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1. 发明专利

JP2011168591A Low-molecular polysulfated hyaluronic acid derivative and medicine containing the same 有权
标题翻译：低分子量聚羟基丙酸衍生物及其含有药物
公开(公告)号：JP2011168591A
公开(公告)日：2011-09-01
申请号：JP2011055681
申请日：2011-03-14
申请人： Otsuka Chem Co Ltd , Otsuka Pharmaceut Co Ltd , 大塚化学株式会社 , 大塚製薬株式会社
发明人： KAKEHI KAZUAKI , ASAI HIROAKI , HAYASHI NAOHIRO , SHIMIZU SATOSHI , GOTO FUMITAKA , KOGA YASUO , TOMOYASU TAKAHIRO , TAKI TAKAO , KATO YUSUKE , NAKAZATO SATORU , TAKABA JUNJI , AZUMA ATSUSHI , HIRANO CHIKO , IZUMI KAZUNARI , KASHIMOTO NENRYU , SAKAMOTO YOKO , HAYASHI TAKASHI , NISHIDA MASARU
IPC分类号： A61K31/728 , A61P11/02 , A61P11/06 , A61P17/00 , A61P27/02 , A61P37/08 , C07H15/04 , C08B37/08
CPC分类号： A61K31/728 , C08B37/0072
摘要： PROBLEM TO BE SOLVED: To provide a low-molecular polysulfated hyaluronic acid derivative useful in the prevention and/or treatment of allergic diseases.
SOLUTION: There is provided a preventive and/or therapeutic agent for an allergic disease selected from pollinosis, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, and asthma, which agent comprises either a low-molecular polysulfated hyaluronic acid derivative represented by formula (IB) or a pharmaceutically acceptable salt thereof as an active ingredient. In the formula, n is a number of 0-15, and R's represent each independently H, SO
3 H or the like.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供可用于预防和/或治疗过敏性疾病的低分子量多硫酸化透明质酸衍生物。提供了选自花粉osis病，过敏性鼻炎，过敏性结膜炎，特应性皮炎和哮喘的过敏性疾病的预防和/或治疗剂，所述药物包含式（I）表示的低分子多硫酸化透明质酸衍生物（IB）或其药学上可接受的盐作为活性成分。在该式中，n为0-15的数，R为H，SO 3 S 3 H等。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2012046511A Pharmaceutical agent containing low molecular weight polysulfated hyaluronic acid derivative 审中-公开
标题翻译：含有低分子量聚对苯二甲酸衍生物的药物代理
公开(公告)号：JP2012046511A
公开(公告)日：2012-03-08
申请号：JP2011167126
申请日：2011-07-29
申请人： Otsuka Chem Co Ltd , Otsuka Pharmaceut Co Ltd , 大塚化学株式会社 , 大塚製薬株式会社
发明人： KAKEHI KAZUAKI , ASAI HIROAKI , HAYASHI NAOHIRO , SHIMIZU SATOSHI , GOTO FUMITAKA , KOGA YASUO , TOMOYASU TAKAHIRO , TAKI TAKAO , KATO YUSUKE , NAKAZATO SATORU , TAKABA JUNJI , AZUMA ATSUSHI , HIRANO CHIKO , IZUMI KAZUNARI , KASHIMOTO NENRYU , SAKAMOTO YOKO , HAYASHI TAKASHI , NISHIDA MASARU
IPC分类号： A61K31/728 , A61K31/7016 , A61K31/702 , A61P11/02 , A61P11/06 , A61P17/04 , A61P27/14 , A61P37/08 , C07H5/06 , C07H7/033 , C07H11/00 , C08B37/00
摘要： PROBLEM TO BE SOLVED: To provide a polysulfated hyaluronic acid derivative useful for preventing and/or treating allergic diseases.SOLUTION: A low molecular weight polysulfated hyaluronic acid derivative expressed by general formula (IA) or (IB) or a pharmaceutically acceptable salt thereof is provided, wherein n represents a number of 0-15; and R each independently represents H, SOH or the like.
摘要翻译：待解决的问题：提供可用于预防和/或治疗过敏性疾病的多硫酸化透明质酸衍生物。解决方案：提供由通式（IA）或（IB）表示的低分子量多硫酸化透明质酸衍生物或其药学上可接受的盐，其中n表示0-15的数; R各自独立地表示H，SO，SB，SO 3等。版权所有（C）2012，JPO＆INPIT

