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1. 发明专利

JP2006131548A Method for producing particle 审中-公开
标题翻译：生产颗粒的方法
公开(公告)号：JP2006131548A
公开(公告)日：2006-05-25
申请号：JP2004322387
申请日：2004-11-05
申请人： Pauretsuku:Kk , 株式会社パウレック
发明人： SAKAMOTO HIROSHI , KOBAYASHI MAKOTO
IPC分类号： A61K9/14 , A61J3/02 , A61K9/50 , A61K31/714 , A61K47/26 , A61K47/38 , A61P3/02 , B01J2/00 , B01J2/28
摘要： PROBLEM TO BE SOLVED: To provide a method for producing particles, capable of efficiently producing the particles having high stability, by using an unstable compound as a raw material powder.
SOLUTION: This method for producing the particles particles comprises adding a binder solution which is formed by dissolving, dispersing, or suspending the compound in a solvent to a powder of the compound, while the powder is moved in a treating container, so that granular particles are produced, wherein the compound comprises a compound which produces chemical or physical interaction with another substance, such as a non-crystalline compound and an amorphous compound, when mixed therewith, becomes unstable, and easily causes degeneration (such as decomposition and degeneration, dissolution and migration, decrease in contents, and deterioration in storage stability and light stability).
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供一种通过使用不稳定化合物作为原料粉末能够有效地制备具有高稳定性的颗粒的颗粒的制造方法。解决方案：用于制备颗粒颗粒的方法包括将粉末在处理容器中移动时，将化合物溶解，分散或悬浮在溶剂中形成的粘合剂溶液加入到化合物的粉末中，因此产生粒状颗粒，其中化合物包含与其它物质如非结晶化合物和无定形化合物混合时产生化学或物理相互作用的化合物，变得不稳定，容易引起变性（例如分解和退化，溶解和迁移，含量降低，储存稳定性和光稳定性的劣化）。版权所有（C）2006，JPO＆NCIPI

2. 发明专利

JP2006116432A Fluidized bed apparatus and method for treating granular substance 审中-公开
标题翻译：流化床设备和处理颗粒物质的方法
公开(公告)号：JP2006116432A
公开(公告)日：2006-05-11
申请号：JP2004307171
申请日：2004-10-21
申请人： Pauretsuku:Kk , 株式会社パウレック
发明人： SAKAMOTO HIROSHI , KOBAYASHI MAKOTO
IPC分类号： B01J2/16 , B01J2/00
摘要： PROBLEM TO BE SOLVED: To provide a fluidized bed apparatus in which the yield and productivity of a product are improved by preventing a product particle from being stuck to a particle contact part in a fluidized bed vessel when the product particle is melted/granulated and to provide a method for treating a granular substance.
SOLUTION: A cooling gas A2 such as cold air is supplied through an air supply pipe 6 to the inside of a fluidized bed F of the (granulated) particle in the fluidized bed vessel 1 to lower the temperature of the (granulated) particle (the fluidized bed F) at a cooling step of cooling the melted/granulated particle. As a result, such a phenomenon can effectively be prevented that the particle is stuck to the particle contact part in the fluidized bed vessel 1 and solidified there at the cooling step.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种流化床装置，其中当产品颗粒熔化时，通过防止产品颗粒粘附到流化床容器中的颗粒接触部分来提高产品的产率和生产率，并且提供一种处理颗粒状物质的方法。解决方案：通过空气供应管6将冷却气体A2（例如冷空气）供应到流化床容器1中的（制粒）颗粒的流化床F的内部，以降低（造粒的）颗粒的温度，颗粒（流化床F）在冷却熔融/造粒颗粒的冷却步骤。结果，可以有效地防止颗粒被粘附到流化床容器1中的颗粒接触部分并且在冷却步骤中固化。版权所有（C）2006，JPO＆NCIPI

3. 发明专利

JP2004148291A Fluidized bed equipment 有权
公开(公告)号：JP2004148291A
公开(公告)日：2004-05-27
申请号：JP2003184917
申请日：2003-06-27
申请人： Pauretsuku:Kk , 株式会社パウレック
发明人： NATSUYAMA SUSUMU , WATANABE NOBUYUKI , OTAKI KAZUMI , NAGATSUMA KENJI , NAGATO TAKUYA , KANO YOSHIYUKI , TABATA RAN , KOBAYASHI MAKOTO
IPC分类号： B01J2/00 , B01J2/16 , B01J8/00 , B01J8/18 , B01J8/38
CPC分类号： B01J2/006 , B01J2/16 , B01J8/006 , B01J8/1818 , B01J8/1854 , B01J8/1863 , B01J8/38 , B01J8/382 , B01J8/386
摘要： PROBLEM TO BE SOLVED: To provide a fluidized bed equipment capable of conducting a coating process for particles having a small particle size and a granulating process for particles having a small finished particle size, efficiently and in a high yield.
SOLUTION: A rotating rotor 4 is arranged at the center of the bottom, a pulverizing mechanism 5 is arranged above the rotating rotor 4, and a cylindrical draft tube 6 is set above the pulverizing mechanism 5. Further, spray nozzles 7 are arranged on the side of the pulverizing mechanism 5. A fluidized bed is formed for granule particles P in the processing vessel 1 by a fluidizing gas injected through a gas dispersing plate 3, wherein the fluidized bed being circulated in an ascending direction through a gap between the outer circumference of the rotating rotor 4 and the inner wall of the processing vessel 1, a space between the pulverizing mechanism 5 and the inner wall of the processing vessel 1, a space between the outer circumference of the draft tube 6 and the inner wall of the processing vessel 1, and descending along the inside of the draft tube 6.
COPYRIGHT: (C)2004,JPO

