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1. 发明专利

JP2002181816A REAGENT AND METHOD FOR DETECTING DUPLEX NUCLEIC ACID 失效
公开(公告)号：JP2002181816A
公开(公告)日：2002-06-26
申请号：JP2000374626
申请日：2000-12-08
申请人： UNIV WASEDA , RIKAGAKU KENKYUSHO
发明人： NOJIMA TAKAHIKO , MATSUMOTO KAZUKO , KONDO YASUMITSU , TASHIRO HIDEO , TAKENAKA SHIGEORI
IPC分类号： G01N33/53 , C09B57/08 , C09B57/10 , C12Q1/68 , G01N21/75 , G01N33/566 , G01N33/58
摘要： PROBLEM TO BE SOLVED: To provide a new reagent for detecting a duplex nucleic acid and a method using this reagent for detecting the duplex nucleic acid formed by hybridization with a probe without labeling any target nucleic acid. SOLUTION: One molecule of this duplex nucleic acid detecting reagent includes a naphthalenediimide group capable of being intercalated in the duplex nucleic acid and a β-diketone group capable of forming a lanthanoid metal complex.

2. 发明专利

JP2002153272A BIOMOLECULE MICROARRAY 失效
公开(公告)号：JP2002153272A
公开(公告)日：2002-05-28
申请号：JP2000358121
申请日：2000-11-24
申请人： RIKAGAKU KENKYUSHO , UNIV WASEDA
发明人： TASHIRO HIDEO , KONDO YASUMITSU , KITSUNAI TOKUJI , TAKENAKA SHIGEORI , MATSUMOTO KAZUKO , NOJIMA TAKAHIKO
IPC分类号： G01N31/22 , B01J19/00 , C07K1/04 , C12M1/00 , C12N15/09 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/53 , G01N37/00 , G01N33/566
摘要： PROBLEM TO BE SOLVED: To provide a biomolecule microarray which can be used for quantitative analyses and has a high S/N ratio. SOLUTION: A photolithography technique and an etching technique are used to form an immobilizing film 14 in which avidin molecules are immobilized in a single layer at only specific probe biomolecule adhesion-desired sites 101 on the surface of a slide glass substrate 11, thus obtaining the surface-treated substrate 100. Since the areas and shapes of the specific sites all are uniform, the numbers of the biotin molecules immobilized on the specific sites 101 are also approximately uniform. Thereby, the numbers of the avidin molecoles bound to the specific sites 101 are identical. The specific sites 101 of the surface- treated substrate 100 are spotted with a solution containing probe DNA treated with biotin to obtain the DNA microarray. Since the numbers of the avidin molecules immobilized on the specific sites 101 are identical in the DNA microarrays, the number of probe DNAs 21 bound to the specific sites 101 is also identical.

3. 发明专利

JP2003131558A METHOD AND APPARATUS FOR MANUFACTURING MOLECULAR STRUCTURE MODEL FROM PDB DATA 审中-公开
公开(公告)号：JP2003131558A
公开(公告)日：2003-05-09
申请号：JP2001326872
申请日：2001-10-24
申请人： RIKAGAKU KENKYUSHO
发明人： YAMAZAWA KENJI , ANZAI MASAHIRO , KASE KIWAMU , TASHIRO HIDEO
IPC分类号： G09B23/26 , G06F17/30
摘要： PROBLEM TO BE SOLVED: To provide a method and device for manufacturing a desired molecular structure model based on PDB (protein data bank) data in a short time and inexpensively. SOLUTION: The apparatus for manufacturing molecular structure model is provided with a molecular structure data transform program 10 which is constituted of a PDB data reading step (A) to read PDB data 1, a basic structure step (B) to obtain, from the PDB data, the position of a ball 3 constituting the molecular structure model 2 and the position and direction of a stick connecting the balls, an element setting step (C) to set the color and size of the ball for each element constituting the molecular structure model, a stick setting step (D) to set the color and thickness of the stick connecting atoms of the molecular structure model, and a STL (stereolithography) data outputting step (E) to transform the molecular structure model into a plurality of color-by- color STL data. Based on the outputted color-by-color STL data, the molecular structure model is manufactured using an RP device capable of multi-color modeling.