3. 发明专利

JP2003070481A Malaria antigen-related peptide 审中-公开
标题翻译：疟疾抗原相关肽
公开(公告)号：JP2003070481A
公开(公告)日：2003-03-11
申请号：JP2001269907
申请日：2001-09-06
申请人： Otsuka Pharmaceut Co Ltd , Tokai Univ , 大塚製薬株式会社 , 学校法人東海大学
发明人： AIKAWA MASAMICHI , ISHIKAWA MASARU , TAKI TAKAO
IPC分类号： C12N15/09 , A61K39/015 , A61P33/06 , C07K7/08 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02
CPC分类号： Y02A50/412
摘要： PROBLEM TO BE SOLVED: To provide a new malaria antigen pseudo-peptide replacing a malaria antigen and a vaccine and a therapeutic agent for malaria utilizing the malaria antigen pseudo-peptide. SOLUTION: The malaria antigen-related peptide composed of a specific amino acid sequence and the malaria antigen-related peptide specifically reacting with an antibody against the malaria antigen-related peptide are provided. The peptide is useful as the vaccine replacing the malaria antigen.
摘要翻译：要解决的问题：利用疟疾抗原假肽提供替代疟疾抗原的新的疟疾抗原假肽和疫苗以及用于疟疾的治疗剂。解决方案：提供由特异性氨基酸序列组成的疟疾抗原相关肽和与针对疟疾抗原相关肽的抗体特异性反应的疟疾抗原相关肽。该肽可用作代替疟疾抗原的疫苗。

4. 发明专利

JP2013188220A Equol-containing extract, method for production thereof, method for extraction of equol, and equol-containing food 审中-公开
标题翻译：含有等离子体提取物，其生产方法，提取方法和含有食品的方法
公开(公告)号：JP2013188220A
公开(公告)日：2013-09-26
申请号：JP2013108439
申请日：2013-05-22
申请人： Otsuka Pharmaceut Co Ltd , 大塚製薬株式会社
发明人： TOMINAGA MICHIAKI , TAKI TAKAO , MATSUMOTO TOSHIAKI , HANYA IZUMI , IMADA TAKUMA , MATSUOKA KUNIHIKO , KISHIMOTO TAKUYA , UCHIYAMA YUKO , TSUNEISHI HIROMASA , TSUJI MACHIKO , VALDES-GONZALEZ TANIA , TADANO KENTARO , KAMEDA KYOKO
IPC分类号： C12P7/22 , A61K31/353 , A61K36/00 , A61K36/48 , A61P3/06 , A61P5/30 , A61P13/08 , A61P15/00 , A61P15/12 , A61P19/10 , A61P35/00
CPC分类号： A23L1/3002 , A21D2/368 , A23C9/1307 , A23C9/1315 , A23C9/1544 , A23C11/02 , A23C11/103 , A23C20/025 , A23F3/163 , A23F5/243 , A23L2/52 , A23L5/23 , A23L7/196 , A23L9/12 , A23L11/09 , A23L13/426 , A23L13/65 , A23L17/70 , A23L21/15 , A23L23/00 , A23L27/50 , A23L27/60 , A23L33/105 , A61K31/353 , A61K36/48
摘要： PROBLEM TO BE SOLVED: To provide a method for efficiently purifying an equol-containing fermented soybean hypocotyl to obtain a highly pure equol, and an extract obtained by extracting useful components containing equol, and a method for producing the same.SOLUTION: The present invention makes it possible to efficiently obtain useful components containing equol from a fermented soybean hypocotyl by subjecting an equol-containing fermented soybean hypocotyl to extraction using an ethanol aqueous solution as an extractant. The present invention reduces the content of saponin, which causes an unpleasant taste, by sequentially subjecting the equol-containing fermented soybean hypocotyl to extraction using an ethanol aqueous solution and ethanol, while efficiently extracting equol and glycitein. Purified equol is extracted from an equol-containing material by silica gel column chromatography.
摘要翻译：要解决的问题：提供一种有效纯化含有雌马酚的发酵大豆下胚轴以获得高纯度牛尿酚的方法，以及通过提取含有雌马酚的有用成分得到的提取物及其制造方法。解决方案：本发明通过使用含有雌马酚的发酵大豆下胚轴用乙醇水溶液萃取剂进行提取，可以有效地从发酵大豆下胚轴中获得含有雌马酚的有用成分。本发明通过依次使用乙醇水溶液和乙醇对含有雌马酚的发酵大豆下胚轴进行萃取，同时有效地提取雌马酚和黄豆黄素，从而降低了引起不愉快味道的皂素含量。通过硅胶柱色谱从含有牛尿酚的材料中提取纯化的牛尿酚。

