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1. 发明专利

JPS61112096A Novel substrate for determination of blood coagulation factor, and determination using same 失效
标题翻译：用于确定血液凝血因子的新基质和使用其的测定
公开(公告)号：JPS61112096A
公开(公告)日：1986-05-30
申请号：JP23374384
申请日：1984-11-06
申请人： Wako Pure Chem Ind Ltd
发明人： SHINTANI AKINORI , SUGIYAMA HARUHIKO , TANAKA TAKUMI , NAKAMURA KENJI
IPC分类号： G01N33/86 , C07K5/02 , C07K5/08 , C07K14/745 , C12Q1/56
CPC分类号： Y02P20/55
摘要： NEW MATERIAL:The compound of formula (R is α-, β-, or γ-amino acid residue which may have protecting group at the N-terminal; A
1 is α-, β- or γ-amino acid residue or dipeptide residue which may be substituted at the side chain functional group if any; A
2 is basic amino acid residue) and its salt.
EXAMPLE: D-valyl-L-prolyl-L-arginyl-4-[N-ethyl-N-(β-hydroxyethyl-)amino]anilide.
USE: Substrate for the determination of blood coagulant factor.
PREPARATION: The compound of formula can be prepared e.g. by reacting the C-terminal amino acid having protected amino group and side-chain functional group with N-ethyl-N-(β-hydroxyethyl)-p-phenylenediamine, removing the amino-protecting group, and reacting successively with amino acids according to the amino acid sequence. The decomposition product produced by the contact of the compound with a blood coagulant factor is condensed with a coupler in the presence of an oxidizing agent to effect the color development, and the color is determined by colorimetry to determine the blood coagulant factor.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：新材料：式（R是在N-末端可具有保护基团的α-，β-或γ-氨基酸残基; A1是α-，β-或γ-氨基酸残基或二肽残基，可以在侧链官能团（如果有的话）被取代; A2是碱性氨基酸残基）及其盐。实施例：D-缬氨酰-L-脯氨酰基-L-精氨酰基-4- [N-乙基-N-（β-羟乙基））氨基]苯胺。用途：用于测定凝血因子的底物。制备：式的化合物可以如通过使具有被保护的氨基的C末端氨基酸和侧链官能团与N-乙基-N-（β-羟乙基） - 对苯二胺反应，除去氨基保护基，并依次与氨基酸反应氨基酸序列。通过化合物与血液凝结剂因子的接触而产生的分解产物在氧化剂的存在下与成色剂冷凝以进行显色，并且通过比色法测定颜色以确定凝血因子。

2. 发明专利

JPH0269432A PRODUCTION OF ALPHA-BRANCHED LONG-CHAIN FATTY ACID 失效
公开(公告)号：JPH0269432A
公开(公告)日：1990-03-08
申请号：JP22209988
申请日：1988-09-05
申请人： WAKO PURE CHEM IND LTD
发明人： IWATA TSUTOMU , IWAMOTO OSAMU , SUGIYAMA HARUHIKO
IPC分类号： C07C51/353 , C07C53/128
摘要： PURPOSE:To simply and advantageously obtain the title compound in one pot and one process, high yield and reduced by-product by reacting long-chain fatty acids corresponding to the aimed compound with an anionating compound to give a dianion and reacting the obtained dianion with a long-chain alkyl halide. CONSTITUTION:An compound expressed by formula I (R is H or alkali metal; n is integer of 11-20) is reacted with an anionating agent such as NaNH2. KNH2, LiNH2, lithiumdiethylamide. lithiumdiisopropylamide, lithium dicyclohexylamide, NaH, LiH, LiCH3, n-butyllithium or phenyllithium to give a dianion, which is then reacted with a compound expressed by formula II (X is halogen; m is integer of 9-20), preferably in the presence of hexamethylphosphoric triamide to advantageously provide the aimed compound expressed by formula III useful as a raw material for lipid A, LB membrane, cosmetic, antimicrobial compound, etc., in a method capable of industrially producing.

3. 发明专利

JPS6426153A NOVEL OXYGEN INDICATOR 失效
公开(公告)号：JPS6426153A
公开(公告)日：1989-01-27
申请号：JP6214188
申请日：1988-03-16
申请人： WAKO PURE CHEM IND LTD
发明人： IWAMOTO OSAMU , HAMADA YOSHIO , SUGIYAMA HARUHIKO
IPC分类号： G01N31/00 , C09B53/02 , G02B6/26
摘要： PURPOSE:To obtain an oxygen indicator which is usable even in a vacuum and is stable for a long period of time by using a specific compd. as a dye. CONSTITUTION:The indoaniline deriv. expressed by formula I is used as the dye. For example, the compd. expressed by formula II is used as the indoaniline deriv. expressed by formula I. More specifically, 40mg compd. expressed by formula II, 50g D-glucose, 40ml aq. 5N-NaOH soln., 40ml diethylene glycol and 100g silica gel are thoroughly mixed to obtain the oxygen indicator as the uniformly mixed blue powder. This oxygen indicator is colorless in the absence of oxygen and is usable even in a vacuum.

