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1. 发明专利

JPH0425277B2 失效
公开(公告)号：JPH0425277B2
公开(公告)日：1992-04-30
申请号：JP23204383
申请日：1983-12-08
申请人： RIKAGAKU KENKYUSHO , TOWA KASEI KOGYO KK , MEKUTO KK
发明人： OGAWA TOMOYA , NUKADA YASUO , KITAJIMA TOORU , SUGIMOTO MAMORU , TAKEMURA MOTOHIRO , SHIDORI YOSHASU
IPC分类号： C07H7/02 , C07H3/06 , C07H7/027 , C07H15/18

2. 发明专利

JPH0536441B2 失效
公开(公告)号：JPH0536441B2
公开(公告)日：1993-05-31
申请号：JP15882383
申请日：1983-08-30
申请人： RIKAGAKU KENKYUSHO , TOWA KASEI KOGYO KK
发明人： OGAWA TOMOYA , NUKADA YASUO , TAKEMURA MOTOHIRO , KITAJIMA TOORU
IPC分类号： C07H15/18 , C08B37/00

3. 发明专利

JPH06796B2 失效
公开(公告)号：JPH06796B2
公开(公告)日：1994-01-05
申请号：JP12395285
申请日：1985-06-07
申请人： RIKAGAKU KENKYUSHO , MEKUTO KK
发明人： OGAWA TOMOYA , SUGIMOTO MAMORU , SHIDORI YOSHASU , ITO MASAYOSHI
IPC分类号： C07H13/06 , A61K31/70 , A61K31/7024 , A61K31/7028 , A61P35/00 , A61P43/00 , C07H15/04 , C07H15/10

4. 发明专利

JPH0149354B2 失效
公开(公告)号：JPH0149354B2
公开(公告)日：1989-10-24
申请号：JP13388184
申请日：1984-06-28
申请人： RIKAGAKU KENKYUSHO , MEKUTO KK
发明人： OGAWA TOMOYA , SUGIMOTO MAMORU , SHIDORI YOSHASU , ITO MASAYOSHI
IPC分类号： C07H7/06 , A61K20060101 , C07D20060101 , C07G20060101 , C07H20060101 , C07H13/02 , C07H13/06 , C07H13/08 , C07H15/04 , C07H15/10 , C07H15/18

5. 发明专利

JPH06795B2 失效
公开(公告)号：JPH06795B2
公开(公告)日：1994-01-05
申请号：JP6974385
申请日：1985-04-02
申请人： RIKAGAKU KENKYUSHO , MEKUTO KK , TEIKOKU KAGAKU SANGYO KK
发明人： OGAWA TOMOYA , SUGIMOTO MAMORU , SHIDORI YOSHASU , HORISAKI TOSHIO , SHINNAI TADAKI
IPC分类号： C07H13/06 , C07H15/10

6. 发明专利

JPH0534359B2 失效
公开(公告)号：JPH0534359B2
公开(公告)日：1993-05-21
申请号：JP4490584
申请日：1984-03-09
申请人： RIKAGAKU KENKYUSHO , MEKUTO KK
发明人： OGAWA TOMOYA , FUJIKURA KAZUSHIGE , SUGIMOTO MAMORU , SHIDORI YOSHASU , ITO MASAYOSHI
IPC分类号： C07H15/10 , A61K31/70 , A61K31/7028 , A61P31/04 , C07H15/04 , C07H15/18

7. 发明专利

JPS6328434B2 失效
公开(公告)号：JPS6328434B2
公开(公告)日：1988-06-08
申请号：JP3843083
申请日：1983-03-09
申请人： RIKAGAKU KENKYUSHO , MEKUTO KK
发明人： OGAWA TOMOYA , SUGIMOTO MAMORU , SHIDORI YOSHASU , ITO MASAYOSHI
IPC分类号： C12N9/00 , A61K31/70 , A61K31/7024 , A61K31/7028 , A61P37/00 , C07H13/06 , C07H15/04 , C07H15/06 , C07H15/18 , C12N9/99 , G01N33/53