4. 发明专利

JP2002230054A METHOD FOR STORING SUBSTANCE DATA OBTAINED BY INTEGRATING SHAPE AND PHYSICAL PROPERTY 失效
公开(公告)号：JP2002230054A
公开(公告)日：2002-08-16
申请号：JP2001025023
申请日：2001-02-01
申请人： RIKAGAKU KENKYUSHO
发明人： KASE KIWAMU , TASHIRO HIDEO , HIMENO RYUTARO , MAKINOUCHI AKITAKE
IPC分类号： G06F17/50 , G06T17/00
摘要： PROBLEM TO BE SOLVED: To provide a method for storing substance data obtained by integrating the shape and physical property of an object with a small storage capacity, and for performing the unitary management of the shape, structure, solidity information, and history of the object, and for managing data related with a series of processes ranging from the design to the working, assembly, test, and evaluation with the same data, and for realizing the unitary management of CAD and simulation. SOLUTION: This method comprises an outside data input step (A) for inputting outside data 12 constituted of the boundary data of an object 1, an octant tree division step (B) for dividing the outside data into stereoscopic cells 13 whose boundary planes are orthogonally crossing by octant tree division, and a cell data storage step (C) for storing various solidity values for each cell. Also, each divided cell 13 is divided into an inside cell 13a positioned inside the object or space and a boundary cell 13b including the boundary face in the octant tree division step (B).

5. 发明专利

JPH10325970A BROAD-BAND HIGH-SPEED WAVELENGTH CONVERSION METHOD AND DEVICE THEREFOR 失效
公开(公告)号：JPH10325970A
公开(公告)日：1998-12-08
申请号：JP20729597
申请日：1997-07-16
申请人： RIKAGAKU KENKYUSHO
发明人： AKAGAWA KAZUYUKI , WADA TOMOYUKI , TASHIRO HIDEO
IPC分类号： G02F1/37 , H01S3/109
摘要： PROBLEM TO BE SOLVED: To enable the alignment to a phase matching angle with respect to a laser beam and to enable high-speed higher modulation conversion without rotating a nonlinear optical crystal by controlling the incident angle of the laser beam made incident on the nonlinear optical crystal according to the dispersion characteristics of a dispersion element and the condensing characteristics of a condenser element. SOLUTION: The exciting laser beam is refracted in the optical path according to the wavelength by a first prism 12 which is the dispersion element, by which the optical path of the beam is divided by each wavelength of the exciting laser beam. The incident angle on the nonlinear optical crystal 10 is adjusted so as to be optimized at respective wavelengths by a first cylindrical concave surface mirror 14 which is the condenser element. On the other hand, the converted laser beam emitted from the nonlinear optical crystal 10 is adjusted in the optical path and is made incident on a second prism 18 by a second cylindrical concave surface mirror 16 which is the condenser element. The laser beam is refracted and is emitted through a prescribed optical path. The alignment of the nonlinear optical crystal 10 to the phase matching angle with respect to the incident laser beam is made possible without rotating the nonlinear optical crystal according to this wavelength conversion method.

6. 发明专利

JPH1039347A LASER WAVELENGTH CONVERTER 失效
公开(公告)号：JPH1039347A
公开(公告)日：1998-02-13
申请号：JP21194696
申请日：1996-07-23
申请人： RIKAGAKU KENKYUSHO
发明人： TASHIRO HIDEO , TSUNEMI AKIRA , SAITO TOKUHITO , NAGASAKA KEIGO
IPC分类号： G02F1/35 , H01S3/106 , H01S3/30
摘要： PROBLEM TO BE SOLVED: To make it possible to attain high Raman conversion efficiency without the increase in size and complication by making the optical axis of the light passing a first resonator back and forth and the optical axis of the light passing a second resonator back and forth coaxial. SOLUTION: The exciting laser beam resonator 16 comprises a reflection mirror 12 for reflecting the exciting laser beam and a reflection mirror 14 for reflection the exciting laser beam and emitting Stokes light. The resonator 20 for Stokes light comprises a reflection mirror 18 for allowing the transmission of the exciting laser beam and reflecting the Stokes light existing therebetween and the reflection mirror 14 for reflecting the exciting laser beam and emitting the Stokes light. A TEA-CO2 laser 22 is arranged between the reflection mirror 12 and reflection mirror 18 in the resonator 16. The reflection mirror 18 and the reflection mirror 14 are fitted to both end faces of a Raman cell 26 in such a manner that the inside thereof is hermetically sealed. Para-hydrogen is (p-H2 ) is fitted in the Raman cell 26. The optical axis of the exciting laser beam passing the inside of the resonator 16 back and forth and the optical axis of the Stokes light passing the inside of the resonator 20 back and forth are aligned.

