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1. 发明专利

JPH0834801A POLYSACCHARIDE SULFATE AND PRODUCTION THEREOF 失效
公开(公告)号：JPH0834801A
公开(公告)日：1996-02-06
申请号：JP17120894
申请日：1994-07-22
申请人： SEIKAGAKU KOGYO CO LTD , MITSUBISHI CHEM CORP
发明人： ASHIKARI TOMOKO , HANEBUCHI HIROKO , KIMATA HIROHARU
IPC分类号： C08B37/00 , A61K31/715 , A61P1/16
摘要： PURPOSE:To obtain a polysaccharide sulfate having a specific affinity for the growth factor of liver parenchima cells and a consequent improved pharmacological effect on the cells by selecting a polysaccharide sulfate containing specified sugar unit structures. CONSTITUTION:This sulfate is a polysaccharide sulfate at least partially consisting of structural units of an octasaccharide or higher saccharides having an affinity for the growth factor of liver parenchima cells. This is obtained for example by bringing a mixture of heparin or heparan sulfate, products of their partial decomposition or products of their limited decomposition into contact with an affinity support to which the growth factor of liver parenchima cells is bonded as a ligand and separating the product into a fraction having an affinity for the growth factor and a fraction having no affinity therefor. The structural unit comprises hexuronic acid and hexosamine or an N-acetyl- substituted product thereof and contains at least four sulfated disaccharide unit structures.

2. 发明专利

JP2002020293A TREATING AGENT FOR CHLAMYDIA INFECTION 失效
公开(公告)号：JP2002020293A
公开(公告)日：2002-01-23
申请号：JP2000197359
申请日：2000-06-29
申请人： SEIKAGAKU KOGYO CO LTD
发明人： YABUSHITA HIROMITSU , NOGUCHI MASAYOSHI , HANEBUCHI HIROKO , KIMATA HIROHARU
IPC分类号： C12Q1/04 , A61K31/726 , A61K31/727 , A61P15/02 , A61P31/04 , C08B37/00 , C08B37/10
摘要： PROBLEM TO BE SOLVED: To obtain a medicine usable for preventing and treating chlamydia infection, having safety and almost no problem such as side effect, etc., in application to the human body. SOLUTION: In a sulfate glycosaminoglycan comprising a repeating unit of a disaccharide unit composed of a hexuronic acid residue and hexosamine residue as a basic skeleton, the chlamydia infection comprises a sulfate glycosaminoglycan containing no sulfate group at hydroxy group at the 2- positions of the whole or a part of hexuronic acid residue or its salt.

3. 发明专利

JPH0789979A S-BETA-D-XYLOPYRANOSIDE COMPOUND 失效
公开(公告)号：JPH0789979A
公开(公告)日：1995-04-04
申请号：JP23312393
申请日：1993-09-20
申请人： SEIKAGAKU KOGYO CO LTD
发明人： SUZUKI AKIRA , SAKURAI KATSUKIYO , HANEBUCHI HIROKO
IPC分类号： C07H15/203 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61P7/02 , A61P9/10 , A61P29/00 , A61P35/00
摘要： PURPOSE:To provide a novel S-beta-D-xylopyranoside compound capable of varying the quality and quantity of complex carbohydrates of a cell and having carcinostatic effect, arteriosclerosis suppressing effect, thrombogenesis suppressing effect, etc. CONSTITUTION:A compound of the formula I [R is naphthalene ringcontaining group of the formula II (X is NH2, SO3H, NO3, halogen, OH or COOH); R is H or lower alkanoyl), concretely 1-naphthalenethiol-beta-D-xylopyranoside. It can be produced preferably by acetylating D-xylose, treating with aluminum chloride, reacting the obtained compound with thionaphthol sodium salt in an acetone solution, dissolving the reaction product in methanol and adding a small amount of sodium hydroxide to carry out the deacetylation of the product and obtain the compound of the formula III, etc.

4. 发明专利

JP2002327002A OLIGOSACCHARIDE HAVING SULFATE GROUP 审中-公开
公开(公告)号：JP2002327002A
公开(公告)日：2002-11-15
申请号：JP2001238952
申请日：2001-08-07
申请人： SEIKAGAKU KOGYO CO LTD
发明人： HANEDA TOMOKO , HANEBUCHI HIROKO , KIMATA HIROHARU
IPC分类号： C12P19/44 , A61K31/727 , A61P43/00 , C08B37/10
摘要： PROBLEM TO BE SOLVED: To provide a novel oligosaccharide having a heparin skeleton. SOLUTION: The oligosaccharide having the heparin skeleton of 6-14 saccharides comprising an uronic acid residue and a glucosamine residue, in which neither hydroxy group at 2-position of the former nor 6-position of the latter is subjected to a sulfuric esterification, is treated with a heparan sulfate 2-O-sulfate group transferase or a heparan sulfate 6-O-sulfate group transferase.