4. 发明专利

JPS61153101A SEPARATION MEMBRANE USING CURDLAN DERIVATIVE AS RAW MATERIAL 失效
公开(公告)号：JPS61153101A
公开(公告)日：1986-07-11
申请号：JP27986784
申请日：1984-12-26
申请人： WAKO PURE CHEM IND LTD , OSAKA CITY
发明人： NISHIMURA MASATO , HASHIDA ISAO , MINAMII NOBUAKI , SUGIYAMA HARUHIKO , IWAMOTO OSAMU
IPC分类号： B01D71/08
摘要： PURPOSE:To obtain an ultrafiltration membrane having excellent fractional separability in the region of fractional mol.wt., high strength, and good stability by using a curdlan derivative shown by a specified formula and obtained by chemically modifying the hydroxyl group of curdlan as the raw material. CONSTITUTION:A curdlan derivative such as acetyl curdlan shown by the general formula [C6H7O2(OR)X(OH)3-X]n is obtained by alkylating or acylating the hydroxyl group of curdlan (beta-1,3-glucan) shown by the formula. In the general formula, R is a 1-4C lower alkyl group or an acyl group shown by R'CO- (where R' is a 1-4C lower alkyl group), X is 1-3, and (n) shows about 200-2,000 integer. The curdlan derivative is dissolved in formic acid to prepare a cast soln. which is spread over a horizontal glass sheet. The solvent is partially evaporated and the material is dipped into water and gelated to obtain a separation membrane. The membrane is capable of separating org. acids from saccharides having about the same mol.wt.

5. 发明专利

JPS5657748A PREPARATION OF OPTICALLY ACTIVE NN 11 METHOXYCARBONYLPROPENN22YL ALPHAAAMINOPHENYLACETIC ACID SALT 失效
公开(公告)号：JPS5657748A
公开(公告)日：1981-05-20
申请号：JP13339979
申请日：1979-10-16
申请人： WAKO PURE CHEM IND LTD
发明人： KASAHARA KAN , SHIMADA HISAHIKO , SUGIYAMA HARUHIKO
IPC分类号： C07C227/34 , C07C67/00 , C07C227/00 , C07C229/36
摘要： PURPOSE:To prepare the titled optically active compound useful as an intermediate of pharmaceuticals, a raw material of organic compounds, etc. especially an intermediate of a semisynthetic penicillin, ampicillin, by crystallizing the DL mixture of the titled compound from a supersaturated solution. CONSTITUTION:An optically active isomer of D- or L-N-(1-methoxycarbonylpropen-2-yl)-alpha-aminophenylacetic acid salt of formula (M is alkali metal) is prepared by the preferential crystallization of the isomer from a supersaturated solution of the DL-mixture of the compound. The preferable solvent of the supersaturated solution is Cellosolve (an ethylene glycol monoether) such as Methyl Cellosolve, Ethyl Cellosolve, etc. The preferential crystallization enables the optical resolution without using an expensive resolving reagent.

6. 发明专利

JPS6438050A NOVEL PRODUCTION PROCESS 失效
公开(公告)号：JPS6438050A
公开(公告)日：1989-02-08
申请号：JP19413487
申请日：1987-08-03
申请人： WAKO PURE CHEM IND LTD
发明人： TANAKA TAKUMI , MASAKI TAKEJI , SOEJIMA MASAMI , TSUNASAWA SUSUMU , SAKIYAMA FUMIO , SUGIYAMA HARUHIKO
IPC分类号： C07K1/06 , C07C231/00 , C07C237/10 , C07C237/20 , C07C237/22 , C07K1/113 , C07K5/06 , C07K14/00 , C07K14/435 , C07K14/81
摘要： PURPOSE:To obtain the titled compound useful as a lysine-specific enzyme inhibitor, etc. in high yield and purity at a low cost, by reacting a lysinal derivative with an amino acid or peptide and removing acetal group and amino- protecting group from the resultant acetal compound. CONSTITUTION:The objective lysinal peptide derivative of formula II (A is amino acid residue or peptide residue) can be produced by (1) reacting a compound of formula I (R is amino-protecting group or H; R is amino-protecting group; R and R are 1-4C alkyl or together form a ring) with an amino acid (e.g. valine or leucine) or a peptide to introduce an amino acid or peptide group to the alpha-amino group and (2) removing the amino-protecting group and aldehyde- protecting group with dilute hydrochloric acid or acetic acid, etc., at the same time or by separate means. The side-reaction product can be easily separated by this process.

