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1. 发明专利

JP2008280325A External preparation for skin, hair restoration or hair growth agent, and external preparation for lip 审中-公开
标题翻译：皮肤，头发修复或头发生长剂的外用制剂，以及LIP的外用制剂
公开(公告)号：JP2008280325A
公开(公告)日：2008-11-20
申请号：JP2007241520
申请日：2007-09-18
申请人： Okayama Taiho Pharmaceutical Co Ltd , 岡山大鵬薬品株式会社
发明人： OKAJIMA KENJI , HARADA NAOAKI
IPC分类号： A61K8/35 , A61K31/12 , A61P17/14 , A61P43/00 , A61Q7/00
摘要： PROBLEM TO BE SOLVED: To provide an external preparation for the skin for improving wrinkle and sagging, external preparation for moisturizing, hair restoration or growth agent, external preparation for promoting the healing of wounds and external preparation for the lips which contain a natural effective component.
SOLUTION: The external preparation for the skin for improving wrinkle and sagging, external preparation for moisturizing, hair restoration or growth agent, external preparation for promoting the healing of wounds and external preparation for the lips contain raspberry ketone as an effective component.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为了提供皮肤用于改善皱纹和下垂的外用制剂，用于保湿，毛发修复或生长剂的外用制剂，用于促进伤口愈合的外用制剂和含有天然有效成分。
解决方案：用于改善皱纹和下垂的外用制剂，用于保湿，毛发修复或生长剂的外用制剂，用于促进伤口愈合的外用剂和用于唇部的外用制剂含有树莓酮作为有效成分。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2002257825A METHOD FOR EVALUATING ITCHING DERIVED FROM INFECTION WITH TRICHOPHYTON 失效
公开(公告)号：JP2002257825A
公开(公告)日：2002-09-11
申请号：JP2001056720
申请日：2001-03-01
申请人： TAIHO PHARMACEUTICAL CO LTD
发明人： FURUKAWA TESSHIN , YASUDA AKIO
IPC分类号： G01N33/50 , G01N33/15
摘要： PROBLEM TO BE SOLVED: To provide a method for evaluating itching derived from infection with trichophyton for applying components selected from among an inorganic saline solution, lower alcohol, and polyhydric alcohol to the skin of body part of a guinea pig infected with the trichophyton and measuring the scratching action of the guinea pig afterwards. SOLUTION: By using an animal experiment model for measuring the itching derived from infection with the trichophyton, it is possible to execute a test for evaluating the effects of a large number of medications in a short period by a testing system regarded equal to human itching when developing the medications with itching assuasive effects (improvement in symptoms) superior to a therapeutic agent for interdigital ringworm commercially available at present.

3. 发明专利

JP2002101877A MONOCLONAL ANTIBODY 审中-公开
公开(公告)号：JP2002101877A
公开(公告)日：2002-04-09
申请号：JP2001243293
申请日：2001-08-10
申请人： TAIHO PHARMACEUTICAL CO LTD
发明人： MIYADERA KAZUTAKA , YAMADA YUJI , TAKEBAYASHI YUJI , AKIYAMA SHINICHI
IPC分类号： C12N15/02 , C07K14/475 , C07K16/22 , C07K16/40 , C12N9/10 , C12P21/08
摘要： PROBLEM TO BE SOLVED: To obtain a monoclonal antibody against the peptide containing the sequence number 1 (refer to the specification) which presents in the endothelial cell growth factor derived from human thymidine phosphorylase and human platelets. SOLUTION: This monoclonal antibody is capable of recognizing the endothelial cell growth factor derived from human thymidine phosphorylase and human platelets and is useful for diagnosing and curing various tumors, diseases and the likes accompanied with their transformations and abnormal proliferations of vascularization.

4. 发明专利

JP2001233772A EXTERNAL PREPARATION COMPOSITION 失效
公开(公告)号：JP2001233772A
公开(公告)日：2001-08-28
申请号：JP2000046376
申请日：2000-02-23
申请人： TAIHO PHARMACEUTICAL CO LTD
发明人： KINOSHITA HIROYUKI , NISHIZAKI MICHIKO , AKAMATSU NAOKI
IPC分类号： A61K9/06 , A61K31/57 , A61K31/573 , A61K47/32 , A61P17/00 , A61P29/00
摘要： PROBLEM TO BE SOLVED: To provide an external preparation composition capable of making steroidal anti-inflammatory agents stable with time, thus useful in treating dermatitis or the like. SOLUTION: This external preparation composition is an anhydrous steroidal anti-inflammatory agent composition containing an acrylic acid polymer. The external preparation composition causes no quality deterioration of the steroidal anti-inflammatory agent as base and is good in preservation stability.

