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1. 发明专利

JP2004361144A Method for detecting cartilage-type fibronectin and method for detecting cartilage tumor 有权
公开(公告)号：JP2004361144A
公开(公告)日：2004-12-24
申请号：JP2003157258
申请日：2003-06-02
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： SEKIGUCHI KIYOTOSHI , OZAKI TOMOHIRO , KIMATA HIROHARU , SUGIURA NOBUO
IPC分类号： G01N33/53 , C12N15/09 , G01N33/566 , G01N33/68
摘要： PROBLEM TO BE SOLVED: To provide a method for searching for a substance having specific affinity to the cartilage-type fibronectin and detecting cartilage-type fibronectin by using the substance, and a method for detecting tumor by using the same method.
SOLUTION: The method for detecting cartilage-type fibronectin comprising, at least: (1) a process for bringing cartilage-type fibronectin in a specimen into contact with chondroitin sulfate E, and (2) a process for detecting a compound material of cartilage-type fibronectin and chondroitin sulfate E produced by the contact, the method for detecting tumor for associating a detection result by such a detection method with the existence of cartilage tumor, and anticartilage-type fibronectin monoclonal antibody for specifically recognizing anticartilage-type fibronectin, are included.
COPYRIGHT: (C)2005,JPO&NCIPI

2. 发明专利

JP2002209586A DNA ENCODING TRANSMEMBRANE DOMAIN-LACKING TYPE N- ACETYLGLUCOSAMINE DEACETYLATION ENZYME 失效
公开(公告)号：JP2002209586A
公开(公告)日：2002-07-30
申请号：JP2001009121
申请日：2001-01-17
申请人： SEIKAGAKU KOGYO CO LTD
发明人： SUGIURA NOBUO , KIMATA HIROHARU
IPC分类号： C12N15/09 , C12N1/21 , C12N9/10 , C12R1/19
摘要： PROBLEM TO BE SOLVED: To efficiently obtain an N-acetylglucosamine deacetylation enzyme. SOLUTION: This DNA encoding the partial polypeptide of the polypeptide of an N-acetylglucosamine N-deacetylation-N-sulfate group transfer enzyme is characterized in that the partial polypeptide obtained by inserting the DNA into an expression vector and then expressing the partial polypeptide does not have the N-terminal domain and C-terminal domain of the polypeptide of the N-acetylglucosamine N-deacetylation-N-sulfate group transfer enzyme in such an extent as capable of having an action for deacetylating the N- acetylglucosamine residue of a sugar chain having a heparin skeleton. A host cell is transformed with an expression vector containing the DNA, and the obtained transformant is cultured.

3. 发明专利

JPH0672893A ANTIRHEUMATIC AGENT 失效
公开(公告)号：JPH0672893A
公开(公告)日：1994-03-15
申请号：JP20355892
申请日：1992-07-30
申请人： SEIKAGAKU KOGYO CO LTD
发明人： AOKI SHIGEHISA , IWASAKI SHINICHI , SUGIURA NOBUO , SUZUKI AKIRA , KIMATA HIROHARU
IPC分类号： A61K31/715 , A61K9/48 , A61K31/661 , A61K31/726 , A61K31/728 , A61P29/00 , C07H5/06 , A61K37/20
摘要： PURPOSE:To obtain the subject medicine useful for treating rheumatoid arthritis, having high therapeutic effects free from side effects, comprising a substance prepared by linking a glucosaminoglycan such as chondroitin sulfate to a lipid such as phosphatidylethanolamine. CONSTITUTION:A glucosaminoglycan or its salt such as chondroitin sulfate or hyaluronic acid is dissolved in water, reacted with 0.1M aqueous solution of iodine in methanol at room temperature for 6 hours. The reaction solution is mixed with 0.1N aqueous solution of potassium hydroxide, passed through a strongly acidic ion exchange resin column and desalted to give an aqueous solution of lactone glucosaminoglycan containing a reduced end, which is reacted with tri-n-butylamine and a lipid such as dipalmitoyl-L-alpha-phosphatidyl) ethanolamine at 70 deg.C for 2 hours to give the objective antirheumatic agent comprising a lipid-linked glucosaminoglycan effective for treating rheumatoid arthritis, having high therapeutic effects and no side effects.

