: A method for crystallizing a compound (1) represented by formula (1) includes mixing a water-miscible solvent-rich solution of the compound (1) and water, wherein a necessary suspension amount of a slurry is previously prepared in order to suppress oiling and scaling of the compound (1), and thereafter, a regular crystallization is carried out in the presence of the slurry. The necessary suspension amount is preferably ≤30 wt.% with respect to the total amount of the compound (1) at the completion of the regular crystallization. In the formula, R is CH, CHOH, CHOCOR, COR, CONRR, OH, CHOR, or CHNRR(wherein Ris a 1-5C alkyl; Ris H or a 1-5C alkyl; Rand Rare each independently H or a 1-5C alkyl); a and b are both double bonds, or one thereof is a single bond and the other is a double bond, or a and b are both single bonds.
    • 待解决的问题:以高产率和高纯度获得特定的羟基羧酸作为结晶。 解决方案:用于结晶由式(1)表示的化合物(1)的方法包括将化合物(1)的与水混溶的富溶剂溶液与水混合,其中预先制备必需的浆料悬浮液量 为了抑制化合物(1)的油化和结垢,然后在浆料存在下进行规则结晶。 相对于正常结晶完成时化合物(1)的总量,必要的悬浮液量优选≤30重量%。 在该式中,R为CH 3 ,CH 2 OH,CH 2 OCOR 1 ,CO 2 R 2 ,CONR 3 R 4 ,OH,CH 2 1 或CH 2 NR 3 R 4 R 1 是1-5C烷基; R 2 是H或1-5C烷基; R 3 和R 4 各自独立地为H或1-5C烷基); a和b都是双键,或者一个是单键,另一个是双键,或a和b都是单键。 版权所有(C)2012,JPO&INPIT