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1. 发明专利

JP2009161551A Piperazine derivative having pgd2 receptor antagonist activity 有权
标题翻译：具有PGD2受体拮抗剂活性的哌嗪衍生物
公开(公告)号：JP2009161551A
公开(公告)日：2009-07-23
申请号：JP2009055295
申请日：2009-03-09
申请人： Shionogi & Co Ltd , 塩野義製薬株式会社
发明人： KUGIMIYA HIROSHI , FUJIOKA MASAHIKO , TACHIBANA HIROKI , MURASHI TAKAKI , ONODERA KIMIHIRO
IPC分类号： C07D211/44 , A61K31/445 , A61K31/495 , A61K31/496 , A61P11/06 , A61P37/08 , A61P43/00 , C07D213/74 , C07D263/32 , C07D295/22 , C07D307/68
CPC分类号： C07D295/26 , C07D207/14 , C07D207/48 , C07D211/58 , C07D211/70 , C07D211/96 , C07D213/38 , C07D213/40 , C07D213/64 , C07D213/71 , C07D213/74 , C07D231/12 , C07D231/40 , C07D235/08 , C07D235/30 , C07D235/32 , C07D243/08 , C07D261/08 , C07D261/18 , C07D263/32 , C07D263/58 , C07D265/36 , C07D271/10 , C07D277/24 , C07D277/28 , C07D285/12 , C07D285/135 , C07D295/096 , C07D295/155 , C07D307/42 , C07D307/52 , C07D307/56 , C07D307/68 , C07D333/36 , C07D401/12 , C07D413/12
摘要： PROBLEM TO BE SOLVED: To provide a piperazine derivative having a prostaglandin D2 receptor antagonistic activity, and the medicinal use of the same. SOLUTION: This piperazine derivative is a compound expressed by formula (III), its pharmaceutically acceptable salt or their hydrates. They can be used as a treating agent of allergic diseases. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供具有前列腺素D2受体拮抗活性的哌嗪衍生物及其药物用途。该哌嗪衍生物是由式（III）表示的化合物，其药学上可接受的盐或其水合物。它们可以用作过敏性疾病的治疗剂。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2014101353A Pharmaceutical composition for alzheimer's disease medical treatment or prevention including oxazin derivative 审中-公开
标题翻译：用于阿尔茨海默病病毒治疗或预防包括氧化衍生物的药物组合物
公开(公告)号：JP2014101353A
公开(公告)日：2014-06-05
申请号：JP2013218780
申请日：2013-10-22
申请人： Shionogi & Co Ltd , 塩野義製薬株式会社
发明人： MASUI MORIYASU , MITSUOKA YASUNORI , YOSHIDA SHUHEI , KUSAKABE KENICHI , ONODERA KIMIHIRO , KUROSE NORIYUKI
IPC分类号： C07D413/12 , A61K31/5355 , A61P25/28 , A61P43/00 , C07D413/14
摘要： PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for Alzheimer's disease medical treatment or prevention.SOLUTION: A pharmaceutical composition for Alzheimer's disease medical treatment or prevention includes a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. In the formula, -X= denotes -CR= or -N=; a ring B denotes a substituted or unsubstituted carbocyclic ring, or substituted or unsubstituted heterocycle; Rdenotes a substituted or unsubstituted alkyl or the like; Rand Reach independently denote hydrogen, a substituted or unsubstituted alkyl or the like; Rand Reach independently denote hydrogen, a halogen, a substituted or unsubstituted alkyl or the like; Rdenotes hydrogen, a substituted or unsubstituted alkyl or the like; Reach independently denotes halogen, hydroxy, a substituted or unsubstituted alkyl or the like; Rdenotes hydrogen, a halogen, hydroxy, a substituted or unsubstituted alkyl or the like; and p denotes an integer of 0-3.
摘要翻译：要解决的问题：提供一种阿尔茨海默氏病药物治疗或预防药物组合物。解决方案：阿尔茨海默氏病药物治疗或预防药物组合物包括式（I）表示的化合物或其药学上可接受的盐。在公式中，-X =表示-CR =或-N =; 环B表示取代或未取代的碳环，或取代或未取代的杂环; R表示取代或未取代的烷基等; Rand Reach独立地表示氢，取代或未取代的烷基等; 兰德接触独立地表示氢，卤素，取代或未取代的烷基等; R表示氢，取代或未取代的烷基等; 独立地表示卤素，羟基，取代或未取代的烷基等; R表示氢，卤素，羟基，取代或未取代的烷基等; p表示0-3的整数。

