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1. 发明专利

JP2017113506A 潤滑性表面を有する医療用具の製造方法审中-公开
公开(公告)号：JP2017113506A
公开(公告)日：2017-06-29
申请号：JP2015257878
申请日：2015-12-25
申请人：株式会社ティーアールエス , Trs:Kk , 株式会社ティーアールエス
发明人： YASUHARA AKIKO , YOSHISUE MASAHIRO , HIRAI KOJI , HASHIMOTO TERUO
IPC分类号： A61L29/00 , A61L31/00
摘要：【課題】治療用ガイドワイヤは今後、益々、細径化の方向にある。しかしながら、細径化に伴う本質的な問題として、操作性、潤滑耐久性、安全性の確保が困難になってくる。これらの背反課題に対して、本発明は、新規な超薄膜親水性コーティング技術を開発することで、これらの課題を総合的に解決しうる細径の治療用イドワイヤを提供する。【解決手段】ガイドワイヤなど医療用具を構成する金属製芯線の表面に、ナノミクロンオーダーの超薄膜プライマーを介して強固に固定された超薄膜親水性コーティングを行うことで、ガイドワイヤの金属芯線の直径を、コーティング層の膜厚が減少した分だけ太くすることが可能となること、また、剥離・脱落など安全性に問題を抱えるテフロンコートに比べて、それらの問題もなく、潤滑性が優れることから、ガイドワイヤの操作性、潤滑特性、安全性を総合的かつ高度に改良した極細径の治療用イドワイヤを提供することができる。【選択図】なし

2. 发明专利

JP2011005206A Medical instrument and manufacturing method thereof 审中-公开
标题翻译：医用仪器及其制造方法
公开(公告)号：JP2011005206A
公开(公告)日：2011-01-13
申请号：JP2009168237
申请日：2009-06-26
申请人： Trs:Kk , 株式会社ティーアールエス
发明人： YASUHARA AKIKO , HIRAI KOJI , HASHIMOTO TERUO
IPC分类号： A61L31/00 , A61M25/00
摘要： PROBLEM TO BE SOLVED: To achieve a medical treatment which has a new function and is excellent in lubricity, lubricating durability, and a water-holding property without spoiling the flexibility of a metal coil even when performing coating a metal base material with a thin film, since securing of the lubricating durability is difficult although various methods for making the film thickness of a coating resin layer as thin as possible are so far examined in manufacturing of a guide wire for PTCA, etc.SOLUTION: A hydrophilic polymer is chemically fixed by coating a surface of the base material, which composes a medical instrument, with a specific polyurethane urea resin, and thereby attaining the object such as the outstanding lubricity when wetted.
摘要翻译：要解决的问题：为了实现具有新功能，具有优异的润滑性，润滑耐久性和保水性的医疗，即使在用薄膜进行金属基材涂覆时也不会破坏金属线圈的柔性由于尽管在制造PTCA导丝等方面尽可能多地制作涂膜树脂层的薄膜的方法尽可能薄，但确保润滑耐久性是困难的。解决方案：亲水性聚合物通过以下方式化学固定：将构成医疗器械的基材的表面与特定的聚氨酯脲树脂进行涂布，从而达到润湿时优异的润滑性的目的。

3. 发明专利

JP2017086843A 医療用ガイドワイヤ审中-公开
公开(公告)号：JP2017086843A
公开(公告)日：2017-05-25
申请号：JP2015236979
申请日：2015-11-16
申请人：株式会社ティーアールエス , Trs:Kk , 株式会社ティーアールエス , 学校法人加計学園 , Kake Educational Institute
发明人： NAKATANI TATSUYUKI , HASHIMOTO TERUO , HIRAI KOJI
IPC分类号： A61M25/09
摘要：【課題】安全性が高く、操作性に優れた細径の治療用ガイドワイヤを提供する。【解決手段】医療用ガイドワイヤの表面に、水素が8at%〜35at%(原子組成百分率)の範囲で含まれる特定の水素化アモルファス炭素膜を50nm〜2μの膜厚さにコーティングし、かつ、ガイドワイヤの曲げ弾性率を15%以上増大するように設定し、振動減衰性の増大を図る構成とする。【選択図】なし

