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    • 8. 发明专利
    • Compressed fiber structural material and method for producing the same
    • 压缩纤维结构材料及其制造方法
    • JP2013078556A
    • 2013-05-02
    • JP2012044751
    • 2012-02-29
    • Shinshu Univ国立大学法人信州大学
    • NAKAYAMA NOBORUHOTTA MASAOMIIZAWA NAOKITAMAI HIROTOSAITO NAOTOUSUI YUKIOGIWARA NOBUHIDE
    • A61L27/00
    • A61F2/28A61F2002/2835A61F2310/00023A61F2310/00425A61L27/04B22F3/002C22C49/11C22F1/183
    • PROBLEM TO BE SOLVED: To provide a method enabling easy production of a sheet-like compressed fiber structural material including mechanical characteristics close to an in vivo bone and characteristics of easily increasing osteoblasts even when there is variation in strength in a region that is a treatment target.SOLUTION: This method for producing the compressed fiber structural material 1 includes steps of: preparing biocompatible fiber 14 having an average diameter of 5-50 μm and an aspect ratio of 20-500; and performing normal-temperature compression shearing of the biocompatible fiber 14 to form the compressed fiber structural material 1 wherein an average pore diameter obtained by the measurement in a mercury press-in method is 60 μm or above and 100 μm or below, and wherein a porosity is present in a range of 25% or above and 50% or below. Furthermore, preferably, the normal-temperature compression shearing is performed by controlling a compression pressure in a range of 200-2,000 MPa, a shear stroke length in a range of 0.2-5 mm, and a shear velocity in a range of 0.5-5 mm/minute.
    • 待解决的问题:提供一种能够容易地生产包含接近体内骨骼的机械特性的片状压缩纤维结构材料和容易增加的成骨细胞的特性的方法,即使在区域的强度变化的情况下, 是治疗目标。 制造压缩纤维结构材料1的方法包括以下步骤:制备平均直径为5-50μm,纵横比为20-500的生物相容性纤维14; 并对生物相容性纤维14进行常压压缩剪切以形成压缩纤维结构材料1,其中通过在汞压入法中测量得到的平均孔径为60μm以上且100μm以下,其中, 孔隙率在25%以上且50%以下的范围内。 此外,优选地,常压压缩剪切是通过将压缩压力控制在200-2,000MPa,剪切行程长度在0.2-5mm的范围内,剪切速度在0.5-5的范围内 毫米/分钟。 版权所有(C)2013,JPO&INPIT