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1. 发明专利

JP4287750B2 Glomerular disease treatment agent 有权
公开(公告)号：JP4287750B2
公开(公告)日：2009-07-01
申请号：JP2003579874
申请日：2003-03-28
申请人：日産化学工業株式会社 , 興和株式会社
发明人：隆中川 , 昌子伊菅 , さや香豊泉
IPC分类号： A61K31/472 , A61K31/00 , A61K31/22 , A61K31/351 , A61K31/40 , A61K31/404 , A61K31/4418 , A61K31/495 , A61K31/519 , A61K31/551 , A61K45/06 , A61P7/02 , A61P13/12 , A61P43/00
CPC分类号： A61K45/06 , A61K31/22 , A61K31/351 , A61K31/40 , A61K31/404 , A61K31/4418 , A61K31/495 , A61K31/519 , A61K31/551 , Y10S514/929 , A61K2300/00
摘要： The present invention relates to a preventive or therapeutic agent for a glomerular disease which comprises an anti-thrombocytic agent and an HMG-CoA reductase inhibitor as active ingredients. The above agent is useful for prevention and therapy of various glomerular diseases including chronic glomerular nephritis.

2. 发明专利

JP2009102386A Intermediate of tetracyclic derivative 审中-公开
标题翻译：四元衍生物的中间体
公开(公告)号：JP2009102386A
公开(公告)日：2009-05-14
申请号：JP2009006669
申请日：2009-01-15
申请人： Icos Corp , アイコス、コーポレーションIcos Corporation
发明人： DAUGAN ALAIN CLAUDE-MARIE
IPC分类号： C07D471/04 , A01K67/033 , A01N63/00 , A61K31/395 , A61K31/495 , A61K31/4985 , A61P1/00 , A61P1/12 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/02 , A61P13/12 , A61P15/00 , A61P27/02 , A61P27/06 , A61P27/14 , A61P27/16 , A61P29/00 , A61P37/08 , A61P43/00 , C07D209/08 , C07D209/14 , C07D209/20 , C07D471/14
CPC分类号： A01N63/00 , C07D471/14 , Y10S514/869 , Y10S514/929 , A01N2300/00
摘要： PROBLEM TO BE SOLVED: To provide a production intermediate of a tetracyclic derivative which is a selective inhibitor of the cyclic guanosine 3'5'-monophosphoric acid-specific phosphodiesterase (cGMP-specific PDE). SOLUTION: The production intermediate is a compound represented by formula (I). COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供作为环鸟嘌呤3'5'-单磷酸特异性磷酸二酯酶（cGMP特异性PDE）的选择性抑制剂的四环衍生物的制备中间体。生产中间体是由式（I）表示的化合物。版权所有（C）2009，JPO＆INPIT

3. 发明专利

JP2004217674A Intermediate for tetracyclic derivative 有权
公开(公告)号：JP2004217674A
公开(公告)日：2004-08-05
申请号：JP2004125881
申请日：2004-04-21
申请人： Icos Corp , アイコス、コーポレーションIcos Corporation
发明人： DAUGAN ALAIN CLAUDE-MARIE
IPC分类号： C07D471/04 , A01K67/033 , A01N63/00 , A61K31/395 , A61K31/495 , A61K31/4985 , A61P1/00 , A61P1/12 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/02 , A61P13/12 , A61P15/00 , A61P27/02 , A61P27/06 , A61P27/14 , A61P27/16 , A61P29/00 , A61P37/08 , A61P43/00 , C07D209/08 , C07D209/14 , C07D209/20 , C07D471/14
CPC分类号： A01N63/00 , C07D471/14 , Y10S514/869 , Y10S514/929 , A01N2300/00
摘要： PROBLEM TO BE SOLVED: To provide an intermediate for producing tetracyclic derivatives of a selective inhibiter for cyclic guanosine-3',5'-monophosphate specific phosphodiesterase (cGMP specific PDE). SOLUTION: The tetracyclic derivatives are represented by formula (I). The intermediates for producing the tetracyclic derivatives are represented by formula (II) or the like. COPYRIGHT: (C)2004,JPO&NCIPI

