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1. 发明专利

JP2006056803A Calcium channel inhibitor with sardine peptide 审中-公开
标题翻译：钙通道抑制剂与SARDINE PEPTIDE
公开(公告)号：JP2006056803A
公开(公告)日：2006-03-02
申请号：JP2004238429
申请日：2004-08-18
申请人： Senmi Ekisu Co Ltd , 仙味エキス株式会社
发明人： OSAJIMA KATSUHIRO , UCHIDA KATSUYUKI , KOGANEI MEGUMI , MOGAMI ORIE
IPC分类号： A61K38/00 , A23L1/305 , A61K35/60 , A61P3/14 , C07K14/46
摘要： PROBLEM TO BE SOLVED: To develop an agent originating from a natural product and having a calcium channel-inhibiting or suppressing action, and to develop a drink or food containing the same. SOLUTION: This calcium channel inhibitor is characterized by containing a sardine peptide as an active ingredient, wherein the sardine peptide is concretely a peptide Y-2 which is a fraction, for example, obtained by thermally denaturing fish meat, hydrolyzing the denatured fish meat with a protease, deactivating the enzyme, subjecting the product to a separation treatment to obtain a peptide, supplying the aqueous solution of the peptide to a peptide-adsorbing resin to make the peptide adsorbed, and then eluting the adsorbed peptide with an ethanol aqueous solution. Additionally, a commercial product (sardine peptide Y-2) can also be used. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：开发来自天然产物并具有钙通道抑制或抑制作用的药剂，并开发含有该物质的饮料或食品。解决方案：该钙通道抑制剂的特征在于含有沙丁鱼肽作为活性成分，其中沙丁鱼肽具体为肽Y-2，其为例如通过热变性鱼肉获得的级分，水解变性用蛋白酶鱼肉，使酶失活，对产物进行分离处理以获得肽，将肽的水溶液供给肽吸附树脂以使肽吸附，然后用乙醇洗脱吸附的肽水溶液。另外，也可以使用市售品（沙丁鱼肽Y-2）。版权所有（C）2006，JPO＆NCIPI

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