4. 发明专利

JP2004170194A Screening method of glycosaminoglycan bonding material 审中-公开
公开(公告)号：JP2004170194A
公开(公告)日：2004-06-17
申请号：JP2002335298
申请日：2002-11-19
申请人： Japan Science & Technology Agency , Seikagaku Kogyo Co Ltd , 独立行政法人科学技術振興機構 , 生化学工業株式会社
发明人： MANABE RIICHIRO , SEKIGUCHI KIYOTOSHI , KIMATA HIROHARU , SUGIURA NOBUO
IPC分类号： G01N33/50 , C07K14/47 , C12N5/10 , C12N15/09 , C12R1/91 , G01N33/15 , G01N33/53 , G01N33/566
摘要： PROBLEM TO BE SOLVED: To provide a new means for screening a glycosaminoglycan bonding material. SOLUTION: A screening method of the glycosaminoglycan bonding material uses a fat bonding glycosaminoglycan having fat bonded to the glycosaminoglycan for a glycosaminoglycan bonding material acquisition material, and has processes (1), (2). In the process (1), the glycosaminoglycan bonding material in a specimen and a fat bonding glycosaminoglycan complex is brought into contacts. In the process (2), a complex of the glycosaminoglycan bonding material and the fat bonding glycosaminoglycan generated by the contact is detected. COPYRIGHT: (C)2004,JPO

5. 发明专利

JP2003335801A Process for producing lipid-linked glycosaminoglycan 有权
标题翻译：用于生产脂质连接的糖蛋白酶的方法
公开(公告)号：JP2003335801A
公开(公告)日：2003-11-28
申请号：JP2002143898
申请日：2002-05-17
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： SUGIURA NOBUO , KANEDA YUJI
IPC分类号： C08B37/08 , C08B37/10
摘要： PROBLEM TO BE SOLVED: To provide a process for producing a lipid-linked glycosaminoglycan in which a lipid is covalently bonded to a reducing end of a glycosaminoglycan through an aminoalkyl bond in a good yield and with high purity.
SOLUTION: The process for producing the lipid-linked glycosaminoglycan comprises reacting an organic solvent-solubilized salt of the glycosaminoglycan and the lipid having a primary amino group in a polar organic solvent in which both the organic solvent-solubilized salt of the glycosaminoglycan and the lipid can be dissolved under the water-free condition in the presence of a reducing agent to form the aminoalkyl bond of a sugar aldehyde group at a reducing end of the glycosaminoglycan with the primary amino group of the lipid.
COPYRIGHT: (C)2004,JPO
摘要翻译：待解决的问题：提供一种脂质连接的糖胺聚糖的制备方法，其中脂质通过氨基烷基键以高收率和高纯度共价键合到糖胺聚糖的还原端。生产脂质连接的糖胺聚糖的方法包括使糖胺聚糖的有机溶剂溶解盐和具有伯氨基的脂质在极性有机溶剂中反应，其中糖胺聚糖的有机溶剂溶解盐脂肪可以在无水条件下在还原剂的存在下溶解，在糖胺聚糖的还原端与脂质的伯氨基形成糖醛基的氨基烷基键。版权所有（C）2004，JPO

