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1. 发明专利

JP2005181311A Amplification of enzymatic reaction for use with enthalpy array 有权
标题翻译：使用强度阵列的酶促反应的放大
公开(公告)号：JP2005181311A
公开(公告)日：2005-07-07
申请号：JP2004358695
申请日：2004-12-10
申请人： Palo Alto Research Center Inc , Scripps Res Inst:The , ザスクリップスリサーチインスティテュート , パロアルトリサーチセンターインコーポレイテッド
发明人： TORRES FRANCISCO E , BRUCE RICHARD H , WILLIAMSON JAMES R , PETER KUHN , STEVENS RAY
IPC分类号： G01N25/48
CPC分类号： G01N25/4846 , G01N25/4866
摘要： PROBLEM TO BE SOLVED: To provide a method of detecting the characteristics of a reaction of interest, including carrying out the reaction of interest, obtaining an amplified heat related to the reaction of interest, measuring the amplified heat, and determining the characteristics of the reaction of interest, using the signal obtained in the step of measuring.
SOLUTION: A nanocalorimeter 10 includes a thermal isolation layer 12, which contains a measurement region 14 and a reference region 16. Regions 14, 16 may also be contained in separate isolation regions. The thermal isolation region 12 provides isolation from surrounding thermal environments, thus increasing the measurement time and reducing thermal noise. Although the layer 12 is used, in this examplary embodiment, to thermally isolate the reaction and temperature sensing components of the nanocalorimeter 10, any means for thermally isolating these components can be used in alternate embodiments.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供一种检测感兴趣的反应特性的方法，包括进行感兴趣的反应，获得与感兴趣的反应相关的放大热，测量放大的热量，以及确定特性的感兴趣的反应，使用在测量步骤中获得的信号。解决方案：纳米尺度计10包括热隔离层12，其包含测量区域14和参考区域16.区域14,16也可包含在单独的隔离区域中。隔热区域12提供与周围热环境的隔离，从而增加测量时间并降低热噪声。虽然使用层12，但是在本示例性实施例中，为了隔离纳米尺度计10的反应和温度感测组件，可以在替代实施例中使用任何用于热隔离这些组件的装置。版权所有（C）2005，JPO＆NCIPI

2. 发明专利

JP2005181312A Coordinate conversion method from scanner image coordinates of rare cell into microscope coordinates using reticle mark on sample medium 审中-公开
标题翻译：使用样品标记在样品介质上的稀有细胞扫描仪图像坐标转换为微观坐标的坐标转换方法
公开(公告)号：JP2005181312A
公开(公告)日：2005-07-07
申请号：JP2004358696
申请日：2004-12-10
申请人： Palo Alto Research Center Inc , Scripps Res Inst:The , ザスクリップスリサーチインスティテュート , パロアルトリサーチセンターインコーポレイテッド
发明人： CURRY DOUGLAS N , BRUCE RICHARD H , KRIVACIC ROBERT T , HSIEH HUANGPIN B , LERNER RICHARD A
IPC分类号： G01B11/00 , G01N15/00 , G01N15/14 , G01N21/27 , G01N21/64 , G06T1/00 , G06T7/00
CPC分类号： G01N15/1475 , G01N15/1468 , G01N2015/0065 , G06K9/00134 , G06K9/32 , G06T7/73 , G06T2207/30024
摘要： PROBLEM TO BE SOLVED: To provide a method of acquiring an objective position, with respect to image formation technology. SOLUTION: A first coordinates space of an image forming system is determined, and the coordinates in the first coordinates space are specified. A second coordinates space of a second image forming system is determined, and the coordinates in the second coordinates space are specified. Coordinate conversion parameter, are calculated by using the coordinates specified by the first coordinates space. Then, the coordinates of at least one object are specified in the first coordinates space, and the coordinates of the first coordinates space of this object are conversed into the specific coordinates in the second coordinates space. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供关于图像形成技术的获取目标位置的方法。解决方案：确定图像形成系统的第一坐标空间，并且指定第一坐标空间中的坐标。确定第二图像形成系统的第二坐标空间，并且指定第二坐标空间中的坐标。坐标转换参数，通过使用由第一个坐标空间指定的坐标进行计算。然后，在第一坐标空间中指定至少一个对象的坐标，并且将该对象的第一坐标空间的坐标转换为第二坐标空间中的特定坐标。版权所有（C）2005，JPO＆NCIPI

