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1. 发明专利

JP2013087069A Monoclonal antibody specifically recognizing h5 subtype influenza virus 审中-公开
标题翻译：单克隆抗体特异性识别H5亚型流感病毒
公开(公告)号：JP2013087069A
公开(公告)日：2013-05-13
申请号：JP2011227748
申请日：2011-10-17
申请人： Toyobo Co Ltd , 東洋紡株式会社 , National Institute Of Infectious Diseases , 国立感染症研究所長 , Osaka Prefecture , 大阪府
发明人： MISAWA SHUHEI , SOYA YOSHIHIRO , NISHIMURA KENGO , YOKOTA KYOKO , ONISHI KAZUO , ADO MANABU , TAKAHASHI YOSHIMASA , OSHIMA MASAMICHI , HIRAYAMA NAKAMI , ITAMURA SHIGEYUKI , KOBAYASHI KAZUO , TAKAHASHI KAZUO
IPC分类号： C07K16/10 , C12P21/08 , C12Q1/70 , G01N33/543 , G01N33/569 , G01N33/577
摘要： PROBLEM TO BE SOLVED: To provide an antibody capable of specifically recognizing an H5 subtype influenza virus among type A influenza viruses.SOLUTION: The monoclonal antibody specifically recognizing an H5 subtype influenza virus among type A influenza viruses is produced by a hybridoma deposited under the accession number FERM BP-11229 or a hybridoma deposited under the accession number FERM BP-11230.
摘要翻译：待解决的问题：提供能够在A型流感病毒中特异性识别H5亚型流感病毒的抗体。 A型流感病毒中特异性识别H5亚型流感病毒的单克隆抗体是以保藏号FERM BP-11229保藏的杂交瘤或以保藏号FERM BP-11230保藏的杂交瘤产生的。版权所有（C）2013，JPO＆INPIT

2. 发明专利

JP2012220357A Specimen pretreating method 有权
标题翻译：样本预处理方法
公开(公告)号：JP2012220357A
公开(公告)日：2012-11-12
申请号：JP2011087142
申请日：2011-04-11
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： NAKAO TAKAHITO , MISAWA SHUHEI , WAKAHARA TAKASHI , MAENO MITSUO
IPC分类号： G01N33/48 , G01N33/543 , G01N33/569
摘要： PROBLEM TO BE SOLVED: To provide fecal matter specimen pretreatment liquid which is essential for correct measurement of various components included in a biological sample such as a fecal matter specimen when measuring components by using the fecal matter specimen and by utilizing immunological reaction and specificity of genomic hybridization, as well as a component measuring kit for measuring components included in feces by using the fecal matter specimen pretreatment liquid and a component measuring method.SOLUTION: A pretreatment method of specimen taken from feces includes a process of suspending the specimen with Gly-HCl buffer solution, Ala-HCl buffer solution or Ser-HCl buffer solution whose pH is kept within the range from 0.5 to 2.9.
摘要翻译：要解决的问题：提供粪便物质样品预处理液体，其是通过使用粪便物质样品和通过利用免疫反应测量成分时，对粪便物质样品等生物样品中包含的各种成分进行正确测定所必需的，基因组杂交的特异性，以及通过使用粪便物质预处理液体测量粪便中的成分的成分测定试剂盒和成分测定方法。解决方案：从粪便中取出的样本的预处理方法包括使用Gly-HCl缓冲溶液，pH值保持在0.5〜2.9范围内的Ala-HCl缓冲溶液或Ser-HCl缓冲液悬浮样品的方法。版权所有（C）2013，JPO＆INPIT

