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1. 发明专利

JP2010133933A Test chip, apparatus for detecting target substance and method for specifically detecting target substance 有权
标题翻译：检测芯片，用于检测目标物质的装置和特异性检测目标物质的方法
公开(公告)号：JP2010133933A
公开(公告)日：2010-06-17
申请号：JP2009226321
申请日：2009-09-30
申请人： Sysmex Corp , シスメックス株式会社
发明人： IWANAGA SHIGEKI , KIRIMURA HIROYA
IPC分类号： G01N27/416 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N27/327
CPC分类号： G01N33/5438 , G01N27/305 , G01N27/3277
摘要： PROBLEM TO BE SOLVED: To provide a test chip with improved detection sensitivity for a target substance, an apparatus for detecting a target substance and a method for specifically detecting a target substance. SOLUTION: The test chip for detecting a target substance modified with a modifying substance releasing electrons upon photoexcitation includes: a semiconductor electrode part having a metal layer formed on a semiconductor layer; a probe that captures the target substance and are immobilized on the metal layer; and a counter electrode part having a conductive layer. An apparatus for detecting a target substance modified with a modifying substance releasing electrons upon photoexcitation includes: a test chip receiving part capable of receiving a test chip; a light source for photoexciting the modifying substance modifying the target substance in the test chip inserted in the test chip receiving part; and an electric current measuring part for measuring an electric current flowing from the target substance modified with the modifying substance upon photoexcitation by the light source. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：为目标物质提供具有改进的检测灵敏度的测试芯片，用于检测目标物质的装置和用于特异性检测目标物质的方法。解决方案：用于检测用光激发释放电子的修饰物质改性的目标物质的测试芯片包括：具有在半导体层上形成的金属层的半导体电极部分; 捕获目标物质并固定在金属层上的探针; 以及具有导电层的对电极部。一种用于检测由光激发释放电子的修饰物质改性的目标物质的装置，包括：能够接收测试芯片的测试芯片接收部分; 光源，用于对插入测试芯片接收部分的测试芯片中修饰目标物质的修饰物质进行光激发; 以及电流测量部件，用于测量由光源光激发后由修饰物质修饰的目标物质流出的电流。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2012117888A Method for electrochemically detecting specimen material 有权
标题翻译：电化学检测样品材料的方法
公开(公告)号：JP2012117888A
公开(公告)日：2012-06-21
申请号：JP2010266819
申请日：2010-11-30
申请人： Sysmex Corp , シスメックス株式会社
发明人： SUZUKI SEIGO , SEIKE SEIKA , IWANAGA SHIGEKI , HORI NOBUYASU , KIRIMURA HIROYA
IPC分类号： G01N27/416 , C12Q1/68
CPC分类号： G01N33/5438
摘要： PROBLEM TO BE SOLVED: To provide a method for electrochemically detecting a specimen material with higher sensitivity than a conventional art.SOLUTION: A specimen material S is captured by a capture substance 10 fixed on a working electrode body 161. A complex is formed on the working electrode 161. The complex comprises: a labeling bonding substance 20 which has a bonding substance 22 bonded with the specimen material S and a modified labeling substance 23 containing a labeling substance 24 on a soluble carrier 21; and the specimen material S. Then, the soluble carrier 21 is dissolved and the modified labeling substance 23 is attracted on the working electrode 161.
摘要翻译：要解决的问题：提供一种比传统技术更高灵敏度的电化学检测样品材料的方法。解决方案：样品材料S被固定在工作电极体161上的捕获物质10捕获。复合体形成在工作电极161上。该复合物包括：粘合物质22，其粘合试样材料S和在可溶性载体21上含有标记物质24的改性标记物质23; 和样品材料S.然后，溶解载体21溶解，并且改性标记物质23被吸引到工作电极161上。版权所有（C）2012，JPO＆INPIT