3. 发明专利

JP2007192819A Novel immunocytostaining method for enhanced dye ratio discrimination in rare event sensing 有权
标题翻译：用于在罕见事件感测中增强染色体比例的新型免疫测定方法
公开(公告)号：JP2007192819A
公开(公告)日：2007-08-02
申请号：JP2007002559
申请日：2007-01-10
申请人： Palo Alto Research Center Inc , パロアルトリサーチセンターインコーポレイテッド
发明人： HSIEH H BEN , LAZARUS NICOLE HANSON , KRIVACIC ROBERT T , CURRY DOUGLAS N , BRUCE RICHARD H
IPC分类号： G01N33/53 , G01N21/64 , G01N21/78
CPC分类号： G01N1/30 , G01N15/1468 , G01N21/6428 , G01N21/6456 , G01N21/6458 , G01N33/56966 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/6482 , G01N2021/6484 , G01N2201/0833
摘要： PROBLEM TO BE SOLVED: To carry out low- and high-density cell sensing and discrimination in a blood smear assay and the like.
SOLUTION: A method of preparing a sample containing cells comprises steps of: placing a first material containing the cells on a slide; adding a first type of antibody; adding a second type of antibody; associating a first marker with one of the first type of antibody and the second type of antibody; and associating a second marker with one of the first type of antibody and the second type of antibody, wherein the prepared sample is configured to emit signals having a spectral resolution sufficient to permit filtering to differentiate and eliminate most false positives from true positive imaging event, and furthermore a confirmation is carried out by a higher resolution sensing method to determine whether they are truly the cells of interest.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：在血液涂片测定等中进行低密度和高密度细胞感测和鉴别。解决方案：制备含有细胞的样品的方法包括以下步骤：将含有细胞的第一材料放置在载玻片上; 加入第一类抗体; 添加第二类抗体; 将第一标记与第一类型的抗体和第二类型抗体之一缔合; 以及将第二标记物与所述第一类型抗体和所述第二类型抗体中的一种缔合，其中所述制备的样品被配置为发射具有足以允许过滤的光谱分辨率的信号以区分并消除来自真阳性成像事件的大多数假阳性，此外，通过更高分辨率的感测方法进行确认，以确定它们是否真正是感兴趣的细胞。版权所有（C）2007，JPO＆INPIT

4. 发明专利

JP2008151784A System and method for removing auto-fluorescence through use of multiple detection channels 有权
标题翻译：通过使用多个检测通道去除自动荧光的系统和方法
公开(公告)号：JP2008151784A
公开(公告)日：2008-07-03
申请号：JP2007319724
申请日：2007-12-11
申请人： Palo Alto Research Center Inc , パロアルトリサーチセンターインコーポレイテッド
发明人： KRIVACIC ROBERT T , HSIEH H BEN , CURRY DOUGLAS N , BRUCE RICHARD H
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , A61B5/0059 , G01N21/6456 , G01N2021/6421 , G01N2021/6482 , G01N2021/6484 , G01N2201/0833
摘要： PROBLEM TO BE SOLVED: To exclude such false substances as to occur due to auto-fluorescent events only through the use of a single laser and a single dye.
SOLUTION: A single probe is adhered to a sample. The sample is excited by a light source of a single wavelength. By emitting a light a distance from the light source, auto-fluorescence can be separated from signals in a system and a method. The light is split, and the split beams of light are collected in two separate channels or more. A first channel among the separate channels is positioned closer to the light source than the second channel is, and the second channel is closer to a discharge frequency of the single probe than the first channel is. The light collected in the first channel and the light collected in the second channel are examined to generate output signals on the basis of the examination.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：仅通过使用单个激光和单个染料来排除由于自发荧光事件而发生的这种假物质。
解决方案：将单个探针粘附到样品上。样品被单个波长的光源激发。通过从光源发射一段距离的光，自动荧光可以与系统和方法中的信号分离。光被分裂，分束光束被收集在两个独立的通道或更多的通道中。分离通道中的第一通道位于比第二通道更靠近光源，并且第二通道比第一通道更靠近单个探针的放电频率。在第一通道中收集的光和在第二通道中收集的光被检查以基于检查产生输出信号。版权所有（C）2008，JPO＆INPIT

