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1. 发明专利

JP2003254959A NEW FORMALDEHYDE MEASURING KIT 审中-公开
公开(公告)号：JP2003254959A
公开(公告)日：2003-09-10
申请号：JP2002375702
申请日：2002-12-26
申请人： WAKO PURE CHEM IND LTD
发明人： KODERA HIROMASA , MATSUO TETSUYA
IPC分类号： G01N31/00 , G01N21/78 , G01N31/22
摘要： PROBLEM TO BE SOLVED: To provide a formaldehyde measuring reagent kit for measuring, simply, quickly and highly sensitively, the formaldehyde concentration in a low concentration region in a test solution, and a formaldehyde measuring method using the kit. SOLUTION: This formaldehyde measuring kit includes as constitutive reagents, a solid alkali reagent composition mainly composed of potassium hydroxide, sodium hydroxide or lithium hydroxide, a solid color reagent composition mainly composed of 4-amino-3-hydrazino-5-mercapto-1,2,4-triazole, and solid or liquid oxidizing reagent composition mainly composed of a meta- periodate. The measuring method of formaldehyde in the test solution using the kit is also provided. COPYRIGHT: (C)2003,JPO

2. 发明专利

JPH0428354B2 失效
公开(公告)号：JPH0428354B2
公开(公告)日：1992-05-14
申请号：JP16297682
申请日：1982-09-18
申请人： WAKO PURE CHEM IND LTD
发明人： SAKATA YOSHITSUGU , SHINTANI AKINORI , MATSUO TETSUYA , SUGYAMA HARUHIKO , TOKIOKA NOBUYUKI
IPC分类号： C07K14/62 , C12N9/52 , C12N11/02 , C12P21/02

3. 发明专利

JPS58187186A Immobilized enzyme 失效
标题翻译：稳定的酶
公开(公告)号：JPS58187186A
公开(公告)日：1983-11-01
申请号：JP6823882
申请日：1982-04-23
申请人： Wako Pure Chem Ind Ltd
发明人： SAKATA YOSHITSUGU , MATSUO TETSUYA , TOKIOKA NOBUYUKI
IPC分类号： C12N9/52 , C12N9/48 , C12N11/02
摘要： PURPOSE: An immobilized enzyme, prepared by linking a lysyl endopeptidase to a water-insoluble carrier or crosslinking the lysyl endopeptidase with a crosslinking agent, having a very high activity, and exhibiting a high stability even in a wide range of pH or various media.
CONSTITUTION: An immobilized enzyme prepared by linking lysyl endopeptidase produced by Achromobacter lyticus M497-1, e.g. Achromobacter protease I , to a water-insoluble carrier, e.g. a polysaccharide such as cellulose, agarose or dextran, or cation exchange resin or cation exchange cellulose, or crosslinking the lysyl endopeptidase with a crosslinking agent, e.g. glutaraldehyde or toluene diisocyanate.
COPYRIGHT: (C)1983,JPO&Japio
摘要翻译：目的：通过将赖氨酰内肽酶与水不溶性载体连接或用交联剂交联赖氨酰内肽酶，具有非常高的活性并且甚至在宽范围的pH或各种培养基中表现出高稳定性的固定化酶。构成：通过将由无色杆菌M497-1产生的赖氨酰内肽酶，例如，无色杆菌蛋白酶I，与水不溶性载体，例如多糖如纤维素，琼脂糖或葡聚糖，或阳离子交换树脂或阳离子交换纤维素，或者用交联剂交联赖氨酰肽链内切酶。戊二醛或甲苯二异氰酸酯。

