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1. 发明专利

JPH0261934B2 失效
公开(公告)号：JPH0261934B2
公开(公告)日：1990-12-21
申请号：JP3692983
申请日：1983-03-07
申请人： RIKAGAKU KENKYUSHO
发明人： OOISHI TAKESHI , HORIKOSHI KOKI , AKITA HIROYUKI , KOSHIJI HIROKO , FURUICHI AKINARI
IPC分类号： C12P7/62 , C07C67/00 , C07C69/734 , C12R1/72

2. 发明专利

JPS5953271B2 失效
公开(公告)号：JPS5953271B2
公开(公告)日：1984-12-24
申请号：JP20078682
申请日：1982-11-15
申请人： RIKAGAKU KENKYUSHO
发明人： OOISHI TAKESHI , NAKADA TADASHI , AKITA HIROYUKI , NAITO TAKANOBU
IPC分类号： C07C69/16 , C07C45/00 , C07C49/733 , C07C67/00 , C07D303/32 , C07D317/18 , C07D317/72 , C07D319/06 , C07D407/04 , C07D493/10 , C07D495/10 , C07F7/18

3. 发明专利

JPS59163348A Synthesis of optically active (-)-oudemansin 失效
标题翻译：光学活性（ - ） - OUDEMANSIN的合成
公开(公告)号：JPS59163348A
公开(公告)日：1984-09-14
申请号：JP3692983
申请日：1983-03-07
申请人： Rikagaku Kenkyusho
发明人： OOISHI TAKESHI , HORIKOSHI KOUKI , AKITA HIROYUKI , KOSHIJI HIROKO , FURUICHI AKINARI
IPC分类号： C12P7/62 , C07C67/00 , C07C69/734 , C12R1/72
摘要： PURPOSE:To prepare the titled compound useful as an antibacterial agent, by reducing a beta-ketoester with a microorganism belonging to Candida genus, and subjecting the resultant beta-hydroxyester to the reaction of several steps. CONSTITUTION:The compound of formula I is reduced to the compound of formula II with microorganism belonging to Candida genus (e.g. Candida albicans), and the product is reduced with LiAlH4 to obtain the compound of formula III(R is H). The product is t-butyldimethylsilylated (SiMe2Bn), and treated with methyl iodide to obtain the compound of formula IV (R is SiMe2Bn). After eliminating the t-butyldimethylsilyl group from the compound, the compound is treated with p-toluenesulfonic acid chloride then with a cyanide, hydrolyzed, methylated with diazomethane, formylated with lithium diisopropylamide and methyl formate, treated with an alkali and finally treated with diazomethane to obtain the objective compound of formula V.
摘要翻译：目的：制备用作抗菌剂的标题化合物，通过用属于念珠菌属的微生物还原β-酮酯，并使得到的β-羟基酯进行几个步骤的反应。构成：将式I化合物用属于念珠菌属（例如白色假丝酵母属）的微生物还原成式II化合物，用LiAlH 4还原产物，得到式Ⅲ化合物（R为H）。产物为叔丁基二甲基甲硅烷基化（SiMe2Bn），用碘甲烷处理得到式Ⅳ化合物（R为SiMe 2 Bn）。在从化合物中除去叔丁基二甲基甲硅烷基后，化合物用对甲苯磺酰氯处理，然后用氰化物处理，水解，用重氮甲烷甲基化，用二异丙基氨基锂和甲酸甲酯甲酰化，用碱处理，最后用重氮甲烷处理得到式Ⅴ的目的化合物。

4. 发明专利

JPS5932471B2 JPS5932471B2 - 失效
公开(公告)号：JPS5932471B2
公开(公告)日：1984-08-09
申请号：JP16876979
申请日：1979-12-24
申请人： Rikagaku Kenkyusho
发明人： OOISHI TAKESHI , NAKADA TADASHI , AKITA HIROYUKI , NAITO TAKANOBU
IPC分类号： C07C69/16 , C07D307/92 , C07D317/72 , C07D407/04

5. 发明专利

JPS5932470B2 JPS5932470B2 - 失效
公开(公告)号：JPS5932470B2
公开(公告)日：1984-08-09
申请号：JP16876779
申请日：1979-12-24
申请人： Rikagaku Kenkyusho
发明人： OOISHI TAKESHI , NAKADA TADASHI , AKITA HIROYUKI , NAITO TAKANOBU
IPC分类号： C07C69/16 , C07D307/92 , C07D317/72

6. 发明专利

JPS596312B2 JPS596312B2 - 失效
公开(公告)号：JPS596312B2
公开(公告)日：1984-02-10
申请号：JP11035878
申请日：1978-09-08
申请人： Rikagaku Kenkyusho
发明人： AKITA HIROYUKI , OOISHI TAKESHI
IPC分类号： C07D307/92 , C07C45/00 , C07C47/445 , C07C67/00

7. 发明专利

JPS5850224B2 JPS5850224B2 - 失效
公开(公告)号：JPS5850224B2
公开(公告)日：1983-11-09
申请号：JP4534280
申请日：1980-04-07
申请人： Rikagaku Kenkyusho
发明人： AKITA HIROYUKI
IPC分类号： C07D307/92 , A61K31/34 , A61K31/343 , A61P31/04 , A61P35/00

8. 发明专利

JPS5850223B2 JPS5850223B2 - 失效
公开(公告)号：JPS5850223B2
公开(公告)日：1983-11-09
申请号：JP4534180
申请日：1980-04-07
申请人： Rikagaku Kenkyusho
发明人： AKITA HIROYUKI
IPC分类号： C07D307/92 , A61K31/34 , A61K31/343 , A61P31/04 , A61P35/00

9. 发明专利

JPS5850222B2 JPS5850222B2 - 失效
公开(公告)号：JPS5850222B2
公开(公告)日：1983-11-09
申请号：JP4533980
申请日：1980-04-07
申请人： Rikagaku Kenkyusho
发明人： AKITA HIROYUKI
IPC分类号： C07D307/92 , A61K31/34 , A61K31/343 , A61P31/04

10. 发明专利

JPS58113146A PREPARATION OF DITERPENE DERIVATIVE COMPOUND 失效
公开(公告)号：JPS58113146A
公开(公告)日：1983-07-05
申请号：JP22910782
申请日：1982-12-27
申请人： RIKAGAKU KENKYUSHO
发明人： AKITA HIROYUKI
IPC分类号： C07C69/716 , C07C67/00 , C07C69/757
摘要： PURPOSE:To obtain the titled compound useful as an intermediate for synthesizing a physiologically active substance, by oxidizing a specific diterpene phenol derivative as a raw material with ozone so that an aromatic ring is subjected to cleavage, reducing catalytically the resultant compound, followed by methylating the reduced compound with diazomethane. CONSTITUTION:A deterpene phenol derivative shown by the formula II (R is CH3 or methoxycarbonyl) obtained easily form an l-abietic acid shown by the formulaI, a main component of a resin of a conifer, is oxidized with extremely excess O3 at -80-0 deg.C in a solvent, reduced catalytically using a catalytically reducing agent such as 10% Pd-C, etc. or zinc-acetic acid at 0-30 deg.C for 30min- 12hr, and methylated with a diazomethane-ether solution, to give the desired compound such as 8-oxo-(13 17)-pentanorlabdan-12-oic acid methyl ester (a novel substance wherein R is CH3) shown by the formula III. USE:An intermediate for synthesizing dimethyl sciadinonate showing growth inhibiting action on larvae of cocoon.

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