5. 发明专利

JP2007010651A Thermal perception 有权
标题翻译：热情
公开(公告)号：JP2007010651A
公开(公告)日：2007-01-18
申请号：JP2006169714
申请日：2006-06-20
申请人： Palo Alto Research Center Inc , パロアルトリサーチセンターインコーポレイテッド
发明人： BRUCE RICHARD H , DE BRUYKER DIRK , FRANCISCO E TORRES , WOLKIN MICHAL V
IPC分类号： G01K3/06 , G01F1/68 , G01K1/00 , G01K7/24 , G01K7/30 , G01K17/00 , G01N25/20 , G01N25/48 , G01N27/00
CPC分类号： G01K7/30 , G01K17/00 , G01K17/006 , G01N25/482
摘要： PROBLEM TO BE SOLVED: To improve a technology for perceiving a thermal stimulation.
SOLUTION: A thermal perception apparatus is provided with a central layer oppositely having the first and second sides and a lateral thermal insulation, the first structure disposed on the first side of the central layer and including a thermal sensor containing a semiconductor material, the second structure disposed on the second side of the central layer, providing the thermal sensor with a thermal input signal and including a thermally conductive component containing a thermally conductive material, and decoupling component for reducing capacitive coupling between the thermally conductive material and the thermal sensor.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：改进感知热刺激的技术。解决方案：热感知装置设置有相对地具有第一和第二侧面的中心层和横向热绝缘体，第一结构设置在中心层的第一侧上，并且包括含有半导体材料的热传感器，所述第二结构设置在所述中心层的第二侧上，为所述热传感器提供热输入信号并且包括包含导热材料的导热部件和用于减小所述导热材料和所述热传感器之间的电容耦合的去耦部件。版权所有（C）2007，JPO＆INPIT

6. 发明专利

JP2008191149A Optical cavity structure for implantation 有权
标题翻译：用于植入的光学结构
公开(公告)号：JP2008191149A
公开(公告)日：2008-08-21
申请号：JP2008017987
申请日：2008-01-29
申请人： Palo Alto Research Center Inc , パロアルトリサーチセンターインコーポレイテッド
发明人： KIESEL PETER , SCHMIDT OLIVER , BASSLER MICHAEL , BRUCE RICHARD H , NOBLE M JOHNSON
IPC分类号： G01N21/35 , G01N21/01
CPC分类号： G01N21/03 , A61B5/0075 , A61B5/0084 , A61B5/14532 , A61B5/1459 , G01N21/0303 , G01N21/274 , G01N21/31
摘要： PROBLEM TO BE SOLVED: To provide various techniques including an implantable product. SOLUTION: A system 10 is an implantable product including members 12 and 14 together connected along a broken line 16. The product is long and narrow, and similar to a short needle. The member 12 has a specimen container 20 while the member 14 has a reference container 22. The containers are separated from each other by a wall part-like structure 24 and the reference container is completely surrounded by a wall part-like structure 26 on the opposite side of the structure 24 while respective end parts are surrounded by wall part-like structures such as the structure 27, for example. Since the specimen container is left open, a bodily fluid 28 can get in and get out through an open end part or an opening in a side wall part 29. Since the bodily fluid is continuously replaced with that in a surrounding area, continuous monitoring can be allowed. The members 12 and 14, being light-transmissive, receive input light via an entrance surface while they provide output light via an exit surface. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供包括可植入产品的各种技术。解决方案：系统10是可植入产品，其包括沿着虚线16连接的构件12和14.产品长而窄，并且类似于短针。构件12具有样本容器20，而构件14具有参考容器22.容器通过壁部分状结构24彼此分离，参考容器完全被壁部分状结构26包围结构24的相对侧，而各个端部被诸如结构27的壁部分状结构包围。由于样本容器保持打开状态，所以能够通过开口端部或侧壁部29的开口而进入体液28。由于身体液体与周围区域连续地替换，所以连续监视可以被）允许。透光的构件12和14经由入口表面接收输入光，同时它们经由出射表面提供输出光。版权所有（C）2008，JPO＆INPIT

