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    • 1. 发明专利
    • Controlled release bioactive agent delivery device
    • 控制释放生物剂递送装置
    • JP2011167551A
    • 2011-09-01
    • JP2011116262
    • 2011-05-24
    • Surmodics Incサーモディクス,インコーポレイティド
    • ANDERSON ARON BLAWIN LAURIE RSHEN BYRON CDE JUAN EUGENEVARNER SIGNE ECHAPPA RALPH A
    • A61M37/00A61K9/00A61K31/58A61K47/32A61P27/02
    • A61K31/58A61F2310/00353A61K9/0051
    • PROBLEM TO BE SOLVED: To provide a delivery device for controlled delivery of one or more bioactive agents to a treatment site within body. SOLUTION: The invention relates to a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension; and a polymeric coated composition including a first polymer, a second polymer, and a bioactive agent in contact with a surface of the body member. In the device, the first polymer comprises polyalkyl(meth)acrylic acid, aromatic poly(meth)acrylic acid, or a combination of polyalkyl(meth)acrylic acid and aromatic poly(meth)acrylic acid, and the second polymer comprises ethylene-vinyl acetic acid copolymer. COPYRIGHT: (C)2011,JPO&INPIT
    • 要解决的问题:提供用于将一种或多种生物活性剂控制递送到体内治疗部位的递送装置。 解决方案:本发明涉及一种控制释放生物活性剂递送装置,其包括具有延伸方向的本体构件,沿着延伸方向的纵向轴线,以及近端和远端,其中至少一部分 身体成员偏离延伸方向; 以及包含第一聚合物,第二聚合物和与本体构件的表面接触的生物活性剂的聚合物涂覆组合物。 在该装置中,第一聚合物包括聚(甲基)丙烯酸烷基酯,芳族聚(甲基)丙烯酸或聚烷基(甲基)丙烯酸和芳族聚(甲基)丙烯酸的组合),第二聚合物包括乙烯 - 乙烯基 乙酸共聚物。 版权所有(C)2011,JPO&INPIT