3. 发明专利

JP2011133285A Allergy testing method 有权
标题翻译：过敏测试方法
公开(公告)号：JP2011133285A
公开(公告)日：2011-07-07
申请号：JP2009291639
申请日：2009-12-24
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： MISAWA SHUHEI , SOYA YOSHIHIRO
IPC分类号： G01N33/53 , G01N33/543
摘要： PROBLEM TO BE SOLVED: To prevent the occurrence of an abnormal measured value of unknown cause occurring even if a blocking agent is used in the test of allergy using solid phase sandwich immunoassay.
SOLUTION: This allergy testing method quantifies the IgE antibody to a specific allergen in a blood sample by the solid phase sandwiching immunoassay. A ligand capturing antibody or the spacer bonded to the ligand capturing antibody is adsorbed and fixed on a solid phase carrier to get the protein adsorbing region other than the ligand capturing antibody adsorbing region or spacer adsorbing region of the solid phase carrier sealed by the blocking agent, next to get a composite of the specific allergen bonded to a ligand and the IgE antibody to the specific allergen sandwiched between the ligand capturing antibody and a labelled anti-IgE antibody, and next to get the labelled anti-IgE antibody subsequently detected, wherein the blocking agent comprises a synthetic polymer not originated from animals and plants.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：为了防止即使在使用固相夹心免疫测定的过敏试验中使用封闭剂时也出现未知原因的异常测量值。解决方案：该过敏测试方法通过固相夹心免疫测定法定量血液样品中特定变应原的IgE抗体。将配体捕获抗体或与配体捕获抗体结合的间隔基吸附固定在固相载体上，得到除了封闭剂密封的固相载体的配体捕获抗体吸附区域或间隔物吸附区域以外的蛋白质吸附区域接下来获得与配体结合的特异性变应原和夹在配体捕获抗体和标记的抗IgE抗体之间的特异性变应原的IgE抗体的复合物，接下来检测随后检测到的标记抗IgE抗体，其中封闭剂包括不是源自动物和植物的合成聚合物。版权所有（C）2011，JPO＆INPIT

4. 发明专利

JP2012220195A Specimen pretreating method 有权
标题翻译：样本预处理方法
公开(公告)号：JP2012220195A
公开(公告)日：2012-11-12
申请号：JP2011082610
申请日：2011-04-04
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： NAKAO TAKAHITO , MISAWA SHUHEI , WAKAHARA TAKASHI , MAENO MITSUO
IPC分类号： G01N33/48 , C12Q1/04 , C12Q1/68 , G01N33/543 , G01N33/569
摘要： PROBLEM TO BE SOLVED: To provide fecal matter specimen pretreatment liquid which is essential for correct measurement of various components included in a biological sample such as a fecal matter specimen when measuring components by using the fecal matter specimen and by utilizing immunological reaction and specificity of genomic hybridization, as well as a component measuring kit for measuring components included in feces by using the fecal matter specimen pretreatment liquid and a component measuring method.SOLUTION: A pretreatment method of specimen taken from feces includes a process of suspending the specimen in a state where the pH range is kept from 0.5 to 2.9.
摘要翻译：要解决的问题：提供粪便物质样品预处理液体，其是通过使用粪便物质样品和通过利用免疫反应测量成分时，对粪便物质样品等生物样品中包含的各种成分进行正确测定所必需的，基因组杂交的特异性，以及通过使用粪便物质预处理液体测量粪便中的成分的成分测定试剂盒和成分测定方法。解决方案：从粪便中取出的样本的预处理方法包括将样品悬浮在pH范围为0.5至2.9的状态的过程。版权所有（C）2013，JPO＆INPIT

5. 发明专利

JP2011027731A Method for sucking reagent 审中-公开
标题翻译：消除试剂的方法
公开(公告)号：JP2011027731A
公开(公告)日：2011-02-10
申请号：JP2010147397
申请日：2010-06-29
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： MISAWA SHUHEI , WAKAHARA TAKASHI , SOYA YOSHIHIRO
IPC分类号： G01N35/10 , G01N1/00
摘要： PROBLEM TO BE SOLVED: To provide a method for sucking a reagent from a reagent cartridge for use in a physiologically active material measurement system, from a point of view of providing such a system in conformity with the idea of POCT. SOLUTION: Before divided injection or discharge of a reagent, a seal is bored through with a syringe or the like in advance so that a hole is made through which air flows into a container in place of a reagent that is sucked in or through which air flows out of a container in place of a reagent that is discharged. Then, by sucking or discharging the reagent by inserting a syringe into a position different from the hole for suction or discharge, stable suction or discharge is carried out, so that stable measured values are obtained. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：从提供符合POCT的想法的观点出发，提供从用于生理活性物质测量系统的试剂盒吸取试剂的方法。解决方案：在试剂分开注射或排放之前，预先用注射器等将密封件穿孔，以便空气流入容器中而不是吸入的试剂，空气从容器流出而不是放出的试剂。然后，通过将注射器插入与用于抽吸或排出的孔不同的位置来吸取或排出试剂，进行稳定的抽吸或排出，从而获得稳定的测量值。版权所有（C）2011，JPO＆INPIT