4. 发明专利

JP2004130194A Fluidized bed apparatus 审中-公开
公开(公告)号：JP2004130194A
公开(公告)日：2004-04-30
申请号：JP2002296429
申请日：2002-10-09
申请人： Pauretsuku:Kk , 株式会社パウレック
发明人： NATSUYAMA SUSUMU , NAGATO TAKUYA , KANO YOSHIYUKI , KOBAYASHI MAKOTO
IPC分类号： B01J2/16 , B01J2/00 , B01J8/24
摘要： PROBLEM TO BE SOLVED: To measure the circulating fluidity of particles in a fluidized bed vessel, especially the flow condition of the particles in a draft tube to be a spray zone and in a section where the particles are apt to be retained exactly in real time.
SOLUTION: Detection light X emitted from a light projection sensor 9a, when there is no particle in the optical path, is received directly by a light receiving sensor 9b, but, when the particles exist in the optical path, the light is scattered by the particles and prevented from being received by the light receiving sensor 9b. Therefore, from the quantity of the light received by the sensor 9b, the concentration of the particles in the optical path of the detection light X can be measured in real time. From the measured value, The quantity of the particles flowing in the draft tube 5 and the quantity of the particles circulating and flowing in the fluidized bed vessel 3 can be calculated.
COPYRIGHT: (C)2004,JPO

5. 发明专利

JP2006102558A Coating method for particle 有权
标题翻译：颗粒涂层方法
公开(公告)号：JP2006102558A
公开(公告)日：2006-04-20
申请号：JP2004288316
申请日：2004-09-30
申请人： Pauretsuku:Kk , 株式会社パウレック
发明人： NATSUYAMA SUSUMU , NAGATO TAKUYA , KANO YOSHIYUKI , KOBAYASHI MAKOTO , TOKUYAMA DAICHI
IPC分类号： B05D1/38 , A61J3/06 , A61K9/54 , A61K47/06 , A61K47/14 , A61K47/26 , A61K47/38 , B01J2/00 , B05D1/18
摘要： PROBLEM TO BE SOLVED: To solve a problem of dissolution and permeation of a particle component into a covering layer by a water based membrane agent liquid, to shorten a treatment time and to realize enhancement of productivity.
SOLUTION: A first covering layer L1 is formed on a surface of a chemical particle P by dry coating of a hydrophobic powder P'. Thereafter, a second covering layer L2 is formed on a surface of the particle P forming the first covering layer L1 by wet coating of the water based membrane agent liquid. The dry coating and the wet coating are successively performed in a single fluidized bed device.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：解决问题：为了解决通过水基膜剂液体将颗粒成分溶解和渗透到覆盖层中的问题，缩短处理时间并实现生产率的提高。解决方案：通过干式涂覆疏水性粉末P'，在化学颗粒P的表面上形成第一覆盖层L1。此后，通过湿法涂覆水基膜剂液体，在形成第一覆盖层L1的颗粒P的表面上形成第二覆盖层L2。干涂层和湿涂层在单一流化床装置中连续进行。版权所有（C）2006，JPO＆NCIPI

6. 发明专利

JP2004035508A Coated particle and method for producing the same 审中-公开
公开(公告)号：JP2004035508A
公开(公告)日：2004-02-05
申请号：JP2002197440
申请日：2002-07-05
申请人： Pauretsuku:Kk , 株式会社パウレック
发明人： SAKAMOTO HIROSHI , KOBAYASHI MAKOTO
IPC分类号： A61J3/02 , A61J3/06 , A61K9/58 , A61K47/08 , A61K47/32 , A61K47/36
摘要： PROBLEM TO BE SOLVED: To realize an eluted state of zero order elution or an eluted state similar thereto.
SOLUTION: Coated particles are obtained by forming an elution control film for controlling the elution of a medicine on the surface of particles in which a medicine layer is formed on the surface of particles or carrier particles containing the medicine. The elution control film is composed of two or more coating layers containing a water-insoluble polymer substance as a film agent solid content and an elution control substance, and in each coating layer, a formulation ratio of the elution control substance to the water-insoluble polymer substance is mutually different. The coated particles exhibit so-called elution state of zero-order elution.
COPYRIGHT: (C)2004,JPO

