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1. 发明专利

JPH02289597A NEW VITAMIN B12 DERIVATIVE, PRODUCTION AND USE THEREOF 失效
公开(公告)号：JPH02289597A
公开(公告)日：1990-11-29
申请号：JP4590590
申请日：1990-02-28
申请人： TEIJIN LTD
发明人： TORATANI TETSUO , ISHIDA ATSUHIKO , UESHIMA YASUHIDE , FUJII KATSUHIKO
IPC分类号： C12N1/20 , A61K31/00 , A61K31/7135 , A61K31/714 , A61P3/00 , A61P3/02 , A61P35/00 , A61P43/00 , C07D487/22 , C07F9/6561 , C07F15/06 , C07H23/00 , C12R1/01
摘要： NEW MATERIAL:A compound expressed by formula I [L is ligand of choline ring to cobalt; B is base having heterocyclic structure; R is (substituted) hydrocarbon]. EXAMPLE:2-(5,6-dimethylbenzimidazolyl) ethylcyanochobinamide phosphate. USE:Suppressing and inhibiting agent against cell propagation, or antitumor agent. PREPARATION:Cyanoaquachobinamide or dicyanochobinamide is subjected to condensation reaction with phosphate derivative expressed by formula II or salt of said derivative to obtain the aimed compound.

2. 发明专利

JPH1133116A POWDER MEDICINE MULTI-DOSING DEVICE 失效
公开(公告)号：JPH1133116A
公开(公告)日：1999-02-09
申请号：JP19112197
申请日：1997-07-16
申请人： TEIJIN LTD
发明人： MATSUKI HIDEO , KAWABE HIROYUKI , UESHIMA YASUHIDE , FUJII TAKAO
IPC分类号： A61M31/00 , A61M13/00
摘要： PROBLEM TO BE SOLVED: To provide a powder medicine multi-dosing device which is portable, easy to operate and use, and is produced relatively at a low cost. SOLUTION: This device consists of the main body 1, an outlet part 4 attached movably at the main body, and a pump part 7 whose wall part is at least partly constituted as a flexible container or a bag. And a stock room 6 where a plural number of does of powder medicine can be stocked and a storing room 3 with a capacity of a single doses of medicine on the wall of the stock room 2. And a filter 6, which is permeated by air but not by the powder medicine, is attached to the storing room 3 on the opposite side of the stock room 2. And in addition, an air pathway 10 is formed so that air permeating the filter 6 can enter the pump part 1.

3. 发明专利

JPH08134050A HIGHLY WATER-SOLUBLE 4H-3,1-BENZOXAZIN-4-ONE COMPOUND AND SERINE PROTEASE INHIBITING PHARMACEUTICAL COMPOSITION THEREFROM 失效
公开(公告)号：JPH08134050A
公开(公告)日：1996-05-28
申请号：JP27226694
申请日：1994-11-07
申请人： TEIJIN LTD
发明人： FUJII KATSUHIKO , UESHIMA YASUHIDE , OSHIDA JUNICHI , KAWABATA HIROSHI , KOKUBO MASAYUKI , SATO OSAMI , KATO YOSHINORI
IPC分类号： C07D265/24 , A61K31/535 , A61K31/536 , A61P9/00 , A61P11/00 , A61P43/00
摘要： PURPOSE: To obtain the subject compound expressed by a specific formula, exhibiting selective and strong inhibitory action on a serine protease, especially human leukocyte elastase, having high solubility in water and applicable also as a bolus injection. CONSTITUTION: This compound is expressed by formula I (R1 is H or a lower alkyl; R2 is a lower alkylene; A is an acidic amino acid residue having protected amino group), e.g. 7-(N-benzyloxycarbonyl-L-glutamyl)amino-2-(3-carboxypropyl) amino-5-methyl-4H-3,1-benzoxazin-4-one. The compound can be produced e.g. by condensing a derivative of formula II (R' is a carboxyl-protecting group) with an acidic amino acid of the formula A'-OH to obtain a derivative of formula III and removing the carboxyl-protecting group and the R' group on the 2-substituent of the derivative.