7. 发明专利

JPS5914798A Process for semisynthesis of human insulin 失效
标题翻译：人胰岛素半胱氨酸的方法
公开(公告)号：JPS5914798A
公开(公告)日：1984-01-25
申请号：JP12391782
申请日：1982-07-16
申请人： Wako Pure Chem Ind Ltd
发明人： SAKATA YOSHITSUGU , SHINTANI AKINORI , MATSUO TETSUYA , SUGIYAMA HARUHIKO , MINAMII NOBUAKI , NAGAOKA JIYOUJI
IPC分类号： C12P21/02
摘要： PURPOSE: To prepare human insulin from swine insulin, in high efficiency, by using water as the reaction solvent and acromobacter.protease I as the catalyst.
CONSTITUTION: Swine insulin is made to react with threonine having carboxyl group protected with substituted or unsubstituted alkyl or aralkyl group in water or in an aqueous solution containing a small amount of an organic solvent miscible with water, in the presence of lysyl endopeptidase (Acromobacter.protease I) produced by Acromobacter lyticus at 0W50°C and 4W10pH, preferably under nearly neutral condition, to effect peptide exchange and obtain a human insulin derivative having carboxyl-protected threonine at B
30 .
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：通过使用水作为反应溶剂和acromobacter.protease I作为催化剂，高效地从猪胰岛素制备人胰岛素。构成：在赖氨酰内肽酶（Acromobacter。）存在下，使猪胰岛素与具有被取代或未取代的烷基或芳烷基保护的羧基的苏氨酸在水中或含有少量可与水混溶的有机溶剂的水溶液中反应。蛋白酶I）在0-50℃和4-10pH，优选在接近中性条件下产生，以实现肽交换并获得在B30具有羧基保护的苏氨酸的人胰岛素衍生物。

8. 发明专利

JPS554333A ENTERIC COATING AGENT 失效
公开(公告)号：JPS554333A
公开(公告)日：1980-01-12
申请号：JP7677378
申请日：1978-06-24
申请人： WAKO PURE CHEM IND LTD
发明人： SHIMADA HISAHIKO , SUGIYAMA HARUHIKO , KIMURA HIROICHI
IPC分类号： A61K47/38 , A61K47/00 , A61K47/30
摘要： NEW MATERIAL:An ethyl carboxyethyl cellulose wherein ethyl groups and carboxyethyl groups are bonded to cellulose through ether linkages. USE:Enteric coating agent. Soluble to non-toxic organic sovents such as ethyl alcohol. The hydrophilic characteristics of the compound can be reduced by introducing ethyl groups to the chain. PROCESS:The objective ethyl carboxyethyl cellulose can be prepared, e.g. by (1) reacting cellulose with alpha- or beta-halogenopropionic acid in the presence of an alkali, in a solvent, thereby introducing the carboxyethyl group to the cellulose skeleton, and (2) introducing ethyl groups to the carboxyethylated cellulose by reacting with an alkylation agent such as ethyl chloride, ethyl bromide, etc., in the presence of an alkali.

9. 发明专利

JPS52152291A MEASURING METHOD OF ACTIVITY OF GAMMAAGLUTAMILLTRANSSPEPTIDASE 失效
公开(公告)号：JPS52152291A
公开(公告)日：1977-12-17
申请号：JP14545076
申请日：1976-12-03
申请人： WAKO PURE CHEM IND LTD
发明人： SAKATA YOSHITSUGU , BUNAN SABUROU , YAMAMOTO JIYUNKO , SUGIYAMA HARUHIKO
IPC分类号： C12Q1/48 , G01N31/22

10. 发明专利

JPH03178961A NEW FULGIMIDE DERIVATIVE 失效
公开(公告)号：JPH03178961A
公开(公告)日：1991-08-02
申请号：JP24666390
申请日：1990-09-17
申请人： WAKO PURE CHEM IND LTD
发明人： IWAMOTO OSAMU , HARA TAIZO , SUGIYAMA HARUHIKO
IPC分类号： C07D403/06 , C07D207/02 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D421/06 , C08F20/34 , C08F20/52 , C08F36/02 , C08F36/04 , C08F220/36 , C08F220/60 , C09K9/02
摘要： NEW MATERIAL:A fulgimide derivative shown by formula I [R , R and R are H, halogen alkyl, alkoxy, cycloalkyl, aryl, aralkyl or aryloxy or R and R are mutually bonded to form cyclic group such as adamanthyl or norbornyl; R is group shown by formula II, formula II, formula VI, etc., (R ' is H, halogen, alkyl, etc.; R ' to R ' are H, alkyl, alkoxy etc.; S is O, S, etc.); X is bifunctional organic residue; R is group shown by formula V, etc., (R' is H or alkyl)]. EXAMPLE:N-(4-Acryloyloxyphenyl)-2-[(E)-1-(2,5-dimehyl-3-furyl)ethylide ne]-3- isopropylidenesuccinimide. USE:Having photochromic action and useful as a recording material, copying material, printing photosensitizer, etc. PREPARATION:For example, a compound shown by formula VI is reacted with a compound shown by formula VII to give a compound shown by formula I.

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