4. 发明专利

JP2003073302A No-donor for treating anal disease and method for the same 审中-公开
标题翻译：用于治疗异常的免疫抑制剂及其方法
公开(公告)号：JP2003073302A
公开(公告)日：2003-03-12
申请号：JP2002243611
申请日：2002-08-23
申请人： Cellegy Pharmaceuticals Inc , セレジィファーマシューティカルス, インコーポレイテッド
发明人： GORFINE STEPHEN R
IPC分类号： A61K9/02 , A61K9/06 , A61K31/21 , A61K31/34 , A61K31/47 , A61K31/56 , A61K33/00 , A61K45/00 , A61K45/08 , A61P1/00 , A61P1/04 , A61P3/00 , A61P9/14 , A61P17/00 , A61P17/02 , A61P25/02 , A61P25/04 , A61P29/00 , A61P43/00
CPC分类号： A61K31/573 , A61K31/21 , A61K31/34 , A61K31/47 , A61K33/00 , Y10S514/882 , Y10S514/929 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To treat anal disease and pain accompanying with it easily.
SOLUTION: This composition is suitable for the administration of an NO- donor to a zone where conventionally its administration is avoided. In order to achieve this and associated purposes, the effective medicinal composition useful for the treatment of the anal disease containing a carrier, optionally a corticosteroid and/or local anesthetic agent together with an organic NO-donor without having a weakening adverse effect is provided in one aspect. In one practicing embodiment, the method for treating the anal disease is to bring an effective amount of NO, preferably the NO delivered by the release from the organic NO-donor, in contact with the suitable anal part.
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：轻松治疗肛门疾病和伴随的疼痛。解决方案：该组合物适用于将NO给体施用于通常其避免给药的区域。为了实现这一目的和相关目的，提供了有用的治疗肛门疾病的有效药物组合物，其含有载体，任选的皮质类固醇和/或局部麻醉剂以及有机的NO-供体而不具有削弱的不良作用。一方面。在一个实践实施方案中，治疗肛门疾病的方法是使有效量的NO，优选由有机NO供体释放释放的NO与合适的肛门部分接触。

5. 发明专利

JPS5929190B2 JPS5929190B2 - 失效
公开(公告)号：JPS5929190B2
公开(公告)日：1984-07-18
申请号：JP7816981
申请日：1981-05-25
申请人： Boehringer Sohn Ingelheim
发明人： ANTON MENTORUUPU , KURUTO SHUROMU , ERUNSUTO OTSUTOO RENTO , BERUNAA TORAUNETSUKAA
IPC分类号： A61K31/18 , A61P9/00 , A61P9/08 , A61P11/08 , C07C67/00 , C07C301/00 , C07C303/34 , C07C307/10 , C07D207/40 , C07D295/22 , C07D295/26 , C07D473/08
CPC分类号： C07D207/40 , C07D295/26 , C07D473/08 , Y10S514/929

6. 发明专利

JPS5967242A 3-propionylsalicylic acid derivative and preparation thereof 失效
标题翻译： 3-丙炔二酸衍生物及其制备方法
公开(公告)号：JPS5967242A
公开(公告)日：1984-04-16
申请号：JP17130482
申请日：1982-09-30
申请人： Oosakashi , Yamamoto Kagaku Kogyo Kk
发明人： INOUE HIROSHIGE , FUKUSHIMA KENICHI , NISHIGUCHI IKUZOU
IPC分类号： C07C67/00 , C07C51/00 , C07C51/353 , C07C51/373 , C07C65/40 , C07C69/84 , C07C69/88 , C07C213/00 , C07C219/12 , C07D205/08 , C07D295/08 , C07D295/088 , C07D311/30
CPC分类号： C07D295/088 , C07C51/373 , C07C65/40 , C07D311/30 , Y10S514/869 , Y10S514/929
摘要： NEW MATERIAL:A 3-propionylsalicyclic acid derivative of formula I [R is H, lower alkyl or formula II (R
1 and R
2 are lower alkyl or R
1 and R
2 together with the nitrogen atom to which they are linked through or not through a hetero atom may form a heterocyclic ring; n is an integer 1W4); X is H or halogen, provided that R represents formula II when X is H atom].
EXAMPLE: Ethyl-5-chloro-3-propionylsalicylate.
USE: Useful as a remedy for preventing the fit of angina pectoris and cardiac infraction, etc. and a remedy for increasing the discharge capacity of the urinary bladder, disappearance of subjective symptom of thamuria, etc. having coronary arterial vasodilator action and coronary blood stream increasing action, and further useful as a synthetic intermediate for compounds useful as a diuretic having the remissive action, e.g. smooth muscle spasm in the lower urinary tract.
PROCESS: A compound of formula III (X' is halogen) is reacted with a propionyl halide by the Friedel-Crafts reaction to give the aimed compound of formula I .
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：新材料：式I的3-丙酰基水杨酸衍生物[R是H，低级烷基或式II（R 1和R 2）是低级烷基或R 1和R 2与氮原子一起它们通过或不与杂原子连接在一起可以形成杂环; n是整数1-4）; X是H或卤素，条件是当X是H原子时，R表示式II）。实施例：乙基-5-氯-3- propionylsalicylate。用途：可用作预防心绞痛和心脏梗死等适应症的补救措施，以及增加膀胱排出能力的补救措施，具有冠状动脉血管扩张作用和冠状动脉血流的饱腹感主要症状消失增加作用，并且还可用作用作具有缓和作用的利尿剂的化合物的合成中间体，例如下尿路平滑肌痉挛。方法：通过Friedel-Crafts反应将式III化合物（X'是卤素）与丙酰卤反应，得到目标化合物I。

