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1. 发明专利

JP2014157018A Spectral image photographing device 审中-公开
标题翻译：光谱图像摄影装置
公开(公告)号：JP2014157018A
公开(公告)日：2014-08-28
申请号：JP2011132566
申请日：2011-06-14
申请人： Olympus Corp , オリンパス株式会社
发明人： WATANABE TOSHIAKI
IPC分类号： G01J3/26 , G01J3/36
CPC分类号： G01J3/26
摘要： PROBLEM TO BE SOLVED: To provide a spectral image photographing device that can photograph a spectral image formed by light of a uniform wavelength all over an entire photographing area.SOLUTION: The spectral image photographing device comprises: a wavelength variable spectral element that changes a wavelength of transmission light by changing a surface interval between counter faces of a pair of optical substrates; a surface interval control section that changes the surface interval between the counter faces of the pair of optical substrates by moving at least one of the pair of optical substrates; and a photographing section that has an image pickup element acquiring image information on an image to be formed by the transmission light of the wavelength variable spectral element. A photographing area of the image pickup element is composed of a plurality of division areas, and the photographing section has image pickup element control means that causes the image pickup element to acquire the image information only from the division area having light of a predetermined wavelength band received. The photographing section acquires the image information all over the entire photographing area as the surface interval control section changes the surface interval between the counter surfaces.
摘要翻译：要解决的问题：提供一种能够在整个拍摄区域拍摄由均匀波长的光形成的光谱图像的光谱图像拍摄装置。解决方案：光谱图像拍摄装置包括：波长可变光谱元件，其改变波长通过改变一对光学基板的相对面之间的表面间隔来实现透射光; 表面间隔控制部，其通过移动所述一对光学基板中的至少一个来改变所述一对光学基板的所述对置面之间的表面间隔; 以及具有图像拾取元件的拍摄部分，其获取要由波长可变光谱元件的透射光形成的图像的图像信息。图像拾取元件的拍摄区域由多个划分区域组成，并且拍摄部分具有图像拾取元件控制装置，其使得图像拾取元件仅从具有预定波长带的光的分割区域获取图像信息接收。当表面间隔控制部分改变对置表面之间的表面间隔时，拍摄部分获取整个拍摄区域上的图像信息。

2. 发明专利

JP2012157383A Endoscope apparatus 审中-公开
标题翻译：内窥镜装置
公开(公告)号：JP2012157383A
公开(公告)日：2012-08-23
申请号：JP2011017085
申请日：2011-01-28
申请人： Olympus Corp , オリンパス株式会社
发明人： WATANABE TOSHIAKI
IPC分类号： A61B1/00 , A61B1/04 , G02B23/24 , G02B23/26
摘要： PROBLEM TO BE SOLVED: To provide an endoscope apparatus which usually displays a white light image and simultaneously, acquires a narrow band light image and a bright near infrared fluorescence image with high SN.SOLUTION: The endoscope apparatus includes: an illumination part 1 of white light and near infrared excitation light; an optical path branch part 2 branching the reflection light into two optical paths and guiding an near infrared fluorescence image only to a second optical path; a white light image acquisition part 3 disposed on the second optical path; a variable spectroscopic optical element 4 disposed on the second optical path; a special light image acquisition part 5 acquiring a narrow band light image or near infrared fluorescence image transmitted by the variable spectroscopic optical element 4; an imaging mode switching part 6 switching the imaging mode to any of a narrow band imaging mode and a near infrared imaging mode; and a control part 7 switching the spectral characteristics of the variable spectral optical element 4 in such a manner that the transmission peak is caused to exist in a desired narrow band within a wavelength band of the white light and to transmit near infrared fluorescence wavelength in the narrow band imaging mode, and the transmission peak is caused to not exist within the wavelength band of white light and to transmit the near infrared fluorescence light wavelength in the near infrared imaging mode.
摘要翻译：解决问题的方案：提供一种通常显示白光图像并同时获取高SN的窄带光图像和亮近红外荧光图像的内窥镜装置。解决方案：内窥镜装置包括：白光的照明部分1和近红外激发光; 将反射光分成两个光路并将近红外荧光图像仅引导到第二光路的光路分支部2; 布置在第二光路上的白光图像获取部3; 设置在第二光路上的可变光谱元件4; 获取由可变分光光学元件4发送的窄带光图像或近红外荧光图像的特殊光图像获取部分5; 成像模式切换部分6将成像模式切换成窄带成像模式和近红外成像模式中的任一者; 以及控制部分7，以可变光谱光学元件4的光谱特性切换，使得发射峰值存在于白光的波长带内的期望的窄带内，并且在窄带成像模式，并且使透射峰不存在于白光的波长带内并且在近红外成像模式中传输近红外荧光光波长。版权所有（C）2012，JPO＆INPIT

