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1. 发明专利

JPH0635445B2 失效
公开(公告)号：JPH0635445B2
公开(公告)日：1994-05-11
申请号：JP31394089
申请日：1989-12-01
申请人： TANABE SEIYAKU CO
发明人： MATSUMOTO KAZUO , HAYASHI MASAAKI , NUMANAMI KENICHI , SATO TADASHI , TAKADA ISAO
IPC分类号： C07D233/64 , A61K31/415 , A61K38/00 , A61P37/00 , C07D233/54 , C07D401/12 , C07K1/02 , C07K1/113 , C07K5/02 , C07K5/06 , C07K5/065 , C07K5/08 , C07K5/087

2. 发明专利

JPH0436245A AGENT FOR IMMUNOREGULATION 失效
公开(公告)号：JPH0436245A
公开(公告)日：1992-02-06
申请号：JP14396990
申请日：1990-05-31
申请人： TANABE SEIYAKU CO
发明人： MATSUMOTO KAZUO , HAYASHI MASAAKI , NUMANAMI KENICHI , SATO TADASHI , TAKADA ISAO
IPC分类号： A61K38/00 , A61K31/415 , A61P3/08 , A61P3/10 , A61P13/02 , A61P15/00 , A61P29/00 , A61P37/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , C07D233/64 , C07D233/66 , C07D233/84 , C07K5/06 , C07K5/08
摘要： NEW MATERIAL:Imidazole-containing peptides of formula I (R is branched alkyl, branched alkoxy or aryl-substituted alkoxy; R and R are H or lower alkyl; R and R are phenyl-substituted lower alkyl; R is H or lower alkoxycarbonyl; R is H or nitrogen-containing heterocyclic group-substituted lower alkylthio; X and X are CH, formula II or N; A is lower alkylene which may be substituted). EXAMPLE:4-{2-[N-(N-tert-butoxycarbonyl-L-phenylalanyl-L-phenylalanyl)- amino]ethyl}-5-methoxycarbonylimidazole. USE:Therapeutic/preventive agent of articular rheumatism, multiple sclerosis, systemic lupus erythematosus, glomerulonephritis, rheumatic fever, type I diabetes and atopic allergy. PREPARATION:A compound of formula III, its salt or its reactive derivative is condensed with a compound of formula IV or its salt to obtain the objective compound of formula I.

3. 发明专利

JPS536483A COMPOSITION HAVING ENZYMATIC ACTIVITY AND ITS PREPARATION 失效
公开(公告)号：JPS536483A
公开(公告)日：1978-01-20
申请号：JP7934676
申请日：1976-07-02
申请人： TANABE SEIYAKU CO
发明人： SENHATA ICHIROU , TOSA TETSUYA , TAKADA ISAO
IPC分类号： C12N11/04 , C12N11/10
摘要： PURPOSE:To prepare a composition which contains enzymatic active substance in the lattice of gel, by the gelation of sulfate group-containing polysaccharides mixed with enzymatic active substance.

4. 发明专利

JPH04234816A IMMUNO-REGULATING ANTIRHEUMATIC AGENT 失效
公开(公告)号：JPH04234816A
公开(公告)日：1992-08-24
申请号：JP13083091
申请日：1991-03-20
申请人： TANABE SEIYAKU CO
发明人： MATSUMOTO KAZUO , SUZUKI MAMORU , YAMAMOTO KOZO , TAKADA ISAO , IWAZAWA YOSHIRO , YAMAMOTO TATSURO
IPC分类号： A61K31/415 , A61K31/44 , A61K31/4427 , A61P29/00 , A61P37/00 , C07D233/06 , C07D233/20 , C07D233/22 , C07D401/04
摘要： PURPOSE:To obtain an immuno-regulating antirheumatic agent by using an imidazoline derivative as an active component. CONSTITUTION:The objective agent contains a compound of formula I (R is halogenophenyl, lower alkylphenyl or pyridyl; X and X are H or lower alkyl) or its pharmacologically permissible salt, e.g. cis-2-(4-chlorophenyl)-4,5- diphenylimidazoline hydrochloride, as an active component. The compound of formula I can be produced by the condensation reaction of the compound of formula II or its acid addition salt with a compound of formula III (R' is lower alkyl).

5. 发明专利

JPS6137912B2 失效
公开(公告)号：JPS6137912B2
公开(公告)日：1986-08-26
申请号：JP1724081
申请日：1981-02-06
申请人： TANABE SEIYAKU CO
发明人： SENHATA ICHIRO , TOSA TETSUYA , TAKADA ISAO
IPC分类号： C12N11/10 , C12N11/04

6. 发明专利

JPS57115179A IMMOBILIZED ENZYMATIC ACTIVE SUBSTANCE AND ITS PREPARATION 失效
公开(公告)号：JPS57115179A
公开(公告)日：1982-07-17
申请号：JP241081
申请日：1981-01-09
申请人： TANABE SEIYAKU CO
发明人： SENHATA ICHIROU , TOSA TETSUYA , TAKADA ISAO
IPC分类号： C12N11/04 , C12N11/10
摘要： PURPOSE:To prepare the titled substance capable of exhibiting high enzymatic activity for a long period, by adding and mixing an enzymatic active substance to an aqueous solution of a polysaccharide having a molecular structure having (substituted) amino group and containing more than specific amount of sulfate group, and including the enzumatic active substance in the gel lattice of the polysaccharide. CONSTITUTION:An aqueous solution of a polysaccharide (e.g. carrageenan) having a molecular structure having introduced amino group or substituted amino group (e.g. monomethylamino group, diethylamino group, etc.) and containing >=10W/W% sulfate group is incorporated and mixed with an enzymatic active substance (e.g. microbial cells containing enzyme such as amino acid oxidase), and the enzymatic active substance is included in the gel lattice obtained by gelatinizing the polysaccharide in the mixture to form the objective immobilized enzymatic active substance. The substance can be used in an enzymatic reaction without loss of the active substance from the gel lattice, exhibiting high enzymatic activity for a long period. It has excellent shape- retainability, strength, elasticity, etc., and can be used in an enzymatic reaction stably for a long period.