3. 发明专利

JP2012150097A Photocurrent detection electrode, manufacturing method thereof, and working electrode substrate 审中-公开
标题翻译：光电检测电极，其制造方法和工作电极基板
公开(公告)号：JP2012150097A
公开(公告)日：2012-08-09
申请号：JP2011257332
申请日：2011-11-25
申请人： Sysmex Corp , シスメックス株式会社
发明人： IWANAGA SHIGEKI , SUZUKI SEIGO , SEIKE SEIKA , HORI NOBUYASU , KIRIMURA HIROYA
IPC分类号： G01N27/327 , C12N15/09 , G01N21/64 , G01N27/30 , G01N27/333 , G01N27/416 , G01N33/543 , G01N33/553
CPC分类号： G01N33/5438 , G01N27/305 , G01N27/3277
摘要： PROBLEM TO BE SOLVED: To provide an electrode and a working electrode substrate which can detect a test substance with high reproducibility and a manufacturing method of obtaining the electrode with a simple operation.SOLUTION: In a photocurrent detection electrode, an adhesion layer including linker molecules is provided between an electrode body composed of a semiconductor receiving electrons from the detection substance by application of excitation light and a metal layer composed of metal.
摘要翻译：要解决的问题：提供一种能够以高再现性检测测试物质的电极和工作电极基底，以及以简单的操作获得电极的制造方法。解决方案：在光电流检测电极中，在由通过施加激发光从检测物质接收电子的半导体和由金属构成的金属层构成的电极体之间设置包括连接分子的粘合层。版权所有（C）2012，JPO＆INPIT

4. 发明专利

JP2012093349A Electrochemical detection method of detection substance, electrochemical detection method of test substance, inspection chip, detection set, probe holding substrate and electrode substrate 有权
标题翻译：检测物质的电化学检测方法，试验物质的电化学检测方法，检查芯片，检测装置，探针保持基板和电极基板
公开(公告)号：JP2012093349A
公开(公告)日：2012-05-17
申请号：JP2011200815
申请日：2011-09-14
申请人： Sysmex Corp , シスメックス株式会社
发明人： IWANAGA SHIGEKI , KIRIMURA HIROYA
IPC分类号： G01N27/416 , G01N21/76 , G01N27/327
CPC分类号： G01N27/3278
摘要： PROBLEM TO BE SOLVED: To provide an electrochemical detection method of a detection substance, an electrochemical detection method of a test substance, an inspection chip, a detection set, a probe holding substrate and an electrode substrate which can successfully detect the test substance without depending on size of the test substance, and further reuse a working electrode.SOLUTION: An electrode substrate 20 with a working electrode 51, a counter electrode 53, and a probe holding substrate 30 having a probe for capturing a mark binding substance in which the test substance or a binding substance for capturing the test substance is marked by a mark substance on a substrate body 30a are used, and the electrode substrate 20 and the probe holding substrate 30 are oppositely arranged with a predetermined gap. Then, after making the probe holding substrate 30 capture the test substance, at least the mark substance is induced to the working electrode 51 to be electrochemically detected.
摘要翻译：要解决的问题：提供检测物质的电化学检测方法，可以成功检测试验的检测物质的电化学检测方法，检查片，检测组，探针保持基板和电极基板物质，而不依赖于测试物质的尺寸，并进一步重新使用工作电极。＆lt; P＆gt;解决方案：具有工作电极51，对电极53和探针保持基板30的电极基板20，具有用于捕获被检物质或用于捕获被检物质的结合物质的标记结合物质的探针使用由基板主体30a上的标记物质标记的电极基板20和探针保持基板30以规定的间隙相对配置。然后，在使探针保持基板30捕获测试物质之后，至少将标记物质感应到工作电极51进行电化学检测。版权所有（C）2012，JPO＆INPIT

5. 发明专利

JP2019027928A 細胞撮像方法、細胞撮像装置、粒子撮像方法および粒子撮像装置审中-公开
公开(公告)号：JP2019027928A
公开(公告)日：2019-02-21
申请号：JP2017147660
申请日：2017-07-31
申请人： SYSMEX CORP
发明人： OKADA MASAYA , IWANAGA SHIGEKI
IPC分类号： G01N21/64 , G01N33/48
摘要：【課題】フローセルを流れる複数の細胞を含む画像をより高品質に生成することが可能な細胞撮像方法、細胞撮像装置を提供する【解決手段】細胞撮像装置10は、複数の細胞を含む試料を流すためのフローセル40と、光源20と、光源20から出射された光から、ライトシート11をフローセル40に対し形成するための照射光学系30と、被写界深度を拡大させる素子を有し、フローセル40を流れる複数の細胞から生じた光を集光するための集光光学系50と、集光光学系50により集光された複数の細胞から生じた光を受光し、複数の細胞を撮像するための撮像素子60と、を備える。【選択図】図1