3. 发明专利

JP2009161552A Sulfonamide derivatives having Pgd2 receptor antagonist activity 有权
标题翻译：具有PGD2受体拮抗剂活性的磺酰胺衍生物
公开(公告)号：JP2009161552A
公开(公告)日：2009-07-23
申请号：JP2009055298
申请日：2009-03-09
申请人： Shionogi & Co Ltd , 塩野義製薬株式会社
发明人： KUGIMIYA HIROSHI , FUJIOKA MASAHIKO , TACHIBANA HIROKI , MURASHI TAKAKI , ONODERA KIMIHIRO
IPC分类号： C07D211/46 , A61K31/40 , A61K31/402 , A61K31/445 , A61K31/4545 , A61K31/495 , A61K31/497 , A61K31/5377 , A61K31/5383 , A61P1/04 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P17/00 , A61P17/04 , A61P25/00 , A61P25/20 , A61P27/14 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07D207/12 , C07D207/14 , C07D211/22 , C07D211/58 , C07D213/38 , C07D213/74 , C07D231/12 , C07D231/40 , C07D235/08 , C07D235/30 , C07D261/18 , C07D263/32 , C07D263/58 , C07D265/36 , C07D271/10 , C07D277/20 , C07D277/28 , C07D277/46 , C07D285/12 , C07D285/135 , C07D295/22 , C07D307/52 , C07D307/68 , C07D333/20 , C07D401/12
CPC分类号： C07D295/26 , C07D207/14 , C07D207/48 , C07D211/58 , C07D211/70 , C07D211/96 , C07D213/38 , C07D213/40 , C07D213/64 , C07D213/71 , C07D213/74 , C07D231/12 , C07D231/40 , C07D235/08 , C07D235/30 , C07D235/32 , C07D243/08 , C07D261/08 , C07D261/18 , C07D263/32 , C07D263/58 , C07D265/36 , C07D271/10 , C07D277/24 , C07D277/28 , C07D285/12 , C07D285/135 , C07D295/096 , C07D295/155 , C07D307/42 , C07D307/52 , C07D307/56 , C07D307/68 , C07D333/36 , C07D401/12 , C07D413/12
摘要： PROBLEM TO BE SOLVED: To provide a medicinal composition having a DP receptor antagonist activity. SOLUTION: This sulfonamide derivative is a compound expressed by formula (IV) [wherein, ring D is a benzene ring or the like; ring E is a pyrrolidine ring or the like; R 1 is hydroxyalkyl or the like; R 2 is a halogen atom or the like; R 3 is an alkyloxy or the like; R 4 , R 5 are each a halogen atom or the like; M is carbonyl or the like; L 3 , Y are each a single bond or the like: Z is N or the like; and (n), (p), (q) are each a number such as 1 etc.], its pharmaceutically acceptable salt or their hydrates. They can be used as a treating agent of allergic diseases. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供具有DP受体拮抗剂活性的药物组合物。该解决方案：该磺酰胺衍生物是由式（Ⅳ）表示的化合物[其中，环D为苯环等; 环E是吡咯烷环等; R SP 1是羟烷基等; R 2是卤素原子等; R 3是烷氧基等; R“SP”4，R“SP 5”均为卤素原子等; M是羰基等; L各自为单键或类似物：Z为N等; 和（n），（p），（q）各自为1等的数字]，其药学上可接受的盐或其水合物。它们可以用作过敏性疾病的治疗剂。版权所有（C）2009，JPO＆INPIT

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