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1. 发明专利

JP2008120835A Cure accelerator for corneal disorder symptom 有权
标题翻译：矫正加速器用于角膜疾病症状
公开(公告)号：JP2008120835A
公开(公告)日：2008-05-29
申请号：JP2008035906
申请日：2008-02-18
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： MIYAUCHI SATOSHI , TAKAHASHI KATSUYA , MATSUZAKA SATOSHI , MORITA MIKA , MIYAZAKI TATSUYA
IPC分类号： A61K31/726 , A61K31/727 , A61K38/17 , A61P27/02 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a cure accelerator effectively accelerating cure of corneal disorder symptom including an intractable corneal disorder apt to prolong, and having high safety. SOLUTION: The cure accelerator for corneal disorder symptom includes glycosamine, its derivative or their pharmacologically acceptable salt as an active ingredient. The cure accelerator for corneal disorder symptom includes a sugar chain having glycosamine having a sulfate group or its derivative as a constituent monosaccharide, its derivative or their pharmacologically approvable salt as an active ingredient. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种治愈促进剂有效加速角膜疾病症状的治愈，包括易于延长并具有高安全性的难治性角膜疾病。解决方案：角膜障碍症状的治疗促进剂包括糖胺，其衍生物或其药理学上可接受的盐作为活性成分。角膜疾病症状的治疗促进剂包括具有硫酸基团的糖胺或其衍生物作为构成单糖，其衍生物或其药理学上可认可的盐作为活性成分的糖链。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JP2000202024A INJECTION APPARATUS FOR HIGHLY VISCOELASTIC SUBSTANCE 失效
公开(公告)号：JP2000202024A
公开(公告)日：2000-07-25
申请号：JP612599
申请日：1999-01-13
申请人： SEIKAGAKU KOGYO CO LTD
发明人： HIRABAYASHI SHIGERU , TAKAHASHI KATSUYA
IPC分类号： A61M3/00 , B05C5/02 , B05C17/005 , B05C17/01
摘要： PROBLEM TO BE SOLVED: To provide an injection apparatus which is ideal for the injection or injection and application of a highly viscoelastic substance for medical use in vivo after the operation or the like. SOLUTION: This injection apparatus is constituted of a syringe 1 filled with a highly viscoelastic substance such as hyaluronic acid or the like, a tubular applicator 2 to be inserted in vivo and a power assist 3 loaded with the syringe 1. The power assist 3 has a syringe fixing means 5 attached to a body 31, a rod 4 to force a gasket 11 of the syringe 1 by the operation of gripping a lever 34 and an applicator support mechanism 6 to regulate movement in each direction at the base end part of the applicator 2.

3. 发明专利

JPH10287570A CURATIVE PROMOTER FOR KERATOPATHY 失效
公开(公告)号：JPH10287570A
公开(公告)日：1998-10-27
申请号：JP9076097
申请日：1997-04-09
申请人： SEIKAGAKU KOGYO CO LTD
发明人： MIYAUCHI SATOSHI , TAKAHASHI KATSUYA , MATSUZAKA SATOSHI , MORITA MIKA , MIYAZAKI TATSUYA
IPC分类号： A61K38/16 , A61K31/70 , A61K31/715 , A61P27/02 , A61K31/725
摘要： PROBLEM TO BE SOLVED: To obtain a curative promoter for keratopathy of high safety that can effectively promote the cure of keratopathy including refractory keratopathy by using a specific amino sugar as an active ingredient. SOLUTION: This curative promoter for keratopathy contains a glycosamine or its derivative or their pharmacologically acceptable salts as an active ingredient. The glycosamine is preferably glucosamine, galactosamine or mannosamine. The glycosamine derivative is preferably N-acylglycosamine, N-sulfated glycosamine derivative and the like. The addition of a substance such as uronic acid to the glycosamine or its derivatives promotes its effects. In addition, this promoter may contain a saccharide chain or its derivative or their salts having a glycosamine bearing a sulfate group or its derivative as a constitution unit.

