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1. 发明专利

JP2008200006A Device for amplifying nucleic acid, container for amplifying the same and method for amplifying the same 有权
标题翻译：用于放大核酸的装置，用于放大核酸的容器和用于使其放大的方法
公开(公告)号：JP2008200006A
公开(公告)日：2008-09-04
申请号：JP2007042608
申请日：2007-02-22
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： KUSUMOTO MASAHIRO , TAKARADA YUTAKA , SOYA YOSHIHIRO
IPC分类号： C12M1/00 , C12N15/09 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a device for amplifying nucleic acid and a container for amplifying the same for performing a nucleic acid-amplifying reaction such as a PCR, etc., simply and in a short time.
SOLUTION: This device for amplifying the nucleic acid is equipped with a loading means for loading the container 10 for amplifying the nucleic acid and a first heating means 2 for forming a multiple number of heating zones adjusted at each of different temperatures on the loading means. Also, the container for amplifying the nucleic acid is provided by installing an opening part 11, a flow passage 12 and a vessel part 13 at a substrate plate 14, joining the opening part 11 with the vessel part 13 by the flow passage and having the opening part 11 as a cylindrical structure protruded from the substrate plate 14.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：简单且在短时间内提供用于扩增核酸的装置和用于扩增核酸的装置和用于进行核酸扩增反应如PCR等的容器。解决方案：用于扩增核酸的装置装备有用于装载用于扩增核酸的容器10的装载装置和用于形成多个加热区域的第一加热装置2，用于形成在每个不同温度下调节的多个加热区域装载手段。此外，用于扩增核酸的容器通过在基板14上安装开口部11，流路12和容器部13而设置，通过流路将开口部11与容器部13接合，并且具有开口部分11作为从基板14突出的圆柱形结构。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JP2007151470A Method for amplifying nucleic acid using sample 审中-公开
标题翻译：使用样品放大核酸的方法
公开(公告)号：JP2007151470A
公开(公告)日：2007-06-21
申请号：JP2005351969
申请日：2005-12-06
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： TAKARADA YUTAKA , NAKATANI AKIHIRO
IPC分类号： C12N15/09 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a method for preserving a sample, in which a nucleic acid can be efficiently amplified even from the sample preserved for a long period by suppressing activity of a nuclease in the sample causing decomposition of nucleic acid, when amplifying the nucleic acid in the sample. SOLUTION: The method for amplifying the sample nucleic acid comprises a first step for adding the sample to a sample-preserving solution containing a monovalent cation salt as an active ingredient, a second step for adding all or a part of a mixture obtained from the first step to a nucleic acid proliferation reaction system and a third step for carrying out nucleic acid proliferation reaction. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：为了提供一种保存样品的方法，其中通过抑制导致核酸分解的样品中的核酸酶的活性，即使从长期保存的样品中也能够有效地扩增核酸，当扩增样品中的核酸时。解决方案：用于扩增样品核酸的方法包括将样品添加到含有一价阳离子盐作为活性成分的保存溶液的溶液中的第一步骤，第二步，将得到的全部或部分混合物从第一步骤到核酸增殖反应系统和进行核酸增殖反应的第三步骤。版权所有（C）2007，JPO＆INPIT

3. 发明专利

JP2006333869A Method for simply detecting genetic polymorph and reagent for detecting the same 审中-公开
标题翻译：用于简单检测遗传多聚体和检测其的试剂的方法
公开(公告)号：JP2006333869A
公开(公告)日：2006-12-14
申请号：JP2006241628
申请日：2006-09-06
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： SOYA YOSHIHIRO , TAKARADA YUTAKA
IPC分类号： C12Q1/68 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a method for clearly and reproducibly detecting genetic polymorph in several sites, especially the genetic polymorph in several sites of cytochrome 2D6, 2C19 and the like, and to provide a reagent therefor.
SOLUTION: The method for detecting the genetic polymorph comprises conducting amplification by using at least one of a wild type-detecting oligonucleotide and a variant-type detecting oligonucleotide and a nucleic acid-specific label, wherein a sequence having at least two variation sites different from each other is detected under an identical amplification condition.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种清楚可重复地检测多个位点遗传多态性的方法，特别是细胞色素2D6,2C19等的几个位点的遗传多态性，并提供其试剂。解决方案：用于检测遗传多态性的方法包括使用野生型检测寡核苷酸和变体型检测寡核苷酸和核酸特异性标记中的至少一种进行扩增，其中具有至少两个变异的序列在相同的扩增条件下检测到彼此不同的位点。版权所有（C）2007，JPO＆INPIT