6. 发明专利

JP2006119011A Method for detecting substance by luminescent reaction on porous carrier and reaction vessel 审中-公开
标题翻译：通过多孔载体和反应容器上的发光反应检测物质的方法
公开(公告)号：JP2006119011A
公开(公告)日：2006-05-11
申请号：JP2004307790
申请日：2004-10-22
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： SAWAMURA HIROSHI , MISAWA SHUHEI , MAENO MITSUO , YONEDA KEIZO
IPC分类号： G01N33/543 , C12M1/34 , C12Q1/26 , C12Q1/34 , C12Q1/42 , G01N21/03 , G01N21/78 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To reduce a background noise from a luminescent reaction, and improve a capability for detecting a measured substance even if a porous carrier as a reaction field is not colored.
SOLUTION: In a method, a complex is formed from a first substance for specifically combining the measured substance in a sample and the measured substance having a labeled low-molecular compound, and a second substance for specifically combining the measured substance in the sample and the measured substance having a labeled luminescent substance or a labeled luminescent reaction inducing substance, the complex is captured by the colorless porous carrier 3 having a previously fixed physiologically active substance for capturing the low-molecular substance labeled in the first substance, and the measured substance is detected by measuring an intensity of luminescence finally generated from the luminescent substance or the luminescent reaction inducing substance labeled in the second substance. The method for detecting the measured substance employs a reaction vessel 1 having a color other than white on a face of a layer 4 located below and contacting the carrier.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：为了降低发光反应的背景噪声，并且即使作为反应场的多孔载体没有着色，也提高了测量物质的检测能力。解决方案：在一种方法中，由用于将样品中测量的物质与具有标记的低分子化合物的测量物质特异性组合的第一物质形成络合物，以及用于将测量物质特异性地组合在第样品和具有标记的发光物质或标记的发光反应诱导物质的测量物质，该复合物被具有预先固定的生理活性物质的无色多孔载体3捕获，用于捕获在第一物质中标记的低分子物质，通过测量由第二物质中标记的发光物质或发光反应诱导物质最终产生的发光强度来检测被测物质。用于检测被测物质的方法采用反应容器1，该反应容器1具有位于下方并接触载体的层4的表面上具有白色以外的颜色。版权所有（C）2006，JPO＆NCIPI

7. 发明专利

JP2011059082A Measuring device for determining setting failure of reagent cartridge container 有权
标题翻译：用于确定试剂盒容器设定失败的测量装置
公开(公告)号：JP2011059082A
公开(公告)日：2011-03-24
申请号：JP2009212255
申请日：2009-09-14
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： MISAWA SHUHEI , WAKAHARA TAKASHI , SOYA YOSHIHIRO
IPC分类号： G01N35/02
摘要： PROBLEM TO BE SOLVED: To substantially completely eliminate occurrence of "careless mistake value" without known cause during measurement, in a device appropriate for POCT using a cartridge container filled with a reagent.
SOLUTION: A measuring device includes the cartridge container that is filled with the reagent and has bar code information printed on its side surface, a setting part for fixing the cartridge container, a dispensing means for sucking the reagent from the cartridge container fixed to the setting part and delivering it in the other place, a reading means for reading the bar code information printed on the cartridge container, and a determining means for determining whether the cartridge container is correctly set in the setting part based on the information read by the reading means. The determination is performed dependently on whether the bar code information is read correctly.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：在使用装有试剂的盒式容器的适于POCT的装置中，基本上完全消除了在测量期间没有已知原因的“粗心错误值”的发生。解决方案：测量装置包括填充有试剂的盒容器，并且其侧表面上印有条形码信息，用于固定盒容器的固定部分，用于从盒容器固定的吸附试剂的分配装置到设置部分并将其传送到另一个位置，读取装置，用于读取打印在盒式磁盘容器上的条形码信息;以及确定装置，用于基于读取的信息确定盒式存储器是否正确地设置在设置部分中阅读手段。决定是否正确读取条形码信息。版权所有（C）2011，JPO＆INPIT