7. 发明专利

JPH02262561A 失效
公开(公告)号：JPH02262561A
公开(公告)日：1990-10-25
申请号：JP31394089
申请日：1989-12-01
申请人： TANABE SEIYAKU CO
发明人： MATSUMOTO KAZUO , HAYASHI MASAAKI , NUMANAMI KENICHI , SATO TADASHI , TAKADA ISAO
IPC分类号： C07D233/64 , A61K31/415 , A61K38/00 , A61P37/00 , C07D233/54 , C07D401/12 , C07K1/02 , C07K1/113 , C07K5/02 , C07K5/06 , C07K5/065 , C07K5/08 , C07K5/087
摘要： NEW MATERIAL:The compound of formula I (R is branched alkyl, branched alkyloxy or aryl-substituted lower alkyloxy; R and R are H or lower alkyl; R and R are phenyl-substituted alkyl; R is H or lower alkoxycarbonyl; R is H or lower alkylthio substituted with nitrogen-containing heterocyclic group; X and X are CH, OCH or N; A is lower alkoxycarbonyl, hydroxymethyl, etc.) and its salt. EXAMPLE:N-tert-butoxycarbonyl-L-phenylalanyl-L-phenylalanyl-L-histidine methyl ester. USE:A treating agent and preventive for arthrorheumatism, multiple sclerosis, systemic lupus erythematosus, etc. PREPARATION:The objective compound of formula I can be produced by condensing a compound of formula II, its salt or its reactive derivative with a compound of formula III or its salt.

8. 发明专利

JPH02101065A IMIDAZOLINE DERIVATIVE 失效
公开(公告)号：JPH02101065A
公开(公告)日：1990-04-12
申请号：JP25339188
申请日：1988-10-06
申请人： TANABE SEIYAKU CO
发明人： MATSUMOTO KAZUO , SUZUKI MAMORU , YAMAMOTO KOZO , TAKADA ISAO , IWAZAWA YOSHIRO
IPC分类号： C07D233/06 , A61K31/415 , A61K31/44 , A61K31/4427 , A61P37/00 , C07D233/20 , C07D233/22 , C07D233/54 , C07D233/64 , C07D401/04
摘要： NEW MATERIAL:An imidazoline derivative expressed by formula I (R is halogenophenyl, lower alkylphenyl or pyridyl; X and X are H or lower alkoxy) or salt thereof. EXAMPLE:cis-2-(4-Chlorophenyl)-4,5-diphenylimidazoline. USE:Immune controlling agent useful as remedy and/or preventive for articular rheumatism, multiple sclerosis, systemic lupus erythematosus, rheumatic fever, having low toxicity and exhibiting high safeness as a medicine. PREPARATION:A compound expressed by formula II or salt thereof is condensed with a compound expressed by formula III (R' is lower alkyl) or salt thereof to provide the compound expressed by formula I. Furthermore, the above- mentioned compound or salt thereof activates migration of inflammatory macrophage, especially staying in chronic inflammation site and causing a tissue disorder to cause the macrophage to withdraw from the inflammation site and simultaneously recover a function of lowered suppressor T cell.

9. 发明专利

JPH0160235B2 失效
公开(公告)号：JPH0160235B2
公开(公告)日：1989-12-21
申请号：JP241081
申请日：1981-01-09
申请人： TANABE SEIYAKU CO
发明人： SENHATA ICHIRO , TOSA TETSUYA , TAKADA ISAO
IPC分类号： C12N11/04 , C12N11/10

10. 发明专利

JPS57132883A PREPARATION OF IMMOBILIZED ENZYMICALLY ACTIVE SUBSTANCE 失效
公开(公告)号：JPS57132883A
公开(公告)日：1982-08-17
申请号：JP1724081
申请日：1981-02-06
申请人： TANABE SEIYAKU CO
发明人： SENHATA ICHIROU , TOSA TETSUYA , TAKADA ISAO
IPC分类号： C12N11/10 , C12N11/04
摘要： PURPOSE:To prepare an immobilized enzymically active substance having a very stable enzymic activity, by gelatinizing a mixture solution of an aqueous solution of a polysaccharide containing sulfuric acid groups with an enzymically active substance in the presence of a polycationic high polymer. CONSTITUTION:An aqueous solution of a polysaccharide, e.g. carrageenan or furcellaran, containing 10%(w/w) or more sulfuric acid groups in the molecular structure is mixed with an enzymically active substance, e.g. an enzyme or microbial cell, and a polycationic high polymer, e.g. a polyalkyleneimine, chitosan, a copolymer of dimethylaminoethyl methacrylate with acrylamide, aminohexylated agarose or dimethylaminoethylated crosslinked dextran, to gelatinize the polysaccharide in the resultant mixture solution.

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