5. 发明专利

JP2000219663A DERIVATIVE OF N DELTA-SUBSTITUTED AMINO ORNITHINE AND ITS SALT 失效
公开(公告)号：JP2000219663A
公开(公告)日：2000-08-08
申请号：JP4018899
申请日：1999-02-18
申请人： TAIHO PHARMACEUTICAL CO LTD
发明人： SAEKI TAKEYORI , ASAO TETSUJI , KAMIMURA ATSUHIKO , SUDA YOSHIMITSU , KATSUNUMA NOBUHIKO
IPC分类号： C07C243/14 , A61K31/00 , A61K31/195 , A61K31/198 , A61P7/00
摘要： PROBLEM TO BE SOLVED: To obtain a new compound comprising specific Nδ-substituted amino ornithine derivative capable of activating ad reinforcing a metabolic pathway of ornithine in urea cycle, useful for therapy of hyperammonemia. SOLUTION: This compound is expressed by the formula (R1 and R2 are each H, a lower alkyl or the like), for example, Nδ-amino ornithine. The compound of the formula is obtained by carrying out a condensation of an oxo oxazoline derivative of glutamic acid of the formula with a derivative of hydrazine utilizing 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide as a condensing agent, under the presence of a base (e.g. trimethylamine or the like), in a solvent (e.g., dichloromethane or the like), at room temperature. The product compound is selectively reduced at the acid-amide part. The reduction is carried out in an organic solvent (e.g. tetrahydrofuran or the like) and using a reducing agent (e.g. sodium borohydride or the like). The compound is obtained by protecting the amino group of the product, ring opening by a base and removing the protecting gourd.

6. 发明专利

JP2000146981A METHOD AND KIT FOR DETERMINATION OF HUMAN THYMIDYLATE SYNTHASE 失效
公开(公告)号：JP2000146981A
公开(公告)日：2000-05-26
申请号：JP24459499
申请日：1999-08-31
申请人： IATRON LAB , TAIHO PHARMACEUTICAL CO LTD
发明人： HOSHINO NOBUHIRO , MATSUYA TAKESHI , FUKUSHIMA MASAKAZU , OKABE HIROYUKI
IPC分类号： C12Q1/48 , C07K16/40 , G01N33/543 , G01N33/573
摘要： PROBLEM TO BE SOLVED: To determine human thymidylate synthase(TS) in a specimen with high sensitivity by a simple immunoassay by using a TS polyclonal antibody which is immobilized to an insoluble carrier. SOLUTION: In this method, human TS is determined immunologically by using an antihuman TS antibody. This determining method for the human TS uses, as the antibody, an antihuman TS polyclonal antibody which is immobilized to at least an insoluble carrier. In addition, the method asses the susceptibility to a fluoropyrimidine-based anticancer drug of cancer cells on the basis of a determined result by the determining method. In addition, this kit determines the human TS which contains the insoluble carrier to which at least one kind of an antihuman TS polyclonal antibody is immobilized. Thereby, human TS in a specimen can be determined by a simple immunoassay.

7. 发明专利

JP2000063269A SOLID PREPARATION 失效
公开(公告)号：JP2000063269A
公开(公告)日：2000-02-29
申请号：JP23411598
申请日：1998-08-20
申请人： TAIHO PHARMACEUTICAL CO LTD
发明人： YAMADA HIROAKI , NAKAI KAZUHIRO
IPC分类号： A61K9/20 , A61K31/135 , A61K31/137 , A61K47/12 , A61P11/10 , A61P11/14
摘要： PROBLEM TO BE SOLVED: To produce stable solid preparations having bronchodilator action, improved in stability in an alkaline region, and having long quality-assurance term and high value of a product by including ephedrines and benzoic acid. SOLUTION: The solid preparations is produced by including (A) (pref. 0.25-15 wt.%) ephedrines or their salt (pref. dl-methylephedrine, l-methylephedrine and phenylpropanolamine), (B) 0.1-50 wt.% benzoic acid or its alkali metal salt (pref. sodium benzoate) and pref. (C) 5-50 wt.% basic substance [pref. dried aluminum hydroxide gel, (synthetic) hydrotalcite or the like]. The content ratio of (ephedrine or its salt/benzoic acid) is pref. (1/0.5)-(1/10). The solid preparations are pref. in a form of powdered medicine, fine subtilae, granule, pill or effervescent tablet.