3. 发明专利

JP2011110216A Fluorescence observation apparatus 有权
标题翻译：荧光观察装置
公开(公告)号：JP2011110216A
公开(公告)日：2011-06-09
申请号：JP2009269156
申请日：2009-11-26
申请人： Olympus Corp , オリンパス株式会社
发明人： WATANABE TOSHIAKI
IPC分类号： A61B1/06 , A61B1/00 , A61B1/04
CPC分类号： G01N21/6458 , A61B1/043 , A61B1/05 , A61B1/063 , A61B1/0638 , A61B1/0646 , A61B5/0071 , A61B5/0084 , G01J1/32 , G01J3/02 , G01J3/027 , G01J3/10 , G01J3/28 , G01J3/2803 , G01J3/4406 , G01N2021/6484
摘要： PROBLEM TO BE SOLVED: To acquire and observe a quantitative fluorescence image with appropriate brightness. SOLUTION: A fluorescence observation apparatus 100 includes: an illumination unit 20 that includes a light source 10 for irradiating an observation target region X with illumination light and excitation light; a fluorescence image acquisition section 42 that acquires a fluorescence image from fluorescence produced in the observation target region X; a white-light image acquisition section 44 that acquires a reference image from return light returning from the observation target region X; exposure-time adjustment units 61, 66 that adjust the exposure time based on the luminance value of the reference image; a diaphragm control section 14 and a semiconductor laser control section 17 that control the intensity of the illumination light and that of the excitation light based on the exposure time; first normalization sections 72, 76 that normalize the luminance of the reference image and the fluorescence image by the exposure time; second normalization sections 74, 78 that normalize the luminance of the reference image and the fluorescence image by the light intensity; and a division processing section 58 that corrects the fluorescence image by the reference image, by using the normalized reference image and fluorescence image. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：以适当的亮度获取和观察定量荧光图像。解决方案：荧光观察装置100包括：照明单元20，其包括用于用观察对象区域X照射照明光和激发光的光源10; 荧光图像获取部42，其从观察对象区域X中产生的荧光获取荧光图像; 白光图像获取部44，其从观察对象区域X返回的返回光获取基准图像; 曝光时间调整单元61,66，其基于参考图像的亮度值调节曝光时间; 基于曝光时间控制照明光强度和激发光强度的光圈控制部14和半导体激光控制部17; 第一归一化部分72,76，其通过曝光时间归一化参考图像和荧光图像的亮度; 第二归一化部分74,78，其通过光强度归一化参考图像的亮度和荧光图像; 以及通过使用归一化参考图像和荧光图像校正荧光图像的分割处理部58。版权所有（C）2011，JPO＆INPIT

4. 发明专利

JP2008229025A Fluorescence observing apparatus 有权
标题翻译：荧光观察装置
公开(公告)号：JP2008229025A
公开(公告)日：2008-10-02
申请号：JP2007073392
申请日：2007-03-20
申请人： Olympus Corp , オリンパス株式会社
发明人： WATANABE TOSHIAKI
IPC分类号： A61B1/00 , G01B11/00 , G01B11/26 , G01N21/64 , G02B23/24
摘要： PROBLEM TO BE SOLVED: To correctly diagnose the lesion by highly precisely correcting an acquired fluorescence image. SOLUTION: The fluorescence observing apparatus 1 comprises: an excitation light emission end 10 for emitting diffusing excitation light L1 to an observation object part X; a fluorescence detection part 21 for detecting fluorescence generated from each position of the observation object part X by irradiation with the excitation light L1 from the excitation light emission end 10; a distance detection part for detecting a distance between the excitation light emission end 10 and each position of the observation object part X; an angle calculation part 26 for calculating an angle formed by a straight line connecting the excitation light emission end 10 and each position of the observation object part X and a normal at each position of the observation object part X on the basis of the distance detected by the distance detection part; and a correction part 27 for correcting the luminance information of the fluorescence detected by the fluorescence detection part 21 on the basis of the distance detected by the distance detection part and the angle calculated by the angle calculation part 26. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：通过高度精确地校正获取的荧光图像来正确诊断病变。荧光观察装置1包括：激发光发射端10，其用于将激发光L1发射到观察对象部分X; 荧光检测部21，用于通过从激发光发射端10照射激发光L1来检测从观察对象部X的各位置产生的荧光; 用于检测激发光发射端10与观察对象部X的各位置之间的距离的距离检测部; 角度计算部分26，用于根据由观测对象部分X检测到的距离计算由连接激发光发射端10的直线和观察对象部分X的每个位置的直线与观察对象部分X的每个位置处的法线形成的角度距离检测部; 以及校正部27，其基于由距离检测部检测出的距离和由角度计算部26计算出的角度来校正由荧光检测部21检测出的荧光的亮度信息。权利要求：（C ）2009，JPO＆INPIT

