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1. 发明专利

JPH11178578A HUMAN RNF5 GENE 失效
公开(公告)号：JPH11178578A
公开(公告)日：1999-07-06
申请号：JP35518397
申请日：1997-12-24
申请人： OTSUKA PHARMA CO LTD
发明人： KIYUUSHIKI HIROYUKI , HORIE MASATO , SUZUKI MIKIO
IPC分类号： C12N15/09 , A61K48/00 , A61P35/00 , C07K14/47 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To obtain the subject new gene comprising a gene comprising a specific amino acid sequence and containing a base sequence encoding a protein having binding properties to an RNF5 and useful for elucidating the morbid state of diseases such as genetic disease or cancer, gene diagnosis, the development, etc., of a therapeutic agent. SOLUTION: This new human RNF5 gene comprises a base sequence capable of encoding a protein comprising an amino acid sequence represented by the formula or a protein comprising an amino acid sequence in which one or several amino acids are deleted, replaced or added in the amino acid sequence and having a binding activity to an RNF5 and is useful for the production, etc., of a human RNF5 protein useful for elucidation or research on the canceration, DNA repair, rearrangement, etc., of immunoglobulin and T cell receptor genes, elucidation of the morbid state of genetic disease, cancer, etc., associated therewith and diagnosis, therapy, etc., thereof. The gene is obtained by carrying out the sequence analysis of a cDNA clone optionally selected from a human fetal brain cDNA library and search for the database and providing the gene from a clone having a high homology with a ring-finger protein gene of a nematode.

2. 发明专利

JPH10286089A HUMAN GENE 失效
公开(公告)号：JPH10286089A
公开(公告)日：1998-10-27
申请号：JP9690897
申请日：1997-04-15
申请人： OTSUKA PHARMA CO LTD
发明人： SHIMIZU FUMIO , SUZUKI MIKIO , HORIE MASATO , TAKEI YOSHIKI
IPC分类号： G01N33/53 , A61K48/00 , C07H21/04 , C07K14/47 , C12N1/21 , C12N15/00 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/19 , C12R1/91 , G01N33/577
摘要： PROBLEM TO BE SOLVED: To obtain the subject new human rab 7GTP-bound similar protein gene containing a base sequence encoding a specific amino acid sequence and useful as an indicator for the condition clarification, prevention, diagnosis and treatment of genetic diseases, cancers, etc. SOLUTION: This new human rab 7GTP-bound similar protein contains a basic sequence encoding an amino acid sequence of the formula, and is used for detecting the expressions of the gene in various tissues, for analyzing the structure and function of the gene, and for the genetic engineering production of a human protein encoding the gene, etc. The analysis of the expression product, etc., enables the condition clarification, diagnoses and treatments of genetic diseases, cancers, etc. The gene is obtained by extracting a mRNA from each tissue such as human fetal brain, adult blood vessel or placenta, constructing a cDNA library with the extracted mRNA, chemically synthesizing a DNA sequence on the basis of information related to the DNA sequence of the gene, and subsequently screening the cDNA library by the use of the chemically synthesized DNA sequence as a probe.

3. 发明专利

JP2002253252A METHOD FOR ASSAYING CYTOTOXIC ACTIVITY 失效
公开(公告)号：JP2002253252A
公开(公告)日：2002-09-10
申请号：JP2001057152
申请日：2001-03-01
申请人： OTSUKA PHARMA CO LTD
发明人： AIHARA KIMITOKU , TANAKA MICHINORI , OGINO KOICHI , HORIE MASATO
IPC分类号： G01N33/50 , A61K39/395 , A61K45/00 , A61P9/08 , A61P25/00 , A61P25/16 , A61P25/28 , C07K14/16 , C07K14/47 , C07K16/10 , C07K16/18 , C07K19/00 , C12N15/09 , C12P21/08 , C12Q1/02 , G01N33/15
摘要： PROBLEM TO BE SOLVED: To provide a new method for assaying a cytotoxic activity, and a method for screening a compound affecting cytotoxic activity using the method. SOLUTION: This fused polypeptide (53 amino acid length) comprises a part of a protein transportation domain located (corresponding to 47-57 residue among 86 amino acid residues) at the C end side of TAT protein of HIV-1 virus and Aβ protein of 42 amino acid length connected to the C end side of the protein of the part.