6. 发明专利

JP2005323506A Protein having hyaluronic acid-synthesizing activity and method for producing hyaluronic acid 审中-公开
标题翻译：具有合成ACA合成活性的蛋白质和产生羟丙酸的方法
公开(公告)号：JP2005323506A
公开(公告)日：2005-11-24
申请号：JP2004141992
申请日：2004-05-12
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： WATANABE MASANORI , ITANO NAOKI , SUGIURA NOBUO
IPC分类号： C12N15/09 , C12N5/10 , C12N7/00 , C12N9/00 , C12P19/26
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide a protein having a hyaluronic acid-synthesizing activity, a new nuclear polyhedrosis virus capable of being applied for the efficient production of hyaluronic acid, insect cells useful for the effective production of the protein having the hyaluronic acid-synthesizing activity or hyaluronic acid, an efficient method for producing the protein having the hyaluronic acid-producing activity and an efficient method for producing hyaluronic acid. SOLUTION: The nuclear polyhedrosis virus holding the DNA encoding the protein having the hyaluronic acid-synthesizing activity, insect-derived cells holding the virus and method for producing the protein having the hyaluronic acid-synthesizing activity by using the cells, and method for producing the hyaluronic acid are provided. As "the DNA encoding the protein having the hyaluronic acid-synthesizing activity", to begin with a DNA encoding the protein consisting of an amino acid sequence expressed by sequence number 2 in a table of sequences (in the specification), and the DNAs having a comparable function with the above can be cited. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：为了提供具有透明质酸合成活性的蛋白质，能够用于有效生产透明质酸的新的核多角体病毒，可用于有效生产具有透明质酸的蛋白质的昆虫细胞酸合成活性或透明质酸，这是生产具有透明质酸产生活性的蛋白质的有效方法和生产透明质酸的有效方法。解决方案：保持编码具有透明质酸合成活性的蛋白质的DNA的核型多角体病毒，携带病毒的昆虫来源的细胞和使用该细胞产生具有透明质酸合成活性的蛋白质的方法以及方法用于制备透明质酸。作为“编码具有透明质酸合成活性的蛋白质的DNA”，开始于编码由序列号（说明书）中的序列号2表示的氨基酸序列组成的蛋白质的DNA，以及具有可以引用与上述相似的功能。版权所有（C）2006，JPO＆NCIPI

7. 发明专利

JPH0930979A THERAPEUTIC AGENT FOR NEUROPATHY 失效
公开(公告)号：JPH0930979A
公开(公告)日：1997-02-04
申请号：JP20740495
申请日：1995-07-24
申请人： SEIKAGAKU KOGYO CO LTD
发明人： SUGIURA NOBUO , KUSHIMA YOICHI , OHIRA ATSUHIKO , KIMATA HIROHARU , GOTO SACHIKO
IPC分类号： C08B37/08 , A61K31/715 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/28 , A61K31/725 , A61K31/73
摘要： PROBLEM TO BE SOLVED: To obtain the subject therapeutic agent comprising a lipid-bonded glycosaminoglycan (lipid bonded GAG) or its salt as an active ingredient, having stretching promoting effect on neurite and recovery promoting action on neurological function, being expected to have reproducing effect on nerve fiber, etc., having extremely low toxicity. SOLUTION: This therapeutic agent for neuropathy comprises a lipid-bonded glycosaminoglycan (lipid bonded GAG) or its salt as an active ingredient, The lipid bonded GAG, for example, is obtained by specifically cleaving a pyranose ring at the reduced end of GAG by oxidizing the saccharide reside at the reduced end of GAG to form carboxyl at the reduced end, subjecting the resultant substance to a lactone formation reaction, then reacting the lactone with a primary amine of a lipid to bond GAG to the lipid by covalent bond. Chondroitin sulfate, hyaluronic acid, and their salts are preferable as GAG of raw material. A primary amino-containing phospholipid is preferable as the lipid. Dipalmitoyl- L-(α-phosphatidyl)ethanolamine-bonded hyaluronic acid, etc., are preferable as the lipid-bonded GAG. palmitoyl. phosphatidyl.