5. 发明专利

JP2008142346A Fluorescence endoscope 有权
标题翻译：荧光内窥镜
公开(公告)号：JP2008142346A
公开(公告)日：2008-06-26
申请号：JP2006333687
申请日：2006-12-11
申请人： Olympus Corp , オリンパス株式会社
发明人： WATANABE TOSHIAKI , OKAWA ATSUSHI , ISHIHARA YASUNARI , KARASAWA AKIRA
IPC分类号： A61B1/00 , A61B1/04
摘要： PROBLEM TO BE SOLVED: To provide a fluorescence endoscope observing the internal circumferential face of a luminal subject in a plurality of directions at a fixed distance using fluorescence in fluorescence observation using a side-view type endoscope. SOLUTION: This fluorescence endoscope is characterized in having: an insertion portion to be inserted into a body cavity 3; a balloon 15 positioning the insertion portion relative to the body cavity 3 in the radial direction of the insertion portion 5 by coming into contact with the inner wall of the body cavity 3 positioned radially to the insertion portion 5; light emission/guide sections 17 and 19 emitting an excitation light irradiated to the inner wall, radially outward the insertion portion, and guiding the fluorescence generated from the inner wall and transmitting through the balloon 15, to the inside of the insertion portion from a plurality of different radial directions of the insertion portion; an image pickup section 21 capturing the fluorescence introduced from the light emission/guide sections 17 and 19; and a moving section 23 moving the image pickup section 21 along the optical axis of the fluorescence entering the image pickup section 21 based on a distance between the contact face of the balloon 15 with the inner wall and the insertion portion 5. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种使用侧视型内窥镜在荧光观察中使用荧光以固定距离在多个方向观察内腔体的内周面的荧光内窥镜。该荧光内窥镜的特征在于具有：插入体腔3的插入部; 气囊15通过与放置在插入部5的径向的体腔3的内壁相接触而相对于体腔3在插入部5的径向方向上定位插入部; 发射/引导部分17和19，发射照射到内壁的激励光，径向向外插入部分，并且引导从内壁产生的荧光，并从多个透射通过球囊15传播到插入部分的内部的插入部分的不同径向方向; 捕获从发光/引导部分17和19引入的荧光的图像拾取部分21; 以及基于球囊15的接触面与内壁和插入部5之间的距离，沿着进入图像拾取部21的荧光的光轴移动图像拾取部21的移动部23。（C）2008，JPO＆INPIT

6. 发明专利

JP2007252727A Endoscope 审中-公开
标题翻译：内窥镜
公开(公告)号：JP2007252727A
公开(公告)日：2007-10-04
申请号：JP2006082654
申请日：2006-03-24
申请人： Olympus Corp , オリンパス株式会社
发明人： WATANABE TOSHIAKI , OKAWA ATSUSHI , SHA TENU
IPC分类号： A61B1/00 , G02B23/24
摘要： PROBLEM TO BE SOLVED: To provide an endoscope having biocompatibility capable of reducing the diameter of the insertion part while keeping the bending function of the insertion part.
SOLUTION: The endoscope comprises an insertion part 5 for inserting to the inside of the observed subject, an irradiation part 15 for irradiating the irradiated light to the observed region of the observed subject from the tip of the insertion part 5, and observing parts 17, 19 which collect the reflective light of the irradiated light in the observed region and taking images of the observed region, and then it is characterized in that the insertion part 5 has a shape-memory outer sheath tube 13 formed of a shape-memory resin which is the same resin as the insertion part 5 and can deform to the prememorized bent shape above the predetermined temperature.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供具有生物相容性的内窥镜，其能够在保持插入部的弯曲功能的同时减小插入部的直径。解决方案：内窥镜包括用于插入观察对象内部的插入部5，用于从被插入部5的前端向照射对象的观察区域照射照射光的照射部15，部分17,19收集观察区域中的照射光的反射光并拍摄观察区域的图像，然后其特征在于，插入部分5具有形状记忆外护套管13，记忆树脂，其与插入部分5是相同的树脂，并且可以变形到高于预定温度的预制弯曲形状。版权所有（C）2008，JPO＆INPIT