8. 发明专利

JP2008157684A Reaction cup storage device and reaction measuring instrument set 有权
标题翻译：反应杯存储装置和反应测量仪器组
公开(公告)号：JP2008157684A
公开(公告)日：2008-07-10
申请号：JP2006344787
申请日：2006-12-21
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： MISAWA SHUHEI , YONEDA KEIZO
IPC分类号： G01N35/04
摘要： PROBLEM TO BE SOLVED: To reduce the risk that a flange-like protrusion of a measuring reaction cup is shifted from a prescribed direction and position, when detecting a measuring objective substance in the measuring reaction cup by an automatic measuring instrument. SOLUTION: This reaction cup storage device 1 includes a recessed part 2 capable of storing the measuring reaction cup 10 provided with a cylindrical part 10a and the flange-like protrusion 10b protruded flange-likely from an outer wall of the cylindrical part 10a, and for storing the cylindrical part 10a of the measuring reaction cup 10, and is formed on an upper face 1a with a locking part having a wall face 3a brought into contact with the protrusion 10b when the cylindrical part 10a is rotated in the recessed part 2, to reduce the risk that the flange-like protrusion 10b of the measuring reaction cup 10 is shifted from the prescribed direction and position. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：为了减少测量反应杯的法兰状突起从规定的方向和位置偏移的风险，当通过自动测量仪器检测测量反应杯中的测量目标物质时。解决方案：该反应杯存储装置1包括凹部2，该凹部2能够容纳具有圆筒部10a的测量反作用杯10和凸出的突出部10b，凸出部10b可能从圆筒部10a的外壁突出并且用于存储测量反作用杯10的圆柱形部分10a，并且当圆柱形部分10a在凹部中旋转时形成在具有与突起10b接触的壁面3a的锁定部分的上表面1a上以减少测量反应杯10的法兰状突起10b从规定方向和位置偏移的风险。版权所有（C）2008，JPO＆INPIT

9. 发明专利

JP2006300523A Improvement method of measurement accuracy, and measuring container 审中-公开
标题翻译：测量精度的改进方法和测量容器
公开(公告)号：JP2006300523A
公开(公告)日：2006-11-02
申请号：JP2005117884
申请日：2005-04-15
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： OKUDA YOHEI , MISAWA SHUHEI , SAWAMURA HIROSHI , YONEDA KEIZO
IPC分类号： G01N21/64 , G01N21/76 , G01N33/53 , G01N33/543 , G01N33/552
摘要： PROBLEM TO BE SOLVED: To provide a means capable of improving measurement accuracy such as improvement of sensitivity or reduction of measured value dispersion without improving an insoluble carrier part where a reaction is performed actually in a measuring container equipped with the insoluble carrier.
SOLUTION: Concerning a method for detecting a measuring object material in a biosample and the measuring container, the measuring container has (1) an opening part, and is equipped with (2) an absorbing element positioned close to the opening part and (3) the insoluble carrier arranged between the opening part and the absorbing element, and having a structure permeable by liquid. In the measuring container, (4) a bonding physiologically active substance capable of capturing the measuring object material directly or through a material forming a bonding pair complex is immobilized beforehand to the insoluble carrier, and the total of each length of the insoluble carrier and the absorbing element before being installed in the measuring container is longer than the substantial storage space length of the measuring container.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种能够提高测量精度的方法，例如提高灵敏度或降低测量值分散，而不改进在装有不溶性载体的测量容器中实际进行反应的不溶性载体部分。解决方案：关于生物样本和测量容器中的测量对象材料的检测方法，测量容器具有（1）开口部分，并且配备有（2）靠近开口部分设置的吸收元件，（3）布置在开口部分和吸收元件之间的不溶性载体，并且具有可被液体渗透的结构。在测量容器中，（4）能够直接或通过形成接合对络合物的材料捕获测量对象材料的接合生理活性物质预先固定在不溶性载体上，并且将不溶性载体和在安装在测量容器中之前的吸收元件比测量容器的实际存储空间长度更长。版权所有（C）2007，JPO＆INPIT

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