4. 发明专利

JP2009298798A Agent for applying to mucosa and its production method 有权
标题翻译：适用于MUCOSA及其生产方法的代理
公开(公告)号：JP2009298798A
公开(公告)日：2009-12-24
申请号：JP2009186548
申请日：2009-08-11
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： MIYAMOTO KENJI , TAKAHASHI KATSUYA , SHIMOJIMA YUJI
IPC分类号： A61K31/726 , A61K31/728 , A61K31/729 , A61P1/00 , A61P13/10 , A61P27/02
CPC分类号： A61K31/7008 , A61K9/0034 , A61K9/0048 , A61K9/006 , A61K31/726 , A61K31/728 , A61K47/61 , A61K49/0043 , A61K49/0054
摘要： PROBLEM TO BE SOLVED: To provide an agent for applying to the mucosa, which can persistently exert therapeutic effects on disorders such as inflammation and lesions in the mucosa even by low-frequency administration because the agent can stay at a diseased site for a long period of time by exhibiting high retentivity in a mucosal epithelial layer. SOLUTION: The agent contains, as an active component, a glycosaminoglycan (GAG) introduced with a hydrophobic group through a bonding chain. The glycosaminoglycan is selected from hyaluronic acid, chondroitin, chondroitin sulfate, heparin, heparan sulfate, dermatan sulfate and keratan sulfate including their salts. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供一种施用于粘膜的药剂，其可以持续地对疾病如粘膜中的炎症和损伤施加治疗效果，即使通过低频给药，因为该药剂可以停留在患病部位通过在粘膜上皮层中表现出高的保持性，长时间地存在。解决方案：该试剂作为活性组分含有通过键合链引入疏水基团的糖胺聚糖（GAG）。糖胺聚糖选自透明质酸，软骨素，硫酸软骨素，肝素，硫酸乙酰肝素，硫酸皮肤素和硫酸角质素，包括它们的盐。版权所有（C）2010，JPO＆INPIT

5. 发明专利

JP2004002369A Pharmaceutical composition 有权
公开(公告)号：JP2004002369A
公开(公告)日：2004-01-08
申请号：JP2003102368
申请日：2003-04-07
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： MIYAUCHI SATOSHI , SAKUMA MAKOTO , TAWADA AKIRA , SAITO KAZUKO , TAKAHASHI KATSUYA
IPC分类号： A61K31/737 , A61K31/7008 , A61P17/02 , A61P27/02
摘要： PROBLEM TO BE SOLVED: To provide a substance exhibiting wound-healing promoting action and more useful as a medicine than a conventional medicine and a medicine using the substance.
SOLUTION: The present invention provides a composition composed of heparan sulfate and glucosamine, and a glucosamine salt of heparan sulfate, based on expression of synergistic wound-healing effect obtained when heparan sulfate and glucosamine are administered at the same time and also provides a medicine using these substances as active ingredients, particularly a medicine useful for healing diseases accompanying damages in skin, mucous membrane, corneal upper cortex, etc.
COPYRIGHT: (C)2004,JPO