4. 发明专利

JP2003313358A Resolvent of polystyrene foam and treatment method of polystyrene foam using the same 审中-公开
标题翻译：聚苯乙烯泡沫的结构和使用聚苯乙烯泡沫的处理方法
公开(公告)号：JP2003313358A
公开(公告)日：2003-11-06
申请号：JP2003041430
申请日：2003-02-19
申请人： Wako Pure Chem Ind Ltd , 和光純薬工業株式会社
发明人： KODERA HIROMASA , MATSUO TETSUYA
IPC分类号： C08J11/08 , B01J2/06
CPC分类号： Y02W30/701
摘要： PROBLEM TO BE SOLVED: To provide a safer resolvent of polystyrene foam (hereinafter, abbreviated to EPS) excellent in solubility (volume reducibility and contractibility) of EPS, a method for treating EPS efficiently at a lower cost using a method which does not cause the environmental pollution followed by recovering PS, and a method for recycling and reuse of PS obtained by treatment of EPS.
SOLUTION: The resolvent of the polystyrene foam comprises N,N-dimethyl formamide and/or N,N-dimethyl acetamide. A dissolving method of the polystyrene foam makes EPS contact with the resolvent. The recovering method and the recycling method of PS are also provided.
COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：提供EPS的溶解度（体积还原性和收缩性）优异的聚苯乙烯泡沫（以下简称为EPS）的更安全的溶剂化方法，使用下述方法以较低的成本有效地处理EPS的方法不会引起环境污染，随后恢复PS，以及通过处理EPS获得的PS的回收利用方法。解决方案：聚苯乙烯泡沫体的溶解度包括N，N-二甲基甲酰胺和/或N，N-二甲基乙酰胺。聚苯乙烯泡沫的溶解方法使EPS与溶剂接触。还提供了PS的回收方法和回收方法。版权所有（C）2004，JPO

5. 发明专利

JPS62110153A METHOD FOR QUANTIFYING ENDOTOXIN 失效
公开(公告)号：JPS62110153A
公开(公告)日：1987-05-21
申请号：JP7029585
申请日：1985-04-03
申请人： WAKO PURE CHEM IND LTD
发明人： SAKATA YOSHITSUGU , MATSUO TETSUYA , TAKAOKA FUMI , OISHI HARUKI
IPC分类号： G01N33/50 , A61K9/08 , A61K38/16 , G01N33/579
摘要： PURPOSE:To accurately and simply measure the quantity of endotoxin in a specimen exerting effect on endotoxin gelling reaction, by comparing calibration curves obtained by adding endotoxin to a specimen to be examined or distilled water at various concns. CONSTITUTION:At first, endotoxin is added to distilled water free from endotoxin at various concns. to form calibration curves. Next, endotoxin is added to a specimen to be examined at various concns. in the same way to form calibration curves in the coexistence of the specimen. In this case, if the specimen to be examined is a substance exerting no gelling reaction (e.g., urokinase and human immunogloblin etc.), each calibration curve in the coexistence of the specimen coinsides with that calculated using distilled water. If said specimen is a substance inhibiting gelling reaction (e.g., mannitol and glucose etc.), each calibration curve in the coexistence of the specimen is upwardly shifted from that in the case of distilled water and, if the specimen is a substance promoting said reaction (e.g., dextran 40 and human serum albumin etc.), said calibration curve is downwardly shifted from that in the case of distilled water. Because both calibration curves originally has parallel relation to that in the case of distilled water, by comparing both of them, the content of endotoxin in the specimen to be examined can be calculated.

6. 发明专利

JPS5914798A Process for semisynthesis of human insulin 失效
标题翻译：人胰岛素半胱氨酸的方法
公开(公告)号：JPS5914798A
公开(公告)日：1984-01-25
申请号：JP12391782
申请日：1982-07-16
申请人： Wako Pure Chem Ind Ltd
发明人： SAKATA YOSHITSUGU , SHINTANI AKINORI , MATSUO TETSUYA , SUGIYAMA HARUHIKO , MINAMII NOBUAKI , NAGAOKA JIYOUJI
IPC分类号： C12P21/02
摘要： PURPOSE: To prepare human insulin from swine insulin, in high efficiency, by using water as the reaction solvent and acromobacter.protease I as the catalyst.
CONSTITUTION: Swine insulin is made to react with threonine having carboxyl group protected with substituted or unsubstituted alkyl or aralkyl group in water or in an aqueous solution containing a small amount of an organic solvent miscible with water, in the presence of lysyl endopeptidase (Acromobacter.protease I) produced by Acromobacter lyticus at 0W50°C and 4W10pH, preferably under nearly neutral condition, to effect peptide exchange and obtain a human insulin derivative having carboxyl-protected threonine at B
30 .
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：通过使用水作为反应溶剂和acromobacter.protease I作为催化剂，高效地从猪胰岛素制备人胰岛素。构成：在赖氨酰内肽酶（Acromobacter。）存在下，使猪胰岛素与具有被取代或未取代的烷基或芳烷基保护的羧基的苏氨酸在水中或含有少量可与水混溶的有机溶剂的水溶液中反应。蛋白酶I）在0-50℃和4-10pH，优选在接近中性条件下产生，以实现肽交换并获得在B30具有羧基保护的苏氨酸的人胰岛素衍生物。

