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1. 发明专利

JPS5740485A Novel antibiotic pa-39504-x3 and its preparation 失效
标题翻译：新型抗生素PA-39504-X3及其制备方法
公开(公告)号：JPS5740485A
公开(公告)日：1982-03-06
申请号：JP11718280
申请日：1980-08-25
申请人： Shionogi & Co Ltd
发明人： TANAKA KENTAROU , KONDOU EIJI , MATSUMOTO KOUICHI , SHIYOUJI JIYUNICHI , TSUJI NAOKI
IPC分类号： C07D477/00 , A61K31/397 , A61K31/40 , A61P31/04 , C07D477/20 , C12P17/18 , C12R1/465
CPC分类号： C07D477/20 , C12P17/184
摘要： NEW MATERIAL:An antibiotic PA-39504-X
3 expressed by the formula and a pharmacologically acceptable salt thereof.
USE: An antimicrobial agent, having an antimicrobial activity against Gram-positive and Gram-negative bacteria and inhibitory action on β-lactamase production, and administered orally or parenterally in a dose of 0.1W30g/day in the case of the subcutaneous administration.
PROCESS: A strain, belonging to the genus Streptomyces, and having the ability to produce an antibiotic PA-39504-X
3 , e.g. Streptomyces sp. PA-39504 (FERM-P No.5265), is cultivated in a liquid nutrient culture medium under aerobic conditions, and the antibiotic PA-39504-X
3 is separated and collected from the resultant culture after the completion of the cultivation. Alternatively, the antibiotic PA- 39504-X
3 can be obtained by refluxing an antibiotic PA-31088-IV in carbon tetrachloride with triphenylphosphine under mild conditions, and deoxidizing the reaction product.
COPYRIGHT: (C)1982,JPO&Japio
摘要翻译：新材料：由下式表示的抗生素PA-39504-X3及其药理学上可接受的盐。用途：具有抗革兰氏阳性和革兰氏阴性细菌的抗微生物活性和对β-内酰胺酶生产的抑制作用的抗微生物剂，并且在皮下给药的情况下以0.1-30g /天的剂量口服或肠胃外给药。方法：属于链霉菌属的菌株，并具有生产抗生素PA-39504-X3的能力，例如，链霉菌属 PA-39504（FERM-P No.5265）在有氧条件下在液体营养培养基中培养，培养完成后从所得培养物中分离收集抗生素PA-39504-X3。或者，可以通过在温和条件下用三苯基膦在四氯化碳中回流抗生素PA-31088-IV并使反应产物脱氧来获得抗生素PA-39504-X3。

2. 发明专利

JPS59151895A Beta-lactam antibiotic, pb-5582-a and its preparation 失效
标题翻译： BETA-LACTAM抗生素，PB-5582-A及其制备
公开(公告)号：JPS59151895A
公开(公告)日：1984-08-30
申请号：JP2598283
申请日：1983-02-17
申请人： Shionogi & Co Ltd
发明人： TANAKA KENTAROU , KONDOU EIJI , MATSUMOTO KOUICHI , HATSUTORI MITSUO , SHIYOUJI JIYUNICHI
IPC分类号： C12P17/10 , A61K35/74 , C07D205/08 , C07D205/085 , C12N1/20 , C12P1/04 , C12R1/01
摘要： NEW MATERIAL:A β-lactam antibiotic PB-5582-A of the formula.
USE: It has antibacterial acitivity against gram-positive bacteria, thus being used as a medicine, animal-use drugs and disinfectant or also used as a starting material of other antibiotics.
PREPARATION: A microorganism in Aeromonus, capable of producing an antibiotic PB-5582-A, e.g., Aeromonus aurantiaca sp.nov. (FERM-6887) is aerobically cultured in an enriched medium at 20W40°C, preferably 25W32°C and about 5.5W 8.5pH for about 20W80hr and the antibiotic PB-5582-A is collected from the culture mixture.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：新材料：配方的β-内酰胺抗生素PB-5582-A。用途：对革兰氏阳性菌具有抗菌活性，用作药物，动物用药物和消毒剂，也可用作其他抗生素的起始物质。制备：能够产生抗生素PB-5582-A（例如Aeromonus aurantiaca sp.nov）的气单胞菌中的微生物。（FERM-6887）在20-40℃，优选25-32℃和约5.5-8.5pH的富集培养基中有氧培养约20-80小时，并将抗生素PB-5582-A从培养液。