4. 发明专利

JP2014133077A Medical device having lubricant surface and manufacturing method thereof 有权
标题翻译：具有润滑表面的医疗装置及其制造方法
公开(公告)号：JP2014133077A
公开(公告)日：2014-07-24
申请号：JP2013016148
申请日：2013-01-11
申请人： Trs:Kk , 株式会社ティーアールエス
发明人： YASUHARA AKIKO , HIRAI KOJI , HASHIMOTO TERUO
IPC分类号： A61L29/00
摘要： PROBLEM TO BE SOLVED: To provide a medical device with new functions, i.e. having excellent lubricity durability of a thin film coated on a metal substrate, sustainable for calcium ions and anticancer agents in blood; while various methods have been conventionally examined in manufacturing medical guide wires or the like so as to make the coating resin layer as thin as possible, having difficulties in securing the lubricity durability itself and problems of reduction in lubricity durability due to presence of calcium ions and anticancer agents in blood.SOLUTION: A maleic anhydride copolymer compound having a specific half ester bond is immobilized on the surface of substrate to constitute a medical device.
摘要翻译：要解决的问题：为了提供具有新功能的医疗器械，即具有优异的涂覆在金属基底上的薄膜的润滑性耐久性，可持续用于血液中的钙离子和抗癌剂; 在制造医疗导丝等时，通常已经对各种方法进行了检查，以使得涂覆树脂层尽可能薄，难以确保润滑性耐久性本身以及由于钙离子的存在而导致的润滑性耐久性降低的问题，血液中的抗癌剂。溶液：具有特定半酯键的马来酸酐共聚物化合物固定在基材表面上以构成医疗装置。

5. 发明专利

JP2009183387A Medical tool having lubricative surface and its manufacturing method 审中-公开
标题翻译：具有润滑表面的医用工具及其制造方法
公开(公告)号：JP2009183387A
公开(公告)日：2009-08-20
申请号：JP2008024815
申请日：2008-02-05
申请人： Japan Stent Technology Co Ltd , Seam Kagaku Kenkyusho:Kk , Trs:Kk , 有限会社Seam化学研究所 , 株式会社ティーアールエス , 株式会社日本ステントテクノロジー
发明人： YAMADA HIROAKI , YAMASHITA SHUZO , HIRAI KOJI , YABUKI OSAMU , YASUHARA AKIKO , WADA TOMIO , HASHIMOTO TERUO
IPC分类号： A61M25/01
摘要： PROBLEM TO BE SOLVED: To provide a medical tool which has a new function and is excellent in lubricity durability by developing a new manufacturing method for directly coating a metal base material with a hydrophilic compound because a variety of method for making film thickness of coating resin layers as thin as possible have been considered but it has been difficult to secure the lubricity durability in manufacturing a treatment guide wire and the like. SOLUTION: On the surface of the metal base material constituting the medical tool, a sulfur-containing compound having a functional group reactive with metals is reacted to introduce a functional group there and the hydrophilic compound is chemically fixed on the metal surface to exist. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：解决问题：为了提供一种具有新功能并且具有优异的润滑性耐久性的医疗工具，通过开发用于由亲水性化合物直接涂覆金属基材的新的制造方法，因为制备膜厚度的各种方法已经考虑到尽可能薄的涂覆树脂层，但是在制造处理导丝等时难以确保润滑性耐久性。解决方案：在构成医疗工具的金属基材的表面上，具有与金属反应的官能团的含硫化合物反应，在其中引入官能团，亲水性化合物化学固定在金属表面上存在。版权所有（C）2009，JPO＆INPIT