5. 发明专利

JPH0928374A HEPARAN SULFATE 2-O-SULFOTRANSFERASE 失效
公开(公告)号：JPH0928374A
公开(公告)日：1997-02-04
申请号：JP18757795
申请日：1995-07-24
申请人： SEIKAGAKU KOGYO CO LTD
发明人： KOBAYASHI MASA , HANEBUCHI HIROKO , HANEBUCHI OSAMI , KIMATA HIROHARU
IPC分类号： C12N9/10 , C12R1/91
摘要： PROBLEM TO BE SOLVED: To obtain a heparan sulfate 2-O-sulfotransferase capable of selectively introducing sulfate group into the 2-position of iduronic acid residue of heparin and the heparan sulfate. SOLUTION: This heparan sulfate 2-O-sulfotransferase having the following properties is collected from a CHO cell (ATCC CCL6l), etc., (1) action: selectively transferring sulfate group from a sulfate donor to hydroxyl group at the 2-position of iduronic acid residue; (2) substrate specificity: transferring the sulfate group to heparan sulfate or an N,O-desulfated and N-resulfated heparin (CDSNS-heparin) without transferring the sulfate group to chondroitin, chondroitin sulfate, dermatan sulfate and keratan sulfate; (3) optimum reactional pH: pH about 5-6.5; (4) optimum ionic strength: about 50-200mM (in the case of sodium chloride) and (5) inhibition and activation: activated with protamine, inhibited with adenosine 3',5'-diphosphate (3',5'-ADP) and hardly affecting the activities with

6. 发明专利

JPH0833483A HEPARAN SULFATE 6-0-SULFATE GROUP TRANSFERASE 失效
公开(公告)号：JPH0833483A
公开(公告)日：1996-02-06
申请号：JP17137994
申请日：1994-07-22
申请人： SEIKAGAKU KOGYO CO LTD
发明人： HANEBUCHI HIROKO , HANEBUCHI NAGAMOTO , KIMATA HIROHARU
IPC分类号： C12N5/00 , C12N5/06 , C12N9/10 , C12R1/91
摘要： PURPOSE:To obtain a heparan sulfate 6-O-sulfate group transferase capable of selectively introducing sulfate group to the 6-site of glucosamine of heparin and heparan sulfate. CONSTITUTION:This heparan sulfate 6-O-sulfate group transferase having the following properties is separated from the cultured liquid of CHO cell, etc. (1) Actions, selectively transfer sulfate group from a sulfate group donor to the 6-site of the N-sulfoglucosamine residue of a heparan sulfate or a heparin having a sulfate group at the 2-site and a hydroxyl group at the 6-site of a glucosamine residue; (2) substrate specificity, transfers sulfate group to a heparan sulfate or a heparin having a sulfate group at the 2-site and a hydroxyl group at the 6-site of glucosamine residue and does not transfer sulfate group to chondroitin and chondroitin-4-sulfate; (3) optimum pH, pH 6-7; (4) optimum ionic strength, 0.1-0.3M (sodium chloride) and (5) inhibition and activation, inhibited by dithiothreitol and adenosine-3',5'-diphosphate and activated by protamine.

7. 发明专利

JP2010011854A Knockout animal 审中-公开
标题翻译：防静电动物
公开(公告)号：JP2010011854A
公开(公告)日：2010-01-21
申请号：JP2009193909
申请日：2009-08-25
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： KIMATA HIROHARU , HANEBUCHI HIROKO , SATO NAOKO
IPC分类号： A01K67/027 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a knock out mouse having disorders in a synthetic system of heparan sulfate.
SOLUTION: The knockout mouse suppressed or deleted in expression of the enzyme activity of a protein having activity to transfer a sulfate group to the carbon atom at 6 position of a hexosamine group existing in the basic skeleton of heparan sulfate encoded by a gene is produced by deleting the gene encoding the enzyme having activity to transfer the sulfate group to the carbon atom at 6 position of the hexosamine group existing in the basic skeleton of heparan sulfate and comprising a base sequence having a specific sequence or ≥90% homogeny to the base sequence.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供在硫酸乙酰肝素的合成体系中具有障碍的敲除小鼠。解决方案：敲除小鼠在存在于由基因编码的硫酸乙酰肝素的碱性骨架中存在的己糖胺基的6位上具有将硫酸基转移到碳原子的蛋白质的酶活性的表达中被抑制或缺失是通过删除编码具有将硫酸根转移到存在于硫酸肝素的碱性骨架中的己糖胺基的6位的碳原子的活性的酶的基因，并且包含具有特定序列或≥90％均匀的碱基序列，基序列。版权所有（C）2010，JPO＆INPIT