7. 发明专利

JP2005156558A Method for preparing and analyzing specimen for high-throughput screening assay 有权
标题翻译：用于高通量筛选测定的准备和分析样本的方法
公开(公告)号：JP2005156558A
公开(公告)日：2005-06-16
申请号：JP2004336764
申请日：2004-11-19
申请人： Palo Alto Research Center Inc , パロ・アルト・リサーチ・センター・インコーポレーテッドPalo Alto Research Center Incorporated
发明人： BRUCE RICHARD H , TORRES FRANCISCO E , BELL ALAN G , PEETERS ERIC
IPC分类号： B01J19/00 , C40B50/08 , G01N25/48 , G01N37/00
CPC分类号： G01N25/4866 , B01J2219/00599 , B01J2219/00702 , C40B50/08 , Y10T436/11 , Y10T436/25 , Y10T436/25125 , Y10T436/2575
摘要： PROBLEM TO BE SOLVED: To provide a method for preparing and analyzing specimens for high-throughput screening assays. SOLUTION: The method for preparing and testing specimens for high-throughput screening assays for identifying bonding between a chemical target and a library compound and the use of a calorimeter device for measuring reaction enthalpy on the bonding are disclosed. The method includes the mixture of the library compound with a specific solvent and the mixture of a target compound solution with a second specific solvent on a calorimeter. The library compound/solvent is merged with the target compound/solvent solution or with a third solvent solution on the calorimeter device. Heat of reaction on each merged solution is detected and compared with each other. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供用于制备和分析用于高通量筛选测定的样品的方法。公开了用于制备和测试用于识别化学靶和文库化合物之间的键合的高通量筛选测定的样品的方法和使用量热仪来测量接合上的反应焓。该方法包括文库化合物与特定溶剂的混合物以及目标化合物溶液与第二特定溶剂在量热计上的混合物。文库化合物/溶剂与目标化合物/溶剂溶液或第三溶剂溶液在量热仪上合并。检测每个合并溶液的反应热量并进行比较。版权所有（C）2005，JPO＆NCIPI

8. 发明专利

JP2005003686A Isoelectric focusing of protein 有权
标题翻译：蛋白质的光电聚焦
公开(公告)号：JP2005003686A
公开(公告)日：2005-01-06
申请号：JP2004174780
申请日：2004-06-11
申请人： Palo Alto Research Center Inc , パロ・アルト・リサーチ・センター・インコーポレーテッドPalo Alto Research Center Incorporated
发明人： LEAN MENG H , FITCH JOHN S , PREAS BRYAN T , BRUCE RICHARD H , FRANCISCO E TORRES , BEN HSIEH H , VOLKEL ARMIN R , ELROD SCOTT A , PEETERS ERIC , CHABINYC MICHAEL L
IPC分类号： C08F2/58 , G01N27/447
CPC分类号： G01N27/44795 , G01N27/44713
摘要： PROBLEM TO BE SOLVED: To shorten a process time considerably while enabling the use of low operation voltage to obtain an analytical result with an enhanced separation capacity. SOLUTION: A gel electrophoretic system 10 for separating biomolecules on the basis of the isoelectric points of them has an electrolytic cell including a first end part, a second end part and the gel medium oriented to the gap between the first and second end parts to provide a pH gradient along the longitudinal direction between the first and second end parts, an electrode grid being an electrode grid including a plurality of electrodes 32 provided in a close vicinity to the gel medium and arranged paralelly at a narrow interval and arranged to a cell so that the electrodes 32 are oriented in the direction almost orthogonal to the longitudinal direction of the cell and voltage controllers 40 and 50 for supplying multiphase electric signals. The multiphase electric signals are either one of positive or negative progressive wave signals and the voltage controllers 40 and 50 are electrically connected to the electrode grid. The progressive wave signals pass to the second region of the electrode grid from the first region of the electrode grid. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：解决的问题：缩短处理时间，同时能够使用低操作电压来获得具有增强的分离能力的分析结果。解决方案：用于基于它们的等电点分离生物分子的凝胶电泳系统10具有包括第一端部，第二端部和凝胶介质的电解槽，该第一端部，第二端部和第二端部之间的间隙部分，以在第一和第二端部之间沿纵向方向提供pH梯度，电极栅极是电极栅格，电极栅格包括设置在凝胶介质附近的多个电极32，并且以窄间隔排列成旁瓣，使得电极32在与电池的纵向几乎正交的方向上定向，并且用于提供多相电信号的电压控制器40和50。多相电信号是正或负行波信号中的一个，电压控制器40和50电连接到电极栅。逐行波信号从电极栅格的第一区域传递到电极栅格的第二区域。版权所有（C）2005，JPO＆NCIPI