6. 发明专利

JP2013240562A Medical guide wire 审中-公开
标题翻译：医疗指导线
公开(公告)号：JP2013240562A
公开(公告)日：2013-12-05
申请号：JP2012128391
申请日：2012-05-17
申请人： Trs:Kk , 株式会社ティーアールエス
发明人： HASHIMOTO TERUO
IPC分类号： A61M25/09
摘要： PROBLEM TO BE SOLVED: To provide a medical guide wire, which is a medical guide wire comprising a body and a front end configured integrally with a titanium-nickel alloy wire as a core material, wherein the body is high in elasticity, and is excellent in pushing properties and torque transmission properties as its straightness is excellent; and the front end has repetition reshaping properties and sufficient flexibility shape preservation properties, and is excellent in operability such as vascular following properties and vascular selectivity or the like.SOLUTION: A medical guide wire includes a body and a front end configured integrally with a titanium-nickel alloy wire as a core material. The titanium-nickel alloy wire is improved in material properties and straightness by mechanical and correctional processing without the need of heat treatment after cold wire drawing processing. The medical guide wire can be obtained which does not exhibit stress-induced martensitic transformation with high elasticity in a wide strain range, and has repetition reshaping properties and form preservation properties with various kinds of excellent operability by means of heat treatment only of the front end in the range of temperature 500-650°C.
摘要翻译：要解决的问题：提供一种医疗用导丝，其是包括主体和作为芯材的钛镍合金丝一体构成的前端的医疗用导丝，其中，身体弹性高，优异推动性能和扭矩传递性能，因为其直线度优良; 并且前端具有重复的成型性能和足够的柔软性形状保存性，并且具有优异的操作性，如血管跟随性和血管选择性等。解决方案：医用导丝包括主体和与钛一体构成的前端镍合金丝为芯材。通过机械和校正处理，钛 - 镍合金线材的材料性能和直线性得到改善，而不需要在冷拉丝加工后进行热处理。可以获得在宽应变范围内不显示高弹性的应力诱发马氏体相变的医疗导丝，并且仅通过前端的热处理具有各种优异的可操作性的重复整形性和形成保存性在500-650℃的温度范围内。

7. 发明专利

JP2011110393A Medical instrument with lubricative surface 有权
标题翻译：具有润滑表面的医用仪器
公开(公告)号：JP2011110393A
公开(公告)日：2011-06-09
申请号：JP2009283388
申请日：2009-11-24
申请人： Trs:Kk , 株式会社ティーアールエス
发明人： HIRAI KOJI , YASUHARA AKIKO , HASHIMOTO TERUO
IPC分类号： A61L31/00 , A61M25/01
摘要： PROBLEM TO BE SOLVED: To achieve medical treatment with new functions excellent in lubricity, lubrication durability, and water retaining property without spoiling flexibility of a metallic coil even when thin film is coated on a metallic substrate in order to eliminate problems of hardness of securing lubrication durability itself though various methods for making the film thickness of a coating resin layer thin as far as possible are studied so far, in manufacturing a guide wire for PTCA etc. SOLUTION: On the surface of a substrate constituting the medical instrument, a silane containing primer resin having a functional group having reactivity with a hydrophilic high polymer in a molecule is coated in a thin film form and the hydrophilic high polymer is chemically fixed to the primer and the lubrication durability is given. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：即使在金属基板上涂覆薄膜以达到润滑性，润滑耐久性和保水性的新功能，也不会破坏金属线圈的柔性，从而消除硬度问题，从而实现医疗迄今为止，在制造PTCA导丝时已经研究了尽可能薄的涂布树脂层的薄膜厚度的各种方法来确保润滑耐久性本身。解决方案：在构成医疗器械中，分子内具有与亲水性高分子具有反应性的官能团的含硅烷的底漆树脂以薄膜状涂布，亲水性高分子化学固定在底漆上，得到润滑耐久性。版权所有（C）2011，JPO＆INPIT