6. 发明专利

JP2014194356A Electrochemical detection method of material to be inspected 有权
标题翻译：要检查的材料的电化学检测方法
公开(公告)号：JP2014194356A
公开(公告)日：2014-10-09
申请号：JP2013070074
申请日：2013-03-28
申请人： Sysmex Corp , シスメックス株式会社
发明人： FUTAMATSU FUMIYA , KIRIMURA HIROYA , IWANAGA SHIGEKI , SUZUKI SEIGO , HORI NOBUYASU , YASUDA YUICHI
IPC分类号： G01N27/416 , G01N27/327
CPC分类号： C12Q1/6825 , C12Q2527/125
摘要： PROBLEM TO BE SOLVED: To provide an electrochemical detection method of a material to be inspected capable of securing a high detection accuracy of the same degree as the case where an electrolytic solution by a non-proton system solvent is used by employing a proton solvent without using a non-proton system solvent having a large environment load, and the electrolytic solution used for the method.SOLUTION: In a method for electrochemically detecting a material to be inspected contained in the specimen under the existence of an electrolytic solution using a work electrode and a counter electrode, the electrolytic solution containing a solution in which an imidazolium iodide compound is melt in pronto solvent is used.
摘要翻译：要解决的问题：为了提供能够确保与通过使用质子溶剂使用非质子系溶剂的电解液相同程度的高检测精度的被检查材料的电化学检测方法而没有使用环境负荷大的非质子体系溶剂和用于该方法的电解液。解决方案：在使用工作电极存在电解液的情况下，电化学检测样品中所含检测材料的方法和对电极，使用含有碘化咪唑鎓化合物在溶剂中熔融的溶液的电解液。

7. 发明专利

JP2010107345A Method for specific detection of object, detection apparatus, and test chip 有权
标题翻译：用于特定检测对象，检测装置和测试芯片的方法
公开(公告)号：JP2010107345A
公开(公告)日：2010-05-13
申请号：JP2008279385
申请日：2008-10-30
申请人： Sysmex Corp , シスメックス株式会社
发明人： IWANAGA SHIGEKI , KIRIMURA HIROYA
IPC分类号： G01N27/416
CPC分类号： G01N33/54366 , G01N27/305 , G01N27/3277 , G01N33/54306
摘要： PROBLEM TO BE SOLVED: To increase the current flowing between a working electrode and a counter electrode, in order to improve the detection sensitivity for an analyte, by promoting reduction reaction of an electrolyte, using a reducing electrode which is disposed on a test chip and reducing the electrolyte.
SOLUTION: A method for specifically detecting the analyte is provided, which employs the test chip 4, includes: the working electrode 21 equipped with a conductive layer 32 and an electron acceptor layer 33; a probe 34 fixed on the electron acceptor layer 33; the counter electrode 24; and the reducing electrode 26. A sample containing the analyte 42 is applied to the test chip 4, and the analyte 42 is captured by the probe 34. Then, a coloring matter 41 of the analyte 42, captured by the probe 34, is irradiated with a light, in a state such that the working electrode 21, the counter electrode 24 and the reduction electrode 26 come into contact with an electrolytic solution 43 containing the electrolyte; and the current flowing between the working electrode 21 and the counter electrode 24, which is caused by the electron migration from the coloring matter 41 excited by the light to the working electrode 21, is measured with an ammeter 6. The reducing electrode 26 promotes the reduction reaction of the electrolyte contained in the electrolytic solution 43.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题为了增加工作电极和对电极之间的电流，为了提高分析物的检测灵敏度，通过促进电解质的还原反应，使用设置在电极上的还原电极测试芯片并减少电解液。提供了一种用于特异性检测分析物的方法，其采用测试芯片4，包括：装备有导电层32和电子受体层33的工作电极21; 固定在电子受体层33上的探针34; 对电极24; 和还原电极26.将含有分析物42的样品施加到测试芯片4，并且通过探针34捕获分析物42。然后，由探针34捕获的分析物42的着色物质41被照射在使工作电极21，对电极24和还原电极26与含有电解质的电解液43接触的状态下具有光，并且由电流计6测量由通过光激发的色素41向工作电极21的电子迁移而引起的工作电极21与对电极24之间的电流。还原电极26促进了包含在电解液43中的电解质的还原反应。版权所有（C）2010，JPO＆INPIT