7. 发明专利

JP2007175704A Fluidized bed apparatus 有权
标题翻译：流化床设备
公开(公告)号：JP2007175704A
公开(公告)日：2007-07-12
申请号：JP2007070900
申请日：2007-03-19
申请人： Pauretsuku:Kk , 株式会社パウレック
发明人： NATSUYAMA SUSUMU , WATANABE NOBUYUKI , OTAKI KAZUMI , NAGATSUMA KENJI , NAGATO TAKUYA , KANO YOSHIYUKI , TABATA RAN , KOBAYASHI MAKOTO
IPC分类号： B01J2/16
摘要： PROBLEM TO BE SOLVED: To perform coating of small-diameter particles, or pelletizing of particles with small finished diameter efficiently at high yield. SOLUTION: A fluidized bed apparatus has a rotary rotor 4 arranged at the bottom center thereof, a disintegrator mechanism 15 arranged above the rotary rotor 4, a cylindrical draft tube 6 installed above the disintegrator mechanism 15, and further spray nozzles 7 arranged on the sides of the disintegrator mechanism 15. A fluidizing gas jetted from a gas dispersion plate 3 causes powder particles in a processing container 1 to form a fluidized bed in which they circulate so as to ascend through the gap between the outer periphery of the rotary rotor 4 and the bottom inner wall of the processing container 1, the space between the disintegrator mechanism 15 and the inner wall of the processing container 1, and the space between the outer periphery of the draft tube 6 and the inner wall of the processing container 1, and descend through the inner portion of the draft tube 6. The inner wall of the processing container 1 located in the vicinity of the upper end part of the draft tube 6 is provided with a cone tapered guide surface 1a. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：以高产率有效地进行小直径颗粒的涂布或成粒直径小的颗粒的造粒。解决方案：流化床设备具有布置在其底部中心的旋转转子4，设置在旋转转子4上方的分解器机构15，安装在破碎机构15上方的圆柱形通流管6和布置在其上的另外的喷嘴7 在分解器机构15的侧面。从气体分散板3喷射的流化气体使处理容器1中的粉末颗粒形成流化床，在该流化床中，流化床循环通过旋转的外周之间的间隙转子4和处理容器1的底部内壁，分解器机构15与处理容器1的内壁之间的空间以及引流管6的外周与处理容器的内壁之间的空间位于引流管6的上端附近的处理容器1的内壁是引流管6的内部。设置有锥形锥形引导表面1a。版权所有（C）2007，JPO＆INPIT

8. 发明专利

JP2004161701A Composition in which bitterness and odor of cysteines are reduced 有权
公开(公告)号：JP2004161701A
公开(公告)日：2004-06-10
申请号：JP2002330954
申请日：2002-11-14
申请人： Kobayashi Pharmaceut Co Ltd , Pauretsuku:Kk , 小林製薬株式会社 , 株式会社パウレック
发明人： WATANABE AIKO , SAKAMOTO HIROSHI , KOBAYASHI MAKOTO , IWANE HIROAKI
IPC分类号： A23L1/305 , A23L1/015 , A61K9/50 , A61K31/198 , A61K47/10 , A61K47/12 , A61K47/22 , A61K47/26 , A61K47/42 , A61P3/02 , A61P17/16 , A61P37/08 , A61P39/02
摘要： PROBLEM TO BE SOLVED: To provide a composition in which nasty bitterness and odor of cysteines are reduced. SOLUTION: The composition in which bitterness and odor of cysteins are reduced comprises cysteins coated with a coating agent and preferably further one or more kinds of substances selected from a group consisting of acidulants (e.g. ascorbic acid) and sweetening agents (e.g. aspartame, saccharin, erythritol, mannitol, sorbitol, xylitol, maltitol, lactitol, sucrose, lactose, fructose, glucose, oligosaccharide, maltose, trehalose and stevia). COPYRIGHT: (C)2004,JPO

9. 发明专利

JP2004160165A Granulation method for galenical component preparation 审中-公开
标题翻译： GALENICAL组分制备的成像方法
公开(公告)号：JP2004160165A
公开(公告)日：2004-06-10
申请号：JP2003142105
申请日：2003-05-20
申请人： Pauretsuku:Kk , 株式会社パウレック
发明人： SAKAMOTO HIROSHI , OKITSU TADAKAZU , KOBAYASHI MAKOTO
IPC分类号： A61J3/06 , A61K9/14 , A61K9/16 , A61K36/07 , A61K36/18 , A61K47/10 , A61P1/14 , A61K35/78 , A61K35/84
摘要： PROBLEM TO BE SOLVED: To provide a galenical component preparation, having a high content of galenical components (effective components), heavy and having a sharp particle distribution. SOLUTION: While one galenical component powder selected from a galenical dry powder, a galenical extract powder and a mixed powder of the galenical dry powder and the galencial extract is let flow in a fluidized layer container, a binder liquid obtained by mixing an aqueous solution containing a galenical extract as the same kind of the selected galenical component powder with 0.01 to 20wt.% alcohol is sprayed to perform granulation. COPYRIGHT: (C)2004,JPO

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