3. 发明专利

JPS5939895A Novel antibiotic pa-41746-d and its preparation 失效
标题翻译：新型抗生素PA-41746-D及其制备方法
公开(公告)号：JPS5939895A
公开(公告)日：1984-03-05
申请号：JP14954482
申请日：1982-08-27
申请人： Shionogi & Co Ltd
发明人： TANAKA KENTAROU , KONDOU EIJI , MATSUMOTO KOUICHI , TSUJI NAOKI
IPC分类号： C07D477/00 , A61K31/397 , A61K31/40 , A61P31/04 , C07D487/04 , C12P1/06 , C12P17/18 , C12R1/465
摘要： NEW MATERIAL:A compound(salt) shown by the formula I , whose disodium salt having the following physical and chemical properties. Electrophoresis mobility of filter paper: 2.3(mobility of epithienamycin A is 1.0). C Nuclear magnetic resonance: deltappm 21.7q, 3.24t, 55.0d, 60,4d, 64,4d, 127.7s, 139.8s, 169.0s, and 179.4s. H Nuclear magnetic resonance: deltappm(J=Hz)0.72d(6.0),2.36d-d(16.5, 11.0), 2.59d-d (16.5, 9.0), 3,01d-d(10.0, 5.5), 3,63q-d(6.0, 10.0), and 3.78m. Infrared absorption spectrum: muKB maxcm 3435, 1755, 1615, 1395, 1220-1200, 1105, 1066, and 1039. Ultraviolet spectrum shown by the formula II. USE:An antibacterial agent. PROCESS:A bacterium (FERM-P 5964) belonging to the genus Streptomyces, capable of producing PA-41746-D, is inoculated into a medium, and a product is separated and collected to give a compound shown by the formula.
摘要翻译：新材料：由式I表示的化合物（盐），其二钠盐具有以下物理和化学性质。滤纸的电泳迁移率：2.3（epithienamycin A的迁移率为1.0）。 13 C核磁共振：deltappm 21.7q，3.24t，55.0d，60,4d，64,4d，127.7s，139.8s，169.0s和179.4s。 1 H核磁共振：deltappm（J = Hz）0.72d（6.0），2.36dd（16.5,11.0），2.59dd（16.5,9.0），3.01d-d（10.0,5.5），3,63q -d（6.0,10.0）和3.78m。红外吸收光谱：muKB maxcm -1,3345,1755,1615,1395,1220-1200,1105,1066和1039。式II所示的紫外光谱。用途：抗菌剂。方法：将能够产生PA-41746-D的属于链霉菌属的细菌（FERM-P 5964）接种到培养基中，分离收集产物，得到式所示的化合物。

4. 发明专利

JPS59205994A Novel antibiotic troposulfenin and its preparation 失效
标题翻译：新型抗生素血友病及其制备
公开(公告)号：JPS59205994A
公开(公告)日：1984-11-21
申请号：JP8132683
申请日：1983-05-09
申请人： Shionogi & Co Ltd
发明人： TANAKA KENTAROU , KONDOU EIJI , MATSUMOTO KOUICHI , HATSUTORI MITSUO , TSUJI NAOKI
IPC分类号： C12P17/14 , A61K31/39 , A61P31/04 , C07D327/04 , C12N1/20
摘要： PURPOSE: To prepare novel antibiotic troposulfenin useful as a drug or an animal drug, having antifungal and antibacterial action, by cultivating a specific bacterium belonging to the genus Pseudomonas, separating and collecting troposulfenin from the culture.
CONSTITUTION: A bacterium such as Pseudomonas troposulfenii sp.nov. (FERM-P 7042) belonging to the genus Pseudomonas, capable of producing novel antibiotic troposulfenin, is cultivated in a medium, and antibiotic froposulfenin shown by the formula I (R is H or CH
3 ) is obtained by separating and collecting it from the prepared culture. Troposulfenin or troposulfenin S-methyl ether shown by the fomula II obtained by methylating it at a mercapto group of 8-position has antifungal and antibacterial actions, and is a novel antibiotic useful as a medicine and animal drug.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：通过培养属于假单胞菌属的特异性细菌，从培养物中分离和收集妥布硫磺蛋白，制备用作药物或动物药物的新型抗生素亚甲基亚砜，具有抗真菌和抗菌作用。构成：一种细菌，例如托氏假单胞菌（Pseudomonas troposulfenii sp.nov）。在培养基中培养属于假单胞菌属（Pseudomonas）的属于假单胞菌属（FERM-P 7042）的化合物，通过从制备的化合物中分离收集式I（R为H或CH 3）所示的抗生素亚磷酸氢盐文化。由甲基化8位巯基所得到的聚丙烯亚磺酸盐或聚丙烯亚磺酸S-甲基醚具有抗真菌和抗菌作用，是用作药物和动物药物的新型抗生素。