8. 发明专利

JP2012233878A Electrochemical detection method for a test substance 审中-公开
标题翻译：用于测试物质的电化学检测方法
公开(公告)号：JP2012233878A
公开(公告)日：2012-11-29
申请号：JP2012075914
申请日：2012-03-29
申请人： Sysmex Corp , シスメックス株式会社
发明人： SUZUKI SEIGO , KIRIMURA HIROYA , SEIKE SEIKA , IWANAGA SHIGEKI , HORI NOBUYASU
IPC分类号： G01N27/327 , G01N27/416
摘要： PROBLEM TO BE SOLVED: To provide an electrochemical detection method for a specimen that can detect a test substance with high sensitivity.SOLUTION: When labeling and detecting the test substance S captured on a working electrode, there is formed a complex containing a label binding substance 90 in which a labeling substance 93 is held via a modification substance 92 that interacts with a working electrode section other than a section where an electrolyte and a capture substance are bound to the test substance S and a binding substance 91 that binds to the test substance S. Then the labeling substance 93 on the working electrode 60 is electro chemically detected.
摘要翻译：要解决的问题：提供能够以高灵敏度检测被检物质的试样的电化学检测方法。解决方案：当标记和检测在工作电极上捕获的测试物质S时，形成了一种复合体，其含有标签结合物质90，其中通过与工作电极部分相互作用的修饰物质92保持标记物质93 除了电解质和捕获物质与测试物质S结合的部分和与测试物质S结合的结合物质91之外。然后对工作电极60上的标记物质93进行电化学检测。版权所有（C）2013，JPO＆INPIT

9. 发明专利

JP2012225885A Electrochemical detection method for test substance 有权
标题翻译：用于测试物质的电化学检测方法
公开(公告)号：JP2012225885A
公开(公告)日：2012-11-15
申请号：JP2011096341
申请日：2011-04-22
申请人： Nara Institute Of Science & Technology , Sysmex Corp , シスメックス株式会社 , 国立大学法人奈良先端科学技術大学院大学
发明人： URAOKA YUKIHARU , JEONG BIN , SUZUKI SEIGO , KIRIMURA HIROYA , SEIKE SEIKA , IWANAGA SHIGEKI , HORI NOBUYASU
IPC分类号： G01N27/416 , G01N27/327 , G01N33/53 , G01N33/536
摘要： PROBLEM TO BE SOLVED: To provide an electrochemical detection method for a test substance, capable of detecting the test substance with high detection sensitivity.SOLUTION: In detecting a test substance S captured on a working electrode, a marker combined substance 90 which at least retains a marker substance 93 and a first binding substance 92 for capturing the test substance S on a substrate 91 of polypeptide comes in contact with the test substance. The marker substance existing on the working electrode is then electrochemically detected.

10. 发明专利

JP2012068235A Electrochemical detection method of detection substance, electrochemical detection method of test substance and detection set 有权
标题翻译：检测物质的电化学检测方法，检测物质和检测装置的电化学检测方法
公开(公告)号：JP2012068235A
公开(公告)日：2012-04-05
申请号：JP2011177514
申请日：2011-08-15
申请人： Sysmex Corp , シスメックス株式会社
发明人： SEIKE SEIKA , HORI NOBUYASU , SUZUKI SEIGO , IWANAGA SHIGEKI , KIRIMURA HIROYA
IPC分类号： G01N27/416 , G01N21/76 , G01N27/30
CPC分类号： G01N27/3278 , G01N27/745
摘要： PROBLEM TO BE SOLVED: To provide an electrochemical detection method of a detection substance, an electrochemical detection method of a test substance and a detection set, having principle merits in measurement sensitivity or the like obtained by a conventional electrochemical detection method using a working electrode on which a capture substance is fixed, and capable of reusing the working electrode or detecting the test substance independently of a size of the test substance.SOLUTION: A detection substance containing a marker substance in a liquid sample is induced to a working electrode 121 in which a capture substance for capturing the detection substance containing the marker substance does not exist, and the detection substance containing the marker substance is electrochemically detected.
摘要翻译：要解决的问题：提供检测物质的电化学检测方法，测试物质的电化学检测方法和检测装置，其具有通过使用以下的常规电化学检测方法获得的测量灵敏度等的主要优点固定有捕获物质的工作电极，能够独立于检测物质的大小重新使用工作电极或检测检测物质。解决方案：将含有液体样品中的标记物质的检测物质诱导到其中不存在含有标记物质的检测物质的捕获物质的工作电极121，含有标记物质的检测物质为电化学检测。版权所有（C）2012，JPO＆INPIT

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