8. 发明专利

JP2010046179A Catheter guide wire 审中-公开
标题翻译：导管指导线
公开(公告)号：JP2010046179A
公开(公告)日：2010-03-04
申请号：JP2008211404
申请日：2008-08-20
申请人： Japan Stent Technology Co Ltd , Seam Kagaku Kenkyusho:Kk , Trs:Kk , 有限会社Seam化学研究所 , 株式会社ティーアールエス , 株式会社日本ステントテクノロジー
发明人： HIRAI KOJI , YASUHARA AKIKO , WADA TOMIO , HASHIMOTO TERUO
IPC分类号： A61L31/00 , A61M25/01
摘要： PROBLEM TO BE SOLVED: To provide a catheter guide wire having wettability to be used when the catheter guide wire, especially for treatment and examination, is introduced into a required region of a body cavity such as a blood vessel, trachea, or digestive tract. SOLUTION: The catheter guide wire has a metal core composed of a center wire 2 made of metal with small elastic modulus, and a coating material made of metal with large elastic modulus to coat the center wire. The distal end of the metal core is tapered, and a coating layer 4 is disposed on the surface of the metal core. In the coating layer 4, hydrophilic macromolecules of a cross-linkage structure having wettability when wetted are chemically combined. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种具有润湿性的导管导丝，当导管导丝特别是用于治疗和检查时，将其导入体腔的所需区域，例如血管，气管或消化道。解决方案：导管导丝具有由具有小弹性模量的金属制成的中心线2和由弹性模量大的金属制成的涂层材料涂覆中心丝的金属芯。金属芯的远端是锥形的，并且在金属芯的表面上设置涂层4。在涂层4中，在润湿时具有润湿性的交联结构的亲水性大分子化学结合。版权所有（C）2010，JPO＆INPIT

9. 发明专利

JP2010240350A Medical instrument having lubricative surface and method for manufacturing the same 有权
标题翻译：具有润滑表面的医用仪器及其制造方法
公开(公告)号：JP2010240350A
公开(公告)日：2010-10-28
申请号：JP2009104517
申请日：2009-03-31
申请人： Trs:Kk , 株式会社ティーアールエス
发明人： YASUHARA AKIKO , HIRAI KOJI , HASHIMOTO TERUO
IPC分类号： A61L33/00 , A61M25/00 , A61M25/01
摘要： PROBLEM TO BE SOLVED: To attain a medical instrument which is excellent in lubricating durability even when a coating is applied in a thin film state to a metal base material, and has new functions by which the lubricating durability does not fall off also to calcium ion in blood by solving the problem that securement itself of the lubricating durability is difficult and furthermore, the lubricating durability falls off by calcium ion in blood since there is the problem though various methods for thinning film thickness of a coating resin layer as much as possible are considered so far in manufacturing of guide wire for treatment or the like. SOLUTION: The medical instrument is constituted by fixing maleic anhydride copolymerization compound which has specific amide bond on the base material surface constituting the medical instrument. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：为了获得即使在薄膜状态下涂覆金属基材也具有优异的润滑耐久性的医疗器械，并且具有润滑耐久性不脱落的新功能通过解决难以固定本身的润滑耐久性的问题，而且通过血液中的钙离子使润滑耐久性下降的问题，由于存在问题，尽管通过各种各样的方法来使涂层树脂层的膜厚变薄在制造用于治疗的导丝等方面尽可能考虑。解决方案：医疗器械由在构成医疗器械的基材表面上固定具有特定酰胺键的马来酸酐共聚合物构成。版权所有（C）2011，JPO＆INPIT

10. 发明专利

JP2008061834A Guidewire for catheter 审中-公开
标题翻译：导管指南
公开(公告)号：JP2008061834A
公开(公告)日：2008-03-21
申请号：JP2006243183
申请日：2006-09-07
申请人： Trs:Kk , 株式会社ティーアールエス
发明人： HASHIMOTO TERUO
IPC分类号： A61M25/01 , A61L33/00
摘要： PROBLEM TO BE SOLVED: To provide a guide wire for a catheter which enables a hold of the distal end shape of the catheter, reduction in peeling and peeling off of coating of a guide wire, and safe and easy execution of the procedure by changing the catheter. SOLUTION: The guide wire for the catheter is constituted of an inner core in which both low rigid ends are integrally shaped. The rigidity of one end portion of both the low rigid end portions has a constant rigidity, and the shape is in a linear direction, the rigidity of the other end is not constant, further the inner core is formed of an elastic metal. COPYRIGHT: (C)2008,JPO&INPIT

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