4. 发明专利

JP2005077247A Image measurement method for surface plasmon resonance method 有权
标题翻译：用于表面等离子体共振方法的图像测量方法
公开(公告)号：JP2005077247A
公开(公告)日：2005-03-24
申请号：JP2003308124
申请日：2003-08-29
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： KYO MOTOKI , TAKARADA YUTAKA
IPC分类号： G01N21/27 , G01N21/41
CPC分类号： G01N21/553
摘要： PROBLEM TO BE SOLVED: To provide an image measurement method for projecting a surface plasmon resonance (SPR) image in the same direction as a pattern on a chip for SPR measurement.
SOLUTION: According to this SPR method, an image photographed by a CCD camera is turned upside-down and/or mirror-reversed and/or rotated by computer operation to perform display and/or operation. It is made easy to specify a position on the chip and to modify displacement of a spot.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种图像测量方法，用于在与用于SPR测量的芯片上的图案相同的方向上投影表面等离子体共振（SPR）图像。
解决方案：根据该SPR方法，通过计算机操作将由CCD照相机拍摄的图像上下颠倒和/或镜像反转和/或旋转以执行显示和/或操作。在芯片上指定位置并修改点的位移变得容易。版权所有（C）2005，JPO＆NCIPI

5. 发明专利

JP2005069981A Surface plasmon resonance measuring method 有权
标题翻译：表面质谱共振测量方法
公开(公告)号：JP2005069981A
公开(公告)日：2005-03-17
申请号：JP2003303245
申请日：2003-08-27
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： KYO MOTOKI , TAKARADA YUTAKA
IPC分类号： G01N21/27
摘要： PROBLEM TO BE SOLVED: To realize a surface plasmon resonance measuring method constituted so as not to form the interference fringe caused by a change in a refractive index due to evaporation by using a substance of which the weight change due to evaporation is reduced in a contact liquid having a high refractive index.
SOLUTION: In the surface plasmon resonance measuring method using the contact liquid between a transparent substrate chip coated with a metal and a prism, the contact liquid, which is changed in its weight by 1% or below when allowed to stand for one hr at 37°C and has a boiling point of 200°C or above, is used.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：实现表面等离子体共振测量方法，其被构造成不会由于通过使用由于蒸发引起的重量变化减小的物质而由于蒸发而导致的折射率变化而形成干涉条纹在具有高折射率的接触液体中。解决方案：在使用涂覆有金属的透明基板芯片和棱镜之间的接触液体的表面等离子体共振测量方法中，当允许静置1时，其重量变化1％或更低的接触液体 hr，沸点为200℃以上。版权所有（C）2005，JPO＆NCIPI

6. 发明专利

JP2005164348A Method for observing interaction of biomolecules 审中-公开
标题翻译：观察生物分子相互作用的方法
公开(公告)号：JP2005164348A
公开(公告)日：2005-06-23
申请号：JP2003402517
申请日：2003-12-02
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： KOGA HISASHI , KYO MOTOKI , TAKARADA YUTAKA
IPC分类号： G01N33/566 , G01N33/543 , G01N33/553
摘要： PROBLEM TO BE SOLVED: To provide a method for observing the precise interaction of biomolecules without causing non-specific adsorption even in a sample in which various substances coexist, in particular in the measurement of surface plasmon resonance.
SOLUTION: A hetero difunctional group type hydrophilic polymer is bonded to a nonionic functional group introduced into a surface in a covalent bonding manner and the biomolecule is immobilized on the surface of a solid by the direct or indirect chemical bond or physical adsorption of the terminal of the hydrophilic polymer and the biomolecule. The interaction of the immobilized biomolecule with a biomolecule or a biomolecule aggregate is observed.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：即使在各种物质共存的样品中，特别是在表面等离子体共振的测量中，也提供了用于观察生物分子的精确相互作用而不引起非特异性吸附的方法。解决方案：将异双官能团型亲水性聚合物以共价键合方式结合到引入表面的非离子官能团上，并通过直接或间接的化学键或物理吸附将生物分子固定在固体的表面上亲水性聚合物的末端和生物分子。观察到固定的生物分子与生物分子或生物分子聚集体的相互作用。版权所有（C）2005，JPO＆NCIPI

7. 发明专利

JP2005069787A Biochip 有权
标题翻译：生物芯片
公开(公告)号：JP2005069787A
公开(公告)日：2005-03-17
申请号：JP2003298027
申请日：2003-08-21
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： KYO MOTOKI , TAKARADA YUTAKA
IPC分类号： G01N33/543 , B82Y35/00 , G01N21/03 , G01N21/27 , G01N21/41 , G01N33/53 , G01N37/00
CPC分类号： G01N21/553
摘要： PROBLEM TO BE SOLVED: To obtain a biochip comprising a metal substrate capable of locating a spot and in particular fitted to a surface plasmon resonance imaging method.
SOLUTION: The biochip has the array part formed on the metal substrate and is equipped with a marker describing the place of the spot. The marker is preferably a discriminable character or figure. Further, the marker is preferably patterned on a monomolecular level.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：获得一种包括能够定位斑点，特别适合于表面等离子体共振成像方法的金属基底的生物芯片。
解决方案：生物芯片具有形成在金属基底上的阵列部分，并配备有描述斑点位置的标记。标记优选地是可辨别的字符或图形。此外，标记优选在单分子水平上图案化。版权所有（C）2005，JPO＆NCIPI