5. 发明专利

JPS59205378A Antibiotic pa-41746-a2 and its preparation 失效
标题翻译：抗生素PA-41746-A2及其制备方法
公开(公告)号：JPS59205378A
公开(公告)日：1984-11-20
申请号：JP8132583
申请日：1983-05-09
申请人： Shionogi & Co Ltd
发明人： TANAKA KENTAROU , KONDOU EIJI , MATSUMOTO KOUICHI , TSUJI NAOKI
IPC分类号： C07D477/00 , A61K31/397 , A61K31/40 , A61P31/04 , C07D487/04 , C12P17/18 , C12R1/465
摘要： NEW MATERIAL:Antibiotic PA-41746-A2 and its salt. USE:Having antibacterial effect on Gram-positive and Gram-negative bacteria, improved beta-lactamase inhibitory action, useful as a drug as an antibacterial agent, an animal drug, or a disinfectant. Being administred to mem and animals orally or parenterally. Usable as a tablet, capsule, or powder as oral administration, and injection, paint, suppository, etc. as parenteral administration. A dose is generally about 1/10 - about several times that of cephalothin. Also usable as a raw material for pluracidomycin A. PREPARATION:A bacterium belonging to the genus Streptomyces, capable of producing PA-41746-A2, is cultivated in a medium, and the titled compound is obtained from the prepared culture. The medium contains a carbon source, nitrogen source, inorganic salt, etc. as a rule, and the cultivation is carried out by a process commonly used in preparation of antibiotic. Preferably the pH of the medium is 5.5-8.5 and the culture temperature is about 20-40 deg.C.
摘要翻译：新材料：抗生素PA-41746-A2及其盐。用途：对革兰氏阳性和革兰氏阴性菌具有抗菌作用，改善β-内酰胺酶抑制作用，作为抗菌剂，动物药物或消毒剂有用。口服或肠胃外给予动物和动物。可作为口服给药的片剂，胶囊或粉剂，以及作为肠胃外给药的注射剂，油漆剂，栓剂等。剂量通常为头孢噻吩的约1/10至约几倍。也可用作pluracidomycin A的原料A.制剂：将能够产生PA-41746-A2的属于链霉菌属的细菌培养在培养基中，从制备的培养物中获得标题化合物。培养基通常含有碳源，氮源，无机盐等，并且通过制备抗生素常用的方法进行培养。优选地，培养基的pH为5.5-8.5，培养温度为约20-40℃。

6. 发明专利

JPS59140893A Carbapenem antibiotic substance and its preparation 失效
标题翻译：卡巴因抗生素及其制备
公开(公告)号：JPS59140893A
公开(公告)日：1984-08-13
申请号：JP1599783
申请日：1983-02-01
申请人： Shionogi & Co Ltd
发明人： TANAKA KENTAROU , KONDOU EIJI , MATSUMOTO KOUICHI , TSUJI NAOKI
IPC分类号： C07D477/00 , A61K31/397 , A61K31/40 , A61P31/04 , C07D487/04 , C12P17/18 , C12R1/465
摘要： NEW MATERIAL:(5R,6R)-3-( 2-Hydroxyethyl )sulfinyl-6-[1(S)-hydroxysulfonyloxyethyl]-7-oxo-1-azabicyclo[3,2,0]-h ept-2-ene-2-carboxylic acid of formula (the configuration of S-oxide is R or S). USE:It has beta-lactamase inhibiting activity and is useful as an antibacterial agent and disinfectant. PREPARATION:A bacterial strain belonging to Streptomyces genus and capable of producing PA-41746E and/or F, e.g. Streptomyces sp. PA-41746 (FERM-BP No. 174), etc. is cultured at 5.5-8.5pH and 25-32 deg.C preferably in a deep, aerating tank.
摘要翻译：新材料：（5R，6R）-3-（2-羟乙基）亚磺酰基-6- [1（S） - 羟基磺酰氧基乙基] -7-氧代-1-氮杂双环[3,2,0] - 庚-2-烯 -2-羧酸（S-氧化物的构型为R或S）。用途：具有β-内酰胺酶抑制活性，可用作抗菌剂和消毒剂。制备：属于链霉菌属的能够产生PA-41746E和/或F的细菌菌株。链霉菌属 PA-41746（FERM-BP No.174）等在5.5-8.5pH和25-32℃，优选在深的充气罐中培养。

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