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    • 5. 发明专利
    • Hydrogel volumetrically expansible in response to environmental change, method for manufacturing the same, and application thereof
    • HYDROGEL可扩展性地响应环境变化,其制造方法及其应用
    • JP2010022847A
    • 2010-02-04
    • JP2009229839
    • 2009-10-01
    • Microvention Incマイクロベンション インコーポレイテッド
    • CRUISE GREGORY MCONSTANT MICHAEL J
    • A61L31/00A61K9/00A61K49/04A61L26/00A61L27/00
    • C08F22/385A61K9/0024A61K49/0457A61L31/145
    • PROBLEM TO BE SOLVED: To provide a composition including hydrogel polymer that is volumetrically expansible in response to protonation and deprotonation of pH sensitivity.
      SOLUTION: The hydrogel polymer is prepared by forming a liquid reaction mixture including (a) a monomer and/or polymer at least part of which are/is sensitive to change in pH, (b) a cross-linking agent, and (c) a polymerization initiator. If desired, a porosigen may be incorporated into the liquid reaction mixture to create pores. After hydrogel is formed, the porosigen is removed to create pores in the hydrogel. The hydrogel can further be treated to maintain non-expanded volume till it expands due to change in pH. These hydrogels can be prepared in various forms including pellets, filaments, and particles. Biomedical applications of these hydrogels include applications wherein the hydrogel is implanted in the body of a patient and an environmental condition at the implantation site causes the hydrogel to expand it in situ.
      COPYRIGHT: (C)2010,JPO&INPIT
    • 要解决的问题:提供包含水凝胶聚合物的组合物,其响应于质子化和pH敏感性的去质子化而体积可膨胀。 解决方案:通过形成液体反应混合物制备水凝胶聚合物,该液体反应混合物包括(a)单体和/或聚合物的至少一部分对pH变化敏感,(b)交联剂,和 (c)聚合引发剂。 如果需要,可以将多孔性原子结合到液体反应混合物中以产生孔。 在形成水凝胶之后,去除孔结构以在水凝胶中产生孔。 可以进一步处理水凝胶以保持非膨胀体积,直到其由于pH变化而膨胀。 这些水凝胶可以以各种形式制备,包括颗粒,细丝和颗粒。 这些水凝胶的生物医学应用包括其中将水凝胶植入患者体内的应用,并且在植入部位的环境条件导致水凝胶原位扩张。 版权所有(C)2010,JPO&INPIT