4. 发明专利

JPH09308492A HUMAN GENE 失效
公开(公告)号：JPH09308492A
公开(公告)日：1997-12-02
申请号：JP6916397
申请日：1997-03-05
申请人： OTSUKA PHARMA CO LTD
发明人： FUJIWARA TSUTOMU , WATANABE TAKESHI , HORIE MASATO , KATAGIRI TOYOMASA
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , C07H21/04 , C07K14/47 , C12N9/00 , C12N9/12 , C12N9/64 , C12N15/12 , C12N15/54 , C12N15/55 , C12P21/02 , C12Q1/68 , C12R1/19
摘要： PROBLEM TO BE SOLVED: To obtain a new human gene coding a GDP dissociation promoting protein, capable of detecting expression in a human tissue, elucidating the state of a disease related to a genetic disease, a cancer, etc., diagnosing and treating the diseases, and producing a human protein by a genetic engineering method. SOLUTION: This new DOP dissociation promoting protein gene contains a base sequence coding an amino acid sequence of the formula and is useful for detecting expression in various human tissues, analyzing the structure and the function of the expression, producing a human protein by a genetic engineering method, elucidating the state of a disease related to a genetic disease, a cancer, etc., and diagnosing and treating the disease. The human gene is obtained by extracting an mRNA from tissues of human fetal brain, adult blood vessel and placenta, synthesizing a cDNA by using the mRNA, preparing a cDNA library by a conventional method and cloning the library by using a primer composed of a part of a GDP dissociation promoting gene by a PCR method.

5. 发明专利

JP2002045190A HUMAN GENE 失效
公开(公告)号：JP2002045190A
公开(公告)日：2002-02-12
申请号：JP2001172415
申请日：2001-06-07
申请人： OTSUKA PHARMA CO LTD
发明人： FUJIWARA TSUTOMU , WATANABE TAKESHI , HORIE MASATO , KATAGIRI TOYOMASA
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , A61P35/00 , C07K16/40 , C12N9/12
摘要： PROBLEM TO BE SOLVED: To obtain a human gene of which the expression in various human tissues can be detected and the structure or function is able to be analyzed and by which a human protein can be produced by gene engineering, and to make the analysis of expressed matters and the elucidation, diagnosis or treatment for the pathological state of diseases participating in genetic disease, cancer or the like possible by these means. SOLUTION: The new GDP dissociation accelerative protein gene containing a base sequence encoding a specific amino acid sequence derived from a human fatal brain is obtained.

6. 发明专利

JP2000109433A THERAPEUTIC AGENT FOR NEURODEGENERATIVE DISEASE 失效
公开(公告)号：JP2000109433A
公开(公告)日：2000-04-18
申请号：JP2916499
申请日：1999-02-05
申请人： OTSUKA PHARMA CO LTD
发明人： HORIE MASATO , HIRANO NAONOBU , KIYUUSHIKI HIROYUKI , MITSUMOTO YASUHIDE , MORI ATSUSHI , WATABE AKIHITO
IPC分类号： C12N15/09 , A61K31/00 , A61K38/00 , A61P25/00 , A61P25/28 , C07K14/47 , C07K14/52 , C12N15/12
摘要： PROBLEM TO BE SOLVED: To obtain the subject therapeutic agent effective for treating a neurodegenerative disease such as Parkinson's disease, Alzheimer's disease, etc., by making the therapeutic agent include a recombination protein functioning as a neurotrophic factor as an active ingredient. SOLUTION: This therapeutic agent for a neurodegenerative disease comprises at least one kind selected from (A) an expression substance containing 34-318 amino acid sequence part of TMP-2 protein of an amino acid sequence of the formula and (B) an expression substance containing an amino acid sequence part in which one or a plurality of amino acids are deleted, substituted or added in the 34-318 amino acid sequence of TMP-2 protein of the amino acid sequence of the formula as an active ingredient. Preferably a substance obtained by bonding histidine 6 residue to C-terminal of the 34-318 amino acid sequence or MBP-TMP-2 fused protein obtained by fusing N-terminal of the 34-318 amino acid sequence with a maltose bond protein is preferably used as the active ingredient.

7. 发明专利

JPH09182588A CLATHRIN-ADAPTOR PROTEIN GENE 失效
公开(公告)号：JPH09182588A
公开(公告)日：1997-07-15
申请号：JP26996
申请日：1996-01-05
申请人： OTSUKA PHARMA CO LTD
发明人： WATANABE TAKESHI , KIYUUSHIKI HIROYUKI , HORIE MASATO
IPC分类号： G01N33/53 , C07H21/04 , C07K14/47 , C07K14/705 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12R1/19 , C12R1/85 , G01N33/574
摘要： PROBLEM TO BE SOLVED: To obtain the subject new gene coding for a clathrin-adaptor protein having a specific amino acid sequence, capable of utilizing for expression and detection of the protein and useful for diagnosis of malignant ulcer and elucidation of condition and development of medicines for preventing and treating these diseases. SOLUTION: This new gene contains a base sequence coding for a clathrin- adaptor protein having an amino acid sequence represented by the formula and is utilizable for expression and detection of the clathrin-adaptor protein and can be utilized for diagnosis and elucidation of condition of various kinds of diseases such as malignant ulcer and screening, evaluation, etc., of medicines for treating and preventing diseases such as malignant ulcer related to the protein. The gene is obtained by carrying out immunological screening of human fetal brain and placenta cDNA library using an antibody specific to clathrin- adaptor protein or screening, etc., of the cDNA library due to hybridization using a probe selectively binding to the target DNA sequence to select a positive clone and then recovering the DNA.

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