7. 发明专利

JP2006102481A Endoscope apparatus and fluorescence determining method using endoscope apparatus 有权
标题翻译：使用内窥镜装置的内窥镜装置和荧光测定方法
公开(公告)号：JP2006102481A
公开(公告)日：2006-04-20
申请号：JP2005212229
申请日：2005-07-22
申请人： Olympus Corp , オリンパス株式会社
发明人： MIURA NAOKI , WATANABE TOSHIAKI
IPC分类号： A61B1/00
CPC分类号： A61B1/00186 , A61B1/00009 , A61B1/043 , A61B1/0638 , A61B1/0646 , A61B5/0071 , A61B5/0084
摘要： PROBLEM TO BE SOLVED: To provide an endoscope apparatus capable of easily observing an area to be observed.
SOLUTION: The endoscope apparatus is equipped with an illuminating means 20 irradiating an illuminating light including a visible wave region light and plural exciting lights exciting fluorescence lights with different wave length region of infrared rays toward the area C to be observed in a body to be observed, an imaging means 35 arranged at the apex of an inserting part 30 to be inserted in the body to be observed and to pick-up a returning light of the illuminating light from the area C to be observed and the fluorescence lights emitted from the area C to be observed, and a cut filter 34 arranged at the light incoming side of the imaging means 35 and shielding at least plural exciting lights.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种能够容易地观察要观察的区域的内窥镜装置。解决方案：内窥镜装置配备有照射装置20，其照射包括可见光区域光的照明光和多个激励光，其具有不同波长的红外线区域的荧光，朝向待观察区域C的身体要观察的是，设置在插入部30的顶点处以插入待观察的身体中的摄像装置35，并且从要观察的区域C拾取照明光的返回光并发出荧光从要观察的区域C和设置在成像装置35的光入射侧的截止滤光器34并屏蔽至少多个激发光。版权所有（C）2006，JPO＆NCIPI

8. 发明专利

JP2013248319A Fluorescent endoscope apparatus 有权
标题翻译：荧光内窥镜装置
公开(公告)号：JP2013248319A
公开(公告)日：2013-12-12
申请号：JP2012126814
申请日：2012-06-04
申请人： Olympus Corp , オリンパス株式会社
发明人： WATANABE TOSHIAKI
IPC分类号： A61B1/00
CPC分类号： A61B1/043 , A61B1/00009 , A61B1/0002 , A61B1/00045 , A61B1/0638 , A61B1/0646 , A61B1/0684
摘要： PROBLEM TO BE SOLVED: To provide a fluorescent endoscope apparatus capable of acquiring a white light image and a plurality of kinds of fluorescent images at a high frame rate with simple configuration.SOLUTION: A fluorescent endoscope apparatus includes a light source part 10 time-divisionally emitting light in a plurality of kinds of irradiation patterns formed by combining two kinds of excitation light with light in a plurality of wavelength bands belonging to two kinds of wavelength regions out of RGB; an imaging part 20 receiving reflected light and two kinds of fluorescent light; and an image processing part 30 outputting the white light image and two kinds of fluorescent images. The imaging part has three kinds of imaging regions, and each receives two kinds of fluorescent light in the first imaging region, and receives reflected light in two kinds of wavelength bands and reflected light in a narrow band near the first imaging region in the second and third imaging regions. The image processing part outputs the first and second fluorescent images respectively using light receiving information on the two kinds of received fluorescent light, and outputs a pseudo white light image using light receiving information on the reflected light in the two kinds of wavelength bands and the reflected light in the narrow band near the first imaging region.
摘要翻译：要解决的问题：提供一种荧光内窥镜装置，其能够以简单的结构获得高帧率的白光图像和多种荧光图像。解决方案：荧光内窥镜装置包括光源部分10，分时通过将属于两个波长区域的多个波长带中的两种激发光与光组合在RGB中，形成多种照射图案; 接收反射光的成像部20和两种荧光; 以及输出白光图像和两种荧光图像的图像处理部30。成像部具有三种成像区域，并且在第一成像区域中接收两种荧光，并且在第二成像区域中接收两种波长带中的反射光和在第二成像区域中的第一成像区域附近的窄带内的反射光，以及第三成像区域。图像处理部分分别使用两种接收的荧光的光接收信息输出第一和第二荧光图像，并且使用在两种波长带中的反射光的光接收信息来输出伪白光图像，并且反射在第一成像区域附近的窄带中的光。