7. 发明专利

JPH062720B2 失效
公开(公告)号：JPH062720B2
公开(公告)日：1994-01-12
申请号：JP23298785
申请日：1985-10-18
申请人： WAKO PURE CHEM IND LTD
发明人： SHINTANI AKINORI , MATSUO TETSUYA , OKAJIMA SATORU , MIKI YUTAKA , HASHIZUME TOSHUKI , TOKIOKA NOBUYUKI
IPC分类号： G01N33/50 , C07C67/00 , C07C213/00 , C07C217/08 , C07C217/92 , C09B53/00

8. 发明专利

JPH0575067B2 失效
公开(公告)号：JPH0575067B2
公开(公告)日：1993-10-19
申请号：JP7029585
申请日：1985-04-03
申请人： WAKO PURE CHEM IND LTD
发明人： SAKATA YOSHITSUGU , MATSUO TETSUYA , TAKAOKA FUMI , OOISHI HARUKI
IPC分类号： G01N33/50 , A61K9/08 , A61K38/16 , G01N33/579

9. 发明专利

JPS6293261A NOVEL DIPHENYLAMINE DERIVATIVE AND MEASUREMENT USING SAID DERIVATIVE AS COLORING COMPONENT 失效
公开(公告)号：JPS6293261A
公开(公告)日：1987-04-28
申请号：JP23298785
申请日：1985-10-18
申请人： WAKO PURE CHEM IND LTD
发明人： SHINTANI AKINORI , MATSUO TETSUYA , OKAJIMA SATORU , MIKI YUTAKA , HASHIZUME TOSHIYOSHI , TOKIOKA NOBUYUKI
IPC分类号： G01N33/50 , C07C67/00 , C07C213/00 , C07C217/08 , C07C217/92 , C09B53/00
摘要： NEW MATERIAL:A diphenylamine derivative expressed by formula I [R , R , R and R each are independently formula II (m and n are integers 1-10; p is an integer 1-100) or alkyl, provided that at least one of R -R is formula II; R and R each are independently H, alkyl, alkoxy, hydroxy, vinyl, alkylene or allyl)]. EXAMPLE:4'-Bis(butoxyethyl)amino-2-methyl-4-dipentylaminodiphenylamine. USE:Useful as a coloring component for measurement of oxidizing substances or peroxidase-like substances, particularly effective as a coloring component for measurement of minor components in biological samples by leading hydrogen peroxide formed by enzymic reaction to a coloring system in the presence of peroxidase and colorimetrically measuring the color. PREPARATION:A compound expressed by formula III and compound expressed by formula IV are oxidatively condensed with periodic acid in an aqueous solution and the resultant compound is reduced to afford the aimed compound expressed by formula I.

10. 发明专利

JPS60120985A NOVEL MODIFICATION ENZYME 失效
公开(公告)号：JPS60120985A
公开(公告)日：1985-06-28
申请号：JP22822083
申请日：1983-12-02
申请人： WAKO PURE CHEM IND LTD
发明人： SAKATA YOSHITSUGU , MATSUO TETSUYA , TOKIOKA NOBUYUKI , KIDA MASAAKI
IPC分类号： C12N9/52 , C12N9/48 , C12R1/025
摘要： PURPOSE:To produce a novel modification enzyme separable easily from the raw material and the reaction products, having high stability, and keeping the enzymatic activity and the water-solubility of the starting enzyme, by carrying out the intermolecular crosslinking of a lysyl-endopeptidase produced by a microbial strain. CONSTITUTION:The intermolecular crosslinking and polymerization of lysylendopeptidase produced by Achromobacter lyticus is carried out by using a crosslinking agent comprising an activated polyalkylene glycol obtained by activating the hydroxyl group of a polyalkylene glycol such as polyethylene glycol, polypropylene glycol, etc. with 1,1-carbonyldiimidazole, cyanuric chloride, etc.

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