4. 发明专利

JPH07285858A BICYCLIC CONDENSED RING COMPOUND DERIVATIVE AND MEDICINAL PREPARATION CONTAINING THE SAME 失效
公开(公告)号：JPH07285858A
公开(公告)日：1995-10-31
申请号：JP23503694
申请日：1994-09-29
申请人： TEIJIN LTD
发明人： HASEGAWA MASAKAZU , UESHIMA YASUHIDE , HORIUCHI HIDEKI , TAKAHASHI KATSUSHI , TAKENOUCHI KAZUYA , KOMORIYA KEIJI , OMORI HITOSHI
IPC分类号： A61K31/165 , A61K31/19 , A61K31/245 , A61P11/08 , A61P17/00 , A61P27/02 , A61P27/14 , A61P27/16 , A61P37/00 , A61P37/08 , C07C233/44 , C07C233/55 , C07C235/24 , C07C235/28 , C07C323/56 , C07C323/62
摘要： PURPOSE:To obtain the subject medicinal agent for allergic diseases, comprising a derivative expressed by a specific formula as an active ingredient, having suppressing actions on the production of IgE antibodies and useful as a prophylactic and therapeutic agent for allergic diseases such as bronchial asthma, allergic rhinitis or allergic conjunctivitis. CONSTITUTION:This agent for allergic diseases comprises a bicyclic condensed ring compound of formula [A is CH2-CH2, CH=CH, C*C (* indicating a triple bond), S-CH2, CH2-S, O-CH2 or CH2-O; B is CH2, CH=CH, C*C, S-CH2 or O-CH2, in the case where A is CH2-CH2, CH=CH or C*C and is CH2, CH=CH or C*C, in case where A is S-CH2, CH2-S, O-CH2 or CH2-O; X is CH=CH-CH=CH, CH2-CH2-CH=CH, CH=CH-CH2-CH2 or (CH2)4; R is H or a 1-4C alkyl; Y is CO2R', NHR'', OH or H (R' and R'' each is H or 1-4C alkyl); n is 0 to 9] or its pharmaceutically permissible salts as an active ingredient.

5. 发明专利

JP2002255795A COMPOSITION FOR PERNASAL ADMINISTRATION 失效
公开(公告)号：JP2002255795A
公开(公告)日：2002-09-11
申请号：JP2001049957
申请日：2001-02-26
申请人： TEIJIN LTD
发明人： MATSUKI HIDEO , SUZUKI NORIE , DOI MASAHIKO , UESHIMA YASUHIDE
IPC分类号： A61K9/14 , A61K47/02 , A61K47/04 , A61K47/08 , A61K47/12 , A61K47/32 , A61K47/36 , A61K47/38
摘要： PROBLEM TO BE SOLVED: To obtain a powdery composition for pernasal administration capable of spraying a constant amount of a drug fillable with a good accuracy from a drug free dispenser for multiple administration with a good accuracy. SOLUTION: This powder composition for pernasal administration is prepared by mixing the drug with a base using a mixer having a shear force.

6. 发明专利

JP2002255794A COMPOSITION FOR PERNASAL ADMINISTRATION CAPABLE OF CARRYING OUT UNIFORM MULTIPLE ADMINISTRATION 失效
公开(公告)号：JP2002255794A
公开(公告)日：2002-09-11
申请号：JP2001049956
申请日：2001-02-26
申请人： TEIJIN LTD
发明人： MATSUKI HIDEO , SUZUKI NORIE , DOI MASAHIKO , UESHIMA YASUHIDE
IPC分类号： A61K9/14 , A61K9/72 , A61K47/02 , A61K47/04 , A61K47/12 , A61K47/32 , A61K47/36 , A61K47/38
摘要： PROBLEM TO BE SOLVED: To obtain a powdery composition for pernasal administration capable of spraying a constant amount of a drug from a drug free dispenser for multiple administration with a good accuracy. SOLUTION: This powdery composition for pernasal administration comprises the drug and a base and is characterized in that the moisture content is within the range of 3.5-5.5% and a uniform amount of the drug is sprayed from the drug free dispenser for pernasal administration.

