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1. 发明专利

JP2000146981A METHOD AND KIT FOR DETERMINATION OF HUMAN THYMIDYLATE SYNTHASE 失效
公开(公告)号：JP2000146981A
公开(公告)日：2000-05-26
申请号：JP24459499
申请日：1999-08-31
申请人： IATRON LAB , TAIHO PHARMACEUTICAL CO LTD
发明人： HOSHINO NOBUHIRO , MATSUYA TAKESHI , FUKUSHIMA MASAKAZU , OKABE HIROYUKI
IPC分类号： C12Q1/48 , C07K16/40 , G01N33/543 , G01N33/573
摘要： PROBLEM TO BE SOLVED: To determine human thymidylate synthase(TS) in a specimen with high sensitivity by a simple immunoassay by using a TS polyclonal antibody which is immobilized to an insoluble carrier. SOLUTION: In this method, human TS is determined immunologically by using an antihuman TS antibody. This determining method for the human TS uses, as the antibody, an antihuman TS polyclonal antibody which is immobilized to at least an insoluble carrier. In addition, the method asses the susceptibility to a fluoropyrimidine-based anticancer drug of cancer cells on the basis of a determined result by the determining method. In addition, this kit determines the human TS which contains the insoluble carrier to which at least one kind of an antihuman TS polyclonal antibody is immobilized. Thereby, human TS in a specimen can be determined by a simple immunoassay.

2. 发明专利

JP2000146965A REAGENT AND KIT FOR IMMUNOLOGICAL ANALYSIS AND IMMUNOLOGICAL ANALYZING METHOD 失效
公开(公告)号：JP2000146965A
公开(公告)日：2000-05-26
申请号：JP31617398
申请日：1998-11-06
申请人： IATRON LAB , MATSUMOTO KAZUKO
发明人： HOSHINO NOBUHIRO , MATSUYA TAKESHI , MATSUMOTO KAZUKO
IPC分类号： G01N33/53 , G01N33/531 , G01N33/532
摘要： PROBLEM TO BE SOLVED: To provide both a reagent for immunological analysis capable of stably maintaining reactivity while developing the advantage of an avidin-biotin reaction and an immunological analyzing method capable of performing speedy, simple, and accurate analysis on compounds to be analyzed. SOLUTION: A reagent for immunological analysis contains a complex of a biotin introducing antibody fragment Fab' or a biotin introducing antigen (1) and a labeled cross-linked avidin (2) subjected to a cross-linking treatment and combined with a labeled substance. The biotin introducing antibody fragment Fab' or the biotin introducing antigen (1) and a post labeled cross-linked avidin (2) combined with a labeled substance after a cross-linking treatment are used for an immunological analyzing method.

3. 发明专利

JP2000171467A NEW ANALYTICAL METHOD 失效
公开(公告)号：JP2000171467A
公开(公告)日：2000-06-23
申请号：JP34687898
申请日：1998-12-07
申请人： IATRON LAB
发明人： MATSUYA TAKESHI
IPC分类号： G01N33/543 , G01N33/566
摘要： PROBLEM TO BE SOLVED: To provide an analytical method which is an analytical method using a fluorescent substance, which is superior and whose sensitivity is high. SOLUTION: A first ligand which is specifically reacted with a substance to be analyzed is immobilized inside the excitation-light irradiation region of a sample carrying face in a reaction container or within its central region. The first ligand (a) which is immobilized, a sample (b) to be inspected and a second ligand (c) which is specifically reacted with the compound, to be analyzed, in a position different from that of the first immobilized ligand and which is labaled with a fluorescent substance are brought into contact with each other. The fluorescent substance is irradiated with excitation light at a specific wavelength. Then, fluorescence is detected in such a way that the second labeled ligand bonded to the complex of the first immobilized ligand with the substance to be analyzed is labeled.

4. 发明专利

JP2001356128A ANALYTIC METHOD USING RARE EARTH METAL COMPLEX 失效
公开(公告)号：JP2001356128A
公开(公告)日：2001-12-26
申请号：JP2000177440
申请日：2000-06-13
申请人： IATRON LAB , MATSUMOTO KAZUKO
发明人： MATSUYA TAKESHI , MATSUMOTO KAZUKO
IPC分类号： G01N21/64 , C12Q1/48 , C12Q1/68 , G01N21/78 , G01N33/52 , G01N33/58
摘要： PROBLEM TO BE SOLVED: To provide a novel analytic method using rare earth metal complex. SOLUTION: An analytic process using a rare earth metal complex formed of a rare earth metal and a ligand capable of forming a fluorescent rare earth metal complex with the rare earth metal as a fluorescent labeled material is performed in the presence of an organic solvent, and the interference of the fluorescence derived from the free rare earth metal complex or derived from the rare earth metal complex bonded to a substance other than the substance to be analyzed is eliminated.

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