8. 发明专利

JPH04342599A NOVEL SUGAR CHAIN FOR TESTING SUGAR TRANSFERASE 失效
公开(公告)号：JPH04342599A
公开(公告)日：1992-11-30
申请号：JP8916191
申请日：1991-03-29
申请人： TOWA KASEI KOGYO KK
发明人： KITAJIMA TORU , YAMAZAKI MASAYOSHI , TANABE YUMI , KATAURA KOICHI , OGAWA TOMOYA , FURUKAWA KIYOSHI , KOBATA AKIRA , ISHII YOSHIFUMI , KATO KAZUAKI
IPC分类号： C07H15/04 , C07H15/20 , C12Q1/48
摘要： PURPOSE:To provide the subject novel sugar chain capable of detecting a sugar transferase acting as a cellular function-manifesting factor, etc., with ultra-violet rays in high sensitivity by introducing an ultra-violet ray-coloring m-nitrobenzyl group into the spacer part of the sugar chain. CONSTITUTION:A compound of formula I (Bn is benzyl) is made to react with two equivalents of a compound of formula II (Ac is acetyl; Phth is phthaloyl). The reactional product is subjected to a phthaloyl group-removing reaction, an acetylation reaction, a catalytic reduction reaction, a deacetylation reaction, a deallylation reaction, a debenzylation reaction, an acetylation reaction and further a hydrazine acetate treatment. The reactional product is subjected to a deacetylation reaction only at the 1-position and reacted with a formula Cl3CCN to produce a compound of formula III [R is C(=NH)CCl3; R , R , R are Ac; R is H], which is subjected to a glycosylation reaction with a compound of formula IV, and further to debenzylation reaction, a deacetylation reaction, an ester exchange reaction, and an ester exchange reaction in m- nitrobenzyl alcohol to produce the objective sugar chain of formula V (R is m-nitrobenzyl; R is N-acetyl-D-glucosamine).

9. 发明专利

JPH0632803A HCG-RELATING HEPTOSE HAPTEN 失效
公开(公告)号：JPH0632803A
公开(公告)日：1994-02-08
申请号：JP21071692
申请日：1992-07-16
申请人： TOWA KASEI KOGYO KK
发明人： KITAJIMA TORU , KOMIYA SHINICHI , OGAWA TOMOYA , KATAURA KOICHI , KATO KAZUAKI
IPC分类号： C08B37/00
摘要： PURPOSE:To provide a heptose hapten having a specific molecular structure, enabling the determination of epitope recognizable by an antibody and necessary for the preparation of monoclonal antibody for the diagnosis of urinary or serological diagnosis of chorionic carcinoma. CONSTITUTION:The heptose hapten expressed by formula (R is methyl; R , R , R and R are H; R is acetyl), the compound of formula wherein R is ethyl, R and R are phthaloyl, R is benzyl, R is H and R is acetyl or the compound of formula wherein R is ethyl, R and R are phthaloyl, R is benzyl, R is p-methoxyphenyl and R is acetyl.

10. 发明专利

JPH05301905A 失效
公开(公告)号：JPH05301905A
公开(公告)日：1993-11-16
申请号：JP21318792
申请日：1992-07-20
申请人： TOWA KASEI KOGYO KK
发明人： KITAJIMA TORU , KOMIYA SHINICHI , OGAWA TOMOYA , KATAURA KOICHI , ISHII YOSHIFUMI , KATO KAZUAKI
IPC分类号： C08B37/00
摘要： PURPOSE:To obtain a nonasaccharine hapten originated from chorionic carcinoma and useful as an immunogen suitable for the preparation of monoclonal antibody for the diagnosis of chorionic carcinoma with urine or serum by designing a molecular form containing a spacer introduced in a natural-type sugar chain structure. CONSTITUTION:The compound of formula I (R is methyl, R and R to R are H and R is acetyl: compound A), (R is ethyl, R and R are phthaloyl, R is benzyl, R is H and R is acetyl: compound B) or (R is ethyl, R and R are phthaloyl, R is benzyl, R is p-methoxyphenyl and R is acetyl: compound C) and the compound of formula II (Ac is acetyl; Bn is benzyl; Et is ethyl; MP is p-methoxyphenyl; Phth is phthaloyl) which is an intermediate for the above compounds. The compound C can be produced by glycosylating the compound of formula II with a compound obtained from pentaacetylmannose via two steps. The de-p-methoxyphenylation of the compound C gives the compound B, which is subjected to debenzylation, deacetylation, transesterification, dephthaloylation and N-acetylation to get the compound A.

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