5. 发明专利

JP2005154349A Platelet production-inducing agent 有权
标题翻译：电极生产诱导剂
公开(公告)号：JP2005154349A
公开(公告)日：2005-06-16
申请号：JP2003396055
申请日：2003-11-26
申请人： Otsuka Pharmaceut Co Ltd , 大塚製薬株式会社
发明人： SOGO SHINJI , HARADA YASUO , TAKEDA KUNIKO , IIMORI YOSHIMASA , TAKI TAKAO
IPC分类号： G01N33/50 , A61K38/00 , A61K48/00 , A61P7/04 , C12N5/07 , C12N5/071 , C12N15/09 , C12Q1/68 , G01N33/15 , C12N5/06
摘要： PROBLEM TO BE SOLVED: To obtain a medicinal composition having platelet production-inducing activity and containing a polypeptide useful for supply of platelet to diseases accompanying thrombocytopenia as an active ingredient, and to provide a method for producing the platelet utilizing the polypeptide and a method, for screening a substance promoting production of the polypeptide, or the like. SOLUTION: The medicinal composition comprises at least one kind of polypeptide selected from the group consisting of (a) a polypeptide composed of a 1-95 amino acid sequence in an amino acid sequence represented by sequence No.1 and (b) a polypeptide composed of an amino acid sequence in which one or a plurality of amino acids are deleted, substituted or added from/for/to the 1-95 amino acid sequence (a) and having platelet production-inducing activity as an active ingredient. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：获得具有血小板产生诱导活性的药物组合物，并含有可用于向血小板减少症伴随血小板减少症的血小板供应的多肽作为活性成分的药物组合物，以及提供利用该多肽的血小板产生方法和用于筛选促进多肽生产的物质的方法等。药物组合物包含至少一种选自以下的多肽：（a）由序列1所示的氨基酸序列中的1-95个氨基酸序列组成的多肽和（b）由1-95个氨基酸序列（a）中缺失，取代或添加一个或多个氨基酸并具有血小板产生诱导活性作为活性成分的氨基酸序列组成的多肽。版权所有（C）2005，JPO＆NCIPI

6. 发明专利

JP2004000060A METHOD FOR SCREENING COMPOUND AFFECTING PRODUCTION OF AMYLOID β 审中-公开
公开(公告)号：JP2004000060A
公开(公告)日：2004-01-08
申请号：JP2002159472
申请日：2002-05-31
申请人： Otsuka Pharmaceut Co Ltd , 大塚製薬株式会社
发明人： SHIMABUKU ALFREDO , OGINO KOICHI , TAKI TAKAO , SHIN TATSUMO , KITAMOTO TETSUYUKI
IPC分类号： C12N15/09 , A61K45/00 , A61P25/28 , C07K14/47 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12Q1/02 , C12Q1/37 , G01N33/68
CPC分类号： C07K14/4711 , C07K2319/02 , C12Q1/37 , G01N33/6896 , G01N2500/00
摘要： PROBLEM TO BE SOLVED: To provide a material for efficiently assaying the production of amyloid β associated with attack of Alzheimer's dementia and a method for screening a substance affecting the production of the amyloid β utilizing the material. SOLUTION: An amyloid β precursor protein, a modified protein, a fusion protein composed of the modified protein and a detectable secretory protein, and a test cell stably expressing the proteins, and the method for screening the substance affecting the production of the amyloid β using the test cell are provided. COPYRIGHT: (C)2004,JPO

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