7. 发明专利

JPS5750966A Novel dopamine benzazepine, manufacture and medicinal composition containing same 失效
标题翻译：新型多巴胺苯并嗪，其制造和药物组合物
公开(公告)号：JPS5750966A
公开(公告)日：1982-03-25
申请号：JP11062281
申请日：1981-07-14
申请人： Smithkline Corp
发明人： ERU MAACHIN BURENNAA
IPC分类号： A61K31/55 , A61P43/00 , C07D223/16
CPC分类号： C07D223/16 , Y10S514/929

8. 发明专利

JPS5713551B2 JPS5713551B2 - 失效
公开(公告)号：JPS5713551B2
公开(公告)日：1982-03-17
申请号：JP6664276
申请日：1976-06-09
IPC分类号： C07D519/04 , A61K31/435 , A61K31/4375 , A61K31/475 , A61P9/08 , A61P9/12 , C07D461/00
CPC分类号： C07D461/00 , Y10S514/929

9. 发明专利

JPS5732281A Nitrogen-containing polycyclic compound and its preparation 失效
标题翻译：含氮的多环化合物及其制备
公开(公告)号：JPS5732281A
公开(公告)日：1982-02-20
申请号：JP10849580
申请日：1980-08-06
申请人： Sumitomo Chem Co Ltd
发明人： ONO KEIICHI , KAWAKAMI HAJIME , KATSUBE SUMIMOTO
IPC分类号： A61K31/435 , A61K31/44 , A61P9/08 , A61P25/28 , C07D461/00
CPC分类号： C07D461/00 , Y10S514/824 , Y10S514/879 , Y10S514/929
摘要： NEW MATERIAL:The nitrogen-containing polycyclic compound of formula I (R
1 is lower alkyl; R
2 is aryl) and its salt.
EXAMPLE: 16-Benzylidene-17-oxo-eburnane.
USE: Vasodilator, antispasmodic agent and cerebral metabolism activating agent useful as a remedy for arteriosclerosis caused by thrombosis, etc. and cerebral and coronary vessel disorder.
PROCESS: The compound of formula I is prepared by reacting the ketone derivative of formula II with the aldehyde derivative of formula R
2 -CHO in a proper solvent (e.g. alcoholic solvent, hydrated alcohol solvent, amide solvent, ether solvent, or aromatic hydrocarbon) in the presence of a base (e.g. metal hydride such as sodium hydride, caustic alkali, alkali metal carbonate, triethylamine, etc.).
COPYRIGHT: (C)1982,JPO&Japio
摘要翻译：新材料：式I的含氮多环化合物（R 1是低级烷基; R 2是芳基）及其盐。实施例：16-亚苄基-17-氧代 - 伊本烷。用途：血管扩张剂，抗痉挛剂和脑代谢活化剂，可用作血栓形成引起的动脉硬化症，脑血管疾病和冠状动脉疾病。方法：式I化合物通过使式II的酮衍生物与式R 2 -CHO的醛衍生物在合适的溶剂（例如醇溶剂，水合醇溶剂，酰胺溶剂，醚溶剂或芳族化合物）中反应来制备碳氢化合物）在碱（例如金属氢化物如氢化钠，苛性碱，碱金属碳酸盐，三乙胺等）存在下反应。

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