8. 发明专利

JPH11255247A PACKAGING BAG 失效
公开(公告)号：JPH11255247A
公开(公告)日：1999-09-21
申请号：JP5645098
申请日：1998-03-09
申请人： TAIHO PHARMACEUTICAL CO LTD , DAINIPPON PRINTING CO LTD
发明人： YOKOUCHI BITETAKE
IPC分类号： B65D33/00 , B65D75/26
摘要： PROBLEM TO BE SOLVED: To provide a packaging body consisting of a lamination body where a non-humid permeable barrier layer and a heat adhesive resin layer are laminated on one side of a paper layer which is compact in structure, excellent in portability, excellent in handling property, and capable of being manufactured at a low cost. SOLUTION: A pillow-like packaging bag where a non-humid permeable barrier layer and a heat adhesive resin layer are laminated on one side of a paper layer is heat-sealed so that the heat adhesive resin layer forms the inner surface, is provided with edge seal parts 7, 8 provided along upper and lower edges, a back seal part which are intersected with the edge seal parts 7, 8, and formed by mitered attachment, a cutting line 10 extending in the transverse direction provided completely or approximately whole periphery in the vicinity of the inner side of the upper edge seal part 7, and a folding line provided on a front side wall extending in the longitudinal direction opposite to the back seal part 9.

9. 发明专利

JPH11246404A PHARMACEUTICAL COMPOSITION IMPROVED IN ABSORBABILITY 失效
公开(公告)号：JPH11246404A
公开(公告)日：1999-09-14
申请号：JP5244198
申请日：1998-03-04
申请人： TAIHO PHARMACEUTICAL CO LTD
发明人： BABA KAZUHIKO , KINOSHITA MASAHIRO , YAMABE KAZU
IPC分类号： A61K47/02 , A61K9/14 , A61K31/40 , A61K47/30 , A61P9/00
摘要： PROBLEM TO BE SOLVED: To obtain the subject composition improved in solubility and absorbability by making a specific indolinone amorphous in the presence of a high molecular substance and inorganic porous substance. SOLUTION: This composition is obtained by making (A) 3-bis(4- methoxyphenyl)methylene-2-indolinone amorphous in the presence of (B) a high molecular substance (e.g. hydroxypropylmethyl cellulose, hydroxypropylmethyl cellulose phthalate, polyvinyl pyrrolidone) and/or (C) pref. an inorganic porous substance (e.g. calcium silicate, hydrous silicon dioxide, light anhydrous silicic acid, synthetic aluminum silicate) in the form of particles having a size of about 1 to 100$ μm. A process for setting the composition amorphous is conducted by a heatfusing method or solvent method using the components A and C or by a solvent method using the component B.

10. 发明专利

JPH10236985A PREPARATION FOR GENE THERAPY 失效
公开(公告)号：JPH10236985A
公开(公告)日：1998-09-08
申请号：JP4216797
申请日：1997-02-26
申请人： TAIHO PHARMACEUTICAL CO LTD
发明人： KIWADA HIROSHI
IPC分类号： C07H15/24 , A61K9/127 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K47/26 , A61K48/00 , A61P1/16 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To obtain the subject preparation capable of efficiently expressing a gene in liver specifically by administration to whole body circulatory system, by adding a gene to express in liver to a lipid endoplasmic teticulum comprising a specific glycyrrhizin derivative as one component of a membrane forming component. SOLUTION: A gene to express in liver is added to a lipid endoplasmic teticulum comprising a 30-position substituted glycyrrhizin derivative of the formula (R is a 12-18C alkyl; X is O or NH) as one component of a membrane forming component. 30-Stearylglycyrrhizin or N-stearyl-30-glycyrrhizinamide is preferable as the compound of the formula. A phospholipid such as phosphatidylcholine, sterols, etc., may be cited as other lipid endoplasmic teticulum-forming component. Cholesterol is preferable as the sterol. The amount of the compound of the formula added is preferably 1-50% (w/w) based on the lipid endoplasmic teticulum. A cancer-restraining gene, an interferon producing gene, a hepatocyte proliferation gene is preferable as the gene.

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