7. 发明专利

JPH08279657A IMAGING METHOD AND DEVICE 失效
公开(公告)号：JPH08279657A
公开(公告)日：1996-10-22
申请号：JP10684895
申请日：1995-04-06
申请人： RIKAGAKU KENKYUSHO
发明人： WADA TOMOYUKI , TASHIRO HIDEO
IPC分类号： H01S3/30 , G01N21/17 , G01N21/21
摘要： PURPOSE: To utilize a laser which emits laser pulses whose width is of the order of nanoseconds by a method wherein a coherent image signal component contained in a probe light and a coherent excitation state induced in a Raman medium are made to interact with each other, and only the coherent image signal component is Raman-converted into an anti-Stokes light. CONSTITUTION: Pulse laser beams of a YAG laser 10 are split into two polarized components by a polarizing spectroscope 14, one of the polarized components is made to irradiate a specimen 20 through the intermediary of total reflection mirrors 16 and 18, and the other component is made to impinge on a Raman cell 26 of Raman medium to put the Raman medium in a coherently stimulated state. A probe light which contains the coherent image signal component and the scattered light component of the specimen passing through it is made to impinge on the Raman cell in a coherently stimulated state. The coherent image signal component and the coherently stimulated state are made to interact with each other to Raman-convert only the coherent image signal component into an anti-Stokes light through a filter 28.

8. 发明专利

JP2511721B2 失效
公开(公告)号：JP2511721B2
公开(公告)日：1996-07-03
申请号：JP8190690
申请日：1990-03-28
申请人： RIKAGAKU KENKYUSHO , DORYOKURO KAKUNENRYO KAIHATSU JIGYODAN
发明人： TASHIRO HIDEO , MIDORIKAWA KATSUMI , SUZUKI YOSHIHISA
IPC分类号： B01D59/34 , H01S3/30

9. 发明专利

JPH0799374A LASER WAVELENGTH CONVERSION AND DEVICE THEREOF 失效
公开(公告)号：JPH0799374A
公开(公告)日：1995-04-11
申请号：JP26290593
申请日：1993-09-27
申请人： RIKAGAKU KENKYUSHO
发明人： TASHIRO HIDEO , TSUNEMI AKIRA
IPC分类号： H01S3/108 , H01S3/30
摘要： PURPOSE:To never cause an increase in the size of the whole device and the complification of the whole device, to make it possible to attain a high Raman conversion efficiency and moreover, to reduce a reflection loss in a Raman cell. CONSTITUTION:A laser wavelength conversion device which enters an excitation laser beam into a Raman medium and makes a laser wavelength conversion by performing a Raman conversion, has a resonator, which is constituted of reflecting mirrors 12 and 14 opposing to each other, a laser oscillator 16, which is arranged in the resonator and is filled with a laser medium which generates the excitation laser beam, and a Raman cell 18, which is arranged in the resonator and at the same time, is filled with the Raman medium arranged in such a way as to superpose on one part or all of the optical path of the excitation laser beam which is generated by the oscillator 16. The excitation laser beam generated by the oscillator 16 is made to perform the Raman conversion by the Raman medium in the cell 18 while being made to resonate in the resonator.

10. 发明专利

JPH06208013A OPTICAL ELEMENT FOR VACUUM ULTRAVIOLET-LIGHT WAVELENGTH SEPARATION 失效
公开(公告)号：JPH06208013A
公开(公告)日：1994-07-26
申请号：JP333893
申请日：1993-01-12
申请人： RIKAGAKU KENKYUSHO
发明人： WADA TOMOYUKI , TOYODA KOICHI , TASHIRO HIDEO
IPC分类号： G02B5/00 , G02B5/04 , G02B5/26
摘要： PURPOSE:To provide the optical element for vacuum ultraviolet-light wavelength separation which can separate high-output vacuum ultraviolet light with wavelength at a low constant angle of deviation and reduce the attenuation of light in an optical element more than before. CONSTITUTION:A 1st prism 1 and a 2nd prism 3 are fixed so that the incidence surface 1a of the 1st prism 1 and the projection surface 3b of the 2nd prism 3 are at 90 deg. and the projection surface 1b of the 1st prism 1 and the incidence surface 3a of the 2nd prism 3 are at 90 deg.. A reflecting mirror 2 is arranged having its reflecting surface 2a at 45 deg. to the projection surface 1b of the 1st prism 1 and the incidence surface 3a of the 2nd prism 3.

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