6. 发明专利

JP2014237704A 関節疾患に対する持続的治療効果を有する薬剤有权
标题翻译：具有治疗性疾病的药物治疗
公开(公告)号：JP2014237704A
公开(公告)日：2014-12-18
申请号：JP2014165127
申请日：2014-08-14
申请人：生化学工業株式会社 , Seikagaku Kogyo Co Ltd
发明人： MIYAMOTO KENJI , YOSHIOKA KEIJI , TAKAHASHI KATSUYA
IPC分类号： A61K31/728 , A61P19/02 , A61P25/04
CPC分类号： A61K31/728 , A61K9/0019 , A61K9/06 , A61K31/738 , A61K47/02 , C08B37/0072
摘要：【課題】1回の注射により、持続的鎮痛効果、長い間の軟骨の保護効果及び抗炎症効果を有する医薬を提供する。【解決手段】ヒアルロン酸の官能基の一部が、架橋点0.6%〜15%で架橋基により架橋された架橋ヒアルロン酸誘導体を、活性成分として、長期に持続する鎮痛効果を示すような量で含有し、更に薬理的に許容しうる担体とから成る関節疾患治療用の関節内投与のための注射溶液、並びに、それぞれ、架橋ヒアルロン酸誘導体と薬理的に許容しうる担体とからなる、関節疾患により引き起こされる軟骨変性を抑制するための鎮痛組成物または関節疾患により引き起こされる軟骨変性または滑膜炎症を抑制するための組成物。【選択図】なし
摘要翻译：要解决的问题：提供具有持续的止痛效果的药物，长期保护软骨的作用和通过单次注射的抗炎作用。解决方案：关节内给药用于治疗关节疾病的注射溶液含有交联透明质酸衍生物，其中透明质酸官能团的一部分通过交联基团在交联点以0.6％至15％的交联度以长时间作为活性成分显示持久的止痛效果的量交联，此外由药理学可接受的载体组成。用于抑制由关节疾病引起的软骨变性的抑制组合物或用于抑制由关节疾病引起的软骨变性或滑膜炎症的组合物，各自由交联的透明质酸衍生物和药理学上可接受的载体组成。

7. 发明专利

JP2012211171A Agent for applying to mucosa and method for production thereof 审中-公开
标题翻译：适用于MUCOSA的代理及其生产方法
公开(公告)号：JP2012211171A
公开(公告)日：2012-11-01
申请号：JP2012144630
申请日：2012-06-27
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： MIYAMOTO KENJI , TAKAHASHI KATSUYA , SHIMOJIMA YUJI
IPC分类号： A61K31/728 , A61P27/02
CPC分类号： A61K31/7008 , A61K9/0034 , A61K9/0048 , A61K9/006 , A61K31/726 , A61K31/728 , A61K47/61 , A61K49/0043 , A61K49/0054
摘要： PROBLEM TO BE SOLVED: To provide an agent for applying to a mucosa which exhibits retentivity and therapeutic effects in the mucosa.SOLUTION: A composition contains "a hydrophobic group binding type glycosaminoglycan" as an active ingredient which is obtained by binding a hydrophobic group to a glycosaminoglycan (GAG) represented by a hyaluronic acid via a binding chain.

8. 发明专利

JP2013209417A Pharmaceutical agent having long-lasting effect of treating arthritic disorder 有权
标题翻译：具有治疗神经疾病长期作用的药物代理
公开(公告)号：JP2013209417A
公开(公告)日：2013-10-10
申请号：JP2013120712
申请日：2013-06-07
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： MIYAMOTO KENJI , YOSHIOKA KEIJI , TAKAHASHI KATSUYA
IPC分类号： A61K31/728 , A61K9/08 , A61K47/36 , A61P19/02 , A61P25/04 , A61P29/00
CPC分类号： A61K31/728 , A61K9/0019 , A61K9/06 , A61K31/738 , A61K47/02 , C08B37/0072
摘要： PROBLEM TO BE SOLVED: To provide pharmaceutical products having a long-lasting analgesic effect, a cartilage protective effect, and an anti-inflammatory effect for a long term by a single injection.SOLUTION: A solution comprises a cross-linked hyaluronic acid derivative wherein part of functional groups of a hyaluronic acid are cross-linked with a cross-linking group to the cross-linking extent of 1 to 7.5% based on a total number of constituent disaccharide unit of hyaluronic acid, wherein the cross-linking group is a residue of cinnamic acid or cinnamic acid derivatives, a degree of substitution of the cross-linking group is from 10% to 25%, and a degree of cross-linking in the cross-linked hyaluronic acid derivative is from 10% to 30%.
摘要翻译：待解决的问题：通过单次注射提供具有持久的镇痛作用，软骨保护作用和长期抗炎作用的药物产品。溶液：溶液包含交联的透明质酸衍生物，其中基于透明质酸的构成二糖单元的总数，透明质酸的官能团的一部分与交联基团交联，交联度为1〜7.5％，其中交联基团为肉桂酸或肉桂酸衍生物的残基，交联基团的取代度为10〜25％，交联透明质酸衍生物的交联度为10〜30％。

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