7. 发明专利

JP2001122768A POWDERY MEDICINAL COMPOSITION FOR DELIVERING MEDICINE TO BRAIN 失效
公开(公告)号：JP2001122768A
公开(公告)日：2001-05-08
申请号：JP30678099
申请日：1999-10-28
申请人： TEIJIN LTD
发明人： DOI MASAHIKO , UESHIMA YASUHIDE
IPC分类号： A61K9/72 , A61K9/14 , A61K31/565 , A61K47/38
摘要： PROBLEM TO BE SOLVED: To obtain a composition for efficiently delivering a medicine to the brain. SOLUTION: This powdery medicine composition is characterized by a composition comprising a medicine and a slightly water-soluble or water-insoluble base having >=90 μm particle diameter and the delivery of the composition through the nasal cavity to the brain by an air flow.

8. 发明专利

JP2001002589A COMPOSITION FOR NASAL ADMINISTRATION ENABLING MILD RAISING OF MEDICINE BLOOD CONCENTRATION 失效
公开(公告)号：JP2001002589A
公开(公告)日：2001-01-09
申请号：JP17222199
申请日：1999-06-18
申请人： TEIJIN LTD
发明人： YAMAMOTO YOJI , DOI MASAHIKO , UESHIMA YASUHIDE
IPC分类号： A61K47/00 , A61K9/14 , A61K31/138 , A61K45/08
摘要： PROBLEM TO BE SOLVED: To obtain the subject composition enabling high absorption without causing rapid increase of medicine blood concentration in order to avoid adverse effect due to rapid increase of medicine blood concentration after administration of medicine by including a medicine and a hydrogel forming base. SOLUTION: This composition comprises (A) a medicine and (B) a hydrogel- forming base. The component A includes preferably a non-peptide, a proteinous medicine (e.g. antiphlogistic steroidal medicine, analgesic antiphlogistic medicine, antitussive expectorant, antihistamic medicine, antiallergic medicine, bronchodilator, antiemetic medicine, medicine for migraine, sleep inducing medicine, sleep sedative or vitamin) or a peptide-proteinous medicine having

9. 发明专利

JPH10309317A MULTIDOSE TYPE POWDERY MEDICINE ADMINISTERING DEVICE 失效
公开(公告)号：JPH10309317A
公开(公告)日：1998-11-24
申请号：JP12057697
申请日：1997-05-12
申请人： TEIJIN LTD
发明人： MATSUKI HIDEO , KAWABE HIROYUKI , UESHIMA YASUHIDE , MAKINO YUJI , FUJII TAKAO
IPC分类号： A61J7/00 , A61M11/00 , A61M13/00
摘要： PROBLEM TO BE SOLVED: To enable portability due to miniaturization, easiness/quickness in operation and simpleness in a production process by pressing/relaxing the flexible wall part of storage part and pump means and spraying the fixed quantity of powdery medicines held on the bottom of holding part through a spray port to the outside. SOLUTION: When using an administering device, an entire main body part is inclined so that the powdery medicines held in a medicine storage part and pump means 1 are moved to a medicine holding part 2, and the main body is lightly shaken so that the medicines just for one time of use are held in the powdery medicine storage space of medicine holding part 2. Then, the flexible wall part of medicine storage part and pump means 1 in combination with an air storage part is pressed in the state of turning a medicine spray port 5 upside and turning a medicine suction port 6 downside so that pressure in an internal space is rapidly increases and internal air tries to flow from the medicine suction port 6 at a medicine lead-out port 4 to the outside. In that case, powdery medicines are sucked into the medicine suction port 6, sprayed from the medicine spray port 5 to the outside and administered to the required patient.

10. 发明专利

JP2004035441A Aseptic aqueous suspension preparation 有权
公开(公告)号：JP2004035441A
公开(公告)日：2004-02-05
申请号：JP2002193400
申请日：2002-07-02
申请人： Teijin Ltd , 帝人株式会社
发明人： NISHIBE YOSHIHISA , NAGANO ATSUHIRO , TAKANASHI KAZUYA , UESHIMA YASUHIDE
IPC分类号： A61K9/10 , A61K31/56 , A61K47/38 , A61M15/08
摘要： PROBLEM TO BE SOLVED: To provide an aqueous suspension preparation which contains a slightly water-soluble medicine and does not contain a preservative.
SOLUTION: This aseptic aqueous suspension preparation not containing the preservative contains the slightly water-soluble medicine, and is sterilized in an autoclave.
COPYRIGHT: (C)2004,JPO

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