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    • 2. 发明专利
    • Vaccine to be applied to mucous membrane
    • 疫苗应用于MUCOUS膜
    • JP2011057605A
    • 2011-03-24
    • JP2009208379
    • 2009-09-09
    • Masami Moriyama雅美 森山
    • MORIYAMA MASAMI
    • A61K39/102A61K9/12A61K9/72A61K31/7105A61K31/713A61K31/716A61K39/002A61K39/02A61K39/39A61K47/32A61K47/36A61K47/38A61P37/04
    • Y02A50/386Y02A50/388Y02A50/39Y02A50/394Y02A50/396Y02A50/412Y02A50/416Y02A50/466
    • PROBLEM TO BE SOLVED: To provide a vaccine to be applied to a mucous membrane that effectively induces production of secretory IgA and/or IgG antibody specific to viruses, by being applied to a mucous membrane, for example, a mucous membrane of an oral or nasal cavity so as to stay there, and further to provide a substance having such an adjuvant function.
      SOLUTION: The vaccine to be applied to a mucous membrane is characterized by including: (a) an inactivated antigen of pathogen origin; (b) an adjuvant; (c) a polysaccharide such as a β-glucan; and (d) a thickener, wherein preferably the adjuvant is Poly (I:C) which is a double-stranded or single-stranded RNA, that is, a TLR (Toll-Like Receptor) ligand, and a fine powder of chitin, chitosan or a sakhalin surf clam. The vaccine to be applied to a mucous membrane is applied to a mucous membrane, preferably to a mucous membrane of an oral or nasal cavity, and stays well on the mucous membrane and thus gives there secretion of the IgA antibody and IgG antibody response in a blood serum.
      COPYRIGHT: (C)2011,JPO&INPIT
    • 待解决的问题:提供一种应用于粘膜的疫苗,其通过施用于粘膜,例如粘膜上的粘膜,有效地诱导分泌型IgA和/或对病毒特异性的IgG抗体的产生 口腔或鼻腔,以便留在那里,并进一步提供具有这种佐剂功能的物质。 应用于粘膜的疫苗的特征在于包括:(a)病原体来源的灭活抗原; (b)佐剂; (c)多糖如β-葡聚糖; 和(d)增稠剂,其中优选佐剂是双链或单链RNA的Poly(I:C),即TLR(Toll样受体)配体和几丁质细粉, 壳聚糖或沙加林冲浪蛤。 将施用于粘膜的疫苗施用于粘膜,优选施用于口腔或鼻腔的粘膜,并且在粘膜上保持良好,从而在IgA抗体和IgG抗体应答中分泌 血清。 版权所有(C)2011,JPO&INPIT
    • 5. 发明专利
    • Powderform secretory iga and/or igg antibody inducer
    • 粉末秘密IGA和/或IGG抗体诱导剂
    • JP2008231037A
    • 2008-10-02
    • JP2007073767
    • 2007-03-21
    • Masami Moriyama雅美 森山
    • MORIYAMA MASAMI
    • A61K39/00A61K39/015A61K39/12A61K39/145A61K39/29A61K39/39A61P1/16A61P31/12A61P31/14A61P33/06A61P37/04
    • Y02A50/386Y02A50/388Y02A50/39Y02A50/394Y02A50/396Y02A50/412Y02A50/416
    • PROBLEM TO BE SOLVED: To provide a secretory IgA and/or IgG antiboty production inducer containing an adjuvant and specific to various kinds of viruses. SOLUTION: The secretory IgA and/or IgG antiboty production inducer is in the form of powder which is obtained by lyophilizing an inactivated antibody derived from one of various kinds of viruses (especially, West Nile virus, hanta virus, dengue virus, Japanese encephalitis virus, yellow fever virus, tick-borne encephalitis virus, influenza virus, hepatitis C virus, etc.) and Poly (I:C) (a polynucleotide copolymer made from inosinic acid : cytidylic acid) as an adjuvant. By pernasal administration (nasal mucosal inoculation) of this inducer, the inducer serves as a pernasal vaccine affording the favorable secretion of IgA antibody on the nasal mucosa and the response of IgG antibody in the serum. COPYRIGHT: (C)2009,JPO&INPIT
    • 待解决的问题:提供含有佐剂的特异性的分泌型IgA和/或IgG抗生素生产诱导剂,对各种病毒具有特异性。 解决方案:分泌型IgA和/或IgG抗生素产生诱导剂是粉末形式,其通过冻干来自各种病毒(特别是西尼罗河病毒,汉坦病毒,登革热病毒, 日本脑炎病毒,黄热病毒,蜱传脑炎病毒,流感病毒,丙型肝炎病毒等)和Poly(I:C)(由肌苷酸:胞苷酸制成的多核苷酸共聚物)作为佐剂。 通过该诱导剂的鼻鼻给药(鼻粘膜接种),诱导剂用作鼻粘膜疫苗,其在鼻粘膜上提供有利的IgA抗体分泌和IgG抗体在血清中的应答。 版权所有(C)2009,JPO&INPIT