9. 发明专利

JP2008304462A Ranking fragment type by calorimetric measurement 有权
标题翻译：通过计量测量排序分类
公开(公告)号：JP2008304462A
公开(公告)日：2008-12-18
申请号：JP2008148930
申请日：2008-06-06
申请人： Palo Alto Research Center Inc , パロ・アルト・リサーチ・センター・インコーポレーテッドPalo Alto Research Center Incorporated
发明人： RECHT MICHAEL I , FRANCISCO E TORRES , BRUCE RICHARD H , BELL ALAN G
IPC分类号： G01N25/20
CPC分类号： G01N25/48
摘要： PROBLEM TO BE SOLVED: To provide an improved method for acquiring information about combination of ligands and targets.
SOLUTION: The method of using an array calorimeter comprises the steps of: supplying samples and each test and the reference groups to each set of array calorimeters having two or more cells; combining at least first and second samples of cell tests and reference groups; supplying each output signal including information about the step of combining the first and the second samples; and ranking target types and fragment types to each set of standard types having one or more sets.
COPYRIGHT: (C)2009,JPO&INPIT

10. 发明专利

JP2010237227A Gel electrophoretic system and method for focusing biomolecule band 有权
标题翻译：凝胶电泳系统和聚焦生物分子带的方法
公开(公告)号：JP2010237227A
公开(公告)日：2010-10-21
申请号：JP2010168508
申请日：2010-07-27
申请人： Palo Alto Research Center Inc , パロ・アルト・リサーチ・センター・インコーポレーテッドPalo Alto Research Center Incorporated
发明人： LEAN MENG H , FITCH JOHN S , PREAS BRYAN T , BRUCE RICHARD H , FRANCISCO E TORRES , BEN HSIEH H , VOLKEL ARMIN R , ELROD SCOTT A , PEETERS ERIC , CHABINYC MICHAEL L
IPC分类号： G01N27/447 , C08F2/58
CPC分类号： G01N27/44795 , G01N27/44713
摘要： PROBLEM TO BE SOLVED: To focus molecules into a narrow band, in electrophoresis. SOLUTION: A gel electrophoretic system 10 for separation includes: an electrophoretic cell comprising a first end, a second end, and a gel medium extending between the first and second ends; an electrode grid disposed in close proximity to the gel which includes a plurality of closely spaced parallel electrodes 32, the electrode grid being disposed with respect to the cell such that the electrodes 32 extend in a direction generally perpendicular to the longitudinal direction of the cell; and voltage controllers 40 and 50 for providing multi-phase electrical signals. With the voltage controllers 40 and 50 electrically connected to the electrode grid, a multi-phase electrical signal which is a first output is provided from the voltage controller 40 to the first end while a multi-phase electrical signal which is a second output is provided from the voltage controller 50 to the second end. The multi-phase electrical signal which is the first output passes from a first region of the electrode grid to a second region of the electrode grid while the multi-phase electrical signal which is the second output passes from the second region of the electrode grid to the first region of the electrode grid. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：在电泳中将分子聚焦成窄带。解决方案：用于分离的凝胶电泳系统10包括：电泳单元，包括在第一和第二端之间延伸的第一端，第二端和凝胶介质; 电极栅极，其布置在紧密的凝胶处，包括多个紧密间隔开的平行电极32，电极栅格相对于电池设置，使得电极32沿大致垂直于电池的纵向的方向延伸; 以及用于提供多相电信号的电压控制器40和50。当电压控制器40和50电连接到电极栅极时，作为第一输出的多相电信号从电压控制器40提供到第一端，同时提供作为第二输出的多相电信号从电压控制器50到第二端。作为第一输出的多相电信号从电极栅格的第一区域通过电极栅极的第二区域，而作为第二输出的多相电信号从电极栅极的第二区域通过电极网格的第一个区域。版权所有（C）2011，JPO＆INPIT

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