8. 发明专利

JPH0480202A GLYCOSAMINOGLYCAN BONDED TO PHOSPHOLIPID 失效
公开(公告)号：JPH0480202A
公开(公告)日：1992-03-13
申请号：JP19381890
申请日：1990-07-24
申请人： SEIKAGAKU KOGYO CO LTD
发明人： SAKURAI KATSUKIYO , SUGIURA NOBUO , KIMATA HIROHARU , SUZUKI AKIRA
IPC分类号： C08B37/08 , A61K31/00 , A61K31/715 , A61P35/00 , C08B37/10
摘要： PURPOSE:To prevent adhesion of cancerous cells to hemangioendotheliocytes or ectocytic matrices and make use as a preventive of cancerus metastasis by providing a phospholipid having a specific structural formula. CONSTITUTION:Glycosaminoglycan is reduced and partially oxidized to thereby cause bond cleavage, giving an aldehyde, which is reacted with a phospholipid having a primary amino group to give (a salt of) a phospholipid-bonded glycosaminoglycan of the formula [wherein P is a phospholipid having a primary amino group; when GAG is a glycosaminoglycan residue formed by removing a glucuronic acid part having a reducing terminal group from hyaluronic acid, chondroitin (sulfate A, C, or E), dermatan sulfate, heparin, or heparan sulfate or when GAG is a glycosaminoglycan residue formed by removing an iduronic acid part having a reducing terminal group from dermatan sulfate, GAG is attached to the 4-position and R to the 3-position; R is COOH; and R is OH].

9. 发明专利

JP2005065565A Modified enzyme 审中-公开
标题翻译：改良酶
公开(公告)号：JP2005065565A
公开(公告)日：2005-03-17
申请号：JP2003298899
申请日：2003-08-22
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： NINOMIYA MASAO , SUGIURA NOBUO , KIMATA HIROHARU
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00
摘要： PROBLEM TO BE SOLVED: To obtain a variant useful for elucidating the function of Escherichia coli-derived chondroitin synthase. SOLUTION: The modified enzyme of chondroitin synthase has properties of (a) transferring GlcUA (GlcUA is D-glucuronic acid) from a GlcUA donor to the non-reducing terminal of sugar chain and (b) substantially having no action of transferring GalNAc (N-acetyl-D-galactosamine) from a GalNAc donor to the non-reducing terminal of sugar chain or (c) transferring GalNAc from a GalNAc donor to the non-reducing terminal of sugar chain and (d) substantially having no action of transferring GlcUA from a GlcUA donor to the non-reducing terminal of sugar chain and has substitution of one-several amino acids. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：获得用于阐明大肠杆菌来源的软骨素合成酶的功能的变体。软骨素合成酶的修饰酶具有（a）将GlcUA（GlcUA为D-葡糖醛酸）从GlcUA供体转移至糖链的非还原末端的特性，（b）基本上不具有转移作用 GalNAc（N-乙酰基-D-半乳糖胺）从GalNAc供体到糖链的非还原末端，或（c）将GalNAc从GalNAc供体转移到糖链的非还原末端，（d）基本上没有作用将GlcUA从GlcUA供体转移到糖链的非还原末端，并取代一个氨基酸。版权所有（C）2005，JPO＆NCIPI

10. 发明专利

JP2003199583A CHONDROITIN SYNTHETASE AND DNA ENCODING THE SAME 审中-公开
公开(公告)号：JP2003199583A
公开(公告)日：2003-07-15
申请号：JP2002103136
申请日：2002-04-05
申请人： SEIKAGAKU KOGYO CO LTD
发明人： NINOMIYA MASAO , SUGIURA NOBUO , KIMATA HIROHARU
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N15/31 , C12N15/54 , C12P19/18 , C12P19/26 , C12R1/19
摘要： PROBLEM TO BE SOLVED: To provide a new chondroitin synthase and a DNA, etc., encoding the same. SOLUTION: This chondroitin synthase having the following properties is provided. (1) Transferring a GlcUA from a GlcUA-donor and a GalNAc from a GalNAc-donor alternately to a non reduced terminal of a sugar chain. (2) Transferring the GlcUA from the GlcUA-donor to an oligo-sugar having the GalNAc at its non-reduced terminal and a chondroitin skeleton, but not substantially transferring the GalNAc from the GalNAc-donor. Transferring GalNAc from the GalNAc-donor to the oligo-sugar having the GlcUA at the non-reduced terminal, but not substantially transfer the GlcUA from the GlcUA-donor. (3) Acting in the presence of Mn 2+ ion, and not substantially acting in the presence of Ca 2+ , Cu 2+ ion or EDTA. COPYRIGHT: (C)2003,JPO

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