8. 发明专利

JP2000060566A SULFATE GROUP-TRANSFERRING ENZYME AND DNA ENCODING THE SAME 失效
公开(公告)号：JP2000060566A
公开(公告)日：2000-02-29
申请号：JP23783598
申请日：1998-08-24
申请人： SEIKAGAKU KOGYO CO LTD
发明人： HANEBUCHI HIROKO , TANAKA MASAYUKI , KIMATA HIROHARU
IPC分类号： C12N15/09 , C12N9/10 , C12R1/91
摘要： PROBLEM TO BE SOLVED: To obtain the new subject DNA encoding a polypeptide of an enzyme capable of transferring a sulfate group from a sulfate group donor to the 6-position OH of an N-sulfated glucosamine residue included in a sulfate group acceptor glycosaminoglycan. SOLUTION: This new DNA encodes a polypeptide of a sulfate group- transferring enzyme. The sulfate group-transferring enzyme has activities for selectively transferring a sulfate group from a sulfate group donor to the 6-position OH of an N-sulfated glucosamine residue included in sulfate group acceptor glycosaminoglycan. The enzyme can transfer the sulfate group to the 6-position hydroxide of the N-sulfated glucosamine residue of heparan sulfate CDSNS (completely desulfated N-sulfated)-heparin, and DAcNS(deacetylated N-sulfated)- heparosan, but does not transfer the sulfate group to chondroitin and keratan sulfate. The enzyme has 54,000-60,000 molecular weight as a calculated value, and 440-530 number of amino acids in the polypeptide composing the enzyme. The enzyme is obtained by screening a mouse cDNA library by using a probe.

9. 发明专利

JPH1169983A POLYPEPTIDE OF HEPARAN SULFATE 6-O-SULFOTRANSFERASE AND DMA CAPABLE OF ENCODING THE SAME 失效
公开(公告)号：JPH1169983A
公开(公告)日：1999-03-16
申请号：JP11757098
申请日：1998-04-27
申请人： SEIKAGAKU KOGYO CO LTD
发明人： HANEBUCHI HIROKO , KOBAYASHI MASA , KIMATA HIROHARU , SUZUKI HIROMASA , TANAKA MASAYUKI
IPC分类号： C12N15/09 , C12N5/00 , C12N5/10 , C12N9/10 , C12N15/00 , C12R1/91
摘要： PROBLEM TO BE SOLVED: To obtain the subject new DNA, comprising a base sequence capable of encoding a polypeptide of a glycosaminoglycan sulfotransferase and capable of mass-producing the enzyme useful for related research or the like of the structure and function of the glycosaminoglycan. SOLUTION: This new DNA has a base sequence, coding a polypeptide of a glycosaminoglycan sulfotansferase, having an amino acid sequence represented by the formula and actions of selectively transferring a sulfate group from a sulfate group donor to the hydroxyl group at the 6-position in an N-sulfated glucosamine residue contained in a glycosaminoglycan which is a sulfate group acceptor, acting on a heparan sulfate or a completely desulfated, N-sulfated (CDSNS)-heparin without acting on chondroitin and chondroitin 4-sulfate, having 6-7 optimal reactional pH and 0.1-0.3 M optimal ionic strength when using NaCl, inhibited with dithiothreitol and adenosine-3',5'-diphosphate and activated with a protamine and is obtained by screening a cDNA library derived from a human fetal brain.

10. 发明专利

JP2005058162A Knockout animal 审中-公开
标题翻译：防静电动物
公开(公告)号：JP2005058162A
公开(公告)日：2005-03-10
申请号：JP2003295726
申请日：2003-08-19
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： KIMATA HIROHARU , HANEBUCHI HIROKO , SATO NAOKO
IPC分类号： A01K67/027 , C12N5/10 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a knockout animal having a trouble in the synthetic system of heparan sulfate. SOLUTION: A gene encoding an enzyme active to transfer sulfate group to the 6-carbon atom of a hexosamine residue in the main skeleton of heparan sulfate is depleted to obtain an embryonic stem cell having depleted expression potential of "the enzyme having the function". The invention provides a knockout animal other than human, prepared by depleting the gene encoding an enzyme active to transfer sulfate group to the 6-carbon atom of a hexosamine residue in the main skeleton of heparan sulfate to deplete the enzyme encoded by the gene. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供在硫酸乙酰肝素的合成体系中有麻烦的敲除动物。解决方案：将硫酸基转移到硫酸肝素的主骨架中的己糖胺残基的6-碳原子上的酶编码基因被耗尽，以获得具有枯竭表达潜力的胚胎干细胞，其具有“ 功能”。本发明提供了一种除人之外的敲除动物，其通过将编码活性硫酸酯酶的基因消耗到硫酸乙酰肝素的主骨架中的己糖胺残基的6-碳原子以消耗由该基因编码的酶而制备。版权所有（C）2005，JPO＆NCIPI

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