9. 发明专利

JP2009291554A Fluorescence endoscope system 有权
标题翻译：荧光内窥镜系统
公开(公告)号：JP2009291554A
公开(公告)日：2009-12-17
申请号：JP2008150854
申请日：2008-06-09
申请人： Olympus Corp , オリンパス株式会社
发明人： WATANABE TOSHIAKI
IPC分类号： A61B1/04 , G01N21/64
摘要： PROBLEM TO BE SOLVED: To correctly and clearly determine a lesion tissue where cancer cells or the like exist by use of a clear fluorescence image with fluorescence to be emitted from fluorescence chemical agents while restricting effects of self-florescence. SOLUTION: A fluorescence endoscope system 1 includes an excitation light source 4 to alternately emit first excitation light to excite fluorescence chemical agent introduced to the living body tissue A and self-fluorescence substances originated from the living body and second excitation light to mainly excite the self-fluorescence substances excited by the first excitation light, an imaging part 10 to image fluorescence of a predetermined wavelength range out of fluorescence respectively emitted from the living body tissue as the first excitation light and the second excitation light from the excitation light source 4 are radiated, and an image correction part 19 to correct a chemical agent florescence image obtained by the imaging part 10 as the first excitation light is radiated based on the self-florescence light image obtained by the imaging part when the second excitation light is radiated. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：通过使用具有荧光的透明荧光图像，通过荧光化学试剂发出荧光，同时限制自花期的作用，正确清楚地确定存在癌细胞等的病变组织。荧光内窥镜系统1包括激发光源4，以交替地发射第一激发光以激发引入生物体组织A的荧光化学试剂和主要来自生物体的自发荧光物质和第二激发光激发由第一激发光激发的自荧光物质，成像部10，从作为第一激发光的生物体组织分别发出的荧光的荧光和来自激发光源的第二激发光成像荧光照射第二激发光，并且基于由成像部获得的自荧光光图像来照射由成像部10获得的化学剂荧光图像作为第一激发光的图像校正部19。。版权所有（C）2010，JPO＆INPIT

10. 发明专利

JP2008289560A Fluorescence endoscope apparatus 有权
标题翻译：荧光内窥镜装置
公开(公告)号：JP2008289560A
公开(公告)日：2008-12-04
申请号：JP2007135804
申请日：2007-05-22
申请人： Olympus Corp , オリンパス株式会社
发明人： WATANABE TOSHIAKI
IPC分类号： A61B1/00
摘要： PROBLEM TO BE SOLVED: To acquire a spectral decomposition image at a high frame rate. SOLUTION: The fluorescence endoscope apparatus 1 includes: a light source unit 3 for generating excitation light to the observation part of a living body to which a fluorescent probe is injected beforehand; a variable spectroscopic element 29 for selecting the return light of a prescribed wavelength range from return light returning from the living body; a CCD 31 for detecting the return light of the wavelength range selected by the variable spectroscopic element 29; an image processing part 43 for decomposing the spectrum of the fluorescent probe on the basis of the return light detected by the CCD 31; an input part 33 for inputting the kind of the fluorescent probe and an observation method; a memory 35 for making the control method of the light source unit 3, the variable spectroscopic element 29 and the image processing part 43 correspond to the kind of the fluorescent probe and the observation method and storing them; and a control part 37 for reading the wavelength range and setting corresponding to the kind of the fluorescent probe and the observation method of the control method input by the input part 33 from the memory 35 and controlling the light source unit 3, the variable spectroscopic element 29 and the image processing part 43. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：以高帧速率获取频谱分解图像。荧光内窥镜装置1包括：用于向预先注入荧光探针的生物体的观察部分产生激发光的光源单元3; 可变分光元件29，用于从从生物体返回的返回光中选择规定波长范围的返回光; 用于检测由可变分光元件29选择的波长范围的返回光的CCD31; 图像处理部43，其根据CCD31检测出的返回光分解荧光探针的光谱; 用于输入荧光探针的种类的输入部33和观察方法; 用于制造光源单元3，可变分光元件29和图像处理部43的控制方法的存储器35对应于荧光探针的种类和观察方法并将其存储; 以及控制部分37，用于从存储器35读取与荧光探针的种类相对应的波长范围和设置以及由输入部分33输入的控制方法的观察方法，并控制光源单元3，可变分光元件 29和图像处理部分43.版权所有（C）2009，JPO＆INPIT

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