8. 发明专利

JP2005017155A Method for manufacturing array on metal substrate 审中-公开
标题翻译：在金属基板上制造阵列的方法
公开(公告)号：JP2005017155A
公开(公告)日：2005-01-20
申请号：JP2003183870
申请日：2003-06-27
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： KYO MOTOKI , TAKARADA YUTAKA
IPC分类号： G01N1/00 , G01N1/28 , G01N21/27 , G01N21/41
摘要： PROBLEM TO BE SOLVED: To establish a method for manufacturing an array on a metal substrate easily, inexpensively, and stably.
SOLUTION: In the method for manufacturing the array, a solution containing a substance to be immobilized is retained by a pin and the pin is brought into contact with the substrate, thus spotting the solution onto a metal substrate chip. In this case, ambient humidity is maintained at least at 70% for preventing a spot from drying and the activity of biomolecules is maintained for obtaining an image having a stable contrast even if a measurement is made by a surface plasmon method.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：容易，廉价且稳定地建立在金属基板上制造阵列的方法。解决方案：在制造阵列的方法中，含有待固定物质的溶液由引脚保持，并使引脚与基片接触，从而将溶液点样到金属基片上。在这种情况下，即使通过表面等离子体激元法进行测量，环境湿度保持在至少70％以防止斑点干燥，并且维持生物分子的活性以获得具有稳定对比度的图像。版权所有（C）2005，JPO＆NCIPI

9. 发明专利

JP2005017153A Method for manufacturing array for immobilizing molecule on metal substrate chip 有权
标题翻译：用于制造金属基板芯片上分子分离的阵列的方法
公开(公告)号：JP2005017153A
公开(公告)日：2005-01-20
申请号：JP2003183868
申请日：2003-06-27
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： KYO MOTOKI , KUROITA TOSHIHIRO , TAKARADA YUTAKA
IPC分类号： G01N33/53 , C12N15/09 , G01N21/27 , G01N33/543 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To establish a method for manufacturing an array on a metal substrate without damaging a metal film easily and inexpensively.
SOLUTION: A solution containing a substance to be immobilized is retained by a pin, the pin, where the area of a tip figure is at least 0.01 mm
2 , is brought into contact with the substrate, and then the solution is spotted onto a metal substrate chip, thus manufacturing the array. Preferably, an ambient temperature is maintained at least at 70%, thus preventing a spot from drying and maintaining the activity of biomolecules. The obtained array can be measured by a surface plasmon measurement.
COPYRIGHT: (C)2005,JPO&NCIPI

10. 发明专利

JP2004283049A Method for judging poor methabolizer in japanese 审中-公开
标题翻译：在日本判断不良甲磺酸盐的方法
公开(公告)号：JP2004283049A
公开(公告)日：2004-10-14
申请号：JP2003077548
申请日：2003-03-20
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： ISHIGURO AKIHIRO , KUBOTA TAKAHIRO , YAMADA YASUHIKO , IGA TATEJI , SOYA YOSHIHIRO , TAKARADA YUTAKA
IPC分类号： G01N33/50 , C12N15/09 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a method for simply and highly accurately judging the poor methabolizer of human cytochrome P450 2D6 in Japanese.
SOLUTION: This method for judging the poor methabolizer of human cytochrome P450 2D6 in Japanese in vitro comprises a process for detecting four to ten kinds of genetic polymorphisms including at least 2D6*36, preferably five to ten kinds of genetic polymorphisms including 2D6*5, 2D6*14, 2D6*18, 2D6*21 and 2D6*36, more preferably six to ten kinds of genetic polymorphisms including 2D6*5, 2D6*14, 2D6*4, 2D6*18, 2D6*21 and 2D6*36, among the human cytochrome P450 2D6.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种用于简单高效地判断日本人细胞色素P450 2D6的差的代谢物的方法。解决方案：用于判断人体细胞色素P450 2D6在体外不良代谢物的方法是一种检测4〜10种遗传多态性的方法，包括至少2D6 * 36，优选5〜10种遗传多态性，包括2D6 * 5，2D6 * 14，2D6 * 18，2D6 * 21和2D6 * 36，更优选6至10种遗传多态性，包括2D6 * 5，2D6 * 14，2D6 * 4，2D6 * 18，2D6 * 21和2D6 * 36，人类细胞色素P450 2D6。版权所有（C）2005，JPO＆NCIPI

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